Abstract:
BACKGROUND AND PURPOSE:Potassium channels are important regulators of resting tone in large cerebral arteries, but their activity and distribution may vary according to vessel location and species studied. In the cerebral microcirculation in vivo, however, these channels appear to be silent at rest. Our goal was to determine the activity of potassium channels of brain arterioles from 2 origins under basal conditions in vitro. METHODS:Penetrating cerebral (40. 9+/-2.2 microm control diameter) and brain stem (36.2+/-1.2 microm) arterioles of rats were prepared from middle cerebral and basilar arteries, respectively. The internal diameter of cannulated and pressurized vessel was monitored with the inverted microscope before and after administration of potassium channel inhibitors. In addition, we studied the effect of nitric oxide synthase inhibition on potassium channel activity. RESULTS:Cerebral and brain stem arterioles were significantly constricted by 4-aminopyridine and low concentration of BaCl(2) but not by glibenclamide. The addition of N:(omega)-nitro-L-arginine to 4-aminopyridine further decreased diameters of both arterioles. Tetraethylammonium ion caused a significant constriction of brain stem but not cerebral arteriole. The brain stem arteriole was further constricted by additional N:(omega)-nitro-L-arginine. CONCLUSIONS:Voltage-dependent and inward-rectifier, but not ATP-sensitive, potassium channels are active under basal conditions of rat cerebral and brain stem arterioles. There is a regional difference in the activity of calcium-activated potassium channels, which, at rest, are open in brain stem but silent in cerebral arterioles. In addition, basal endogenous nitric oxide may not contribute to the activation of voltage-dependent and calcium-activated potassium channels.
journal_name
Strokejournal_title
Strokeauthors
Horiuchi T,Dietrich HH,Tsugane S,Dacey RG Jrdoi
10.1161/01.str.32.1.218subject
Has Abstractpub_date
2001-01-01 00:00:00pages
218-24issue
1eissn
0039-2499issn
1524-4628journal_volume
32pub_type
杂志文章相关文献
STROKE文献大全abstract::Continuous-wave Doppler sonography is a reliable method for detecting severe subclavian stenosis and occlusion as well as subclavian steal. Intermediate stages leading to subclavian steal can also be detected. These are characterized by a cardiac-phase-dependent alternating flow direction in the vertebral artery. Some...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.9.3.229
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. METHODS:Using the Nationwide In...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002567
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of percutaneous transluminal coronary angioplasty (PTCA) to treat coronary artery disease is now commonplace. The occurrence of microemboli during invasive procedures such as cardiac angiography and bypass surgery is well documented, although neurological complications are relatively unco...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.11.2367
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis and is linked with mortality, cardiovascular events, and stroke. However, the role of FGF23 as a risk factor for subclinical cerebrovascular damage is unclear. METHODS:We used multivariable linear and logistic regressio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.012379
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to determine whether lobar cerebellar microbleeds or concomitant lobar cerebellar and deep microbleeds, in the presence of lobar cerebral microbleeds, attribute to underlying advanced cerebral amyloid angiopathy pathology or hypertensive arteriopathy. METHODS:We categorized 71 patients ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.028487
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite its low efficacy, aspirin is the most widely used drug for secondary stroke prevention. The reasons why stroke recurs while patients are on aspirin are unknown. We have analyzed a series of patients who had recurrent strokes while on aspirin. METHODS:Out of 2231 consecutive patients who ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.25.2.275
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little is known about the pattern of cerebrovascular disease (CVD) for diabetic and nondiabetic patients or about the cost of treatment for CVD in the United Kingdom. The purpose of this study was to extend previous work to describe the epidemiology and cost of acute care of CVD as a frequent com...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.6.1142
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited data are available on management of outpatients with stroke or transient ischemic attack (TIA) and on clinicians' reasons for withholding procedures recommended by guidelines. We assessed to what extent guidelines are appropriately applied after ischemic stroke or TIA, in admitted patient...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000226463.17988.a3
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000014773.57733.3e
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction. METHODS:We conducted a randomized, multicenter, blinded pi...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.107.493544
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1325
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The current work is based on our previous finding that in neuronal cells, nmol/L concentrations of alpha-tocotrienol (TCT), but not alpha-tocopherol (TCP), blocked glutamate-induced death by suppressing early activation of c-Src kinase and 12-lipoxygenase. METHODS:The single neuron microinjectio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000181082.70763.22
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS:Adult male wild-type or PAR-1 knock...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.661819
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported on the correlation of ultrasonic carotid plaque morphology, cerebrovascular symptoms, and intraplaque hemorrhage. This study correlates ultrasonic carotid plaque morphology with the degree of carotid stenosis. METHODS:Carotid arteries (n=2460) were examined by using...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000019127.11189.b5
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:[18F]fluoromisonidazole (FMISO) positron emission tomography has been used to image hypoxia early after human stroke. To further study the role of hypoxia in stroke and the binding characteristics of FMISO, we aimed to develop [3H]FMISO autoradiography in an animal stroke model. We hypothesized t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000226908.93295.9d
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with atrial fibrillation have a high risk of stroke and other vascular events even if anticoagulated. The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group. METHODS:This study was a subsidiary a...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/01.STR.0000181115.59173.42
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To verify the hemorheological effects of isovolemic hemodilution on hemodynamics and cerebral perfusion of normal humans, we tested the efficacy of isovolemic hemodilution in systemic hemodynamics and cerebral bood flow augmentation and its influences in vascular reserve. METHODS:Isovolemic hemo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.3.441
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:20% of ischemic stroke is in the posterior circulation, but there is little prospective data on early recurrent stroke risk and whether vertebrobasilar stenosis predicts a high recurrence risk. This natural history data are important as it is technically possible to stent such lesions. Contrast e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.553859
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.015957
更新日期:2017-04-01 00:00:00
abstract::Background and Purpose- We aimed to determine whether low-frequency electric field navigated repetitive transcranial magnetic stimulation to noninjured motor cortex versus sham repetitive transcranial magnetic stimulation avoiding motor cortex could improve arm motor function in hemiplegic stroke patients when combine...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.117.020607
更新日期:2018-09-01 00:00:00
abstract::In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.1.86
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.017305
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several hundred studies have been published over the last few years on imaging and measurement of carotid stenosis. Despite all this research, there is still no consensus about how best to image and measure stenosis. One possible explanation for this is that many of the studies have not been larg...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.31.6.1444
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:This systematic review summarizes the effectiveness of mirror therapy for improving motor function, activities of daily living, pain, and visuospatial neglect in patients after stroke. METHODS:We searched the Cochrane Stroke Group’s Trials Register (June 2011), the Cochrane Central Register of Controlled Tr...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/strokeaha.112.673087
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is the second leading cause of death in Japan. We sought to examine changes in stroke mortality rates by age, sex, and birth cohorts from 1950 to 1997. METHODS:The numbers of deaths from stroke and the population by age and sex in subjects aged 55 to 79 years between 1950 and 1997 were ob...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.8.1745
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim was to explore whether the mismatch in lesion visibility between b1000 and b0 images is an alternative to mismatch between diffusion-weighted imaging and fluid-attenuated inversion recovery imaging as a surrogate marker of stroke age. METHODS:We analyzed patients from the European multic...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.115.011501
更新日期:2016-03-01 00:00:00
abstract::To study the effects of antithrombotic therapy in experimental stroke, we have characterized a baboon model of acute cerebrovascular thrombosis. In this model an inflatable silastic balloon cuff has been implanted by transorbital approach around the right middle cerebral artery (MCA), proximal to the take-off of the l...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1254
更新日期:1986-11-01 00:00:00
abstract::The effect of ischemia on catecholamine and 5-hydroxytryptamine (5-HT) levels in brain cortex was examined in the gerbil stroke model. Unilateral common carotid artery occlusion produced bilateral decrease in cortical dopamine levels in gerbils both symptomatic and asymptomatic of cerbral ischemia. The 5-HT progressiv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.3.341
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2074
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The influence of stroke lateralization on functional and cardiovascular outcome after stroke is not well established. We evaluated the influence of hemispheric lateralization among patients enrolled in prospective acute stroke trials. METHODS:We obtained data from the VISTA database for acute st...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.523365
更新日期:2008-12-01 00:00:00