Abstract:
BACKGROUND AND PURPOSE:Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized that tPA could be involved in the pathophysiology of IA. METHODS:Immunofluorescence analyses of tPA and its main substrate within the aneurysmal wall of murine and human samples were performed. We then compared the formation and rupture of IAs in wild-type, tPA-deficient and type 1 plasminogen activator inhibitor-deficient mice subjected to a model of elastase-induced IA. The specific contribution of vascular versus global tPA was investigated by performing hepatic hydrodynamic transfection of a cDNA encoding for tPA in tPA-deficient mice. The formation and rupture of IAs were monitored by magnetic resonance imaging tracking for 28 days. RESULTS:Immunofluorescence revealed increased expression of tPA within the aneurysmal wall. The number of aneurysms and their symptomatic ruptures were significantly lower in tPA-deficient than in wild-type mice. Conversely, they were higher in plasminogen activator inhibitor-deficient mice. The wild-type phenotype could be restored in tPA-deficient mice by selectively increasing circulating levels of tPA via hepatic hydrodynamic transfection of a cDNA encoding for tPA. CONCLUSIONS:Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of IAs. Thus, tPA should be considered as a possible new target for the prevention of IAs formation and rupture.
journal_name
Strokejournal_title
Strokeauthors
Labeyrie PE,Goulay R,Martinez de Lizarrondo S,Hébert M,Gauberti M,Maubert E,Delaunay B,Gory B,Signorelli F,Turjman F,Touzé E,Courthéoux P,Vivien D,Orset Cdoi
10.1161/STROKEAHA.117.017305subject
Has Abstractpub_date
2017-09-01 00:00:00pages
2574-2582issue
9eissn
0039-2499issn
1524-4628pii
STROKEAHA.117.017305journal_volume
48pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198872.75377.34
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although our previous study demonstrated that dementia of the Binswanger type may be a disconnection dementia caused by leukoaraiosis, some hypertensive patients with marked leukoaraiosis do not develop dementia. The goal of the present study is to elucidate the pathophysiology of nondemented hyp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.11.1673
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Diffusion-weighted imaging (DWI) is the most sensitive MR sequence in acute arterial ischemic stroke but has not yet been evaluated in venous cerebral ischemia. We describe a patient with DWI performed at the acute phase of a venous ischemic stroke. CASE DESCRIPTION:A rapid cerebral MRI including DWI and fa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2649
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Purinergic nucleoside inosine elicits protection and regeneration during various injuries. The purpose of this study was to examine the protective effects of inosine against cerebral ischemia. METHODS:Adult Sprague-Dawley rats were anesthetized. Inosine, hypoxathine, or vehicle was administered ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000155747.15679.04
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited systemic microangiopathy with prevalently cerebral manifestations. Among the causes of death, sudden unexpected death seems to occur in a significant number of CADASIL patients. Be...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000254530.38417.07
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy. METHODS:In a randomized, double-blind, sham-controlled crossover trial, we assessed if anodal transcranial direct current stimulation compared to cath...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.110.609032
更新日期:2011-07-01 00:00:00
abstract::We studied 1,273 patients with ischemic cerebral infarction who were entered into the Stroke Data Bank, a prospective, observational study involving four university hospitals and the Biometry and Field Studies Branch of the National Institute of Neurological Disorders and Stroke. Forty patients had noniatrogenic recur...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.983
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Outcome after mechanical thrombectomy for ischemic stroke may be influenced by blood pressure (BP). This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy. METHODS:SIESTA (Sedation vs Intub...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.117.019709
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our aim was to estimate the cost-effectiveness of transferring patients with intracerebral hemorrhage from centers without specialized neurological intensive care units (neuro-ICUs) to centers with neuro-ICUs. METHODS:Decision analytic models were developed for the lifetime horizons. Model input...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006653
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate the incidence of retrograde flow from complex plaques (> or =4-mm-thick, ulcerated, or superimposed thrombi) of the descending aorta (DAo) and its potential role in embolic stroke. METHODS:Ninety-four consecutive acute stroke patients with aortic plaques > or =3-mm-thick in transe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.577775
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endovascular therapy has increasingly become the most common treatment for unruptured cerebral aneurysms in the United States. We evaluated a national, multi-hospital database to examine recent utilization trends and compare periprocedural outcomes between clipping and coiling treatments of unrup...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000196
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ischemic postconditioning, a brief episode of ischemia after a prolonged ischemic insult, has been found to reduce the delayed neuronal loss after stroke. However, the mechanisms underlying such endogenous neuroprotective strategy remain obscure. In this study, we try to explore the excitatory po...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.680181
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In 2008, the Ministry of Health and Welfare of South Korea initiated the Regional Comprehensive Stroke Center (CSC) program to decrease the incidence and mortality of stroke nationwide. We evaluated the performance of acute ischemic stroke management after the Regional CSC program was introduced....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006134
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Toll-like receptors (TLRs) and the scavenger receptor CD36 are key molecular sensors for the innate immune response to invading pathogens. However, these receptors may also recognize endogenous "danger signals" generated during brain injury, such as cerebral ischemia, and trigger a maladaptive in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.572552
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS:Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers w...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000073788.81170.1C
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Shoulder pain is a common complication after stroke that can impede participation in rehabilitation and has been associated with poorer outcomes. Evidence-based treatments for hemiplegic shoulder pain are limited. Suprascapular nerve block (SSNB) is a safe and effective treatment of shoulder pain...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.113.002471
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Microembolic signals (MESs) are detectable within the transcranial Doppler frequency spectrum downstream from vascular atherothrombotic or cardiothrombotic lesions. A frequent occurrence of MESs has also been shown during bypass surgery or after mechanical valve implantation. We sought to compile...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.107.491241
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:TIMI angiographic classification measures coronary residual flow and recanalization. We developed a Thrombolysis in Brain Ischemia (TIBI) classification by using transcranial Doppler (TCD) to noninvasively monitor intracranial vessel residual flow signals. We examined whether the emergent TCD TIB...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.str.32.1.89
更新日期:2001-01-01 00:00:00
abstract::A 39-year-old woman had an embolic upper division middle cerebral artery branch occlusion 3 hours after smoking the free base of cocaine ("crack"). Radionuclide ventriculography demonstrated cardiomyopathy, and echocardiography documented a left atrial thrombus. This case demonstrates that embolism is one mechanism of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.11.1632
更新日期:1990-11-01 00:00:00
abstract::Seventy-four patients with hypertensive putaminal hemorrhage (HPH) were followed at least 6 months after treatment and estimated by ADL. They were graded according to the state of consciousness on admission. The grading consists of 6 grades: Grade 1, fully conscious; Grade 2, somnolent; Grade 3, stuporous; Grade 4, se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.4.480
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous work has shown that cerebral microembolism detected with transcranial Doppler sonography distal to internal carotid artery stenosis occurs more frequently in recently symptomatic compared with asymptomatic patients. It has remained unclear whether cerebral microembolism also indicates a ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.11.2184
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke patients have a 15-fold increased risk of recurrent stroke, and those with > or =1 risk factor have a further increased risk of recurrence. Previous work found management of physiological risk factors after stroke to be unsatisfactory, but there is little information on behavioral risks wi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.8.1877
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We used a rat model of reversible spinal ischemia to assess the effect of spinal cord temperature on the development of neurological and histopathologic changes after 20 minutes of reversible aortic occlusion. Spinal cord blood flow and CO2 reactivity was tested by using laser Doppler before and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.10.2038
更新日期:1994-10-01 00:00:00
abstract::Although the blood flow tracer hexamethylpropyleneamine oxime is now widely used for cerebral blood flow mapping using single-photon emission computed tomography, its uptake into acutely ischemic brain has not been well studied. We performed a double-label autoradiographic study in which 99mTc-hexamethylpropyleneamine...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.10.1284
更新日期:1991-10-01 00:00:00
abstract::The present study deals with the factors affecting the prognosis in the acute stage of 29 cases with hypertensive thalamic hemorrhage diagnosed by CT scan. It was thought that the following factors were significantly related to the outcome of the patients who were unable to lead daily life, remained in vegetative stat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.4.493
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.015957
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to investigate the relationship between early NT-proBNP (N-terminal probrain natriuretic peptide) and all-cause death in patients receiving reperfusion therapy, including intravenous thrombolysis and endovascular thrombectomy (EVT). METHODS:This study included 1039 acute ischemic stroke...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029593
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to assess the long-term predictive usefulness of bone mineral density (BMD) for stroke incidence and stroke mortality. METHODS:The First National Health and Nutrition Examination Survey data were obtained from a nationally representative sample of noninstitutionalized civilians. A coho...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000065826.23815.A5
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.9.1881
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Few studies currently assess the health-related quality of life of individuals following a stroke. One of the major challenges of assessing quality of life is the high likelihood that after a stroke a patient will not be able to complete such an assessment. One practical solution is to have a fam...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.10.1888
更新日期:1997-10-01 00:00:00