Inosine reduces ischemic brain injury in rats.

abstract：BACKGROUND AND PURPOSE:Previously published meta-analyses exploring the effect of statins on stroke incidence included 20,000 patients and found a 2% to 30% risk reduction. It is not clear whether this is attributable to low-density lipoprotein-cholesterol (LDL-C) reduction. Statin trials have now included >90,000 pati...

journal_title：Stroke

authors： Amarenco P,Labreuche J,Lavallée P,Touboul PJ

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A pulsatility index (PI) represents vascular resistance distal to an examined artery. The purpose of the present study was to evaluate an association between plasma total homocysteine (tHcy) and PIs of the cerebral arteries in patients with ischemic stroke. METHODS:Consecutive patients with isch...

journal_title：Stroke

authors： Lim MH,Cho YI,Jeong SK

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of...

journal_title：Stroke

authors： Zhao W,Che R,Shang S,Wu C,Li C,Wu L,Chen J,Duan J,Song H,Zhang H,Ling F,Wang Y,Liebeskind D,Feng W,Ji X

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this experiment was to study the serial changes in brain intracellular pH, cerebral blood flow, and the oxidation/reduction level of intramitochondrial nicotinamide adenine dinucleotide fluorescence across the cortical surface during severe incomplete global ischemia. METHODS:Reduced ...

journal_title：Stroke

authors： Tomlinson FH,Anderson RE,Meyer FB

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased knowledge of stroke risk factors in the general population may lead to improved prevention of stroke. The objective of the present study was to assess knowledge of stroke risk factors and to determine factors associated with knowledge. METHODS:In a population-based survey, we sent a qu...

journal_title：Stroke

authors： Müller-Nordhorn J,Nolte CH,Rossnagel K,Jungehülsing GJ,Reich A,Roll S,Villringer A,Willich SN

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To clarify hemodynamic risk factors for hemorrhage in arteriovenous malformations (AVMs), the mean transit time (MTT) of feeding arteries and draining veins in AVMs with and without hemorrhage was measured and analyzed. METHODS:Morphological features such as the number and diameter of draining a...

journal_title：Stroke

authors： Todaka T,Hamada J,Kai Y,Morioka M,Ushio Y

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...

journal_title：Stroke

authors： Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease that clinically involves only the brain. Particularly early in the disease, patients can show substantial or complete recovery after individual strokes. Cortic...

journal_title：Stroke

authors： Reddy H,De Stefano N,Mortilla M,Federico A,Matthews PM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral microembolic signals detected by transcranial Doppler are frequent during carotid angioplasty with stenting and carotid endarterectomy (CEA). Their potential harmful effects on the brain are, however, unclear. The aim of this study was to relate the frequency and type of per-procedural m...

journal_title：Stroke

authors： Skjelland M,Krohg-Sørensen K,Tennøe B,Bakke SJ,Brucher R,Russell D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Current US guideline statements regarding primary and secondary cardiovascular risk prediction and prevention use absolute risk estimates to identify patients who are at high risk for vascular disease events and who may benefit from specific preventive interventions. These guidelines do not expli...

journal_title：Stroke

authors： Lackland DT,Elkind MS,D'Agostino R Sr,Dhamoon MS,Goff DC Jr,Higashida RT,McClure LA,Mitchell PH,Sacco RL,Sila CA,Smith SC Jr,Tanne D,Tirschwell DL,Touzé E,Wechsler LR,American Heart Association Stroke Council.,Council on

更新日期：2012-07-01 00:00:00

abstract：:Longitudinal stretch of the rabbit basilar artery produces local injury followed by prolonged circular constriction. After stretching and rapid release in vitro localized constrictions promptly occurred. This could be prevented by prior treatment with cyanide or calcium-free solution. Once produced, constrictions pers...

journal_title：Stroke

authors： Duckles SP,Bevan RD,Bevan JA

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Aspirin is preventive against stroke not only because of its antithrombotic properties but also by other direct effects. The aim of this study was to elucidate its direct neuroprotective effects. METHODS:Viability parameters, glutamate release and uptake, and ATP levels were measured in cultured...

journal_title：Stroke

authors： De Cristóbal J,Cárdenas A,Lizasoain I,Leza JC,Fernández-Tomé P,Lorenzo P,Moro MA

更新日期：2002-01-01 00:00:00

abstract：:Background and Purpose- Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic hydrocephalus and poor neurological outcomes. Iron has been implicated in ventriculomegaly, hippocampal injury, and poor outcomes following IVH. We hypothesized that levels of cerebrospinal fluid blood break...

journal_title：Stroke

authors： Mahaney KB,Buddhala C,Paturu M,Morales D,Limbrick DD Jr,Strahle JM

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) enables visualization of the intracranial parenchymal structures and measurement of blood flow velocity in the basal cerebral arteries. The present study aims to evaluate prospectively the clinical usefulness of TCCS in patients with acute stroke....

journal_title：Stroke

authors： Seidel G,Kaps M,Gerriets T

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Hypertension occurs frequently after carotid endarterectomy and may lead to cerebral vascular complications and myocardial infarction. Its pathophysiology has recently been related to surgically induced damage of carotid baroreceptors. CASE DESCRIPTION:A 45-year-old normotensive man with no history of epile...

journal_title：Stroke

authors： Ille O,Woimant F,Pruna A,Corabianu O,Idatte JM,Haguenau M

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Discharge ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification) codes have been used to identify patients with acute stroke for epidemiological, quality of care, and cost studies. The aim of this study was to determine if the accuracy of the primary ICD-9-CM cod...

journal_title：Stroke

authors： Goldstein LB

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The reliability of the National Institutes of Health Stroke Scale (NIHSS) has been established through testing its use in live and videotaped patients. This reliability testing has primarily focused on the use of the scale by neurologists. We sought to determine the reliability of the NIHSS as us...

journal_title：Stroke

authors： Goldstein LB,Samsa GP

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The relationship between the pattern of alcohol intake and the risk of stroke is unclear, in particular the increased risk observed in abstainers and the possible protective effect of light to moderate drinking. For that reason, we examined in a large prospective study the role of alcohol consump...

journal_title：Stroke

authors： Wannamethee SG,Shaper AG

更新日期：1996-06-01 00:00:00

abstract：:Life table analysis is a powerful statistical tool that has become the preferred technique for studying both the natural history of and the effect of treatment on disease outcome. We have found only one report using life table analysis to study rehabilitation outcome after stroke. We assessed the recovery of both inde...

journal_title：Stroke

authors： Reding MJ,Potes E

更新日期：1988-11-01 00:00:00

abstract：:Glycosylated hemoglobin concentration (GHb), which is considered an indication of glycemia over the preceding several months, was examined in 50 patients hospitalized for recent stroke or transient ischemic attacks (TIA), and compared to that in several reference populations. Patients with stroke or TIA had GHb (mean ...

journal_title：Stroke

authors： Riddle MC,Hart J

更新日期：1982-05-01 00:00:00

abstract：:The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...

journal_title：Stroke

authors： Roth EJ,Mueller K,Green D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL ...

journal_title：Stroke

authors： Liu ML,Ylitalo K,Nuotio I,Salonen R,Salonen JT,Taskinen MR

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pretreatment lesion size on diffusion-weighted imaging (DWI) is a risk factor for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment. Here, we investigated whether the Alberta Stroke Programme Early CT Score (ASPECTS) applied to DWI images (DWI-ASPECTS) predicts sI...

journal_title：Stroke

authors： Singer OC,Kurre W,Humpich MC,Lorenz MW,Kastrup A,Liebeskind DS,Thomalla G,Fiehler J,Berkefeld J,Neumann-Haefelin T,MR Stroke Study Group Investigators.

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...

journal_title：Stroke

authors： Husemann B,Müller F,Krewer C,Heller S,Koenig E

更新日期：2007-02-01 00:00:00

abstract：:Background and Purpose- We aimed to compare outcomes of ischemic stroke patients with nonvalvular atrial fibrillation between earlier and later initiation of direct oral anticoagulants (DOACs) after stroke onset. Methods- From data for 1192 nonvalvular atrial fibrillation patients with acute ischemic stroke or transie...

journal_title：Stroke

authors： Mizoguchi T,Tanaka K,Toyoda K,Yoshimura S,Itabashi R,Takagi M,Todo K,Shiozawa M,Yagita Y,Yoshimoto T,Terasaki T,Yamagami H,Takizawa S,Inoue M,Kamiyama K,Ihara M,Okada Y,Kitazono T,Koga M,SAMURAI Study Investigators.

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...

journal_title：Stroke

authors： Harari D,Norton C,Lockwood L,Swift C

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Apoptotic-like pathways may contribute to brain cell death after intracerebral hemorrhage. In this study, we used a simplified in vitro model of hemoglobin neurotoxicity to map the caspase cascades involved and to document the role of oxidative stress. METHODS:Primary neuronal cultures were obta...

journal_title：Stroke

authors： Wang X,Mori T,Sumii T,Lo EH

更新日期：2002-07-01 00:00:00

abstract：:The authors report an autopsy case with repeated transient ischemic attacks and subsequent strokes demonstrating evidence of artery-to-artery embolism from thrombi generated in the stenotic middle cerebral artery to the distal cortical branches. This case substantiates the existence of intracranial artery-to-artery em...

journal_title：Stroke

authors： Masuda J,Ogata J,Yutani C,Miyashita T,Yamaguchi T

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic-ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology. METHODS:On postnatal day 7, mice wer...

journal_title：Stroke

authors： Ten VS,Wu EX,Tang H,Bradley-Moore M,Fedarau MV,Ratner VI,Stark RI,Gingrich JA,Pinsky DJ

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In Asian populations, few studies investigated the association between stroke and common carotid artery intima-media thickness (IMT). Our previous case-control studies showed that low end-diastolic velocity (EDV) in common carotid artery, a potential hemodynamic marker of intracranial resistance,...

journal_title：Stroke

authors： Chuang SY,Bai CH,Chen JR,Yeh WT,Chen HJ,Chiu HC,Shiu RS,Pan WH

更新日期：2011-05-01 00:00:00