Abstract:
BACKGROUND AND PURPOSE:The reliability of the National Institutes of Health Stroke Scale (NIHSS) has been established through testing its use in live and videotaped patients. This reliability testing has primarily focused on the use of the scale by neurologists. We sought to determine the reliability of the NIHSS as used by non-neurologists in the context of a clinical trial. METHODS:In anticipation of the initiation of a randomized trial of a new therapy for patients with acute ischemic stroke, 30 physician investigators (30% of whom were not neurologists) and 29 non-physician study coordinators were trained in the use of the NIHSS at an informational and training conference using standardized videotaped patient examinations. A series of 4 patients were rated initially. After 3 months, the same 4 patients were rerated, providing a measure of intraobserver reliability. An additional series of 4 new patients were also rated after 3 months and, with the initial 4 ratings, provided data for assessment of interobserver reliability. RESULTS:Overall, 28% of the raters had previous experience with the NIHSS, and 22% had previously used the videotapes as used in the present trial. The coefficients of determination (r2) were each greater than .95 when the means of the two ratings of the same 4 cases were compared between (1) neurologists and other types of physicians, (2) physicians and study coordinators, (3) raters who had prior experience with the NIHSS and those without prior experience, and (4) raters who had used the videotapes in the past and those who had never viewed the tapes. The calculated r2s were greater than .98 for the initial rating of the first 4 cases and for the later rating of the 4 new cases. The slopes of the regression lines were all near 1, indicating that the raters were similarly calibrated. The intraclass correlation coefficients were .93 and .95, reflecting high levels of intraobserver and interobserver reliability. CONCLUSIONS:These data extend the previously demonstrated reliability of the NIHSS to non-neurologists and show that both a variety of physician investigators and nurse study coordinators can be rapidly trained to reliably apply the scale in the context of an actual clinical trial.
journal_name
Strokejournal_title
Strokeauthors
Goldstein LB,Samsa GPdoi
10.1161/01.str.28.2.307subject
Has Abstractpub_date
1997-02-01 00:00:00pages
307-10issue
2eissn
0039-2499issn
1524-4628journal_volume
28pub_type
杂志文章相关文献
STROKE文献大全abstract::Exposure of Mongolian gerbils to a 100% oxygen atmosphere after 15 minutes of global brain ischemia resulted in a marked increase in the production of pentane, an in vivo product of lipid peroxidation. Much less pentane production occurred in animals subjected to global brain ischemia then exposed to an air atmosphere...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.426
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Accumulating evidence indicates that inflammatory responses cause secondary injury after intracerebral hemorrhage (ICH). We recently demonstrated the involvement of toll-like receptor 4 (TLR4) signaling in these processes. The purpose of the current study was to investigate the protective effect ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001038
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when pro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020980
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Emergency medical services routing of patients with acute stroke to designated centers may increase the proportion of patients receiving care at facilities meeting national standards and augment recruitment for prehospital stroke research. METHODS:We analyzed consecutive patients enrolled within...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.010264
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the efficacy of endovascular treatment (EVT) in patients with anterior circulation ischemic stroke (AIS) is well documented, early neurological deterioration after EVT remains a serious issue associated with poor outcome. Besides obvious causes, such as lack of reperfusion, procedural co...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.029494
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The best method of selecting endarterectomy candidates for cerebral angiography is controversial. Carotid duplex ultrasound (CDUS) is widely used, but its performance varies across institutions. The clinical utility of CDUS could be improved with test criteria based on patient outcome rather than...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.6.1094
更新日期:1996-06-01 00:00:00
abstract::We studied ultrastructurally cerebral perforating arteries in 60 stroke-prone spontaneously hypertensive rats (SHRSP), which were sequentially killed at 4-52 weeks of age before showing symptoms of stroke. Another 24 SHRSP were killed soon after they showed symptoms of cerebral infarction. The initial vascular lesions...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.4.733
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Three-dimensional MRI segmentation may be useful to better understand the physiopathology of lacunar infarctions. Using this technique, the distribution of lacunar infarctions volumes has been recently reported in patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.520825
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy, which mainly involves the brain causing stroke and dementia. Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, b...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.490029
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment. METHODS:The consecutive 585 patients with ICH admitted ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006661
更新日期:2014-09-01 00:00:00
abstract::A patient with diffuse and focal cerebral dysfunction was found to have absent peripheral pulses. Cerbral angiography revealed evidence of an arteritis with bilateral high grade carotid stenosis. When there was no laboratory confirmation of the arteritis, an iatrogenic etiology (ergotism) was suspected. This was later...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.1.88
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates of the absolute and relative risks of stroke recurrence in an unselected cohort of patients with a first-ever stroke. METHODS:Six hundred seventy-five patients were...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.2.333
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies. We sought to determine whether white blood cell count (WBC) is associated with carotid plaque thickness in a stroke-free, multiethnic cohort. METHODS:For this cross-se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.4.842
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.26.10.1811
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Urinary incontinence (UI) is a common and distressing problem after stroke. Although there is evidence of new, effective UI poststroke rehabilitation intervention, it is unknown whether occupational therapists (OTs)' and physical therapists (PTs)' actual practices reflect best practices. We sough...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486035
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual Internat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.106.473579
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The shape and exact size of lacunar infarcts have been investigated only postmortem. Recent imaging techniques based on triangulation and connectivity can now be used for 3D segmentation of cerebral lesions. The shape and size of lacunar infarcts was investigated using these techniques in 10 cere...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000185678.26296.38
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the safety and feasibility of partial aortic occlusion immediately after intravenous tissue plasminogen activator. METHODS:We conducted an open-label pilot study of partial aor...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.607846
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited systemic fibrinolysis and reduced dosage are features of intra-arterial thrombolyis (IAT) that may be advantageous in the treatment of postoperative strokes. However, IAT may increase the risk of surgical bleeding. We sought to determine the safety of postoperative IAT. METHODS:This was ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.6.1365
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The collagen alpha2(I) gene (COL1A2) on chromosome 7q22.1, a positional and functional candidate for intracranial aneurysm (IA), was extensively screened for susceptibility in Japanese IA patients. METHODS:Twenty-one single nucleotide polymorphisms (SNPs) of COL1A2 were genotyped in genomic DNA ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000110788.45858.DC
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). METHODS:Clinical and angiograp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.6.1167
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The current report details our initial periprocedural experience with Wingspan (Boston Scientific/Target), the first self-expanding stent system designed for the treatment of intracranial atheromatous disease. METHODS:All patients undergoing angioplasty and stenting with the Gateway balloon-Wing...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000257963.65728.e8
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to demonstrate the contribution of axonal remodeling of the corticospinal tract (CST) in the spinal cord to functional outcome after stroke. METHODS:Bilateral pyramidotomy (BPT) or sham-BPT was performed in mice with transgenic yellow fluorescent protein labeling in the CST subjected t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001162
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Combined effects of socioeconomic position and well-established risk factors on stroke incidence have not been formally investigated. METHODS:In a pooled cohort study of 68 643 men and women aged 30 to 70 years in Denmark, we examined the combined effect and interaction between socioeconomic pos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005252
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We describe the clinical, diagnostic, and outcome features of a cohort of white patients with idiopathic moyamoya disease treated in a German institution. METHODS:Our cohort included 21 white patients with moyamoya disease. Clinical and diagnostic features were obtained by retrospective chart re...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.513408
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral sinovenous thrombosis is a rare disease with severe neurological sequelae. The aim of this retrospective multicenter study was to investigate the clinical course, possible risk factors, and outcome of a cohort of neonatal patients with sinovenous thrombosis and, second, to estimate the i...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.583542
更新日期:2010-07-01 00:00:00
abstract::Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.1.59
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198872.75377.34
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite a high incidence of poststroke dementia, there is no specific treatment for this condition. Because the evaluation of poststroke cognitive deficits in animal models of stroke is exceedingly challenging, the preclinical evaluation of candidate drugs is limited. We aimed to explore the impa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001907
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The efficacy and safety of different antiplatelet regimes for prevention of stroke in patients at high risk were investigated in a systematic review and meta-analysis. METHODS:We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Web of Science. Twenty-two studies comprisi...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.113.002590
更新日期:2014-02-01 00:00:00