Abstract:
:We studied ultrastructurally cerebral perforating arteries in 60 stroke-prone spontaneously hypertensive rats (SHRSP), which were sequentially killed at 4-52 weeks of age before showing symptoms of stroke. Another 24 SHRSP were killed soon after they showed symptoms of cerebral infarction. The initial vascular lesions observed in the asymptomatic group included focal cytoplasmic necrosis in the outer layers of the media. This change progressed to widespread medial necrosis with time. In the infarction group, numerous monocytes were seen adhering to the endothelium of the arteries having advanced medial damage. Following the adherence of monocytes to the endothelium, large amounts of plasma components were visible in the arterial wall. The accumulation of the plasma components (especially fibrin) thickened the wall, narrowed the lumen, and resulted in occlusion. These results suggest that monocytes may affect the endothelium, perhaps disturbing the so-called blood-brain barrier to proteins. The monocytes may therefore be closely related to the occurrence of arterial occlusion with resultant cerebral infarction.
journal_name
Strokejournal_title
Strokeauthors
Tagami M,Nara Y,Kubota A,Sunaga T,Maezawa H,Fujino H,Yamori Ydoi
10.1161/01.str.18.4.733subject
Has Abstractpub_date
1987-07-01 00:00:00pages
733-40issue
4eissn
0039-2499issn
1524-4628journal_volume
18pub_type
杂志文章相关文献
STROKE文献大全abstract::We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the x...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.12.1662
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral ischemia and stroke are leading causes of morbidity and mortality. An approach to protecting the brain during ischemia is to try to increase the delivery of oxygen via the residual blood flow through and around ischemic tissue. To test this hypothesis, we used a novel oxygen delivery age...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.8.1624
更新日期:1997-08-01 00:00:00
abstract::The trends in age adjusted and age and sex specific mortality rates for the period 1968-1980 are compared for ischaemic heart disease and cerebrovascular disease. For both sexes and at all ages over 45 the mortality rates for cerebrovascular disease have fallen significantly. However, the mortality rates for ischaemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.5.582
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used (14)C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.005461
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lower concentrations of albumin have been positively related to coronary disease. The aim of this project was to assess the association between serum albumin and carotid atherosclerosis. METHODS:B-mode ultrasound was used to assess carotid plaques and intima-media thickness (IMT) among white sub...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.0000048675.97975.84
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this experiment was to study the serial changes in brain intracellular pH, cerebral blood flow, and the oxidation/reduction level of intramitochondrial nicotinamide adenine dinucleotide fluorescence across the cortical surface during severe incomplete global ischemia. METHODS:Reduced ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.3.435
更新日期:1993-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). METHODS:Clinical and angiograp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.6.1167
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with function...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000126482.86708.37
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Enhanced angiogenesis facilitates neurovascular remodeling processes and promotes brain functional recovery after stroke. Previous studies from our laboratory demonstrated that valproate (VPA), a histone deacetylase inhibitor, protects against experimental brain ischemia. The present study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.652545
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We assessed the influence of different visual stimuli and the reproducibility and habituation of evoked flow responses using simultaneous two-channel transcranial Doppler monitoring and flow velocity averaging. METHODS:We measured stimulus-related percentage changes in posterior cerebral, basila...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.12.2256
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of our study was to compare lesion location between moyamoya disease-related intracerebral hemorrhage (MMD-ICH) and primary intracerebral hemorrhage (P-ICH). METHODS:Ninety-three patients each with MMD-ICH and P-ICH were compared. In patients with MMD-ICH, angiographic findings were ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.654004
更新日期:2012-07-01 00:00:00
abstract::Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in v...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.1085
更新日期:1989-08-01 00:00:00
abstract::Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021981
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study was conducted to analyze the association between reported risk factors for Alzheimer's disease, apolipoprotein E epsilon4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer's disease. METHODS:Our data are based on clinical and pos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.3.613
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The prevalence of constipation after stroke varies from 30% to 60%. The incidence of new-onset constipation during the early stage of stroke remains uncertain. The present study was designed to investigate the prevalence of new-onset constipation, its risk factors, and its impact on stroke outcom...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.534776
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this investigation was to compare the respective efficacy of transcranial Doppler sonography (TCD) and magnetic resonance angiography (MRA) for the assessment of intracranial hemodynamics in patients with extracranial occlusion or severe stenosis of the internal carotid artery (ICA). ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.2.214
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) may increase the risk of embolic stroke of undetermined source (ESUS). Guidelines suggest anticoagulation may be more effective than antiplatelets in preventing stroke in patients with ESUS and PFO when interventional closure is not performed. METHODS:Patients with ESU...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031237
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND AND PURPOSE:Although lacunar stroke (LS) and deep intracerebral hemorrhage (dICH) represent acute manifestations of the same pathological process involving cerebral small vessels (small vessel disease), it remains unclear what factors predispose to one phenotype rather than the other at individual level. ME...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013722
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To establish a less invasive and reproducible focal ischemia model in the rat, we adopted a 2-laser system (ie, photothrombosis and YAG laser-induced reperfusion). METHODS:The distal middle cerebral artery (MCA) of spontaneously hypertensive rats was occluded by 568-nm krypton laser and intraven...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000094730.38343.73
更新日期:2003-11-01 00:00:00
abstract::The frequency of angiographically defined asymptomatic CAD in patients with carotid disease is 40%. Although the prognosis of patients with asymptomatic 1-vessel or 2-vessel CAD is good (annual cardiac mortality rate less than 2%), the prognosis of asymptomatic 3-vessel disease or left main CAD is substantially less f...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.23.3.433
更新日期:1992-03-01 00:00:00
abstract::Acute cerebral circulatory changes following experimental cerebral hemorrhage were investigated in eight cats. The cerebral hemorrhage was produced in the right basal ganglia by introducing arterial blood via a thin catheter, using the systemic arterial blood pressure of the cat as a driving force. Local cerebral bloo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.8.991
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Findings on transesophageal echocardiography (TEE) after ischemic stroke predict recurrent embolic events and prompt therapy; however, the additive predictive power of TEE findings on long-term mortality is unknown. Our goal was to study the impact of TEE findings on all cause mortality in ischem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196939.12313.16
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The majority of ischemic stroke patients receiving endovascular recanalization therapy (EVT) experience variable changes of neurological severities during the hyperacute period. We hypothesized that the National Institutes of Health Stroke Scale (NIHSS) score after EVT is a better prognostic fact...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.020587
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pending the results of randomized controlled trials, the benefit and safety of bridging therapy (combined intravenous and intra-arterial thrombolysis) remain to be determined. The aim of this analysis was to give reliable estimates of efficacy and safety outcomes of bridging therapy. METHODS:We ...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.111.635029
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke-induced neuroinflammation and white matter damage are associated with neurological deficits. Whether D-4F, an apolipoprotein A-I mimetic peptide, treatment of stroke decreases neuroinflammation and white matter damage and improves functional outcome has not been investigated. METHODS:Adul...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.011046
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The collagen alpha2(I) gene (COL1A2) on chromosome 7q22.1, a positional and functional candidate for intracranial aneurysm (IA), was extensively screened for susceptibility in Japanese IA patients. METHODS:Twenty-one single nucleotide polymorphisms (SNPs) of COL1A2 were genotyped in genomic DNA ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000110788.45858.DC
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although our previous study demonstrated that dementia of the Binswanger type may be a disconnection dementia caused by leukoaraiosis, some hypertensive patients with marked leukoaraiosis do not develop dementia. The goal of the present study is to elucidate the pathophysiology of nondemented hyp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.11.1673
更新日期:1992-11-01 00:00:00
abstract::To study the effects of antithrombotic therapy in experimental stroke, we have characterized a baboon model of acute cerebrovascular thrombosis. In this model an inflatable silastic balloon cuff has been implanted by transorbital approach around the right middle cerebral artery (MCA), proximal to the take-off of the l...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1254
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial Doppler (TCD) and carotid duplex (CD) provide rapid and safe screening for stroke patients but are highly operator dependent. We explored the feasibility of telemedicine (TM)-guided TCD/CD administered by a health care provider inexperienced with ultrasound. METHODS:Dual video scree...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000196988.45318.97
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke Health and Risk Education Project was a cluster-randomized, faith-based, culturally sensitive, theory-based multicomponent behavioral intervention trial to reduce key stroke risk factor behaviors in Hispanics/Latinos and European Americans. METHODS:Ten Catholic churches were randomize...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.010678
更新日期:2015-10-01 00:00:00