Breathing 100% oxygen after global brain ischemia in Mongolian Gerbils results in increased lipid peroxidation and increased mortality.

abstract：:The study of focal central nervous system ischemia has been impeded by the lack of animal models that are both reproducible and simulate human ischemic strokes. To circumvent these problems, we have developed a rabbit spinal cord infarction model. Infarction of the caudal lumbar cord is produced by temporary occlusion...

journal_title：Stroke

authors： Zivin JA,DeGirolami U

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...

journal_title：Stroke

authors： Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

更新日期：2015-07-01 00:00:00

abstract：:A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The initial thrombus was present only in the right channel of a congenitally bifurcated superior sagittal sinus. This diagnosis and subsequent thrombus extension were readily shown by magnetic resonance imaging in contrast...

journal_title：Stroke

authors： Hosley MA,Fisher M,Lingley JF

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although our previous study demonstrated that dementia of the Binswanger type may be a disconnection dementia caused by leukoaraiosis, some hypertensive patients with marked leukoaraiosis do not develop dementia. The goal of the present study is to elucidate the pathophysiology of nondemented hyp...

journal_title：Stroke

authors： Yao H,Sadoshima S,Ibayashi S,Kuwabara Y,Ichiya Y,Fujishima M

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition has been hypothesized to provide neuroprotective efficacy after cerebral ischemia on the basis of the activity in experimental ischemia models of a variety of compounds with varying selectivity for AMPA over other...

journal_title：Stroke

authors： Menniti FS,Buchan AM,Chenard BL,Critchett DJ,Ganong AH,Guanowsky V,Seymour PA,Welch WM

更新日期：2003-01-01 00:00:00

abstract：:We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...

journal_title：Stroke

authors： Yaqub BA,Shamena AR,Kolawole TM,Patel PJ

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aims of this study were to determine the magnitude of the increase in fracture risk after hospitalization for stroke, and in particular to determine the time course of this risk. METHODS:The records of the Swedish register of patients admitted during 1987-1996 were examined to identify all p...

journal_title：Stroke

authors： Kanis J,Oden A,Johnell O

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The joint effect of risk factors on the risk of aneurysmal SAH (aSAH) has been studied sparsely. METHODS:We examined the potential synergism between cigarette smoking, hypertension, and regular alcohol consumption and the risk of aSAH in a prospective, population-based cohort of participants fro...

journal_title：Stroke

authors： Lindekleiv H,Sandvei MS,Romundstad PR,Wilsgaard T,Njølstad I,Ingebrigtsen T,Vik A,Mathiesen EB

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The absence of a widely available and sensitive diagnostic test for acute cerebral ischemia remains a significant limitation in the diagnosis and management of stroke. The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of...

journal_title：Stroke

authors： Lynch JR,Blessing R,White WD,Grocott HP,Newman MF,Laskowitz DT

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Physiologically, it appears plausible for physical activity to decrease stroke risk; however, epidemiological studies have produced mixed findings. Furthermore, few studies have examined specific kinds and intensities of activities. The purpose of this study was to examine the association between...

journal_title：Stroke

authors： Lee IM,Paffenbarger RS Jr

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador. METHODS:O...

journal_title：Stroke

authors： Del Brutto VJ,Zambrano M,Mera RM,Del Brutto OH

更新日期：2015-07-01 00:00:00

abstract：:True, three-dimensional proton nuclear magnetic resonance imaging at 0.147 tesla was performed postmortem on 2 patients embodying various stroke syndromes, including chronic (4 and 15 years) infarction, subacute (within 1 week) bland infarction, acute (2 days) hemorrhagic infarction, and hematoma secondary to ruptured...

journal_title：Stroke

authors： DeWitt LD,Kistler JP,Miller DC,Richardson EP Jr,Buonanno FS

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dichloroacetate facilitates a decrease in brain lactate during reperfusion after incomplete ischemia. This study examined the possible activation of pyruvate dehydrogenase enzyme by dichloroacetate to explain this effect. Because the duration of ischemia and hyperglycemia exacerbate ischemic brai...

journal_title：Stroke

authors： Dimlich RV,Nielsen MM

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Milk fat globule-EGF factor-8 (MFGE8) has been reported to be neuroprotective in ischemic stroke. However, the effects of MFGE8 in early brain injury after subarachnoid hemorrhage (SAH) have not been investigated. We investigated the role of MFGE8 in early brain injury and the potential mechanism...

journal_title：Stroke

authors： Liu F,Hu Q,Li B,Manaenko A,Chen Y,Tang J,Guo Z,Tang J,Zhang JH

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Data are scarce on both stroke incidence rates and outcomes in Greece and in rural areas in particular. We performed a prospective population-based study evaluating the incidence of first-ever stroke in the Evros prefecture, a region of a total 147 947 residents located in North Eastern Greece. ...

journal_title：Stroke

authors： Tsivgoulis G,Patousi A,Pikilidou M,Birbilis T,Katsanos AH,Mantatzis M,Asimis A,Papanas N,Skendros P,Terzoudi A,Karamanli A,Kouroumichakis I,Zebekakis P,Maltezos E,Piperidou C,Vadikolias K,Heliopoulos I

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Variation in the outcome after aneurysmal subarachnoid hemorrhage (SAH) is not fully explained by known prognostic factors. APOE genotype is the most important genetic determinant of susceptibility to Alzheimer's disease, and it is also shown to be associated with the outcome after traumatic brai...

journal_title：Stroke

authors： Niskakangas T,Ohman J,Niemelä M,Ilveskoski E,Kunnas TA,Karhunen PJ

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolyti...

journal_title：Stroke

authors： Cesarman-Maus G,Cantú-Brito C,Barinagarrementeria F,Villa R,Reyes E,Sanchez-Guerrero J,Hajjar KA,Latorre EG

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prediction of stroke in healthy individuals is challenging and there is a diurnal variation of stroke onset. We hypothesized that heart rate variability with a focus on nighttime heart rate variability will predict the risk of stroke in apparently healthy middle-age and elderly subjects. METHODS...

journal_title：Stroke

authors： Binici Z,Mouridsen MR,Køber L,Sajadieh A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Some strokes of unknown etiology may be the result of a paradoxical embolism traversing through a nonfused foramen ovale (patent foramen ovale [PFO]). The utility of percutaneously placed devices for treatment of patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO is unkno...

journal_title：Stroke

authors： Furlan AJ,Reisman M,Massaro J,Mauri L,Adams H,Albers GW,Felberg R,Herrmann H,Kar S,Landzberg M,Raizner A,Wechsler L,CLOSURE I Investigators.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricu...

journal_title：Stroke

authors： Naff N,Williams MA,Keyl PM,Tuhrim S,Bullock MR,Mayer SA,Coplin W,Narayan R,Haines S,Cruz-Flores S,Zuccarello M,Brock D,Awad I,Ziai WC,Marmarou A,Rhoney D,McBee N,Lane K,Hanley DF Jr

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with atrial fibrillation have a high risk of stroke and other vascular events even if anticoagulated. The primary objective here is to determine whether routine blood pressure-lowering provides additional protection for this high-risk patient group. METHODS:This study was a subsidiary a...

journal_title：Stroke

authors： Arima H,Hart RG,Colman S,Chalmers J,Anderson C,Rodgers A,Woodward M,MacMahon S,Neal B,PROGRESS Collaborative Group.

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...

journal_title：Stroke

authors： Zhang F,Wang S,Signore AP,Chen J

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid angioplasty and stenting (CAS) has a higher incidence of periprocedural stroke compared with endarterectomy. Identifying CAS steps with the highest likelihood of embolization may have important implications. We evaluated CAS safety by correlating the findings of procedural transcranial Do...

journal_title：Stroke

authors： Almekhlafi MA,Demchuk AM,Mishra S,Bal S,Menon BK,Wiebe S,Clement FM,Wong JH,Hill MD,Goyal M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory cytokines are involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). This study was conducted to examine the role of p38 mitogen-activated protein kinase (MAPK) in the development of vasospasm and cytokine production. METHODS:We measured the expressi...

journal_title：Stroke

authors： Sasaki T,Kasuya H,Onda H,Sasahara A,Goto S,Hori T,Inoue I

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mechanisms of initiation, progression and rupture of cerebral aneurysms have not yet been fully understood despite its clinical significance. Matrix metalloproteinases (MMPs) are a family of proteinases which are involved in the remodeling of vascular walls. In the present study, we investigated ...

journal_title：Stroke

authors： Aoki T,Kataoka H,Morimoto M,Nozaki K,Hashimoto N

更新日期：2007-01-01 00:00:00

abstract：:Intravenously injected metaraminol induced a larger blood pressure increase in spontaneously hypertensive rats (SHR) than in normotensive controls (NR) when the pressure was raised from the same starting level. Cerebral blood flow (CBF) response in NR was either perfect autoregulation, partial autoregulation or "break...

journal_title：Stroke

authors： Johansson BB,Nilsson B

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We have previously reported that extracellular ATP activates P(2u) receptors and increases intracellular free Ca(2+) ([Ca(2+)](i)) by G protein/phospholipase C/inositol 1,4,5-triphosphate pathways in cerebral artery smooth muscle cells. However, the possible contribution of other signaling pathwa...

journal_title：Stroke

authors： Aoki K,Zubkov AY,Parent AD,Zhang JH

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The visual analogue scale is a self-reported, validated tool to measure quality of life (QoL). Our purpose was to determine whether baseline QoL predicted strokes in the ALLHAT study (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) and evaluate determinants of poststr...

journal_title：Stroke

authors： Shams T,Auchus AP,Oparil S,Wright CB,Wright J,Furlan AJ,Sila CA,Davis BR,Pressel S,Yamal JM,Einhorn PT,Lerner AJ,ALLHAT Collaborative Research Group.

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pivotal National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials excluded patients with ischemic stroke with specific minor presentations or rapidly improving symptoms. The recombinant tissue plasminogen activator product label notes that its use...

journal_title：Stroke

authors： Khatri P,Kleindorfer DO,Yeatts SD,Saver JL,Levine SR,Lyden PD,Moomaw CJ,Palesch YY,Jauch EC,Broderick JP

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis and quantification of microangiopathy in dementia is difficult. The assessment of small-vessel disease requires expensive and sophisticated nuclear medicine techniques. This study was performed to identify microangiopathy related to the integrity of cerebral microcirculation by sono...

journal_title：Stroke

authors： Puls I,Hauck K,Demuth K,Horowski A,Schliesser M,Dörfler P,Scheel P,Toyka KV,Reiners K,Schöning M,Becker G

更新日期：1999-11-01 00:00:00