Safety and feasibility of collateral blood flow augmentation after intravenous thrombolysis.

Abstract:

BACKGROUND AND PURPOSE:Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the safety and feasibility of partial aortic occlusion immediately after intravenous tissue plasminogen activator. METHODS:We conducted an open-label pilot study of partial aortic occlusion after thrombolysis. The primary end point was all serious adverse events within 30 days of treatment. RESULTS:None of the 22 patients enrolled developed symptomatic parenchymal hemorrhages. Asymptomatic hemorrhagic transformation occurred in 9 patients. Procedure-related adverse events were limited to groin complications (n=13). Seventy-seven percent of patients experienced neurological improvement (≥4-point improvement of the National Institutes of Health Stroke Scale score). CONCLUSIONS:Partial aortic occlusion as an adjunct to thrombolysis in the treatment of acute stroke appears safe. Studies aimed at determining the efficacy of this therapeutic approach are warranted. CLINICAL TRIAL REGISTRATION INFORMATION:URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01006993.

journal_name

Stroke

journal_title

Stroke

authors

Emery DJ,Schellinger PD,Selchen D,Douen AG,Chan R,Shuaib A,Butcher KS

doi

10.1161/STROKEAHA.110.607846

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

1135-7

issue

4

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.110.607846

journal_volume

42

pub_type

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