Abstract:
BACKGROUND AND PURPOSE:Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the safety and feasibility of partial aortic occlusion immediately after intravenous tissue plasminogen activator. METHODS:We conducted an open-label pilot study of partial aortic occlusion after thrombolysis. The primary end point was all serious adverse events within 30 days of treatment. RESULTS:None of the 22 patients enrolled developed symptomatic parenchymal hemorrhages. Asymptomatic hemorrhagic transformation occurred in 9 patients. Procedure-related adverse events were limited to groin complications (n=13). Seventy-seven percent of patients experienced neurological improvement (≥4-point improvement of the National Institutes of Health Stroke Scale score). CONCLUSIONS:Partial aortic occlusion as an adjunct to thrombolysis in the treatment of acute stroke appears safe. Studies aimed at determining the efficacy of this therapeutic approach are warranted. CLINICAL TRIAL REGISTRATION INFORMATION:URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01006993.
journal_name
Strokejournal_title
Strokeauthors
Emery DJ,Schellinger PD,Selchen D,Douen AG,Chan R,Shuaib A,Butcher KSdoi
10.1161/STROKEAHA.110.607846subject
Has Abstractpub_date
2011-04-01 00:00:00pages
1135-7issue
4eissn
0039-2499issn
1524-4628pii
STROKEAHA.110.607846journal_volume
42pub_type
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