Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population.

abstract：BACKGROUND AND PURPOSE:Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17-92 cluster promotes oligodendrogenesis, neurogenesis, and axonal outgrowth. We, therefore, investigated whether the miR-17-92 cluster-enriched exosomes har...

journal_title：Stroke

authors： Xin H,Katakowski M,Wang F,Qian JY,Liu XS,Ali MM,Buller B,Zhang ZG,Chopp M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the stroke rate associated with atrial fibrillation has declined over the last 10 years, the emerging atrial fibrillation epidemic threatens to increase the incidence of cardioembolic stroke. Summary of Review-Oral anticoagulants are superior antithrombotic agents but are underused due t...

journal_title：Stroke

authors： Medi C,Hankey GJ,Freedman SB

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of the present study was to evaluate the impact of basilar artery (BA) vasospasm on outcome in patients with severe vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). METHODS:Sixty-five patients with clinically suspect severe cerebral vasospasm after aSAH underwent cerebral a...

journal_title：Stroke

authors： Sviri GE,Newell DW,Lewis DH,Douville C,Ghodke B,Chowdhary M,Lam AM,Haynor D,Zaaroor M,Britz GW

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There have been very few population-based cohort studies of long-term prognosis and risk factors for death after stroke. We examined the 10-year prognosis, causes, and risk factors of death after stroke in a Japanese cohort. METHODS:During a 26-year follow-up of a cohort of 1621 subjects > or =4...

journal_title：Stroke

authors： Kiyohara Y,Kubo M,Kato I,Tanizaki Y,Tanaka K,Okubo K,Nakamura H,Iida M

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous studies reported that Tat-NR2B9c, a peptide disrupting the N-methyl-d-aspartate receptor-postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine wheth...

journal_title：Stroke

authors： Zhou HH,Tang Y,Zhang XY,Luo CX,Gao LY,Wu HY,Chang L,Zhu DY

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although both general and abdominal adiposity are well-established risk factors for coronary heart disease, their associations with stroke are less well characterized, particularly in generally lean Asian populations. METHODS:We evaluated associations of body mass index (BMI), waist-hip ratio (W...

journal_title：Stroke

authors： Zhang X,Shu XO,Gao YT,Yang G,Li H,Zheng W

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impair...

journal_title：Stroke

authors： Sykora M,Diedler J,Turcani P,Hacke W,Steiner T

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994. METHODS:The Carotid Revascularization Endarterectomy ...

journal_title：Stroke

authors： Mantese VA,Timaran CH,Chiu D,Begg RJ,Brott TG,CREST Investigators.

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute cocaine use has been temporally associated with aneurysmal subarachnoid hemorrhage (aSAH). This study analyzes the impact of cocaine use on patient presentation, complications, and outcomes. METHODS:Data of patients admitted with aSAH between 1991 and 2009 were reviewed to determine impact...

journal_title：Stroke

authors： Chang TR,Kowalski RG,Caserta F,Carhuapoma JR,Tamargo RJ,Naval NS

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. METHODS:Antibody titers to 5 common infectious microorganisms (ie, C...

journal_title：Stroke

authors： Elkind MS,Luna JM,Moon YP,Boden-Albala B,Liu KM,Spitalnik S,Rundek T,Sacco RL,Paik MC

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP me...

journal_title：Stroke

authors： Lin L,Bivard A,Levi CR,Parsons MW

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is important to know the costs of hospitalization for patients undergoing endovascular embolectomy so that comparisons can be made with payments to hospitals. METHODS:Using the National Inpatient Sample, we evaluated the costs of hospitalization for patients treated with endovascular embolect...

journal_title：Stroke

authors： Brinjikji W,Kallmes DF,Rabinstein AA,Lanzino G,Cloft HJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite the social, health, and economic burdens associated with cognitive impairment poststroke, there is considerable uncertainty about the types of interventions that might preserve or restore cognitive abilities. The objective of this systematic review and meta-analysis was to evaluate the ef...

journal_title：Stroke

authors： Oberlin LE,Waiwood AM,Cumming TB,Marsland AL,Bernhardt J,Erickson KI

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hyperglycemia on admission is common after ischemic stroke. It is associated with unfavorable outcome after treatment with intravenous thrombolysis and after intra-arterial treatment. Whether hyperglycemia influences the effect of reperfusion treatment is unknown. We assessed whether increased ad...

journal_title：Stroke

authors： Osei E,den Hertog HM,Berkhemer OA,Fransen PSS,Roos YBWEM,Beumer D,van Oostenbrugge RJ,Schonewille WJ,Boiten J,Zandbergen AAM,Koudstaal PJ,Dippel DWJ,MR CLEAN Investigators.

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A transient ischemic attack (TIA) in the brain is classically considered a syndrome lasting <24 hours. Having previously shown that an experimental challenge with the GABAA agonist midazolam in recovered stroke patients can reinduce the acute clinical state, we determined whether TIA patients wou...

journal_title：Stroke

authors： Lazar RM,Fitzsimmons BF,Marshall RS,Mohr JP,Berman MF

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poststroke cognitive decline and white matter lesions (WML) are related to poor poststroke survival. Whether cognitive reserve as reflected by educational history associates with cognitive decline, recurrent strokes, and poststroke mortality independent of WML is not known. METHODS:A total of 48...

journal_title：Stroke

authors： Ojala-Oksala J,Jokinen H,Kopsi V,Lehtonen K,Luukkonen L,Paukkunen A,Seeck L,Melkas S,Pohjasvaara T,Karhunen P,Hietanen M,Erkinjuntti T,Oksala N

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic-ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology. METHODS:On postnatal day 7, mice wer...

journal_title：Stroke

authors： Ten VS,Wu EX,Tang H,Bradley-Moore M,Fedarau MV,Ratner VI,Stark RI,Gingrich JA,Pinsky DJ

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although lacunar stroke (LS) and deep intracerebral hemorrhage (dICH) represent acute manifestations of the same pathological process involving cerebral small vessels (small vessel disease), it remains unclear what factors predispose to one phenotype rather than the other at individual level. ME...

journal_title：Stroke

authors： Morotti A,Paciaroni M,Zini A,Silvestrelli G,Del Zotto E,Caso V,Dell'Acqua ML,Simone AM,Lanari A,Costa P,Poli L,De Giuli V,Gamba M,Ciccone A,Ritelli M,Di Castelnuovo A,Iacoviello L,Colombi M,Agnelli G,Grassi M,de G

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...

journal_title：Stroke

authors： Millan M,Sobrino T,Castellanos M,Nombela F,Arenillas JF,Riva E,Cristobo I,García MM,Vivancos J,Serena J,Moro MA,Castillo J,Dávalos A

更新日期：2007-01-01 00:00:00

abstract：:Recent success with thrombolytic therapy for acute myocardial infarction has stimulated interest in its use for stroke. To determine the hemorrhagic potential of thrombolytic therapy in experimental cerebral infarction, we compared a group of tissue plasminogen activator-treated rabbits (n = 4) with 2 groups of strept...

journal_title：Stroke

authors： Slivka A,Pulsinelli W

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute ischemic stroke in humans is associated with profound alterations in the immune system. Hallmarks of this stroke-induced immunodepression syndrome are: lymphocytopenia, impairment of T helper cell and monocyte function. We studied which stroke-specific factors predict these immunologic alte...

journal_title：Stroke

authors： Hug A,Dalpke A,Wieczorek N,Giese T,Lorenz A,Auffarth G,Liesz A,Veltkamp R

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The remaining limitations of ultrasonographic imaging in accurately quantifying internal carotid stenosis or diagnosing internal carotid occlusion may be overcome by enhancing the echogenicity of flowing arterial blood with contrast agents. This study assessed the usefulness of the intravenous (t...

journal_title：Stroke

authors： Sitzer M,Fürst G,Siebler M,Steinmetz H

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Identifying occult coronary artery stenosis may improve secondary prevention of stroke patients. The aim of this study was to derive and validate a simple score to predict severe occult coronary artery stenosis in stroke patients. METHODS:We derived a score from a French hospital-based cohort of...

journal_title：Stroke

authors： Calvet D,Song D,Yoo J,Turc G,Sablayrolles JL,Choi BW,Heo JH,Mas JL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several studies have reported poor outcomes in patients too good to treat with intravenous thrombolysis because of mild or rapidly improving symptoms. We sought to determine baseline clinical and imaging predictors of poor outcome in these patients. METHODS:Among 3950 consecutive stroke admissio...

journal_title：Stroke

authors： Ali SF,Siddiqui K,Ay H,Silverman S,Singhal A,Viswanathan A,Rost N,Lev M,Schwamm LH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pial arterioles transiently dilate during cortical spreading depression (CSD), although the mechanisms are unclear. We tested the hypothesis that increased production of nitric oxide (NO) promotes arteriolar dilation. METHODS:Urethane-anesthetized rabbits were equipped with cranial windows, and ...

journal_title：Stroke

authors： Colonna DM,Meng W,Deal DD,Busija DW

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes. METHODS:Chimeric (hRN/hANG-Tg) mice were generated by mating o...

journal_title：Stroke

authors： Inaba S,Iwai M,Tomono Y,Senba I,Furuno M,Kanno H,Okayama H,Mogi M,Higaki J,Horiuchi M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...

journal_title：Stroke

authors： Rouhl RP,van Oostenbrugge RJ,Damoiseaux J,Tervaert JW,Lodder J

更新日期：2008-07-01 00:00:00

abstract：:Background and Purpose- Although older age is one of the most important risk factor for stroke in atrial fibrillation (AF), the appropriate age threshold (eg, CHA2DS2-VASc score [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vas...

journal_title：Stroke

authors： Kim TH,Yang PS,Yu HT,Jang E,Uhm JS,Kim JY,Pak HN,Lee MH,Joung B,Lip GYH

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The first goal of this study was to determine the effect of glutamate on permeability and reactivity of the cerebral microcirculation. The second goal of this study was to determine a possible role for nitric oxide in the effects of glutamate on the cerebral microcirculation. METHODS:We examined...

journal_title：Stroke

authors： Mayhan WG,Didion SP

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...

journal_title：Stroke

authors： Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

更新日期：1999-09-01 00:00:00