当前位置： SCI文献检索 > STROKE期刊下所有文献 > Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study.

Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study.

Abstract：

BACKGROUND AND PURPOSE:Preclinical data suggest that cell-based therapies have the potential to improve stroke outcomes. METHODS:Eighteen patients with stable, chronic stroke were enrolled in a 2-year, open-label, single-arm study to evaluate the safety and clinical outcomes of surgical transplantation of modified bone marrow-derived mesenchymal stem cells (SB623). RESULTS:All patients in the safety population (N=18) experienced at least 1 treatment-emergent adverse event. Six patients experienced 6 serious treatment-emergent adverse events; 2 were probably or definitely related to surgical procedure; none were related to cell treatment. All serious treatment-emergent adverse events resolved without sequelae. There were no dose-limiting toxicities or deaths. Sixteen patients completed 12 months of follow-up at the time of this analysis. Significant improvement from baseline (mean) was reported for: (1) European Stroke Scale: mean increase 6.88 (95% confidence interval, 3.5-10.3; P<0.001), (2) National Institutes of Health Stroke Scale: mean decrease 2.00 (95% confidence interval, -2.7 to -1.3; P<0.001), (3) Fugl-Meyer total score: mean increase 19.20 (95% confidence interval, 11.4-27.0; P<0.001), and (4) Fugl-Meyer motor function total score: mean increase 11.40 (95% confidence interval, 4.6-18.2; P<0.001). No changes were observed in modified Rankin Scale. The area of magnetic resonance T2 fluid-attenuated inversion recovery signal change in the ipsilateral cortex 1 week after implantation significantly correlated with clinical improvement at 12 months (P<0.001 for European Stroke Scale). CONCLUSIONS:In this interim report, SB623 cells were safe and associated with improvement in clinical outcome end points at 12 months. CLINICAL TRIAL REGISTRATION:URL: https://www.clinicaltrials.gov. Unique identifier: NCT01287936.

journal_name

Stroke

journal_title

Stroke

authors

Steinberg GK,Kondziolka D,Wechsler LR,Lunsford LD,Coburn ML,Billigen JB,Kim AS,Johnson JN,Bates D,King B,Case C,McGrogan M,Yankee EW,Schwartz NE

doi

10.1161/STROKEAHA.116.012995

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1817-24

issue

7

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.116.012995

journal_volume

47

pub_type

杂志文章

相关文献

STROKE文献大全
  • Association of asymptomatic peripheral arterial disease with vascular events in patients with stroke or transient ischemic attack.

    abstract：BACKGROUND AND PURPOSE:Patients with stroke and patients with transient ischemic attack (TIA) are at high risk for vascular events and may not exhibit the signs and symptoms of peripheral arterial disease (PAD). We investigated if asymptomatic PAD detected by ankle brachial index <0.9 is independently associated with r...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.109.559278

    authors： Sen S,Lynch DR Jr,Kaltsas E,Simmons J,Tan WA,Kim J,Beck J,Rosamond W

    更新日期：2009-11-01 00:00:00

  • Prevalence and predictors of paroxysmal atrial fibrillation on Holter monitor in patients with stroke or transient ischemic attack.

    abstract：BACKGROUND AND PURPOSE:Our aims were to quantify the yield of Holter monitor for detection of paroxysmal atrial fibrillation (PAF) in patients with stroke and TIA, and to determine potential predictors of PAF to allow more focused testing. METHODS:We reviewed records of 1128 consecutive patients attending a university...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.109.570382

    authors： Alhadramy O,Jeerakathil TJ,Majumdar SR,Najjar E,Choy J,Saqqur M

    更新日期：2010-11-01 00:00:00

  • Relative value of normalized sonographic in vitro analysis of arteriosclerotic plaques of internal carotid artery.

    abstract：BACKGROUND AND PURPOSE:A close correlation between B-mode sonography and the histopathology and surface structure of plaque is rarely seen in vivo with high-grade stenoses of the extracranial carotid artery. The goal of this study was to determine whether normalized gray scale analysis and surface analysis of the plaqu...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000081982.85010.A8

    authors： Denzel C,Balzer K,Müller KM,Fellner F,Fellner C,Lang W

    更新日期：2003-08-01 00:00:00

  • Remodeling of the corticospinal innervation and spontaneous behavioral recovery after ischemic stroke in adult mice.

    abstract：BACKGROUND AND PURPOSE:To elucidate how the motor pathways rewire the denervated tissue after stroke, we investigated remodeling of the corticospinal tract (CST) in transgenic mice with yellow fluorescent protein CST labeling in conjunction with transsynaptic pseudorabies virus retrograde tracing. METHODS:Adult male C...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.109.547265

    authors： Liu Z,Zhang RL,Li Y,Cui Y,Chopp M

    更新日期：2009-07-01 00:00:00

  • ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells.

    abstract：BACKGROUND AND PURPOSE:Cells lacking the ATM (ataxia telangectasia mutated) gene are hypersensitive to DNA damage caused by a variety of insults. ATM may regulate oxidative stress-induced signaling cascades involving nuclear factor-kappaB (NF-kappaB), a transcription factor that is upstream of a wide variety of stress-...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.0000030316.79601.03

    authors： Yin KJ,Chen SD,Lee JM,Xu J,Hsu CY

    更新日期：2002-10-01 00:00:00

  • A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats.

    abstract：BACKGROUND AND PURPOSE:Proven behavioral assessment strategies for testing potential therapeutic agents in rat stroke models are needed. Few studies include tasks that demand higher levels of sensorimotor and cognitive function. Because behavioral outcome and rate of recovery vary among ischemia models, there is a need...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/hs1101.097397

    authors： Roof RL,Schielke GP,Ren X,Hall ED

    更新日期：2001-11-01 00:00:00

  • Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group.

    abstract：BACKGROUND AND PURPOSE:We sought to identify variables associated with intracerebral hemorrhage in patients with acute ischemic stroke who receive tissue plasminogen activator (t-PA). METHODS:We performed subgroup analyses of data from a randomized, double-blind, placebo-controlled trial of intravenous t-PA administer...

    journal_title：Stroke

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1161/01.str.28.11.2109

    authors：

    更新日期：1997-11-01 00:00:00

  • Electrocardiographic changes and myocardial damage in patients with acute cerebrovascular accidents.

    abstract：:In 100 consecutive patients with acute cerebrovascular accident, due to cerebral thrombosis in 72, cerebral hemorrhage in 12, embolus in 6, and subarachnoid hemorrhage in 10, there were 90 who had electrocardiographic abnormalities during the first three days after admission, compared to 50% in a control group. The pa...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.8.4.448

    authors： Dimant J,Grob D

    更新日期：1977-07-01 00:00:00

  • Transesophageal two-dimensional echocardiography in young patients with cerebral ischemic events.

    abstract：:Using transesophageal echocardiography, cardiac structures can be imaged with high resolution. The aim of our study was to evaluate whether transesophageal echocardiography is superior in detecting mitral valve prolapse and other cardiac abnormalities compared with transthoracic echocardiography in an age-matched cont...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.19.3.345

    authors： Zenker G,Erbel R,Krämer G,Mohr-Kahaly S,Drexler M,Harnoncourt K,Meyer J

    更新日期：1988-03-01 00:00:00

  • Late measures of brain injury after neonatal hypoxia-ischemia in mice.

    abstract：BACKGROUND AND PURPOSE:This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic-ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology. METHODS:On postnatal day 7, mice wer...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000137768.25203.df

    authors： Ten VS,Wu EX,Tang H,Bradley-Moore M,Fedarau MV,Ratner VI,Stark RI,Gingrich JA,Pinsky DJ

    更新日期：2004-09-01 00:00:00

  • Impact of acute cocaine use on aneurysmal subarachnoid hemorrhage.

    abstract：BACKGROUND AND PURPOSE:Acute cocaine use has been temporally associated with aneurysmal subarachnoid hemorrhage (aSAH). This study analyzes the impact of cocaine use on patient presentation, complications, and outcomes. METHODS:Data of patients admitted with aSAH between 1991 and 2009 were reviewed to determine impact...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.111.000749

    authors： Chang TR,Kowalski RG,Caserta F,Carhuapoma JR,Tamargo RJ,Naval NS

    更新日期：2013-07-01 00:00:00

  • Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke.

    abstract：BACKGROUND AND PURPOSE:Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as ...

    journal_title：Stroke

    pub_type： 临床试验,杂志文章

    doi：10.1161/STROKEAHA.117.019896

    authors： Ducroux C,Di Meglio L,Loyau S,Delbosc S,Boisseau W,Deschildre C,Ben Maacha M,Blanc R,Redjem H,Ciccio G,Smajda S,Fahed R,Michel JB,Piotin M,Salomon L,Mazighi M,Ho-Tin-Noe B,Desilles JP

    更新日期：2018-03-01 00:00:00

  • Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 3: effects on brain water and electrolytes in the late phase of acute MCA stroke.

    abstract：:Experimental regional cerebral ischemia was produced in the middle cerebral artery (MCA) territory in primates (M. mulatta) by macrosphere embolization. Determinations of percentage tissue dry weight and tissue sodium and potassium concentrations were obtained in samples from the ischemic and non-ischemic hemispheres ...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.9.4.387

    authors： Bremer AM,Yamada K,West CR

    更新日期：1978-07-01 00:00:00

  • Microglial Calcium Waves During the Hyperacute Phase of Ischemic Stroke.

    abstract：BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.120.032766

    authors： Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

    更新日期：2021-01-01 00:00:00

  • Blood pressure control and risk of stroke: a population-based prospective cohort study.

    abstract：BACKGROUND AND PURPOSE:Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. METHODS:A total o...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000158925.12740.87

    authors： Li C,Engström G,Hedblad B,Berglund G,Janzon L

    更新日期：2005-04-01 00:00:00

  • Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness: The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke).

    abstract：BACKGROUND AND PURPOSE:The effect of statins on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT in Japanese patients with noncardioembolic ischemic stroke. METHODS:This ...

    journal_title：Stroke

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/STROKEAHA.117.018387

    authors： Koga M,Toyoda K,Minematsu K,Yasaka M,Nagai Y,Aoki S,Nezu T,Hosomi N,Kagimura T,Origasa H,Kamiyama K,Suzuki R,Ohtsuki T,Maruyama H,Kitagawa K,Uchiyama S,Matsumoto M,J-STARS Investigators.

    更新日期：2018-01-01 00:00:00

  • Posterior cerebral artery laterality on magnetic resonance angiography predicts long-term functional outcome in middle cerebral artery occlusion.

    abstract：BACKGROUND AND PURPOSE:Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cereb...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.112.674101

    authors： Ichijo M,Miki K,Ishibashi S,Tomita M,Kamata T,Fujigasaki H,Mizusawa H

    更新日期：2013-02-01 00:00:00

  • Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage.

    abstract：BACKGROUND AND PURPOSE:Deep intracerebral hemorrhage (ICH) and lacunar infarcts are the result of small vessel disease, whereas nonlacunar infarcts are often caused by large artery atherosclerosis or cardiac embolism. We hypothesized that patients with deep ICH and lacunar infarcts have similar retinal microvascular si...

    journal_title：Stroke

    pub_type： 杂志文章,多中心研究

    doi：10.1161/STROKEAHA.109.569764

    authors： Baker ML,Hand PJ,Liew G,Wong TY,Rochtchina E,Mitchell P,Lindley RI,Hankey GJ,Wang JJ,Multi-Centre Retinal Stroke Study Group.

    更新日期：2010-04-01 00:00:00

  • Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils.

    abstract：BACKGROUND AND PURPOSE:We investigated changes in locomotor activity, passive avoidance task performance, and hippocampal CA1 neurons induced by cerebral ischemia in Mongolian gerbils to examine the relation between these behavioral changes and CA1 neuronal damage. METHODS:Spontaneous locomotor activity was measured u...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.25.3.645

    authors： Karasawa Y,Araki H,Otomo S

    更新日期：1994-03-01 00:00:00

  • Localized retinal nerve fiber layer defects and stroke.

    abstract：BACKGROUND AND PURPOSE:Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS:Patients with acute ischemic stroke as part of a hospital-based study group were compared with t...

    journal_title：Stroke

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/STROKEAHA.113.004629

    authors： Wang D,Li Y,Wang C,Xu L,You QS,Wang YX,Zhao L,Wei WB,Zhao X,Jonas JB

    更新日期：2014-06-01 00:00:00

  • Predictors of Unexplained Early Neurological Deterioration After Endovascular Treatment for Acute Ischemic Stroke.

    abstract：BACKGROUND AND PURPOSE:Although the efficacy of endovascular treatment (EVT) in patients with anterior circulation ischemic stroke (AIS) is well documented, early neurological deterioration after EVT remains a serious issue associated with poor outcome. Besides obvious causes, such as lack of reperfusion, procedural co...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.120.029494

    authors： Girot JB,Richard S,Gariel F,Sibon I,Labreuche J,Kyheng M,Gory B,Dargazanli C,Maier B,Consoli A,Daumas-Duport B,Lapergue B,Bourcier R,ETIS Investigators*.

    更新日期：2020-10-01 00:00:00

  • Documentation of Improved Outcomes for Intracranial Aneurysm Management Over a 15-Year Interval.

    abstract：BACKGROUND AND PURPOSE:Despite rapid advancements in intracranial aneurysm management, there is no evidence as of yet that this has translated into improvement in overall prognosis. METHODS:We compared 2 periods of aneurysm management, 1998 to 2003 (n=1023 aneurysms) and 2007 to 2013 (n=1499 aneurysms), at a single, h...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.115.011959

    authors： Chua MH,Griessenauer CJ,Stapleton CJ,He L,Thomas AJ,Ogilvy CS

    更新日期：2016-03-01 00:00:00

  • Grading scale for prediction of outcome in primary intracerebral hemorrhages.

    abstract：BACKGROUND AND PURPOSE:This study aimed to independently derive an intracerebral hemorrhage grading scale (ICH-GS) for prediction of 3 outcome measures. METHODS:We evaluated 378 patients with primary ICH at hospital arrival and during the next 30 days. Independent predictors were identified by multivariate models of i...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.106.478222

    authors： Ruiz-Sandoval JL,Chiquete E,Romero-Vargas S,Padilla-Martínez JJ,González-Cornejo S

    更新日期：2007-05-01 00:00:00

  • Time course of tissue plasminogen activator-induced recanalization in acute cardioembolic stroke: a case-control study.

    abstract：BACKGROUND AND PURPOSE:The relationship between arterial recanalization, infarct size, and outcome in patients treated with intravenous thrombolytics remains unclear. Therefore, we aimed to determine the time course of recombinant tissue plasminogen activator (rtPA)-induced recanalization in patients with cardioembolic...

    journal_title：Stroke

    pub_type： 临床试验,杂志文章

    doi：10.1161/hs1201.99821

    authors： Molina CA,Montaner J,Abilleira S,Arenillas JF,Ribó M,Huertas R,Romero F,Alvarez-Sabín J

    更新日期：2001-12-01 00:00:00

  • Thrombolysis-related hemorrhagic infarction: a marker of early reperfusion, reduced infarct size, and improved outcome in patients with proximal middle cerebral artery occlusion.

    abstract：BACKGROUND AND PURPOSE:The role of early and delayed recanalization after thrombolysis in the development of hemorrhagic transformation (HT) subtypes remains uncertain. We sought to explore the association between the timing of recanalization and HT risk in patients with proximal middle cerebral artery (MCA) occlusion ...

    journal_title：Stroke

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.str.0000016323.13456.e5

    authors： Molina CA,Alvarez-Sabín J,Montaner J,Abilleira S,Arenillas JF,Coscojuela P,Romero F,Codina A

    更新日期：2002-06-01 00:00:00

  • Brain microbleeds and global cognitive function in adults without neurological disorder.

    abstract：BACKGROUND AND PURPOSE:Increasing attention has been paid to associations between cognitive dysfunction and brain microbleeds (MBs). Because all previous studies have investigated patients with neurological disorders, we examined subjects without neurological disorder in order to clarify pathogenic relationships. METH...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.108.516112

    authors： Yakushiji Y,Nishiyama M,Yakushiji S,Hirotsu T,Uchino A,Nakajima J,Eriguchi M,Nanri Y,Hara M,Horikawa E,Kuroda Y

    更新日期：2008-12-01 00:00:00

  • Blood-Brain Barrier Leakage: A New Biomarker in Transient Ischemic Attacks.

    abstract：:Background and Purpose- The diagnosis of transient ischemic attack is challenging. Evidence of acute ischemia on MRI diffusion-weighted imaging is highly variable and confirmed in only about one-third of patients. This study investigated the significance of blood-brain barrier dysfunction (BBBD) mapping in patients wi...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.119.025247

    authors： Serlin Y,Ofer J,Ben-Arie G,Veksler R,Ifergane G,Shelef I,Minuk J,Horev A,Friedman A

    更新日期：2019-05-01 00:00:00

  • Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA.

    abstract：BACKGROUND AND PURPOSE:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies. METHODS:We conducted a prospective study of patients with acute TIA who presented to the ED. Clinical risk sco...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.109.553545

    authors： Cucchiara BL,Messe SR,Sansing L,MacKenzie L,Taylor RA,Pacelli J,Shah Q,Kasner SE

    更新日期：2009-07-01 00:00:00

  • Trends in 10-year survival of patients with stroke hospitalized between 1980 and 2000: the Minnesota stroke survey.

    abstract：BACKGROUND AND PURPOSE:We report on trends in poststroke survival, both in the early period after stroke and over the long term. We examine these trends by stroke subtype. METHODS:The Minnesota Stroke Survey is a study of all hospitalized patients with acute stroke aged 30 to 74 years in the Minneapolis-St Paul metrop...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.114.005512

    authors： Lakshminarayan K,Berger AK,Fuller CC,Jacobs DR Jr,Anderson DC,Steffen LM,Sillah A,Luepker RV

    更新日期：2014-09-01 00:00:00

  • Neuropsychometric changes in patients after carotid endarterectomy.

    abstract：BACKGROUND AND PURPOSE:One hundred twelve patients undergoing elective carotid endarterectomy for symptomatic and asymptomatic carotid artery stenosis were enrolled in a prospective study to evaluate the incidence of change in postoperative cerebral function. METHODS:Patients were evaluated preoperatively and postoper...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.29.6.1110

    authors： Heyer EJ,Adams DC,Solomon RA,Todd GJ,Quest DO,McMahon DJ,Steneck SD,Choudhri TF,Connolly ES

    更新日期：1998-06-01 00:00:00