Late measures of brain injury after neonatal hypoxia-ischemia in mice.


BACKGROUND AND PURPOSE:This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic-ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology. METHODS:On postnatal day 7, mice were subjected to HI. At 7 to 9 weeks after HI neurofunctional outcome was assessed by water-maze, rota-rod, and open-field test performance, followed by cerebral MRI and histopathology evaluation. RESULTS:At 10 weeks after HI, MRI revealed ipsilateral brain atrophy alone or with porencephalic cyst formation and contralateral ventriculomegaly. Adult HI-affected mice, especially those that developed a porencephalic cyst, demonstrated significant neurofunctional deficit compared with age-matched naïve mice. HI-affected mice with ipsilateral cerebral atrophy but without porencephaly demonstrated no or an intermediate level of neurofunctional deficit. Neurobehavioral assessment of mice subjected to HI insult revealed a strong correlation between degree of brain injury and functional neurohandicap. CONCLUSIONS:This is the first study to demonstrate that long-term neurofunctional outcome in mice after a neonatal HI correlates tightly with anatomical pattern/extent of cerebral damage, defined by MRI and histopathology.






Ten VS,Wu EX,Tang H,Bradley-Moore M,Fedarau MV,Ratner VI,Stark RI,Gingrich JA,Pinsky DJ




Has Abstract


2004-09-01 00:00:00
















  • Admission Brain Cortical Volume: An Independent Determinant of Poststroke Cognitive Vulnerability.

    abstract:BACKGROUND AND PURPOSE:Several markers of poststroke cognitive impairment have been reported. The role of brain cortical volume remains uncertain. The aim of this study was to evaluate the influence of brain cortical volume on cognitive outcomes using a voxel-based morphometry approach in subjects without prestroke dem...


    pub_type: 杂志文章


    authors: Sagnier S,Catheline G,Dilharreguy B,Munsch F,Bigourdan A,Poli M,Debruxelles S,Olindo S,Renou P,Rouanet F,Dousset V,Tourdias T,Sibon I

    更新日期:2017-08-01 00:00:00

  • Extracorporeal rheopheresis in the treatment of acute ischemic stroke: A randomized pilot study.

    abstract:BACKGROUND AND PURPOSE:Extracorporeal rheopheresis is a safe method to optimize hemorheology. Our aim was to determine whether treatment with extracorporeal rheopheresis in patients with acute ischemic hemispheric stroke improves cerebral perfusion as assessed with serial 99mTc-ethyl-cysteinate-dimer single-photon emis...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Berrouschot J,Barthel H,Köster J,Hesse S,Rössler A,Knapp WH,Schneider D

    更新日期:1999-04-01 00:00:00

  • Nitric oxide and the cerebral circulation.

    abstract:BACKGROUND:Nitric oxide (NO) is a potent vasodilator that was initially described as the mediator of endothelium-dependent relaxation (endothelium-derived relaxing factor, EDRF). It is now known that NO is produced by a variety of other cell types. SUMMARY OF REVIEW:Endothelium produces NO (EDRF) under basal condition...


    pub_type: 杂志文章,评审


    authors: Faraci FM,Brian JE Jr

    更新日期:1994-03-01 00:00:00

  • Posterior cerebral artery laterality on magnetic resonance angiography predicts long-term functional outcome in middle cerebral artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cereb...


    pub_type: 杂志文章


    authors: Ichijo M,Miki K,Ishibashi S,Tomita M,Kamata T,Fujigasaki H,Mizusawa H

    更新日期:2013-02-01 00:00:00

  • Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study.

    abstract:BACKGROUND AND PURPOSE:Cerebral microbleeds are frequently seen in the general elderly population, but it is unknown at what rate they occur with aging and whether once present can disappear over time. METHODS:As part of the Rotterdam Scan Study, 831 persons (mean age, 68.5 years) underwent repeated brain MRI with a m...


    pub_type: 杂志文章


    authors: Poels MM,Ikram MA,van der Lugt A,Hofman A,Krestin GP,Breteler MM,Vernooij MW

    更新日期:2011-03-01 00:00:00

  • Increased body iron stores are associated with poor outcome after thrombolytic treatment in acute stroke.

    abstract:BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...


    pub_type: 杂志文章,多中心研究


    authors: Millan M,Sobrino T,Castellanos M,Nombela F,Arenillas JF,Riva E,Cristobo I,García MM,Vivancos J,Serena J,Moro MA,Castillo J,Dávalos A

    更新日期:2007-01-01 00:00:00

  • Role of Computed Tomography Perfusion in Identification of Acute Lacunar Stroke Syndromes.

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    pub_type: 杂志文章


    authors: Garcia-Esperon C,Visser M,Churilov L,Miteff F,Bivard A,Lillicrap T,Levi CR,Spratt NJ,Parsons MW

    更新日期:2021-01-01 00:00:00

  • Hippocampal lesion patterns in acute posterior cerebral artery stroke: clinical and MRI findings.

    abstract:BACKGROUND AND PURPOSE:Reports of ischemic stroke affecting the hippocampus are rare. In this study we used diffusion-weighted MRI (DWI) to characterize patients with posterior circulation stroke involving the hippocampus. METHODS:Fifty-seven consecutive acute stroke patients with hippocampal infarct (HI) on DWI were ...


    pub_type: 杂志文章


    authors: Szabo K,Förster A,Jäger T,Kern R,Griebe M,Hennerici MG,Gass A

    更新日期:2009-06-01 00:00:00

  • Reduction in distal emboli with proximal flow control during mechanical thrombectomy: a quantitative in vitro study.

    abstract:BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...


    pub_type: 杂志文章


    authors: Chueh JY,Kühn AL,Puri AS,Wilson SD,Wakhloo AK,Gounis MJ

    更新日期:2013-05-01 00:00:00

  • A proposed method for using a reimbursement moratorium to encourage recruitment for a randomized study of carotid endarterectomy.

    abstract::As indicated by Barnett, Plum and Walton, a definitive clinical trial to resolve the issue of the effectiveness of carotid endarterectomy is clearly needed. A proposal to foster such a trial, through a moratorium on third-party reimbursement other than for randomized patients, has herein been presented. ...


    pub_type: 杂志文章


    authors: Jonas S

    更新日期:1986-11-01 00:00:00

  • Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats.

    abstract:BACKGROUND AND PURPOSE:Inflammatory and immune mechanisms can precipitate cerebrovascular thrombosis and hemorrhage. Immunologic tolerance can be induced to a specific antigen by intranasal instillation of that antigen. Lymphocytes tolerized in this way provide local immunosuppression on restimulation with the same ant...


    pub_type: 杂志文章


    authors: Takeda H,Spatz M,Ruetzler C,McCarron R,Becker K,Hallenbeck J

    更新日期:2002-09-01 00:00:00

  • Effects of surgical revascularization on cerebral oxygen metabolism in patients with Moyamoya disease: an 15O-gas positron emission tomographic study.

    abstract:BACKGROUND AND PURPOSE:This prospective study was aimed to evaluate the effects of surgical revascularization on cerebral oxygen metabolism in moyamoya disease. METHODS:This study included totally 69 hemispheres of 42 patients who underwent superficial temporal artery to middle cerebral artery anastomosis and indirect...


    pub_type: 杂志文章


    authors: Kuroda S,Kashiwazaki D,Hirata K,Shiga T,Houkin K,Tamaki N

    更新日期:2014-09-01 00:00:00

  • Effects of some guanidino compounds on human cerebral arteries.

    abstract:BACKGROUND AND PURPOSE:Accumulation of endogenous guanidino-substituted analogues of L-arginine in chronic renal failure might contribute to some of the vascular and neurological disorders of this pathology. We tested the hypothesis that in human cerebral arteries, some guanidino compounds may increase vascular tone, t...


    pub_type: 临床试验,杂志文章


    authors: Segarra G,Medina P,Ballester RM,Lluch P,Aldasoro M,Vila JM,Lluch S,Pelligrino DA

    更新日期:1999-10-01 00:00:00

  • Shape and volume of lacunar infarcts: a 3D MRI study in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

    abstract:BACKGROUND AND PURPOSE:The shape and exact size of lacunar infarcts have been investigated only postmortem. Recent imaging techniques based on triangulation and connectivity can now be used for 3D segmentation of cerebral lesions. The shape and size of lacunar infarcts was investigated using these techniques in 10 cere...


    pub_type: 杂志文章


    authors: Hervé D,Mangin JF,Molko N,Bousser MG,Chabriat H

    更新日期:2005-11-01 00:00:00

  • Effect of blood pressure on prevalence of carotid atheroma.

    abstract::In an attempt to elucidate the mechanism by which hypertension acts as a risk factor for major non-haemorrhagic stroke, its effect on the prevalence of carotid atheroma has been studied angiographically. The carotid angiograms of 269 patients with cerebral tumours have been reviewed for evidence of coincidental athero...


    pub_type: 杂志文章


    authors: Harrison MJ,Wilson LA

    更新日期:1983-07-01 00:00:00

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    abstract::We have investigated the effects of a reduced regional or a reduced body temperature, on pial arteriolar response to a variety of vasoactive stimuli. This has been done by studying the effects of these stimuli on groups of mice with different body temperatures, or with different temperatures of the artificial cerebros...


    pub_type: 杂志文章


    authors: Rosenblum WI,Segreti AC

    更新日期:1978-11-01 00:00:00

  • A multifactorial analysis of risk factors for recurrence of ischemic stroke.

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    pub_type: 杂志文章


    authors: Lai SM,Alter M,Friday G,Sobel E

    更新日期:1994-05-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:We sought to investigate the direct costs of acute hospitalization for patients with first-ever ischemic stroke in Taiwan. METHODS:Data were prospectively collected from 360 first-ever ischemic stroke patients. Hospital charges were used for analysis. Multiple linear regression analysis was used...


    pub_type: 杂志文章


    authors: Chang KC,Tseng MC

    更新日期:2003-11-01 00:00:00

  • Establishing Recommendations for Stroke Systems in the Thrombectomy Era: The Upstate New York Stakeholder Proceedings.

    abstract:BACKGROUND AND PURPOSE:The American Heart Association/American Stroke Association and Department of Health Stroke Coverdell Program convened a stakeholder meeting in upstate NY to develop recommendations to enhance stroke systems for acute large vessel occlusion. METHODS:Prehospital, hospital, and Department of Health...


    pub_type: 杂志文章


    authors: Magdon-Ismail Z,Benesch C,Cushman JT,Brissette I,Southerland AM,Brandler ES,Sozener CB,Flor S,Hemmitt R,Wales K,Parrigan K,Levine SR,Upstate New York Stroke Work Groups.

    更新日期:2017-07-01 00:00:00

  • Carotid plaque ultrasonic heterogeneity and severity of stenosis.

    abstract:BACKGROUND AND PURPOSE:Several studies have reported on the correlation of ultrasonic carotid plaque morphology, cerebrovascular symptoms, and intraplaque hemorrhage. This study correlates ultrasonic carotid plaque morphology with the degree of carotid stenosis. METHODS:Carotid arteries (n=2460) were examined by using...


    pub_type: 杂志文章


    authors: AbuRahma AF,Wulu JT Jr,Crotty B

    更新日期:2002-07-01 00:00:00

  • Use of follow-up imaging in isolated perimesencephalic subarachnoid hemorrhage: a meta-analysis.

    abstract:BACKGROUND AND PURPOSE:Multiple studies have shown that negative computed tomographic angiograms (CTAs) are reliable in excluding aneurysms in patients with isolated perimesencephalic subarachnoid hemorrhage (pSAH). We evaluate the use of digital subtraction angiography versus CTA for initial diagnosis and of angiograp...


    pub_type: 杂志文章,meta分析


    authors: Kalra VB,Wu X,Matouk CC,Malhotra A

    更新日期:2015-02-01 00:00:00

  • Endothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm.

    abstract:BACKGROUND AND PURPOSE:While it has been widely reported that the vasospasm following subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor antagonists selective for the ET(A) receptor and by nonselective ET receptor antagonists, ie, antagonists of both the ET(A) and ET(B) receptors, there are...


    pub_type: 杂志文章


    authors: Zuccarello M,Boccaletti R,Romano A,Rapoport RM

    更新日期:1998-09-01 00:00:00

  • Asymptomatic coronary artery disease in patients with stroke. Prevalence, prognosis, diagnosis, and treatment.

    abstract::The frequency of angiographically defined asymptomatic CAD in patients with carotid disease is 40%. Although the prognosis of patients with asymptomatic 1-vessel or 2-vessel CAD is good (annual cardiac mortality rate less than 2%), the prognosis of asymptomatic 3-vessel disease or left main CAD is substantially less f...


    pub_type: 杂志文章,评审


    authors: Chimowitz MI,Mancini GB

    更新日期:1992-03-01 00:00:00

  • A systematic review of the risks of stroke and death due to endarterectomy for symptomatic carotid stenosis.

    abstract:BACKGROUND AND PURPOSE:Carotid endarterectomy reduces the risk of carotid territory ischemic stroke ipsilateral to a recently symptomatic severe carotid stenosis. However, the benefit is limited by the risks of stroke and death associated with the operation. Although reported surgical risks vary enormously, there has b...


    pub_type: 杂志文章,评审


    authors: Rothwell PM,Slattery J,Warlow CP

    更新日期:1996-02-01 00:00:00

  • Incidence and risk factors for diffusion-weighted imaging (+) lesions after intracranial stenting and its relationship with symptomatic ischemic complications.

    abstract:BACKGROUND AND PURPOSE:Little is known about high-signal lesions in magnetic resonance diffusion-weighted imaging (DWI [+]) after stenting for intracranial atherosclerotic stenosis. This study aimed to evaluate the incidence, distribution, risk factors, and clinical implications of DWI (+) after intracranial stenting. ...


    pub_type: 杂志文章


    authors: Park KY,Kim BM,Kim DJ,Kim DI,Heo JH,Nam HS,Kim YD,Song D

    更新日期:2014-11-01 00:00:00

  • Blood Pressure after Endovascular Therapy for Ischemic Stroke (BEST): A Multicenter Prospective Cohort Study.

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    pub_type: 杂志文章,多中心研究


    authors: Mistry EA,Sucharew H,Mistry AM,Mehta T,Arora N,Starosciak AK,De Los Rios La Rosa F,Siegler JE 3rd,Barnhill NR,Patel K,Assad S,Tarboosh A,Dakay K,Salwi S,Cruz AS,Wagner J,Fortuny E,Bennett A,James RF,Jagadeesan B,S

    更新日期:2019-12-01 00:00:00

  • Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study.

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    pub_type: 杂志文章


    authors: Bos MJ,Koudstaal PJ,Hofman A,Witteman JC,Breteler MM

    更新日期:2006-06-01 00:00:00

  • Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness: The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke).

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Koga M,Toyoda K,Minematsu K,Yasaka M,Nagai Y,Aoki S,Nezu T,Hosomi N,Kagimura T,Origasa H,Kamiyama K,Suzuki R,Ohtsuki T,Maruyama H,Kitagawa K,Uchiyama S,Matsumoto M,J-STARS Investigators.

    更新日期:2018-01-01 00:00:00

  • Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors.

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    pub_type: 杂志文章,meta分析


    authors: Blauw GJ,Lagaay AM,Smelt AH,Westendorp RG

    更新日期:1997-05-01 00:00:00

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    pub_type: 信件,多中心研究


    authors: Hinchey JA,Shephard T,Tonn ST,Ruthazer R,Selker HP,Kent DM

    更新日期:2008-05-01 00:00:00