Abstract:
BACKGROUND AND PURPOSE:The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown. METHODS:Four hundred five patients with acute cerebral infarction underwent carotid, femoral artery, thoracic, and abdominal aorta ultrasound examination. Of 342 patients with no known coronary heart disease, 315 underwent coronary angiography. We evaluated the 2-year risk of major vascular events (myocardial infarction, resuscitation after cardiac arrest, hospitalization for unstable angina or heart failure, stroke, or major peripheral arterial disease events) in patients with known coronary heart disease (n=63), and in the no known coronary heart disease group (n=315) as a function of coronary angiographic status (n=315). RESULTS:At 2 years, the estimated risk of major vascular events was 11.0% (95% confidence interval, 8.2-14.7). According to baseline coronary angiography, estimated risk was 3.4% in patients with no coronary artery disease (n=120), 8.0% with asymptomatic coronary artery stenosis <50% (n=113), 16.2% with asymptomatic coronary artery stenosis ≥ 50% (n=81), and 24.1% with known coronary heart disease (P<0.0001). Using no coronary artery disease as the reference, the age- and sex-adjusted hazard ratio (95% confidence interval) of vascular events was 2.10 (0.63-6.96) for asymptomatic coronary stenosis <50%, 4.36 (1.35-14.12) for asymptomatic coronary stenosis ≥ 50%, and 6.86 (2.15-21.31) for known coronary artery disease. CONCLUSIONS:In patients with nonfatal cerebral infarction, presence and extent of asymptomatic stenoses on coronary angiography are strong predictors of major vascular events within 2 years.
journal_name
Strokejournal_title
Strokeauthors
Amarenco P,Lavallée PC,Labreuche J,Ducrocq G,Juliard JM,Feldman L,Cabrejo L,Meseguer E,Guidoux C,Adraï V,Ratani S,Kusmierek J,Lapergue B,Klein IF,Gongora-Rivera F,Jaramillo A,Abboud H,Olivot JM,Mazighi M,Touboul PJdoi
10.1161/STROKEAHA.111.000142subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1505-11issue
6eissn
0039-2499issn
1524-4628pii
STROKEAHA.111.000142journal_volume
44pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Identification of single-nucleotide polymorphisms (SNPs) associated with increased risk of new intracranial hemorrhage (ICH) after brain arteriovenous malformation (BAVM) diagnosis would facilitate risk stratification and identify potential targets for therapeutic intervention. METHODS:Patients ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000195133.98378.4b
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Global cerebral blood flow (CBF) is an important yet largely unknown quantity in the treatment of neurological intensive care patients. Color duplex sonography of the extracranial cerebral arteries can be used to measure global CBF volume directly at the bedside. To establish reference data on gl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.1.147
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.27.9.1688
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data from prospective studies on the associations between B vitamin plasma levels and the risk of stroke are limited. We investigated the individual and combined effects of plasma folate, vitamin B12, and pyridoxal 5-phosphate (PLP) levels on the risk of ischemic stroke and transient ischemic att...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486068
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts at public education to improve adults' response to stroke symptoms continue to be disappointing, and very little has been developed to improve the knowledge base of children regarding brain attacks. Children may be able to exert a positive influence on adult behavior and to learn positive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0202.102728
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cavernous malformations of the brain (CMs) cause intracranial hemorrhage, but its reported frequency varies, partly attributable to study design. To improve the validity of future research, we aimed to develop a robust definition of CM hemorrhage. METHODS:We systematically reviewed the published...
journal_title:Stroke
pub_type: 共识发展会议,指南,杂志文章,评审
doi:10.1161/STROKEAHA.108.515544
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The craniospinal epidural spaces can be categorized into 3 different compartments related to their specific drainage role of the bone and central nervous system, the ventral epidural, dorsal epidural, and lateral epidural groups. We propose this new classification system for dural arteriovenous s...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.516757
更新日期:2008-10-01 00:00:00
abstract::Background and Purpose- The relationship between infarct dimensions and neurological progression in patients with acute pontine infarctions remains unclear. This study aimed to investigate the morphometric predictive value of magnetic resonance imaging for early neurological deterioration (END) in acute pontine infarc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027239
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The influence of a nocturnal blood pressure dip on stroke recurrence has not yet been clarified. In this pilot study, we attempted to establish a correlation of the nocturnal blood pressure dip with stroke recurrence and development of new silent ischemic lesions in patients with chronic ischemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.8.1373
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Persons with early stages of chronic kidney disease, defined by a decreased glomerular filtration rate (GFR), have an increased risk of cardiovascular disease. It is unclear whether decreased GFR is a risk factor for stroke. We assessed the association between GFR and stroke in a prospective popu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.489807
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cardiovascular and pulmonary factors contributing to impaired peak oxygen uptake (VO2) in patients with stroke (SP) are not well known. We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects. METHODS:Ten h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.515346
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.658427
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The rarity of intracranial vascular malformations (IVMs) and the infrequency of their outcomes make large, prolonged cohort studies the best means to evaluate their frequency and prognosis. METHODS:The Scottish Intracranial Vascular Malformation Study (SIVMS) is a prototype prospective, populati...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000069012.23858.69
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Variations in blood-brain barrier (BBB) opening after ischemia have been suggested by some tracer and magnetization transfer studies, although direct in vivo proof is still lacking. Contrast-enhanced magnetic resonance imaging (MRI) is also often used to visualize BBB damage in stroke. We hypothe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.496059
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:While it has been widely reported that the vasospasm following subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor antagonists selective for the ET(A) receptor and by nonselective ET receptor antagonists, ie, antagonists of both the ET(A) and ET(B) receptors, there are...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.9.1924
更新日期:1998-09-01 00:00:00
abstract::Cerebral blood flow and clinical parameters were studied in 30 stroke patients at 15th, 30th, 60th, 90th days after the cerebral insult (Xenon 133 inhalation method). The clinical improvement was not accompanied by a progressive normalization of the CBF at rest. No relationship was found between the clinical data and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.1.77
更新日期:1983-01-01 00:00:00
abstract::The etiology of cerebrovascular disease (CDV) in young patients is difficult to establish if the common causes of a focal neurological deficit are excluded by appropriate investigations. Since in some observations prolapse of the mitral-valve (MVP), alterations of platelet function, or both have been linked with cereb...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.4.454
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to identify quantitative trait loci (QTL) for carotid intima-media thickness (CIMT) a risk factor for stroke and cardiovascular disease. METHODS:Probands were selected from Caribbean Hispanic subjects of the population-based Northern Manhattan Study. CIMT was measured b...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.554121
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. METHODS:A total of 1198 patients with major ischemic stroke a...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/hs0102.101478
更新日期:2002-01-01 00:00:00
abstract::Cerebral blood flow (CBF) was determined in the rat under 70% nitrous oxide anesthesia and pentobarbital anesthesia. The application of the Fick principle technique of Kety et al. was modified utilizing 133Xe infused intravenously steadily for 30 seconds, at which time the animal was decapitated and the head frozen in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.6.630
更新日期:1975-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Epidemiological studies have shown mixed findings on the association between hypertension and stroke in the oldest old. Heterogeneity of the populations under study may underlie variation in outcomes. We examined whether the level of physical and cognitive function moderates the association betwe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.663062
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of genetics in cerebrovascular disease remains controversial. The purpose of this study was to assess the influence of family history on atherothrombotic infarction or transient ischemic attack. METHODS:Ninety patients with stroke or transient ischemic attack and 90 age- and sex-matched...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.8.1599
更新日期:1994-08-01 00:00:00
abstract::We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.9.1173
更新日期:1991-09-01 00:00:00
abstract::Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,评审
doi:10.1161/01.str.19.8.1043
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes. METHODS:In a prospective multicenter cohort study of imaging selection for endovascular thrombectomy (SELECT [Optimizing Patient's Selection for Endovascular Treatmen...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030912
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Timing of carotid endarterectomy after stroke in a patient with a fixed neurological deficit remains an important but unresolved question. Early surgery has been associated with cerebral hemorrhage and infarct extension. Delayed endarterectomy exposes the patient to recurrent stroke and carotid occlusion. Th...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.28.12.2563
更新日期:1997-12-01 00:00:00
abstract::The gerbil model was used to assess the therapeutic effects of the calcium antagonist nimodipine on cerebral ischemia. Transient cerebral ischemia was produced in each gerbil by bilateral common carotid occlusion of 10-, 15- or 20-min duration. Nimodipine (0.01 or 0.1 mg/kg) was administered intraperitoneally just bef...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.748
更新日期:1986-07-01 00:00:00
abstract::There is a strong link between antiphospholipid antibodies and stroke. Retrospective studies indicate that these patients are generally young, often have had prior thrombotic events including stroke, frequently complain of headaches, and often experience amaurosis fugax. Cardiac valvular lesions, particularly involvin...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to describe the frequency and characteristics of acute ischemic stroke and transient ischemic attacks presenting predominantly with amnesia (ischemic amnesia) and to identify clinical clues for differentiating them from transient global amnesia (TGA). METHODS:We retrospectively analyzed...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.017420
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Preischemic spontaneous locomotor activity was distinguished in this laboratory as a factor influencing outcome after 15 and 20 minutes of forebrain ischemia in gerbils. Histological investigations were carried out to analyze potential relations between postischemic survival and a reduction of ce...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.9.1862
更新日期:1994-09-01 00:00:00