The effect of the calcium antagonist nimodipine on the gerbil model of experimental cerebral ischemia.

abstract：:Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...

journal_title：Stroke

authors： Puy L,Barbay M,Roussel M,Canaple S,Lamy C,Arnoux A,Leclercq C,Mas JL,Tasseel-Ponche S,Constans JM,Godefroy O,GRECogVASC Study Group.

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral arteries develop stretch-induced myogenic tone, which plays an important role in the regulation of blood flow to the brain. Although the effect of oxidized LDL (Ox-LDL) on many aspects of the vascular endothelial and smooth muscle cell function have been extensively investigated, its inf...

journal_title：Stroke

authors： Xie H,Bevan JA

更新日期：1999-11-01 00:00:00

abstract：:Of 171 patients evaluated prospectively and consecutively for cerebral ischemia, 26 (15%) developed symptoms while hospitalized. Cerebral ischemia complicated operative procedures in 12 patients, unsuccessful cardioversion in one and coronary angiography in another. Twelve patients had apparent cerebral embolism and 1...

journal_title：Stroke

authors： Kelley RE,Kovacs AG

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Treatment of cerebral sinus thrombosis with heparin is controversial. We conducted a double-blind, placebo-controlled multicenter trial to examine whether anticoagulant treatment improves outcome in patients with sinus thrombosis. METHODS:Patients were randomized between body weight-adjusted sub...

journal_title：Stroke

authors： de Bruijn SF,Stam J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multiple brain infarcts are often seen on diffusion-weighted images in cardioembolic stroke patients. Recently, mobile aortic plaques (MAPs) have been proposed as embolic sources. However, the clinical characteristics of patients with MAPs are unclear. METHODS:We prospectively studied patients w...

journal_title：Stroke

authors： Ueno Y,Kimura K,Iguchi Y,Shibazaki K,Inoue T,Hattori N,Urabe T

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypothermia to core temperatures ranging from 16 degrees C to 24 degrees C has become an established procedure to extend the "safe" interval of cardiac arrest during open heart surgery in human infants. The present experiment was designed to ascertain whether differences in core (rectal) temperat...

journal_title：Stroke

authors： Mujsce DJ,Towfighi J,Heitjan DF,Vannucci RC

更新日期：1994-07-01 00:00:00

abstract：:The value of the concomittant use of a real time frequency analyzer along with a continuous wave carotid Doppler scanner is demonstrated in this study of 118 cases. With a colour-coded Doppler scanner alone, internal carotid stenoses greater than 35% were diagnosed with a sensitivity of 95% and a specificity of 82%. W...

journal_title：Stroke

authors： Johnston KW,Brown PM,Kassam M

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pathophysiology of borderzone infarcts is not well understood. We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts. METHODS:Seventeen patients with borderzone i...

journal_title：Stroke

authors： Chaves CJ,Silver B,Schlaug G,Dashe J,Caplan LR,Warach S

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. METHODS:Antibody titers to 5 common infectious microorganisms (ie, C...

journal_title：Stroke

authors： Elkind MS,Luna JM,Moon YP,Boden-Albala B,Liu KM,Spitalnik S,Rundek T,Sacco RL,Paik MC

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) causes acute vasoconstriction that contributes to ischemic brain injury shortly after the initial bleed. It has been theorized that decreased availability of nitric oxide (NO) may contribute to acute vasoconstriction. Therefore we examined the effect of the NO donor ...

journal_title：Stroke

authors： Sehba FA,Ding WH,Chereshnev I,Bederson JB

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...

journal_title：Stroke

authors： Santiago-Sim T,Depalma SR,Ju KL,McDonough B,Seidman CE,Seidman JG,Kim DH

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke MRI protocols provide useful information about underlying vessel pathologies in the anterior circulation by means of intracranial time-of-flight angiography. However, these protocols mostly fail in the posterior circulation to differentiate between congenital variants and secondary thrombo...

journal_title：Stroke

authors： Freund W,Kassubek J,Aschoff AJ,Huber R

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clinical development of novel neuroprotection therapies for the treatment of brain injury has been unsuccessful. One critical limitation is the lack of a viable therapeutic treatment window (TW). In this study, we evaluated the neuroprotection TW for the proteosome inhibitor MLN519 after ischemia...

journal_title：Stroke

authors： Williams AJ,Berti R,Dave JR,Elliot PJ,Adams J,Tortella FC

更新日期：2004-05-01 00:00:00

abstract：:Hyperventilation to extremely low arterial carbon dioxide tension (PaCO2) has been used in the management of persistent pulmonary hypertension in newborn infants. With progressive hypocarbia, cerebral vasoconstriction occurs, raising the concern that extreme hypocarbia may result in cerebral oxygen deprivation. Theref...

journal_title：Stroke

authors： Rosenberg AA

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid...

journal_title：Stroke

authors： Phan TG,Beare RJ,Jolley D,Das G,Ren M,Wong K,Chong W,Sinnott MD,Hilton JE,Srikanth V

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...

journal_title：Stroke

authors： Khoury JC,Kleindorfer D,Alwell K,Moomaw CJ,Woo D,Adeoye O,Flaherty ML,Khatri P,Ferioli S,Broderick JP,Kissela BM

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Telestroke has been effective in the management of acute ischemic stroke. This study characterizes and compares stroke specialist (SS) and emergency physician (EP) perceptions of telestroke and identifies barriers preventing increased implementation. METHODS:A survey was developed and distribute...

journal_title：Stroke

authors： Moskowitz A,Chan YF,Bruns J,Levine SR

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal ...

journal_title：Stroke

authors： Athappan G,Chacko P,Patvardhan E,Gajulapalli RD,Tuzcu EM,Kapadia SR

更新日期：2014-01-01 00:00:00

abstract：:As part of the Ni-Hon-San Study, stroke incidence was compared in the Japan and Hawaii cohorts. Stroke cases were classified in two types, intracranial hemorrhage (ICH) and thrombo-embolic stroke (T-E). For each type the incidence in Japan was about three times as great as in Hawaii. The ratio ICH/T-E was 1/2.2 and 1/...

journal_title：Stroke

authors： Takeya Y,Popper JS,Shimizu Y,Kato H,Rhoads GG,Kagan A

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...

journal_title：Stroke

authors： Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Potassium intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between potassium intake and stroke risk. METHODS:Pertinent studies were identified by a search of PubMed from January 1966 through March ...

journal_title：Stroke

authors： Larsson SC,Orsini N,Wolk A

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous work has shown that rates of cerebral microemboli downstream of high-grade internal carotid artery stenosis are higher in recently symptomatic compared with asymptomatic patients. In addition, microembolic rates decline after carotid endarterectomy. We conducted a prospective investigati...

journal_title：Stroke

authors： Sitzer M,Müller W,Siebler M,Hort W,Kniemeyer HW,Jäncke L,Steinmetz H

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The underlying mechanisms for reductions in cerebral blood flow (CBF) during orthostasis are not completely understood. This study tested the hypothesis that sympathetic activation causes cerebral vasoconstriction leading to reductions in CBF during lower body negative pressure (LBNP). METHODS:C...

journal_title：Stroke

authors： Zhang R,Levine BD

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Waist circumference has been shown to be a better predictor of cardiovascular risk than body mass index (BMI). Our case-control study aimed to evaluate the contribution of obesity and abdominal fat mass to the risk of stroke and transient ischemic attacks (TIA). METHODS:We recruited 1137 partici...

journal_title：Stroke

authors： Winter Y,Rohrmann S,Linseisen J,Lanczik O,Ringleb PA,Hebebrand J,Back T

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...

journal_title：Stroke

authors： Wijdicks EF,Sheth KN,Carter BS,Greer DM,Kasner SE,Kimberly WT,Schwab S,Smith EE,Tamargo RJ,Wintermark M,American Heart Association Stroke Council.

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:In the United States, stroke mortality is higher in the south than in other regions. Hypertension is the main risk factor for stroke among older adults; however, few studies have examined group-specific regional and urbanization differences in hypertension prevalence. METHODS:Data from the Third National He...

journal_title：Stroke

authors： Obisesan TO,Vargas CM,Gillum RF

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because the diagnosis and treatment of carotid artery disease may reduce the rate of stroke, the aim of this study was to determine whether a diet intervention was associated with incident carotid artery disease. METHODS:Participants were 48 835 postmenopausal women aged 50 to 79 years who were ...

journal_title：Stroke

authors： Allison MA,Aragaki A,Eaton C,Li W,Van Horn L,Daviglus ML,Berger JS

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To study the longitudinal relationship of functional change in walking ability and change in time-dependent covariates and to develop a multivariate regression model to predict longitudinal change of walking ability. METHODS:A total of 101 acute stroke patients with first-ever ischemic middle ce...

journal_title：Stroke

authors： Kollen B,van de Port I,Lindeman E,Twisk J,Kwakkel G

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...

journal_title：Stroke

authors： Weise J,Sandau R,Schwarting S,Crome O,Wrede A,Schulz-Schaeffer W,Zerr I,Bähr M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Spontaneous dissection of the cervical internal carotid artery (sICAD) is mainly assessed with MRI and magnetic resonance angiography (MRA), which are not always at hand. In contrast, color duplex sonography (CDS) is readily available. We undertook this prospective study to examine the accuracy o...

journal_title：Stroke

authors： Benninger DH,Georgiadis D,Gandjour J,Baumgartner RW

更新日期：2006-02-01 00:00:00