Gene therapy for cerebral vascular disease.

abstract：BACKGROUND AND PURPOSE:In perimesencephalic nonaneurysmal hemorrhage (PMH), subarachnoid blood accumulates around the midbrain. Clinical and radiological characteristics suggest a venous origin of PMH. We compared the venous drainage of the midbrain between patients with PMH and aneurysmal subarachnoid hemorrhage (aSAH...

journal_title：Stroke

authors： van der Schaaf IC,Velthuis BK,Gouw A,Rinkel GJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We earlier reported that risk factors for stroke prepare brain stem tissue for a modified Shwartzman reaction, including the development of ischemia and hemorrhage and the production of tumor necrosis factor-alpha, after a provocative dose of lipopolysaccharide. In the present study, we sought to...

journal_title：Stroke

authors： Sirén AL,Liu Y,Feuerstein G,Hallenbeck JM

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...

journal_title：Stroke

authors： Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Shoulder pain is a common complication after stroke that can impede participation in rehabilitation and has been associated with poorer outcomes. Evidence-based treatments for hemiplegic shoulder pain are limited. Suprascapular nerve block (SSNB) is a safe and effective treatment of shoulder pain...

journal_title：Stroke

authors： Adey-Wakeling Z,Crotty M,Shanahan EM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose was to investigate the occurrence of self-reported falls in people with stroke at 3, 6, and 12 months and 6 years post stroke and predictors for falls during 6 years. METHODS:A prospective study involving 121 people with stroke. Data were obtained through structured interviews and as...

journal_title：Stroke

authors： Minet LR,Peterson E,von Koch L,Ytterberg C

更新日期：2015-09-01 00:00:00

abstract：:Background and Purpose- Information on what effect disability before stroke can have on stroke outcome is lacking. We assessed prestroke disability in relation to poststroke hospital outcome. Methods- Analysis of prospectively collected data from the Sentinel Stroke National Audit Programme. A total of 1656 men (mean ...

journal_title：Stroke

authors： Han TS,Fry CH,Gulli G,Affley B,Robin J,Irvin-Sellers M,Fluck D,Kakar P,Sharma S,Sharma P

更新日期：2020-02-01 00:00:00

abstract：:The nature of alpha-adrenergic receptors in human cerebral arteries was characterized, and alteration of these receptors after subarachnoid hemorrhage was examined using a radioligand binding assay. Norepinephrine content of control arteries was also analyzed and compared with that of arteries after subarachnoid hemor...

journal_title：Stroke

authors： Tsukahara T,Taniguchi T,Miwa S,Shimohama S,Fujiwara M,Nishikawa M,Handa H

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic su...

journal_title：Stroke

authors： Hernandez DA,Bokkers RP,Mirasol RV,Luby M,Henning EC,Merino JG,Warach S,Latour LL

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral sinovenous thrombosis is a rare disease with severe neurological sequelae. The aim of this retrospective multicenter study was to investigate the clinical course, possible risk factors, and outcome of a cohort of neonatal patients with sinovenous thrombosis and, second, to estimate the i...

journal_title：Stroke

authors： Berfelo FJ,Kersbergen KJ,van Ommen CH,Govaert P,van Straaten HL,Poll-The BT,van Wezel-Meijler G,Vermeulen RJ,Groenendaal F,de Vries LS,de Haan TR

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized ...

journal_title：Stroke

authors： Labeyrie PE,Goulay R,Martinez de Lizarrondo S,Hébert M,Gauberti M,Maubert E,Delaunay B,Gory B,Signorelli F,Turjman F,Touzé E,Courthéoux P,Vivien D,Orset C

更新日期：2017-09-01 00:00:00

abstract：:Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...

journal_title：Stroke

authors： Jonas S

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. We investigated the validity, reliability, and feasibility of the Montr...

journal_title：Stroke

authors： Wong A,Nyenhuis D,Black SE,Law LS,Lo ES,Kwan PW,Au L,Chan AY,Wong LK,Nasreddine Z,Mok V

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased amount of therapy seems to be beneficial for motor recovery after stroke. The primary aim of the present study was to evaluate the effect of a 4-week community-based intensive motor training program combined with early supported discharge after initial treatment in a comprehensive strok...

journal_title：Stroke

authors： Askim T,Mørkved S,Engen A,Roos K,Aas T,Indredavik B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) lower serum cholesterol and decrease the incidence of stroke and cardiovascular disease. There is growing evidence that statins exert some of their beneficial effects independent of cholesterol lowering. Indeed, we...

journal_title：Stroke

authors： Amin-Hanjani S,Stagliano NE,Yamada M,Huang PL,Liao JK,Moskowitz MA

更新日期：2001-04-01 00:00:00

abstract：:Background and Purpose- If a relationship between stroke etiology and thrombus computed tomography characteristics exists, assessing these characteristics in clinical practice could serve as a useful additional diagnostic tool for the identification of stroke subtype. Our purpose was to study the association of stroke...

journal_title：Stroke

authors： Boodt N,Compagne KCJ,Dutra BG,Samuels N,Tolhuisen ML,Alves HCBR,Kappelhof M,Lycklama À Nijeholt GJ,Marquering HA,Majoie CBLM,Lingsma HF,Dippel DWJ,van der Lugt A,Coinvestigators MR CLEAN Registry.

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vorapaxar is an antiplatelet agent that antagonizes thrombin-mediated activation of the protease-activated receptor-1 on platelets. We tested the efficacy and safety of vorapaxar in a prespecified analysis in the stroke subcohort from a multinational, randomized, placebo-controlled trial. METHOD...

journal_title：Stroke

authors： Morrow DA,Alberts MJ,Mohr JP,Ameriso SF,Bonaca MP,Goto S,Hankey GJ,Murphy SA,Scirica BM,Braunwald E,Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events–TIMI 50 Steering Committee and Investigators

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricu...

journal_title：Stroke

authors： Naff N,Williams MA,Keyl PM,Tuhrim S,Bullock MR,Mayer SA,Coplin W,Narayan R,Haines S,Cruz-Flores S,Zuccarello M,Brock D,Awad I,Ziai WC,Marmarou A,Rhoney D,McBee N,Lane K,Hanley DF Jr

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS:We evaluated over time changes in stroke ...

journal_title：Stroke

authors： Ukraintseva S,Sloan F,Arbeev K,Yashin A

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of the study is to compare the reliability of the Barthel activities of daily living score, which assesses disability, with the Rankin scale, which assesses handicap, and to determine their mutual agreement. METHODS:Fifty patients with stroke of varying severity were identified by a ...

journal_title：Stroke

authors： Wolfe CD,Taub NA,Woodrow EJ,Burney PG

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...

journal_title：Stroke

authors： Diringer MN,Skolnick BE,Mayer SA,Steiner T,Davis SM,Brun NC,Broderick JP

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The relationship between diabetic retinopathy and ischemic stroke is uncertain and examined in this study. METHODS:A population-based, prospective cohort study of 1617 middle-aged persons with diabetes. Diabetic retinopathy signs were ascertained from retinal photographs, and incident ischemic s...

journal_title：Stroke

authors： Cheung N,Rogers S,Couper DJ,Klein R,Sharrett AR,Wong TY

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The overall burden of prior infections may contribute to atherosclerosis and stroke risk. We hypothesized that serological evidence of common infections would be associated with carotid plaque thickness in a multiethnic cohort. METHODS:Antibody titers to 5 common infectious microorganisms (ie, C...

journal_title：Stroke

authors： Elkind MS,Luna JM,Moon YP,Boden-Albala B,Liu KM,Spitalnik S,Rundek T,Sacco RL,Paik MC

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of percutaneous transluminal coronary angioplasty (PTCA) to treat coronary artery disease is now commonplace. The occurrence of microemboli during invasive procedures such as cardiac angiography and bypass surgery is well documented, although neurological complications are relatively unco...

journal_title：Stroke

authors： Bladin CF,Bingham L,Grigg L,Yapanis AG,Gerraty R,Davis SM

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of our study was to compare outcome and its determinants in familial subarachnoid hemorrhage and in sporadic subarachnoid hemorrhage in a large and well-documented patient population. METHODS:Patients with aneurysmal subarachnoid hemorrhage (SAH) treated at the Department of Neurosurgery...

journal_title：Stroke

authors： Ronkainen A,Niskanen M,Piironen R,Hernesniemi J

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The influence of stroke lateralization on functional and cardiovascular outcome after stroke is not well established. We evaluated the influence of hemispheric lateralization among patients enrolled in prospective acute stroke trials. METHODS:We obtained data from the VISTA database for acute st...

journal_title：Stroke

authors： Fink JN,Frampton CM,Lyden P,Lees KR,Virtual International Stroke Trials Archive Investigators.

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Combined effects of socioeconomic position and well-established risk factors on stroke incidence have not been formally investigated. METHODS:In a pooled cohort study of 68 643 men and women aged 30 to 70 years in Denmark, we examined the combined effect and interaction between socioeconomic pos...

journal_title：Stroke

authors： Nordahl H,Osler M,Frederiksen BL,Andersen I,Prescott E,Overvad K,Diderichsen F,Rod NH

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study was conducted to analyze the association between reported risk factors for Alzheimer's disease, apolipoprotein E epsilon4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer's disease. METHODS:Our data are based on clinical and pos...

journal_title：Stroke

authors： Irina A,Seppo H,Arto M,Paavo R Sr,Hilkka S

更新日期：1999-03-01 00:00:00

abstract：:Blood flow velocity of the middle cerebral artery was monitored during cardiopulmonary bypass procedures by means of transcranial Doppler ultrasonography. Our investigation was carried out in a group of 16 patients with severe carotid stenosis or occlusion and in a control group of 42 patients with no or stenosis of l...

journal_title：Stroke

authors： von Reutern GM,Hetzel A,Birnbaum D,Schlosser V

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Historically, the use of tissue plasminogen activator (tPA) thrombolysis in pregnancy has been regarded as relatively contraindicated. Underlying this stance has been the concern over the risk of bleeding complications in both mother and child. SUMMARY OF CASE:We report the successful use of int...

journal_title：Stroke

authors： Wiese KM,Talkad A,Mathews M,Wang D

更新日期：2006-08-01 00:00:00

abstract：:A previously healthy young woman presented with sudden onset of quadriplegia, anesthesia below the C3 dermatome, respiratory paralysis, vertical nystagmus, ocular bobbing and cortical blindness. After partial resolution of the latter deficits, she remained quadriplegic, with a C3 level of anesthesia, and in respirator...

journal_title：Stroke

authors： Kase CS,Varakis JN,Stafford JR,Mohr JP

更新日期：1983-05-01 00:00:00