Abstract:
:Background and Purpose- If a relationship between stroke etiology and thrombus computed tomography characteristics exists, assessing these characteristics in clinical practice could serve as a useful additional diagnostic tool for the identification of stroke subtype. Our purpose was to study the association of stroke etiology and thrombus computed tomography characteristics in patients with acute ischemic stroke due to a large vessel occlusion. Methods- For 1429 consecutive patients enrolled in the MR CLEAN Registry, we determined stroke cause as defined by the TOAST (Trial of ORG 10172 in Acute Stroke Treatment) criteria. The association of stroke etiology with the hyperdense artery sign, clot burden score, and thrombus location was estimated with univariable and multivariable binary and ordinal logistic regression. Additionally, for 367 patients with available thin-section imaging, we assessed the association of stroke etiology with absolute and relative thrombus attenuation, distance from internal carotid artery-terminus to thrombus, thrombus length, and thrombus attenuation increase with univariable and multivariable linear regression. Results- Compared with cardioembolic strokes, noncardioembolic strokes were associated with presence of hyperdense artery sign (odds ratio, 2.2 [95% CI, 1.6-3.0]), lower clot burden score (common odds ratio, 0.4 [95% CI, 0.3-0.6]), shift towards a more proximal thrombus location (common odds ratio, 0.2 [95% CI, 0.2-0.3]), higher absolute thrombus attenuation (β, 3.6 [95% CI, 0.9-6.4]), decrease in distance from the ICA-terminus (β, -5.7 [95% CI, -8.3 to -3.0]), and longer thrombi (β, 8.6 [95% CI, 6.5-10.7]), based on univariable analysis. Thrombus characteristics of strokes with undetermined cause were similar to those of cardioembolic strokes. Conclusions- Thrombus computed tomography characteristics of cardioembolic stroke are distinct from those of noncardioembolic stroke. Additionally, our study supports the general hypothesis that many cryptogenic strokes have a cardioembolic cause. Further research should focus on the use of thrombus computed tomography characteristics as a diagnostic tool for stroke cause in clinical practice.
journal_name
Strokejournal_title
Strokeauthors
Boodt N,Compagne KCJ,Dutra BG,Samuels N,Tolhuisen ML,Alves HCBR,Kappelhof M,Lycklama À Nijeholt GJ,Marquering HA,Majoie CBLM,Lingsma HF,Dippel DWJ,van der Lugt A,Coinvestigators MR CLEAN Registry.doi
10.1161/STROKEAHA.119.027749subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1727-1735issue
6eissn
0039-2499issn
1524-4628journal_volume
51pub_type
杂志文章,多中心研究,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Toll-like receptors (TLRs) and the scavenger receptor CD36 are key molecular sensors for the innate immune response to invading pathogens. However, these receptors may also recognize endogenous "danger signals" generated during brain injury, such as cerebral ischemia, and trigger a maladaptive in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.572552
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Montreal Cognitive Assessment (MoCA) and Addenbrooke's Cognitive Examination-Revised (ACE-R) are proposed as short cognitive tests for use after stroke, but there are few published validations against a neuropsychological battery. We studied the relationship between MoCA, ACE-R, Mini-Mental S...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.633586
更新日期:2012-02-01 00:00:00
abstract::A 51-yearold man with moderate intermittent hypertension had a rapidly progressive, profound dementia in the absence of significant localizing neurological signs. Postmortem examination disclosed the vascular alterations and diffuse white matter degeneration which characterize subcortical arteriosclerotic encephalopat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.6.626
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute basilar artery occlusion, intra-arterial thrombolysis or endovascular mechanical recanalization may result in higher recanalization rates than intravenous thrombolysis. However, many patients are admitted to community hospitals, where endovascular therapy is usually not readily available...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.109.567552
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tacrolimus, an immunosuppressant agent, has been shown to reduce tissue injury and leukocyte accumulation after transient ischemia. This study was designed to evaluate quantitatively the inhibitory effects of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation in vivo after t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.7.1431
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pial arterioles transiently dilate during cortical spreading depression (CSD), although the mechanisms are unclear. We tested the hypothesis that increased production of nitric oxide (NO) promotes arteriolar dilation. METHODS:Urethane-anesthetized rabbits were equipped with cranial windows, and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.12.2463
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cavernous malformations of the brain (CMs) cause intracranial hemorrhage, but its reported frequency varies, partly attributable to study design. To improve the validity of future research, we aimed to develop a robust definition of CM hemorrhage. METHODS:We systematically reviewed the published...
journal_title:Stroke
pub_type: 共识发展会议,指南,杂志文章,评审
doi:10.1161/STROKEAHA.108.515544
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of percutaneous transluminal coronary angioplasty (PTCA) to treat coronary artery disease is now commonplace. The occurrence of microemboli during invasive procedures such as cardiac angiography and bypass surgery is well documented, although neurological complications are relatively unco...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.11.2367
更新日期:1998-11-01 00:00:00
abstract::A multi-centered cooperative study is being undertaken to determine the role of carotid endarterectomy in the treatment of asymptomatic carotid stenosis. The primary objective is to compare the incidence of transient ischemic attacks, stroke, and death in previously asymptomatic patients with arteriographically confir...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.17.3.534
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Symptomatic intracranial hemorrhage (SICH) is the most feared complication after tissue plasminogen activator (tPA) stroke treatment. Endogenous fibrinolysis inhibitors play an essential role in the coagulation/fibrinolysis balance and may be involved in the bleeding process. We aim to determine ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000137608.73660.4c
更新日期:2004-09-01 00:00:00
abstract::Background and Purpose- The optimal antithrombotic strategy to balance thromboembolic and bleeding events, especially acute stroke, for patients with atrial fibrillation following coronary stenting remains a matter of debate. We conducted a network meta-analysis to identify the antithrombotic regimen associated with t...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.119.026078
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Variation in the outcome after aneurysmal subarachnoid hemorrhage (SAH) is not fully explained by known prognostic factors. APOE genotype is the most important genetic determinant of susceptibility to Alzheimer's disease, and it is also shown to be associated with the outcome after traumatic brai...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.5.1181
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The collagen alpha2(I) gene (COL1A2) on chromosome 7q22.1, a positional and functional candidate for intracranial aneurysm (IA), was extensively screened for susceptibility in Japanese IA patients. METHODS:Twenty-one single nucleotide polymorphisms (SNPs) of COL1A2 were genotyped in genomic DNA ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000110788.45858.DC
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pathogenesis of periventricular hyperintensity (PVH) is still uncertain. We investigated the relationship between PVH and risk factors for cerebrovascular diseases, especially extracranial carotid artery stenosis (ECAS). METHODS:We studied PVH and ECAS in 323 subjects between 1991 and 1994. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.11.2174
更新日期:1997-11-01 00:00:00
abstract::We evaluated the effects of aging and hypertension on endothelium-dependent relaxation of rat common carotid arteries using 14-week-old (young) and 11-month-old (old) Wistar-Kyoto rats (WKY) and age-matched spontaneously hypertensive rats (SHR). Isometric tension of common carotid artery ring segments was measured. Wi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.892
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previously, we have shown that hyperthermia significantly increased neuronal damage after ischemic injury in a focal embolic model of stroke in rats. In the present study, we examined the effects of hyperthermia on the efficacy of thrombolytic therapy in this stroke model. METHODS:In part A, eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000155684.20864.58
更新日期:2005-03-01 00:00:00
abstract::The cardiac conditions most commonly associated with cerebral embolism are rheumatic heart disease (RHD), atherosclerotic heart disease (myocardial infarction and atrial arrhythmias) and other kinds of nonvalvular atrial fibillation (AF). The natural history of cerebral embolism from these cardiac sources is reviewed....
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.11.5.433
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There have been few community-based studies of long-term prognosis after acute stroke. This study aims to provide precise estimates of the absolute and relative risks of stroke recurrence in an unselected cohort of patients with a first-ever stroke. METHODS:Six hundred seventy-five patients were...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.2.333
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Visit-to-visit variability in systolic blood pressure (SBP) is associated with an increased risk of stroke and was reduced in randomized trials by calcium channel blockers and diuretics but not by renin-angiotensin system inhibitors. However, time of day effects could not be determined. Day-to-da...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005982
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. We investigated the validity, reliability, and feasibility of the Montr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007253
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Little is known about the pattern of cerebrovascular disease (CVD) for diabetic and nondiabetic patients or about the cost of treatment for CVD in the United Kingdom. The purpose of this study was to extend previous work to describe the epidemiology and cost of acute care of CVD as a frequent com...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.6.1142
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To evaluate the periprocedural outcome after carotid artery stenting with embolic brain protection (EBP+) versus without embolic brain protection (EBP-). METHODS:We retrospectively reviewed data from a prospective nonrandomized database of 357 patients who underwent carotid artery stenting in th...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.607820
更新日期:2011-07-01 00:00:00
abstract::We produced cerebral vasospasm in 29 dogs by the "two-hemorrhage" method of intracisternal injections, 2 days apart, of autogenous arterial blood. Leukotriene (LT) C4, LTD4, and LTE4 were purified from incubated basilar artery, medulla oblongata, hypothalamus, median eminence, and blood clot from around the basilar ar...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.4.527
更新日期:1989-04-01 00:00:00
abstract::Background and Purpose- Hypertrophic cardiomyopathy patients with atrial fibrillation are at increased risk of stroke, and anticoagulation is strongly recommended. However, limited data are available regarding the safety and effectiveness of non-vitamin K antagonist oral anticoagulants (NOACs) for primary prevention o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026048
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Although a host of genetic, biochemical, physiological, anatomic, and histological factors have been implicated, to varying degrees, in the pathogenesis of stroke, biophysical factors are believed t...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.28.10.2067
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We systematically compared and appraised contemporary guidelines on management of asymptomatic and symptomatic carotid artery stenosis. METHODS:We systematically searched for guideline recommendations on carotid endarterectomy (CEA) or carotid angioplasty/stenting (CAS) published in any language...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.115.003390
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke education, 1 of 8 endorsed stroke performance measures, consists of 5 specific subcomponents: risk factors, stroke warning signs, emergency medical service activation, physician follow-up, and discharge medications. We identified predictors of stroke education performance measure complianc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000763
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It remains uncertain whether lower dose intravenous tissue-type plasminogen activator (tPA) for stroke is as effective and safe as the standard dose. METHODS:We analyzed data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Patients who were treate...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.005989
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A previous systematic review of randomized trials suggested a positive effect of antiplatelet therapy in patients with aneurysmal subarachnoid hemorrhage (SAH). We performed a randomized controlled trial to assess whether acetylsalicylic acid (ASA) reduces the risk of delayed ischemic neurologica...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000236841.16055.0f
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. METHODS:A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001187
更新日期:2013-07-01 00:00:00