Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations.

abstract：BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is a valid, reproducible scale that measures neurological deficit. Of 42 possible points, 7 points are directly related to measurement of language compared with only 2 points related to neglect. METHODS:We examined the placebo arm of the NIN...

journal_title：Stroke

authors： Woo D,Broderick JP,Kothari RU,Lu M,Brott T,Lyden PD,Marler JR,Grotta JC

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There are significant variations in mortality rates from stroke in Europe. A European Union BIOMED Concerted Action was established to assess and determine the reasons for the variations in case fatality and disability after stroke. METHODS:Hospital-based stroke registers were established in 12 ...

journal_title：Stroke

authors： Wolfe CD,Tilling K,Beech R,Rudd AG

更新日期：1999-02-01 00:00:00

abstract：:Thromboxane synthetase activity is selectively inhibited by (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046). A single dose of 100 mg OKY-046 was orally administered to patients with ischemic cerebrovascular disease and healthy volunteers. Platelet aggregation and thromboxane B...

journal_title：Stroke

authors： Uyama O,Nagatsuka K,Nakabayashi S,Isaka Y,Yoneda S,Kimura K,Abe H

更新日期：1985-03-01 00:00:00

abstract：:Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibiti...

journal_title：Stroke

authors： Endres M,Laufs U

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral white matter changes (WMC) and lacunar infarct are both believed to be consequence of small vessel disease. Whether the extent of WMC affect the type and degree of cognitive impairment in patients with lacunar infarct is not clear. The study was undertaken to determine if WMC influences ...

journal_title：Stroke

authors： Wen HM,Mok VC,Fan YH,Lam WW,Tang WK,Wong A,Huang RX,Wong KS

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Clinical trials have demonstrated improved 90-day outcomes for patients with acute ischemic stroke treated with stent retriever thrombectomy plus tissue-type plasminogen activator (SST+tPA) compared with tPA. Previous studies suggested that this strategy may be cost-effective, but models were der...

journal_title：Stroke

authors： Shireman TI,Wang K,Saver JL,Goyal M,Bonafé A,Diener HC,Levy EI,Pereira VM,Albers GW,Cognard C,Hacke W,Jansen O,Jovin TG,Mattle HP,Nogueira RG,Siddiqui AH,Yavagal DR,Devlin TG,Lopes DK,Reddy VK,du Mesnil de Rochemo

更新日期：2017-02-01 00:00:00

abstract：:Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...

journal_title：Stroke

authors： Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:A number of clinical syndromes describing the presentation of deep brain infarcts are called lacunar syndromes resulting from small vessel occlusion (SVO). To verify the reliability of the clinical diagnosis "lacunar syndrome," the value was investigated with diffusion-weighted MRI (DWI). METHODS AND RESULT...

journal_title：Stroke

authors： Wessels T,Röttger C,Jauss M,Kaps M,Traupe H,Stolz E

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We investigated changes in locomotor activity, passive avoidance task performance, and hippocampal CA1 neurons induced by cerebral ischemia in Mongolian gerbils to examine the relation between these behavioral changes and CA1 neuronal damage. METHODS:Spontaneous locomotor activity was measured u...

journal_title：Stroke

authors： Karasawa Y,Araki H,Otomo S

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Glutamate receptor antagonists are protective in animal models of focal cerebral ischemia. Lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) is an anticonvulsant drug that blocks voltage-gated sodium channels and inhibits the ischemia-induced release of glutamate. We describe the ce...

journal_title：Stroke

authors： Smith SE,Meldrum BS

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies using animal models of stroke have shown that human serum albumin (HSA) significantly ameliorates cerebral ischemic injury after both transient and permanent ischemia, even when administered after the onset of ischemia or reperfusion. The mechanism of this effect remains uncertain, and pr...

journal_title：Stroke

authors： Gum ET,Swanson RA,Alano C,Liu J,Hong S,Weinstein PR,Panter SS

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The consequences of stroke are a major health concern. This study was conducted to compare the health-related quality of life among long-term survivors of stroke with that of the general population. METHODS:Our data are taken from a population-based case-control study of all 6-year survivors of ...

journal_title：Stroke

authors： Hackett ML,Duncan JR,Anderson CS,Broad JB,Bonita R

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our aims were to quantify the yield of Holter monitor for detection of paroxysmal atrial fibrillation (PAF) in patients with stroke and TIA, and to determine potential predictors of PAF to allow more focused testing. METHODS:We reviewed records of 1128 consecutive patients attending a university...

journal_title：Stroke

authors： Alhadramy O,Jeerakathil TJ,Majumdar SR,Najjar E,Choy J,Saqqur M

更新日期：2010-11-01 00:00:00

abstract：:Background and Purpose- There is debate over an optimal systolic blood pressure (SBP) in secondary stroke prevention of patients with symptomatic intracranial atherosclerotic stenosis (sICAS). We investigated whether translesional pressure gradient across sICAS would alter the relationship between SBP and risk of recu...

journal_title：Stroke

authors： Feng X,Chan KL,Lan L,Abrigo J,Ip VHL,Soo YOY,Leung TW,Leng X

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, whi...

journal_title：Stroke

authors： Reidler P,Thierfelder KM,Fabritius MP,Sommer WH,Meinel FG,Dorn F,Wollenweber FA,Duering M,Kunz WG

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ventricular assist devices (VADs) have advanced the management of end-stage heart failure. However, these devices are associated with hemorrhagic and thrombotic complications, including stroke. We assessed the incidence, risk factors, and outcomes of ischemic and hemorrhagic stroke after VAD plac...

journal_title：Stroke

authors： Parikh NS,Cool J,Karas MG,Boehme AK,Kamel H

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mild stroke (MS) and rapidly improving stroke (RIS) symptoms are common stroke presentations. Our objective is to describe the short-term outcomes in this population. METHODS:A retrospective analysis of patients with ischemic stroke in the Get With The Guidelines-Stroke registry who arrived ≤4.5...

journal_title：Stroke

authors： Romano JG,Smith EE,Liang L,Gardener H,Campo-Bustillo I,Khatri P,Bhatt DL,Fonarow GC,Sacco RL,Schwamm LH

更新日期：2016-05-01 00:00:00

abstract：:We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...

journal_title：Stroke

authors： Yaqub BA,Shamena AR,Kolawole TM,Patel PJ

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Arterial stiffness is associated with an increased risk of myocardial infarction and stroke, independent of classical vascular risk factors. Vascular factors and stroke are associated with cognitive function and dementia. We examined whether arterial stiffness was independently associated with co...

journal_title：Stroke

authors： Poels MM,van Oijen M,Mattace-Raso FU,Hofman A,Koudstaal PJ,Witteman JC,Breteler MM

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although insulin resistance and hyperinsulinemia play a crucial role in the pathogenesis of atherosclerosis, little is known about their roles in ischemic stroke. The purpose of this study was to clarify whether insulin resistance and hyperinsulinemia are causative factors in the pathogenesis of ...

journal_title：Stroke

authors： Shinozaki K,Naritomi H,Shimizu T,Suzuki M,Ikebuchi M,Sawada T,Harano Y

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Loss of movement coordination is the main postacute symptom after cerebellar infarction. Although the course of motor recovery has been described previously, detailed kinematic descriptions of acute stage ataxia are rare and no attempt has been made to link improvements in motor function to measu...

journal_title：Stroke

authors： Konczak J,Pierscianek D,Hirsiger S,Bultmann U,Schoch B,Gizewski ER,Timmann D,Maschke M,Frings M

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intraventricular thrombolysis (IVT) is a promising treatment in facilitating intraventricular clot resolution after intraventricular hemorrhage. We examined in-hospital outcomes and resource utilization after thrombolysis in patients with intraventricular hemorrhage requiring ventriculostomy in a...

journal_title：Stroke

authors： Moradiya Y,Murthy SB,Newman-Toker DE,Hanley DF,Ziai WC

更新日期：2014-09-01 00:00:00

abstract：:Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment with antagonists of platelet-activating factor, no study has proved endogenous production of plate...

journal_title：Stroke

authors： Lindsberg PJ,Yue TL,Frerichs KU,Hallenbeck JM,Feuerstein G

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q. METHODS:We analyzed all the common variations using 16-tag sin...

journal_title：Stroke

authors： Ruigrok YM,Rinkel GJ,Wijmenga C

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pial arterioles transiently dilate during cortical spreading depression (CSD), although the mechanisms are unclear. We tested the hypothesis that increased production of nitric oxide (NO) promotes arteriolar dilation. METHODS:Urethane-anesthetized rabbits were equipped with cranial windows, and ...

journal_title：Stroke

authors： Colonna DM,Meng W,Deal DD,Busija DW

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The efficacy of neuroprotective approaches in stroke may be influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia (NBO) in normotensive versus hypertensive rats subjected to transient focal cerebral ischemia. METHODS:Male Sprague-Dawley and spontaneously hyp...

journal_title：Stroke

authors： Lan J,Esposito E,Ayata C,Singhal AB,Lo EH,Ji X

更新日期：2018-06-01 00:00:00

abstract：:Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...

journal_title：Stroke

authors： Chang CF,Massey J,Osherov A,Angenendt da Costa LH,Sansing LH

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to determine the effects of aging on regional cerebral blood flow and ischemic brain damage in transient cerebral ischemia in rats. METHODS:Five adult (5-6 months) and five aged (18-22 months) female spontaneously hypertensive rats were subjected to 20 minutes of bilateral carotid occl...

journal_title：Stroke

authors： Yao H,Sadoshima S,Ooboshi H,Sato Y,Uchimura H,Fujishima M

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17-92 cluster promotes oligodendrogenesis, neurogenesis, and axonal outgrowth. We, therefore, investigated whether the miR-17-92 cluster-enriched exosomes har...

journal_title：Stroke

authors： Xin H,Katakowski M,Wang F,Qian JY,Liu XS,Ali MM,Buller B,Zhang ZG,Chopp M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of first-ever stroke and transient ischemic attack (TIA) and 30-day case-fatality rates in a population-based setting in Tandil, Argentina. METHODS:We prospectively i...

journal_title：Stroke

authors： Bahit MC,Coppola ML,Riccio PM,Cipriano LE,Roth GA,Lopes RD,Feigin VL,Borrego Guerrero B,De Martino M,Díaz A,Ferrante D,Funaro F,Lavados P,Lewin ML,López DH,Macarrone P,Marciello R,Marino D,Martens C,Martínez P,Odr

更新日期：2016-06-01 00:00:00