Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations.


BACKGROUND AND PURPOSE:Identification of single-nucleotide polymorphisms (SNPs) associated with increased risk of new intracranial hemorrhage (ICH) after brain arteriovenous malformation (BAVM) diagnosis would facilitate risk stratification and identify potential targets for therapeutic intervention. METHODS:Patients with BAVM were longitudinally followed. Primary outcome was new ICH after diagnosis; censoring events were last follow-up or any BAVM treatment. We genotyped 4 promoter SNPs in 2 inflammatory cytokine genes: interleukin-6 (IL-6-174G>C; IL-6-572G>C) and tumor necrosis factor-alpha (TNF-alpha-238G>A; TNF-alpha-308G>A). Association of genotype with risk of new ICH was screened using chi2; SNPs associated with new ICH were further characterized using Cox proportional hazards. RESULTS:We genotyped 280 patients (50% female; 59% white, mean+/-SD age at diagnosis 37+/-17 years; 40% presenting with ICH). TNF-alpha-238G>A was associated with increased risk of new ICH after diagnosis (chi2; P=0.003). After adjusting for age, race/ethnicity, and clinical presentation, the risk of new ICH was increased for patients with TNF-alpha-238 AG genotype (hazard ratio, 4.01; P=0.015). No other SNP was found to be associated with new ICH. CONCLUSIONS:A TNF-alpha SNP was associated with increased risk of new ICH in the natural course of BAVMs. The role of inflammatory cytokines in the pathogenesis of BAVM hemorrhage merits further study.






Achrol AS,Pawlikowska L,McCulloch CE,Poon KY,Ha C,Zaroff JG,Johnston SC,Lee C,Lawton MT,Sidney S,Marchuk DA,Kwok PY,Young WL,UCSF BAVM Study Project.




Has Abstract


2006-01-01 00:00:00
















  • Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs.

    abstract:BACKGROUND AND PURPOSE:The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS:In 44 0- to 3-day-old piglets, hypoxic-ische...


    pub_type: 杂志文章


    authors: LeBlanc MH,Huang M,Vig V,Patel D,Smith EE

    更新日期:1993-07-01 00:00:00

  • Hypoglycemia presenting as basilar artery thrombosis.

    abstract:BACKGROUND AND PURPOSE:Following our treatment of a patient with hypoglycemia-induced brain stem symptoms, we examined the possible mechanisms for hypoglycemia presenting as basilar artery disease. CASE DESCRIPTION:We describe a patient who had progressive brain stem symptoms due to a diet-induced hypoglycemia initial...


    pub_type: 杂志文章


    authors: Röther J,Schreiner A,Wentz KU,Hennerici M

    更新日期:1992-01-01 00:00:00

  • Visualization of brain perfusion with harmonic gray scale and power doppler technology : an animal pilot study.

    abstract:BACKGROUND AND PURPOSE:It is unclear which harmonic imaging mode (power Doppler or gray-scale imaging) is superior and which measuring method is the most robust for the description of brain perfusion. METHODS:We performed an animal study on 6 beagles through the intact skull using a SONOS 5500 device and Optison injec...


    pub_type: 杂志文章


    authors: Seidel G,Algermissen C,Christoph A,Katzer T,Kaps M

    更新日期:2000-07-01 00:00:00

  • Patterns of alcohol intake and risk of stroke in middle-aged British men.

    abstract:BACKGROUND AND PURPOSE:The relationship between the pattern of alcohol intake and the risk of stroke is unclear, in particular the increased risk observed in abstainers and the possible protective effect of light to moderate drinking. For that reason, we examined in a large prospective study the role of alcohol consump...


    pub_type: 杂志文章


    authors: Wannamethee SG,Shaper AG

    更新日期:1996-06-01 00:00:00

  • Adiponectin and risk of stroke: prospective study and meta-analysis.

    abstract:BACKGROUND AND PURPOSE:The favorable cardiovascular effects attributed to adiponectin may lower risk of stroke. We investigated this in a prospective study and meta-analysis. METHODS:A case-cohort study nested within the Potsdam cohort of the European Prospective Investigation into Cancer was performed, with 170 incid...


    pub_type: 杂志文章,meta分析


    authors: Arregui M,Buijsse B,Fritsche A,di Giuseppe R,Schulze MB,Westphal S,Isermann B,Boeing H,Weikert C

    更新日期:2014-01-01 00:00:00

  • Experimental regional cerebral ischemia in the middle cerebral artery territory in primates. Part 3: effects on brain water and electrolytes in the late phase of acute MCA stroke.

    abstract::Experimental regional cerebral ischemia was produced in the middle cerebral artery (MCA) territory in primates (M. mulatta) by macrosphere embolization. Determinations of percentage tissue dry weight and tissue sodium and potassium concentrations were obtained in samples from the ischemic and non-ischemic hemispheres ...


    pub_type: 杂志文章


    authors: Bremer AM,Yamada K,West CR

    更新日期:1978-07-01 00:00:00

  • Late-phase contrast-enhanced ultrasound reflects biological features of instability in human carotid atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Development of translational functional imaging modalities for atherosclerosis risk stratification is sought for stroke prediction. Our group has developed late-phase contrast-enhanced ultrasound (LP-CEUS) to quantify microbubble contrast retention within carotid atherosclerosis and shown it to s...


    pub_type: 杂志文章


    authors: Shalhoub J,Monaco C,Owen DR,Gauthier T,Thapar A,Leen EL,Davies AH

    更新日期:2011-12-01 00:00:00

  • Contraction of human brain endothelial cells induced by thrombogenic and fibrinolytic factors. An in vitro cell culture model.

    abstract:BACKGROUND AND PURPOSE:Vasogenic brain edema is a frequent complication of ischemic stroke. The mechanism of the blood-brain barrier opening that underlies the edema formation is poorly understood. In the present study we examined the response of endothelial cells cultured from adult human brain to thrombogenic and fib...


    pub_type: 杂志文章


    authors: Nagy Z,Kolev K,Csonka E,Pék M,Machovich R

    更新日期:1995-02-01 00:00:00

  • Sympathetic control of the cerebral vasculature in humans.

    abstract:BACKGROUND AND PURPOSE:The role of the sympathetic nervous system in cerebral autoregulation remains poorly characterized. We examined cerebral blood flow responses to augmented arterial pressure oscillations with and without sympathetic blockade and compared them with responses in the forearm circulation. METHODS:An ...


    pub_type: 杂志文章


    authors: Hamner JW,Tan CO,Lee K,Cohen MA,Taylor JA

    更新日期:2010-01-01 00:00:00

  • Cerebrovascular disease in Saudi Arabia.

    abstract::We studied the pattern and outcome of strokes in 200 Saudi patients. Cerebral infarction constituted 87% of strokes, subarachnoid hemorrhage 4.5%, cerebral hemorrhage 6.5%, and venous infarction 2%. The vessel most commonly involved was part or all of the middle cerebral artery, constituting 52% (90) of the 174 arteri...


    pub_type: 杂志文章


    authors: Yaqub BA,Shamena AR,Kolawole TM,Patel PJ

    更新日期:1991-09-01 00:00:00

  • Presynaptic and postsynaptic alpha 2-adrenergic receptors in human cerebral arteries and their alteration after subarachnoid hemorrhage.

    abstract::The nature of alpha-adrenergic receptors in human cerebral arteries was characterized, and alteration of these receptors after subarachnoid hemorrhage was examined using a radioligand binding assay. Norepinephrine content of control arteries was also analyzed and compared with that of arteries after subarachnoid hemor...


    pub_type: 杂志文章


    authors: Tsukahara T,Taniguchi T,Miwa S,Shimohama S,Fujiwara M,Nishikawa M,Handa H

    更新日期:1988-01-01 00:00:00

  • Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery.

    abstract:BACKGROUND AND PURPOSE:The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some still question the importance of these changes in cognitive funct...


    pub_type: 杂志文章


    authors: Newman MF,Grocott HP,Mathew JP,White WD,Landolfo K,Reves JG,Laskowitz DT,Mark DB,Blumenthal JA,Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center.

    更新日期:2001-12-01 00:00:00

  • Persistent use of secondary preventive drugs declines rapidly during the first 2 years after stroke.

    abstract:BACKGROUND AND PURPOSE:To prevent new cardiovascular events after stroke, prescribed preventive drugs should be used continuously. This study measures persistent use of preventive drugs after stroke and identifies factors associated with persistence. METHODS:A 1-year cohort (21,077 survivors) from Riks-Stroke, the Swe...


    pub_type: 杂志文章


    authors: Glader EL,Sjölander M,Eriksson M,Lundberg M

    更新日期:2010-02-01 00:00:00

  • Bone mineral density and stroke.

    abstract:BACKGROUND AND PURPOSE:We sought to assess the long-term predictive usefulness of bone mineral density (BMD) for stroke incidence and stroke mortality. METHODS:The First National Health and Nutrition Examination Survey data were obtained from a nationally representative sample of noninstitutionalized civilians. A coho...


    pub_type: 杂志文章


    authors: Mussolino ME,Madans JH,Gillum RF

    更新日期:2003-05-01 00:00:00

  • Acute stroke teams: results of a national survey. National Acute Stroke Team Group.

    abstract:BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...


    pub_type: 杂志文章


    authors: Alberts MJ,Chaturvedi S,Graham G,Hughes RL,Jamieson DG,Krakowski F,Raps E,Scott P

    更新日期:1998-11-01 00:00:00

  • Hyperglycemia, recognized and unrecognized, as a risk factor for stroke and transient ischemic attacks.

    abstract::Glycosylated hemoglobin concentration (GHb), which is considered an indication of glycemia over the preceding several months, was examined in 50 patients hospitalized for recent stroke or transient ischemic attacks (TIA), and compared to that in several reference populations. Patients with stroke or TIA had GHb (mean ...


    pub_type: 杂志文章


    authors: Riddle MC,Hart J

    更新日期:1982-05-01 00:00:00

  • Prevention with low-dose aspirin plus dipyridamole in patients with disabling stroke.

    abstract:BACKGROUND AND PURPOSE:The combination of low-dose aspirin and dipyridamole is more effective than aspirin alone in reducing the risk of recurrent stroke and other major cardiovascular events in patients with a recent transient ischemic attack or minor stroke. It is unknown whether this also applies to patients with a ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Dippel DW,Maasland L,Halkes P,Kappelle LJ,Koudstaal PJ,Algra A,ESPRIT Study Group and the ESPS-2 Investigators.

    更新日期:2010-11-01 00:00:00

  • Management of cerebral embolism of cardiac origin.

    abstract::The cardiac conditions most commonly associated with cerebral embolism are rheumatic heart disease (RHD), atherosclerotic heart disease (myocardial infarction and atrial arrhythmias) and other kinds of nonvalvular atrial fibillation (AF). The natural history of cerebral embolism from these cardiac sources is reviewed....


    pub_type: 杂志文章,评审


    authors: Easton JD,Sherman DG

    更新日期:1980-09-01 00:00:00

  • Tacrolimus (FK506) attenuates leukocyte accumulation after transient retinal ischemia.

    abstract:BACKGROUND AND PURPOSE:Tacrolimus, an immunosuppressant agent, has been shown to reduce tissue injury and leukocyte accumulation after transient ischemia. This study was designed to evaluate quantitatively the inhibitory effects of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation in vivo after t...


    pub_type: 杂志文章


    authors: Tsujikawa A,Ogura Y,Hiroshiba N,Miyamoto K,Kiryu J,Honda Y

    更新日期:1998-07-01 00:00:00

  • Isolated and borderline isolated systolic hypertension relative to long-term risk and type of stroke: a 20-year follow-up of the national health and nutrition survey.

    abstract:BACKGROUND AND PURPOSE:Although the short-term risks of stroke and types of stroke associated with isolated systolic hypertension (ISH) and borderline isolated systolic hypertension (BISH) have been described, the long-term effects of these hypertensive conditions, particularly in younger individuals, are unclear. We p...


    pub_type: 杂志文章


    authors: Qureshi AI,Suri MF,Mohammad Y,Guterman LR,Hopkins LN

    更新日期:2002-12-01 00:00:00

  • Transcranial Doppler sonography monitoring of local intra-arterial thrombolysis in acute occlusion of the middle cerebral artery.

    abstract:BACKGROUND AND PURPOSE:The aim of this study is to report on the use of transcranial Doppler ultrasonography as a noninvasive diagnostic monitoring tool during local intra-arterial thrombolysis in a patient with acute embolic occlusion of the middle cerebral artery. CASE DESCRIPTION:We describe a 41-year-old woman wit...


    pub_type: 杂志文章


    authors: Karnik R,Stelzer P,Slany J

    更新日期:1992-02-01 00:00:00

  • Effects of formaldehyde fixation on basilar artery caliber.

    abstract::The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to...


    pub_type: 杂志文章


    authors: Hart MN,O'Donnell SL

    更新日期:1980-01-01 00:00:00

  • Biophysical mechanisms of stroke.

    abstract:BACKGROUND:Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Although a host of genetic, biochemical, physiological, anatomic, and histological factors have been implicated, to varying degrees, in the pathogenesis of stroke, biophysical factors are believed t...


    pub_type: 杂志文章,评审


    authors: Hademenos GJ,Massoud TF

    更新日期:1997-10-01 00:00:00

  • Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis.

    abstract:BACKGROUND AND PURPOSE:Improved methods of identifying patients at high risk of thromboembolism would allow improved targeting of therapy. One such situation is carotid artery stenosis. This is associated with an increased risk of stroke, which can be reduced by carotid endarterectomy. However, the risk-benefit ratio i...


    pub_type: 杂志文章


    authors: Molloy J,Markus HS

    更新日期:1999-07-01 00:00:00

  • Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.

    abstract:BACKGROUND AND PURPOSE:The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS:Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or...


    pub_type: 杂志文章


    authors: Gaberel T,Gakuba C,Hebert M,Montagne A,Agin V,Rubio M,Emery E,Vivien D,Gauberti M

    更新日期:2013-12-01 00:00:00

  • Virtual reality-induced cortical reorganization and associated locomotor recovery in chronic stroke: an experimenter-blind randomized study.

    abstract:BACKGROUND AND PURPOSE:Virtual reality (VR) is a new promising computer-assisted technology to promote motor recovery in stroke patients. VR-induced neuroplasticity supporting locomotor recovery is not known. We investigated the effects of VR intervention on cortical reorganization and associated locomotor recovery in ...


    pub_type: 杂志文章,随机对照试验


    authors: You SH,Jang SH,Kim YH,Hallett M,Ahn SH,Kwon YH,Kim JH,Lee MY

    更新日期:2005-06-01 00:00:00

  • Ischemic stroke and transient ischemic attack after head and neck radiotherapy: a review.

    abstract:BACKGROUND AND PURPOSE:Cerebrovascular disease can complicate head and neck radiotherapy and result in transient ischemic attack and ischemic stroke. Although the incidence of radiation vasculopathy is predicted to rise with improvements in median cancer survival, the pathogenesis, natural history, and management of th...


    pub_type: 杂志文章,评审


    authors: Plummer C,Henderson RD,O'Sullivan JD,Read SJ

    更新日期:2011-09-01 00:00:00

  • Ultrasonic demonstration of external and internal carotid patency with common carotid occlusion: a preliminary report.

    abstract::Non-invasive ultrasonic imaging of the carotid bifurcation by duplex scanning and ultrasonic arteriography combined with pulsed Doppler spectrum analysis demonstrated patency of the external and internal carotid arteries distal to a common carotid occlusion in 3 patients. Common carotid occlusion is not invariably ass...


    pub_type: 杂志文章


    authors: Blackshear WM Jr,Phillips DJ,Bodily KC,Strandness DE Jr

    更新日期:1980-05-01 00:00:00

  • Marked Regional Variation in Acute Stroke Treatment Among Medicare Beneficiaries.

    abstract:BACKGROUND AND PURPOSE:Little is known about how regions vary in their use of thrombolysis (intravenous tissue-type plasminogen activator and intra-arterial treatment) for acute stroke. We sought to determine regional variation in thrombolysis treatment and investigate the extent to which regional variation is accounte...


    pub_type: 杂志文章


    authors: Skolarus LE,Meurer WJ,Shanmugasundaram K,Adelman EE,Scott PA,Burke JF

    更新日期:2015-07-01 00:00:00

  • Quality of hospital and outpatient care after stroke or transient ischemic attack: insights from a stroke survey in the Netherlands.

    abstract:BACKGROUND AND PURPOSE:Limited data are available on management of outpatients with stroke or transient ischemic attack (TIA) and on clinicians' reasons for withholding procedures recommended by guidelines. We assessed to what extent guidelines are appropriately applied after ischemic stroke or TIA, in admitted patient...


    pub_type: 杂志文章,多中心研究


    authors: Scholte op Reimer WJ,Dippel DW,Franke CL,van Oostenbrugge RJ,de Jong G,Hoeks S,Simoons ML

    更新日期:2006-07-01 00:00:00