当前位置： SCI文献检索 > STROKE期刊下所有文献 > Intraventricular thrombolysis in intracerebral hemorrhage requiring ventriculostomy: a decade-long real-world experience.

Intraventricular thrombolysis in intracerebral hemorrhage requiring ventriculostomy: a decade-long real-world experience.

Abstract：

BACKGROUND AND PURPOSE:Intraventricular thrombolysis (IVT) is a promising treatment in facilitating intraventricular clot resolution after intraventricular hemorrhage. We examined in-hospital outcomes and resource utilization after thrombolysis in patients with intraventricular hemorrhage requiring ventriculostomy in a real-world setting. METHODS:We identified adult patients with primary diagnosis of nontraumatic intracerebral hemorrhage requiring ventriculostomy from the Nationwide Inpatient Sample from 2002 to 2011. We compared demographic and hospital characteristics, comorbidities, inpatient outcomes, and resource utilization measures between patients treated with IVT and those managed with ventriculostomy, but without IVT. Population estimates were extrapolated using standard Nationwide Inpatient Sample weighting algorithms. RESULTS:We included 34 044 patients in the analysis, of whom 1133 (3.3%) received IVT. The thrombolysis group had significantly lower inpatient mortality (32.4% versus 41.6%; P=0.001) and it remained lower after controlling for baseline demographics, hospital characteristics, comorbidity, case severity, and withdrawal of care status (adjusted odds ratio, 0.670; 95% confidence interval, 0.520-0.865; P=0.002). There was a trend toward favorable discharge (home or rehabilitation) among the thrombolysis cohort (adjusted odds ratio, 1.335; 95% confidence interval, 0.983-1.812; P=0.064). The adjusted rates of bacterial meningitis and ventricular shunt placement were similar between groups. The thrombolysis group had longer length of stay and higher inflation-adjusted cost of care, but cost of care per day length of stay was similar to the non-IVT group. CONCLUSIONS:IVT for intracerebral hemorrhage requiring ventriculostomy resulted in lower inpatient mortality and a trend toward favorable discharge outcome with similar rates of inpatient complications compared with the non-IVT group.

journal_name

Stroke

journal_title

Stroke

authors

Moradiya Y,Murthy SB,Newman-Toker DE,Hanley DF,Ziai WC

doi

10.1161/STROKEAHA.114.006067

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

2629-35

issue

9

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.114.006067

journal_volume

45

pub_type

杂志文章

相关文献

STROKE文献大全
  • Predictors of Early Neurologic Deterioration in Acute Pontine Infarction.

    abstract：:Background and Purpose- The relationship between infarct dimensions and neurological progression in patients with acute pontine infarctions remains unclear. This study aimed to investigate the morphometric predictive value of magnetic resonance imaging for early neurological deterioration (END) in acute pontine infarc...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.119.027239

    authors： Li H,Dai Y,Wu H,Luo L,Wei L,Zhou L,Lin Y,Wang Q,Lu Z

    更新日期：2020-02-01 00:00:00

  • Nonsteroidal lazaroid U78517F in models of focal and global ischemia.

    abstract：:U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：

    authors： Hall ED,Pazara KE,Braughler JM,Linseman KL,Jacobsen EJ

    更新日期：1990-11-01 00:00:00

  • Subarachnoid hemorrhage: a preventable disease with a heritable component.

    abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, and almost 40% of affected patients die within 30 days despite the best current therapy. Prevention of SAH is therefore of paramount importance. We present a preliminary analysi...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.0000014773.57733.3e

    authors： Kissela BM,Sauerbeck L,Woo D,Khoury J,Carrozzella J,Pancioli A,Jauch E,Moomaw CJ,Shukla R,Gebel J,Fontaine R,Broderick J

    更新日期：2002-05-01 00:00:00

  • Association of Low Lysosomal Enzymes Activity With Brain Arterial Dilatation.

    abstract：:Background and Purpose- Absent or diminished α-galactosidase A (GLA) and acid α-glucosidase (GAA) enzyme activity are core features of Fabry and Pompe disease, respectively. Patients with Fabry or Pompe disease may have dilated intracranial arteries but whether lower GLA or GAA enzyme activity relates to brain arteria...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.118.021964

    authors： Shah H,Liong C,Levy OA,Waters C,Fahn S,Marder K,Kang UJ,Wolf P,Oliva P,Zhang K,Alcalay RN,Gutierrez J

    更新日期：2018-08-01 00:00:00

  • Progression of White Matter Hyperintensities Preceded by Heterogeneous Decline of Microstructural Integrity.

    abstract：BACKGROUND AND PURPOSE:White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when pro...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.118.020980

    authors： van Leijsen EMC,Bergkamp MI,van Uden IWM,Ghafoorian M,van der Holst HM,Norris DG,Platel B,Tuladhar AM,de Leeuw FE

    更新日期：2018-06-01 00:00:00

  • Dysphagia after stroke: incidence, diagnosis, and pulmonary complications.

    abstract：OBJECTIVE:To determine the incidence of dysphagia and associated pulmonary compromise in stroke patients through a systematic review of the published literature. METHODS:Databases were searched (1966 through May 2005) using terms "cerebrovascular disorders," "deglutition disorders," and limited to "humans" for origina...

    journal_title：Stroke

    pub_type： 杂志文章,评审

    doi：10.1161/01.STR.0000190056.76543.eb

    authors： Martino R,Foley N,Bhogal S,Diamant N,Speechley M,Teasell R

    更新日期：2005-12-01 00:00:00

  • Mechanism of ATP-induced [Ca(2+)](i) mobilization in rat basilar smooth muscle cells.

    abstract：BACKGROUND AND PURPOSE:We have previously reported that extracellular ATP activates P(2u) receptors and increases intracellular free Ca(2+) ([Ca(2+)](i)) by G protein/phospholipase C/inositol 1,4,5-triphosphate pathways in cerebral artery smooth muscle cells. However, the possible contribution of other signaling pathwa...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.31.6.1377

    authors： Aoki K,Zubkov AY,Parent AD,Zhang JH

    更新日期：2000-06-01 00:00:00

  • Role of platelet function in symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

    abstract：:To evaluate the role of platelet function in the pathogenesis of cerebral vasospasm, we compared sequential changes of platelet aggregability and beta-thromboglobulin and thromboxane B2 concentrations in blood samples from the internal jugular and peripheral vein of 13 patients with aneurysmal subarachnoid hemorrhage....

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.22.7.854

    authors： Ohkuma H,Suzuki S,Kimura M,Sobata E

    更新日期：1991-07-01 00:00:00

  • Stroke symptoms in individuals reporting no prior stroke or transient ischemic attack are associated with a decrease in indices of mental and physical functioning.

    abstract：BACKGROUND AND PURPOSE:Stroke symptoms in the absence of recognized stroke are common, but potential associated dysfunctions have not been described. METHODS:We assessed quality-of-life measures using the Physical and Mental Component Summary scores of the Short Form 12 (PCS-12 and MCS-12) in the REasons for Geographi...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.106.478032

    authors： Howard G,Safford MM,Meschia JF,Moy CS,Howard VJ,Pulley L,Gomez CR,Crowther M

    更新日期：2007-09-01 00:00:00

  • beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients.

    abstract：BACKGROUND AND PURPOSE:This study was conducted to analyze the association between reported risk factors for Alzheimer's disease, apolipoprotein E epsilon4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer's disease. METHODS:Our data are based on clinical and pos...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.30.3.613

    authors： Irina A,Seppo H,Arto M,Paavo R Sr,Hilkka S

    更新日期：1999-03-01 00:00:00

  • Factors affecting changes in blood pressure after acute stroke.

    abstract：BACKGROUND AND PURPOSE:We sought to establish the pattern of blood pressure (BP) change after hospitalization for acute hemispheric stroke. METHODS:In 292 patients from the Leicester teaching hospitals with acute hemispheric stroke within the previous 24 hours (139 men; median age, 75 years [range, 42 to 98 years]), w...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.25.9.1726

    authors： Harper G,Castleden CM,Potter JF

    更新日期：1994-09-01 00:00:00

  • Inaccuracy of angiography in the diagnosis of carotid ulceration.

    abstract：:It is generally stated that ulceration of the carotid bifurcation plaque may give rise to embolization and symptoms of cerebral ischemia. It has been suggested that prophylactic carotid endarterectomy is indicated in asymptomatic patients if the angiogram is interpreted as showing ulceration. We therefore determined t...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.14.6.882

    authors： Eikelboom BC,Riles TR,Mintzer R,Baumann FG,DeFillip G,Lin J,Imparato AM

    更新日期：1983-11-01 00:00:00

  • Tuberculosis and the risk of ischemic stroke: a 3-year follow-up study.

    abstract：BACKGROUND AND PURPOSE:The aim of this study is to estimate the risk of ischemic stroke during a 3-year follow-up period after a tuberculosis diagnosis using a nationwide, population-based study and a retrospective cohort design. METHOD:The study cohort comprised 2283 patients who had received treatment for tuberculos...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.109.567735

    authors： Sheu JJ,Chiou HY,Kang JH,Chen YH,Lin HC

    更新日期：2010-02-01 00:00:00

  • Patent foramen ovale size and embolic brain imaging findings among patients with ischemic stroke.

    abstract：BACKGROUND AND PURPOSE:Although the cause of stroke among patients with patent foramen ovale (PFO) may be due to paradoxical cerebral embolism (PCE), this mechanism is often difficult to prove. The aim of our study was to evaluate the association between brain imaging findings suggestive of embolism and PFO among ische...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.29.5.944

    authors： Steiner MM,Di Tullio MR,Rundek T,Gan R,Chen X,Liguori C,Brainin M,Homma S,Sacco RL

    更新日期：1998-05-01 00:00:00

  • Deletion of cellular prion protein results in reduced Akt activation, enhanced postischemic caspase-3 activation, and exacerbation of ischemic brain injury.

    abstract：BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000217262.03192.d4

    authors： Weise J,Sandau R,Schwarting S,Crome O,Wrede A,Schulz-Schaeffer W,Zerr I,Bähr M

    更新日期：2006-05-01 00:00:00

  • Transient aortic arch syndrome with dysphasia due to ergotism.

    abstract：:A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.14.5.811

    authors： Feneley MP,Morgan JJ,McGrath MA,Egan JD

    更新日期：1983-09-01 00:00:00

  • Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population.

    abstract：BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Swe...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.STR.0000174188.04716.8d

    authors： Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg D

    更新日期：2005-08-01 00:00:00

  • Detection of hyperacute primary intraparenchymal hemorrhage by magnetic resonance imaging.

    abstract：BACKGROUND:MRI has become increasingly used in the acute setting to manage patients with stroke. There has been concern that MRI may not be sensitive in the detection of acute intracranial hemorrhage. We assessed whether strongly susceptibility-weighted MRI would be sensitive to intraparenchymal hemorrhage in the first...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.27.12.2321

    authors： Patel MR,Edelman RR,Warach S

    更新日期：1996-12-01 00:00:00

  • Third European Stroke Science Workshop.

    abstract：:Lake Eibsee, Garmisch-Partenkirchen, November 19 to 21, 2015: The European Stroke Organization convened >120 stroke experts from 27 countries to discuss latest results and hot topics in clinical, translational, and basic stroke research. Since its inception in 2011, the European Stroke Science Workshop has become a co...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.116.013516

    authors： Dichgans M,Planas AM,Biessels GJ,van der Worp B,Sudlow C,Norrving B,Lees K,Mattle HP

    更新日期：2016-07-01 00:00:00

  • Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

    abstract：BACKGROUND AND PURPOSE:Apolipoprotein E polymorphism may influence the early development of coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. METHODS:The apolipoprotein E phenotypes of 69 patients (mean +/- SD age, 72 +/- 11 years) who had suffered comple...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.24.5.661

    authors： Couderc R,Mahieux F,Bailleul S,Fenelon G,Mary R,Fermanian J

    更新日期：1993-05-01 00:00:00

  • Targeted Infarction of the Internal Capsule in the Rat Using Microstimulation Guidance.

    abstract：:Background and Purpose- Lacunar strokes are subcortical infarcts with small size and high disability rates, largely due to injury of the corticospinal tract in the internal capsule (IC). Current rodent models of lacunar infarcts are created based on stereotactic coordinates. We tested the hypothesis that better unders...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.119.025646

    authors： Wen TC,Sindhurakar A,Ramirez VC,Park H,Gupta D,Carmel JB

    更新日期：2019-09-01 00:00:00

  • Functional changes in human pial arteries (300 to 900 micrometer ID) within 48 hours of aneurysmal subarachnoid hemorrhage.

    abstract：BACKGROUND AND PURPOSE:Animal studies of cerebral arteries 2 to 3 days after experimental subarachnoid hemorrhage (SAH) provide evidence of arterial change such as hyperresponsiveness to contractile agonists. There is evidence that small arteries, as well as those large enough to be seen on angiography, may be involved...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/01.str.29.12.2575

    authors： Bevan JA,Bevan RD,Walters CL,Wellman T

    更新日期：1998-12-01 00:00:00

  • Safety of thrombolysis in stroke mimics: results from a multicenter cohort study.

    abstract：BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment of patients with an alternate diagnosis (stroke...

    journal_title：Stroke

    pub_type： 杂志文章,多中心研究

    doi：10.1161/STROKEAHA.111.000126

    authors： Zinkstok SM,Engelter ST,Gensicke H,Lyrer PA,Ringleb PA,Artto V,Putaala J,Haapaniemi E,Tatlisumak T,Chen Y,Leys D,Sarikaya H,Michel P,Odier C,Berrouschot J,Arnold M,Heldner MR,Zini A,Fioravanti V,Padjen V,Beslac-Bu

    更新日期：2013-04-01 00:00:00

  • Comparison of definitions of metabolic syndrome in relation to the risk of developing stroke and coronary heart disease in Finnish and Swedish cohorts.

    abstract：BACKGROUND AND PURPOSE:The purpose of this study was to compare definitions of metabolic syndrome with regard to their prediction of stroke and coronary heart disease incidence. METHODS:The study comprises 4041 men and 3812 women of 6 Finnish and Swedish cohorts aged 25 to 74 years at baseline. Hazard ratio was estima...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.108.518878

    authors： Qiao Q,Laatikainen T,Zethelius B,Stegmayr B,Eliasson M,Jousilahti P,Tuomilehto J

    更新日期：2009-02-01 00:00:00

  • Optimization of Prehospital Triage of Patients With Suspected Ischemic Stroke.

    abstract：:Background and Purpose- Prehospital routing algorithms for patients with suspected stroke because of large vessel occlusions should account for likelihood of benefit from endovascular therapy (EVT), risk of alteplase delays, and transport times. We built a mathematical model to give a real-time, location-based optimal...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.118.022041

    authors： Ali A,Zachrison KS,Eschenfeldt PC,Schwamm LH,Hur C

    更新日期：2018-10-01 00:00:00

  • Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques.

    abstract：BACKGROUND AND PURPOSE:Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear. METHODS:This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of as...

    journal_title：Stroke

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/STROKEAHA.113.004251

    authors： Amarenco P,Davis S,Jones EF,Cohen AA,Heiss WD,Kaste M,Laouénan C,Young D,Macleod M,Donnan GA,Aortic Arch Related Cerebral Hazard Trial Investigators.

    更新日期：2014-05-01 00:00:00

  • Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke.

    abstract：BACKGROUND AND PURPOSE:Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke, but the underlying mechanisms remain unclear. In this study, we aimed to validate the use of PTEN regulation of gamma-amino...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.110.579011

    authors： Liu B,Li L,Zhang Q,Chang N,Wang D,Shan Y,Li L,Wang H,Feng H,Zhang L,Brann DW,Wan Q

    更新日期：2010-05-01 00:00:00

  • Establishing Recommendations for Stroke Systems in the Thrombectomy Era: The Upstate New York Stakeholder Proceedings.

    abstract：BACKGROUND AND PURPOSE:The American Heart Association/American Stroke Association and Department of Health Stroke Coverdell Program convened a stakeholder meeting in upstate NY to develop recommendations to enhance stroke systems for acute large vessel occlusion. METHODS:Prehospital, hospital, and Department of Health...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.117.017412

    authors： Magdon-Ismail Z,Benesch C,Cushman JT,Brissette I,Southerland AM,Brandler ES,Sozener CB,Flor S,Hemmitt R,Wales K,Parrigan K,Levine SR,Upstate New York Stroke Work Groups.

    更新日期：2017-07-01 00:00:00

  • Urgent carotid surgery and stenting may be safe after systemic thrombolysis for stroke.

    abstract：BACKGROUND AND PURPOSE:Early carotid surgery or stenting after thrombolytic treatment for stroke has become more common during recent years. It is unclear whether this carries an increased risk of postoperative complications and death. The aim of this nationwide population-based study was, therefore, to investigate the...

    journal_title：Stroke

    pub_type： 杂志文章

    doi：10.1161/STROKEAHA.113.003763

    authors： Koraen-Smith L,Troëng T,Björck M,Kragsterman B,Wahlgren CM,Swedish Vascular Registry and the Riks-Stroke Collaboration.

    更新日期：2014-03-01 00:00:00

  • Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

    abstract：BACKGROUND AND PURPOSE:There are uncertainties surrounding the optimal management of patients with brain swelling after an ischemic stroke. Guidelines are needed on how to manage this major complication, how to provide the best comprehensive neurological and medical care, and how to best inform families facing complex ...

    journal_title：Stroke

    pub_type： 杂志文章,实务指引

    doi：10.1161/01.str.0000441965.15164.d6

    authors： Wijdicks EF,Sheth KN,Carter BS,Greer DM,Kasner SE,Kimberly WT,Schwab S,Smith EE,Tamargo RJ,Wintermark M,American Heart Association Stroke Council.

    更新日期：2014-04-01 00:00:00