Mechanism of ATP-induced [Ca(2+)](i) mobilization in rat basilar smooth muscle cells.

abstract：BACKGROUND AND PURPOSE:Striatal GABAergic neuron is known as a key regulator in adult neurogenesis. However, the specific role of striatal GABAergic neuronal activity in the promotion of neurological recovery after ischemic stroke remains unknown. Here, we used optogenetic approach to investigate these effects and mech...

journal_title：Stroke

authors： Jiang L,Li W,Mamtilahun M,Song Y,Ma Y,Qu M,Lu Y,He X,Zheng J,Fu Z,Zhang Z,Yang GY,Wang Y

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Earlier tissue-type plasminogen activator (tPA) treatment for acute ischemic stroke increases efficacy, prompting national efforts to reduce door-to-needle times. We used lean process improvement methodology to develop a streamlined intravenous tPA protocol. METHODS:In early 2011, a multidiscipl...

journal_title：Stroke

authors： Ford AL,Williams JA,Spencer M,McCammon C,Khoury N,Sampson TR,Panagos P,Lee JM

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to assess the association of vitamin D deficiency and indices of mineral metabolism with subclinical carotid markers that predict cardiovascular events. METHODS:Two hundred three community-dwelling adults (Northern Manhattan Study; age, 68 ± 11; age range, 50 to 93 ...

journal_title：Stroke

authors： Carrelli AL,Walker MD,Lowe H,McMahon DJ,Rundek T,Sacco RL,Silverberg SJ

更新日期：2011-08-01 00:00:00

abstract：:Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 ...

journal_title：Stroke

authors： Bradley RH,Kent TA,Eisenberg HM,Quast MJ,Ward GA,Campbell GA,Hillman G

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cells lacking the ATM (ataxia telangectasia mutated) gene are hypersensitive to DNA damage caused by a variety of insults. ATM may regulate oxidative stress-induced signaling cascades involving nuclear factor-kappaB (NF-kappaB), a transcription factor that is upstream of a wide variety of stress-...

journal_title：Stroke

authors： Yin KJ,Chen SD,Lee JM,Xu J,Hsu CY

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke-related physical disability can diminish quality of daily living, place care burden on families, and increase need for long-term institutionalization. We developed a prognostic index for use in research and with potential for adaptation to clinical practice that establishes the likelihood ...

journal_title：Stroke

authors： Stineman MG,Maislin G,Fiedler RC,Granger CV

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence of a relationship of fish intake to stroke incidence or mortality is weak. This report examines the association of fish consumption with stroke. METHODS:A cohort of 2107 men aged 40 to 55 years from the Chicago Western Electric Study who were free of coronary heart disease and stroke th...

journal_title：Stroke

authors： Orencia AJ,Daviglus ML,Dyer AR,Shekelle RB,Stamler J

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We evaluated the neuroprotective effect of UK-279,276 (also referred to as recombinant neutrophil inhibitory factor), a selective CD11b/CD18 antagonist, in combination with thrombolytic therapy on focal cerebral ischemia. METHODS:Male Wistar rats (n=88) were subjected to embolic middle cerebral ...

journal_title：Stroke

authors： Zhang L,Zhang ZG,Zhang RL,Lu M,Krams M,Chopp M

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It has been proposed that spin trap agents such as N:-t-butyl-phenylnitrone (PBN) may be useful as neuroprotective agents in the treatment of ischemia and stroke. However, to date, there is little information concerning the effectiveness of spin trap agents when administered in combination with t...

journal_title：Stroke

authors： Lapchak PA,Chapman DF,Zivin JA

更新日期：2001-01-01 00:00:00

abstract：:Lake Eibsee, Garmisch-Partenkirchen, November 19 to 21, 2015: The European Stroke Organization convened >120 stroke experts from 27 countries to discuss latest results and hot topics in clinical, translational, and basic stroke research. Since its inception in 2011, the European Stroke Science Workshop has become a co...

journal_title：Stroke

authors： Dichgans M,Planas AM,Biessels GJ,van der Worp B,Sudlow C,Norrving B,Lees K,Mattle HP

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The cause and clinical significance of residual dysplastic vessels after surgery for brain arteriovenous malformations (AVM) are unclear. We studied predictors and frequency of residual dysplastic vessels on cerebral angiography after AVM surgery. METHODS:The 240 prospectively enrolled surgical ...

journal_title：Stroke

authors： Stapf C,Connolly ES,Schumacher HC,Sciacca RR,Mast H,Pile-Spellman J,Mohr JP

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Improvements in cardiac surgery mortality and morbidity have focused interest on the neurological injury such as stroke and cognitive decline that may accompany an otherwise successful operation. We aimed to investigate (1) the rate of stroke, new ischemic change on MRI, and cognitive impairment ...

journal_title：Stroke

authors： Barber PA,Hach S,Tippett LJ,Ross L,Merry AF,Milsom P

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Data from recent multicenter carotid endarterectomy trials have questioned the validity and reliability of Doppler ultrasound in the assessment of carotid stenosis. METHODS:We prospectively analyzed 45 patients undergoing carotid angiography to compare the North American Symptomatic Carotid Enda...

journal_title：Stroke

authors： Alexandrov AV,Bladin CF,Maggisano R,Norris JW

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The mechanisms underlying smooth muscle relaxations of cerebral arteries in response to nitric oxide (NO) and cyclic GMP (cGMP) are still not completely understood. The present study was designed to determine the role of potassium channels in the relaxations to NO donors 3-morpholinosydnonimine (...

journal_title：Stroke

authors： Onoue H,Katusic ZS

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The proteoglycan versican is an excellent candidate gene for intracranial aneurysms (IAs) because it plays an important role in extracellular matrix assembly and is localized in a previously implicated locus for IAs on chromosome 5q. METHODS:We analyzed all the common variations using 16-tag sin...

journal_title：Stroke

authors： Ruigrok YM,Rinkel GJ,Wijmenga C

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Increased cortical microvascularization has been proposed to be a Moyamoya disease (MMD)-specific characteristic. It was the aim of our study to characterize the anatomic pattern and microhemodynamics of cortical microvascularization in MMD. METHODS:Intraoperative indocyanine green videoangiogra...

journal_title：Stroke

authors： Czabanka M,Peña-Tapia P,Schubert GA,Woitzik J,Vajkoczy P,Schmiedek P

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in yo...

journal_title：Stroke

authors： den Hartog AG,Halliday AW,Hayter E,Pan H,Kong X,Moll FL,de Borst GJ,Asymptomatic Carotid Surgery Trial Collaborators.

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To date, studies on neonatal stroke have mainly focused on cortical stroke. We have focused on perforator strokes, noncortical strokes in the arterial vascular perforator area. We sought to identify risk factors and evaluate clinical presentation and neuroimaging findings for neonatal perforator ...

journal_title：Stroke

authors： Ecury-Goossen GM,Raets MM,Lequin M,Feijen-Roon M,Govaert P,Dudink J

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The benefits of chronic disease self-management programs for stroke survivors are uncertain because individuals with severe impairments have been excluded from previous research. We undertook a phase II randomized controlled trial to determine whether a self-management program designed for surviv...

journal_title：Stroke

authors： Cadilhac DA,Hoffmann S,Kilkenny M,Lindley R,Lalor E,Osborne RH,Batterbsy M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies. We sought to determine whether white blood cell count (WBC) is associated with carotid plaque thickness in a stroke-free, multiethnic cohort. METHODS:For this cross-se...

journal_title：Stroke

authors： Elkind MS,Cheng J,Boden-Albala B,Paik MC,Sacco RL,Northern Manhattan Stroke Study.

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Acute ischemic stroke in humans is associated with profound alterations in the immune system. Hallmarks of this stroke-induced immunodepression syndrome are: lymphocytopenia, impairment of T helper cell and monocyte function. We studied which stroke-specific factors predict these immunologic alte...

journal_title：Stroke

authors： Hug A,Dalpke A,Wieczorek N,Giese T,Lorenz A,Auffarth G,Liesz A,Veltkamp R

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients. METHODS:Logistic regression was used to evaluate baseline characteristics and recan...

journal_title：Stroke

authors： Linfante I,Walker GR,Castonguay AC,Dabus G,Starosciak AK,Yoo AJ,Abou-Chebl A,Britz GW,Marden FA,Alvarez A,Gupta R,Sun CH,Martin C,Holloway WE,Mueller-Kronast N,English JD,Malisch TW,Bozorgchami H,Xavier A,Rai AT,F

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is associated with a temporal pattern of stroke incidence. We hypothesized that natural oscillations in gene expression controlling circadian rhythm affect the severity of neuronal injury. We moreover predict that heme oxygenase-1 (HO-1/Hmox1) and its product carbon ...

journal_title：Stroke

authors： Schallner N,Lieberum JL,Gallo D,LeBlanc RH 3rd,Fuller PM,Hanafy KA,Otterbein LE

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epidemiological and laboratory studies suggest that increasing concentrations of plasma homocysteine (total homocysteine [tHcy]) accelerate cardiovascular disease by promoting vascular inflammation, endothelial dysfunction, and hypercoagulability. METHODS:We conducted a randomized controlled tri...

journal_title：Stroke

authors： Dusitanond P,Eikelboom JW,Hankey GJ,Thom J,Gilmore G,Loh K,Yi Q,Klijn CJ,Langton P,van Bockxmeer FM,Baker R,Jamrozik K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Kinesthesia, the sense of body motion, is essential to proper control and execution of movement. Despite its importance for activities of daily living, no current clinical measures can objectively measure kinesthetic deficits. The goal of this study was to use robotic technology to quantify preva...

journal_title：Stroke

authors： Semrau JA,Herter TM,Scott SH,Dukelow SP

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral mic...

journal_title：Stroke

authors： Terao S,Yilmaz G,Stokes KY,Russell J,Ishikawa M,Kawase T,Granger DN

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study is to estimate the risk of ischemic stroke during a 3-year follow-up period after a tuberculosis diagnosis using a nationwide, population-based study and a retrospective cohort design. METHOD:The study cohort comprised 2283 patients who had received treatment for tuberculos...

journal_title：Stroke

authors： Sheu JJ,Chiou HY,Kang JH,Chen YH,Lin HC

更新日期：2010-02-01 00:00:00

abstract：:In 24 patients with cerebrovascular disease and 6 without organic brain lesions, the increased velocity of blood flow in both the internal carotid and vertebral arteries during a contralateral carotid compression was compared with the angiographic appearance of the circle of Willis. The flow velocity was measured usin...

journal_title：Stroke

authors： Yoneda S,Nukada T,Kimura K,Tanaka K,Ashida K,Asai T,Etani H,Imaizumi M,Abe H

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebrovascular reserve (CVR) by both transcranial Doppler ultrasonography (TCD) and quantitative cerebral blood flow (CBF) can identify subgroups of patients at increased risk for stroke. A direct comparison of CVR measurements obtained with both technologies in patients with cerebrovascular occ...

journal_title：Stroke

authors： Pindzola RR,Balzer JR,Nemoto EM,Goldstein S,Yonas H

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Symptomatic hemorrhage contributes to an increased risk of repeated bleeding and morbidity in cerebral cavernous malformation (CCM). A better understanding of morbidity after CCM hemorrhage would be helpful to identify patients of higher risk for unfavorable outcome and tailor individualized mana...

journal_title：Stroke

authors： Ma L,Zhang S,Li Z,Wu CX,Wang Z,Zhan L,Hao Q,Wang H,Ye X,Chen X,Liu YO,Wang S,Zhao YL

更新日期：2020-10-01 00:00:00