Abstract:
BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is associated with a temporal pattern of stroke incidence. We hypothesized that natural oscillations in gene expression controlling circadian rhythm affect the severity of neuronal injury. We moreover predict that heme oxygenase-1 (HO-1/Hmox1) and its product carbon monoxide (CO) contribute to the restoration of rhythm and neuroprotection. METHODS:Murine SAH model was used where blood was injected at various time points of the circadian cycle. Readouts included circadian clock gene expression, locomotor activity, vasospasm, neuroinflammatory markers, and apoptosis. In addition, cerebrospinal fluid and peripheral blood leukocytes from SAH patients and controls were analyzed for clock gene expression. RESULTS:Significant elevations in the clock genes Per-1, Per-2, and NPAS-2 were observed in the hippocampus, cortex, and suprachiasmatic nucleus in mice subjected to SAH at zeitgeber time (ZT) 12 when compared with ZT2. Clock gene expression amplitude correlated with basal expression of HO-1, which was also significantly greater at ZT12. SAH animals showed a significant reduction in cerebral vasospasm, neuronal apoptosis, and microglial activation at ZT12 compared with ZT2. In animals with myeloid-specific HO-1 deletion (Lyz-Cre-Hmox1 fl/fl ), Per-1, Per-2, and NPAS-2 expression was reduced in the suprachiasmatic nucleus, which correlated with increased injury. Treatment with low-dose CO rescued Lyz-Cre-Hmox1 fl/fl mice, restored Per-1, Per-2, and NPAS-2 expression, and reduced neuronal apoptosis. CONCLUSIONS:Clock gene expression regulates, in part, the severity of SAH and requires myeloid HO-1 activity to clear the erythrocyte burden and inhibit neuronal apoptosis. Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH.
journal_name
Strokejournal_title
Strokeauthors
Schallner N,Lieberum JL,Gallo D,LeBlanc RH 3rd,Fuller PM,Hanafy KA,Otterbein LEdoi
10.1161/STROKEAHA.116.016165subject
Has Abstractpub_date
2017-09-01 00:00:00pages
2565-2573issue
9eissn
0039-2499issn
1524-4628pii
STROKEAHA.116.016165journal_volume
48pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Fish consumption has been postulated to reduce the risk of stroke. We conducted a dose-response meta-analysis to summarize the evidence from prospective studies regarding the association between fish consumption and stroke risk. METHODS:Pertinent studies were identified by searching Embase and P...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.111.630319
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program systematically implements, at the time of acute transient ischemic attack (TIA) or ischemic stroke admission, 8 medication/behavioral secondary prevention measures known to improve outcome in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000147967.49567.d6
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Follow-up imaging is often performed in intracranial aneurysms that are not treated. We performed a systematic review and meta-analysis on patient- and aneurysm-specific risk factors for aneurysm growth. METHODS:We searched EMBASE and MEDLINE for cohort studies describing risk factors for aneury...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.115.012162
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated. METHODS:We examined gender differences in the prevalence of prese...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.543371
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1616
更新日期:1999-08-01 00:00:00
abstract::We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.9.1326
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A number of studies have shown that reduced intrauterine growth and low birth weight are associated with raised rates of fatal and nonfatal stroke in adult life. Whether this increased risk of stroke is modified by growth in childhood or by socioeconomic status in adult life is not known. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.4.869
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador. METHODS:O...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.009594
更新日期:2015-07-01 00:00:00
abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.2.322
更新日期:1990-02-01 00:00:00
abstract::We tested the reproducibility of consecutive measurements of regional cerebral blood flow (rCBF) made in 13 areas of each hemisphere in patients with cerebrovascular diseases by the atraumatic 133Xe intravenous injection method. The data were analysed by a two-compartment model similar to that used in the Obrist inhal...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.1.82
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients. METHODS:Logistic regression was used to evaluate baseline characteristics and recan...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.115.009530
更新日期:2015-08-01 00:00:00
abstract::The reactivity of cerebral blood vessels to changes in PaCO2 in areas of the cerebral cortex with or without diaschisis was investigated in 13 patients in a subacute or chronic stage after a small capsular infarct. A focal area of hypoperfusion (area of diaschisis) was detected in the ipsilateral sensorimotor cortex i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.840
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The use of lithium as a neuroprotective agent has been demonstrated using various models in which improvements in infarct size, DNA damage, and neurological function were reported. We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.492215
更新日期:2008-02-01 00:00:00
abstract::Background and Purpose- There is debate over an optimal systolic blood pressure (SBP) in secondary stroke prevention of patients with symptomatic intracranial atherosclerotic stenosis (sICAS). We investigated whether translesional pressure gradient across sICAS would alter the relationship between SBP and risk of recu...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.119.028616
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There have not been any new epidemiological studies related to stroke in Tibet for 20 years. This study aimed to collect stroke data from The City Staff Medical Insurance Registry in Lhasa, Tibet, to describe the incidence, clinical subtypes, and associated risk factors of stroke. METHODS:We use...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.586669
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determin...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609339
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) may increase the risk of embolic stroke of undetermined source (ESUS). Guidelines suggest anticoagulation may be more effective than antiplatelets in preventing stroke in patients with ESUS and PFO when interventional closure is not performed. METHODS:Patients with ESU...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031237
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND AND PURPOSE:Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000151329.84830.37
更新日期:2005-02-01 00:00:00
abstract::In normothermic anesthetized cats cerebral blood flow was interrupted completely for one hour by arterial clamping and induced hypotension. The effect of ischemia on the ionic gradients of the cerebral cortex was assayed by determining total cortical electrolytes and by recording the activities of extracellular potass...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.1.77
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcircula...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.5.1153
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000217262.03192.d4
更新日期:2006-05-01 00:00:00
abstract::Background and Purpose- Cerebral small vessel disease (SVD) is a major cause of stroke and dementia, but underlying disease mechanisms are still largely unknown, partly because of the difficulty in assessing small vessel function in vivo. We developed a method to measure blood flow velocity pulsatility in perforating ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.022516
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND AND PURPOSE:The impact of anesthesia technique on the outcomes of mechanical thrombectomy for acute ischemic stroke remains an issue of debate. We investigated the association of general anesthesia with outcomes in patients undergoing mechanical thrombectomy for ischemic stroke. METHODS:We performed a cohor...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015343
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our objective was to study age-specific prevalence, computed tomographic (CT) characteristics, risk factors, and the prognostic influence on stroke outcome of silent infarction in acute stroke patients. METHODS:The study was prospective and community-based and included 801 acute stroke patients,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.1.97
更新日期:1994-01-01 00:00:00
abstract::In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this mate...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.670
更新日期:1986-07-01 00:00:00
abstract::We investigated the temporal threshold for focal cerebral infarction in the spontaneously hypertensive rat. The right middle cerebral artery and common carotid artery were occluded for 0, 1, 2, 3, 4, or 24 hours, and all the animals were sacrificed 24 hours after the onset of ischemia. Cortical infarct volumes and ede...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.8.1032
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to evaluate the diagnostic accuracy of ultrasound criteria for recanalization during real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures in acute ischemic stroke patients in an international, multicenter study. METHODS:Consecutive acute ischemic stroke pa...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.112.675074
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Minor strokes and rapidly improving stroke symptoms are frequent exclusions for intravenous tissue-type plasminogen activator. We explored factors influencing tissue-type plasminogen activator treatment decision for minor strokes/rapidly improving stroke symptoms. METHODS:A pilot survey, includi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.008290
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in reducing future vascular events for patients with coronary heart disease is established, less is known about the precise benefit of these agents among patients with stroke. We evaluated whether ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.111.632596
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.9.1881
更新日期:1999-09-01 00:00:00