Abstract:
:The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlusion. The mean volume of the infarct in the cerebral cortex was reduced by 33% in the group treated with methionine sulfoximine (p less than 0.01). This protective effect may be mediated by a presynaptic mechanism; methionine sulfoximine profoundly inhibits brain glutamine synthetase, thereby interrupting the astrocyte-neuron glutamate shuttle and impairing neuronal glutamate release. Methionine sulfoximine also increases brain glycogen stores, and this increased energy reserve may benefit penumbral tissue during the peri-infarct period. Further study of the mechanisms by which methionine sulfoximine decreases infarct volume could lead to new therapeutic approaches for stroke.
journal_name
Strokejournal_title
Strokeauthors
Swanson RA,Shiraishi K,Morton MT,Sharp FRdoi
10.1161/01.str.21.2.322subject
Has Abstractpub_date
1990-02-01 00:00:00pages
322-7issue
2eissn
0039-2499issn
1524-4628journal_volume
21pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.12.2457
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purposes of this study were to assess the relationships between anatomic and technical factors and the 30-day risk of stroke or death after carotid angioplasty and stenting in the Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial and to perform...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验,评审
doi:10.1161/STROKEAHA.110.588772
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Decompressive surgery (hemicraniectomy) for life-threatening massive cerebral infarction represents a controversial issue in neurocritical care medicine. We report here the 30-day mortality and 6- and 12-month functional outcomes from the DESTINY trial. METHODS:DESTINY (ISRCTN01258591) is a pros...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.107.485649
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Identification of single-nucleotide polymorphisms (SNPs) associated with increased risk of new intracranial hemorrhage (ICH) after brain arteriovenous malformation (BAVM) diagnosis would facilitate risk stratification and identify potential targets for therapeutic intervention. METHODS:Patients ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000195133.98378.4b
更新日期:2006-01-01 00:00:00
abstract::We report two patients with mixed transcortical aphasia following left frontal lobe infarctions. Although there was no evidence of anatomic isolation of the speech area on computed tomograms or magnetic resonance imaging scans, single-photon emission computed tomography in one case demonstrated diminished blood flow o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.6.953
更新日期:1990-06-01 00:00:00
abstract::A standardized neurologic assessment scoring instrument was developed and tested for use in a multicenter trial of hypervolemic hemodilution in acute hemispheric stroke. Components of the neurologic examination pertinent to hemispheric stroke syndromes were emphasized. The scale was evaluated using 16 acute stroke pat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.3.665
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1325
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining if decreasing vasospasm is associated with alleviatio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.604728
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:High-sensitivity C-reactive protein (hsCRP), a marker of inflammation, is associated with atherosclerosis, hypertensive target organ damage, and cardiovascular events. In the general Japanese population, the level of hsCRP is reported to be lower than that in Western countries, and the relationsh...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000258115.46765.f1
更新日期:2007-03-01 00:00:00
abstract::Two patients with left middle cerebral artery (MCA) distribution infarctions fulfilled the "hot stroke" criteria on sequential 99m Tc pertechnetate flow and static gamma camera studies. The radioisotopic finding of a paradoxical relative increased flow to the affected hemisphere correlated with serial angiography show...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.5.517
更新日期:1975-09-01 00:00:00
abstract::Background and Purpose- Carotid web (CW) is a rare form of focal fibromuscular dysplasia defined as an abnormal shelf-like projection of intimal fibrous tissue into the carotid bulb. It is theorized that CW leads to ischemic stroke secondary to blood flow stasis and subsequent embolization. The natural history and opt...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021907
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Fibrocartilaginous embolism from the nucleus pulposus has been reported as a rare cause of spinal cord ischemia. We were unable to find previous reports of embolism from this source to cerebral arteries. CASE DESCRIPTION:A previously healthy 17-year-old girl fell during a basketball game. Left h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.5.738
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In 6% to 9% of patients with subarachnoid hemorrhage (SAH), familial aggregation occurs; truly familial cases carry a worse prognosis than sporadic cases and raise the question of screening. If relatives have died from SAH, the family history is often the only available clue to the diagnosis, but...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.4.630
更新日期:1996-04-01 00:00:00
abstract::Background and Purpose- Prehospital routing algorithms for patients with suspected stroke because of large vessel occlusions should account for likelihood of benefit from endovascular therapy (EVT), risk of alteplase delays, and transport times. We built a mathematical model to give a real-time, location-based optimal...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.022041
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:High-intensity transient signals (HITS) detected by transcranial Doppler ultrasonography correspond to microemboli in intracranial arteries. The purpose of this study was to develop new diagnostic criteria for the differentiation of these microembolic signals from artifact, based on a high-resolu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.3.668
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS:Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002045
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Mechanical thrombectomy (MT) is the recommended treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. However, despite a high rate of reperfusion, the clinical response to successful MT remains highly variable in the early time window where optimal imaging sel...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031929
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The shape and exact size of lacunar infarcts have been investigated only postmortem. Recent imaging techniques based on triangulation and connectivity can now be used for 3D segmentation of cerebral lesions. The shape and size of lacunar infarcts was investigated using these techniques in 10 cere...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000185678.26296.38
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000251798.25803.e0
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Exogenous delivery of vascular endothelial growth factor gene (VEGF) may provide a useful approach to the treatment of brain ischemia. We investigated the use of a hypoxia-responsive element to control VEGF expression given for neuroprotection. METHODS:Three groups (n=36) of mice received AAVH9-...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000240407.14765.e8
更新日期:2006-10-01 00:00:00
abstract::Recent clinical studies emphasize the importance of early (less than 12 hours after onset) treatment of patients with acute ischemic stroke. Therapies have been proposed as being effective because of early clinical improvement. The frequency and degree of spontaneous improvement in such patients, however, is unknown. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.7.1008
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multicenter clinical trials attempt to select sites that can move rapidly to randomization and enroll sufficient numbers of patients. However, there are few assessments of the success of site selection. METHODS:In the CREST-2 (Carotid Revascularization and Medical Management for Asymptomatic Car...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.016976
更新日期:2017-09-01 00:00:00
abstract::Background and Purpose- We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods- Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Pati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021856
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Noninvasive studies are used with increasing frequency to assess the carotid bifurcation before endarterectomy. Therefore, assessment of their diagnostic accuracies is essential for appropriate patient management. We prospectively evaluate two noninvasive tests, magnetic resonance angiography (MR...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.26.10.1753
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Optimizing prehospital stroke care is important because effective treatments for acute stroke require a narrow therapeutic time window. We developed a smartphone-assisted prehospital medical information system (SPMIS) to facilitate research on prehospital stroke care. METHODS:Prehospital medical...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.004872
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Tetrahydrobiopterin (THBP) is an essential cofactor for nitric oxide synthase (NOS), which is responsible for the synthesis of the endothelium-derived relaxing factor (EDRF) responsible for mediating the vasorelaxation produced by acetylcholine (ACh). Previous publications suggest that EDRFACh is...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.1.186
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Unaccustomed strenuous physical exertion can trigger myocardial infarction, but little is known about the mechanisms precipitating subarachnoid hemorrhage (SAH). METHODS:We identified all cases of first-ever SAH among the combined populations (2.8 million) of 4 urban centers in Australia and New...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000077015.90334.A7
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.107.493601
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:With the exception of atrial fibrillation (AF), little scientific attention has been given the associations between cardiac arrhythmias and incidence of stroke. We sought to study whether atrial and ventricular arrhythmias assessed during a 24-hour ambulatory ECG registration are associated with ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.12.2925
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013204
更新日期:2016-09-01 00:00:00