Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.

Abstract:

BACKGROUND AND PURPOSE:The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS:Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or NBO. The effects of NBO were also investigated on perfusion-weighted imaging, susceptibility-weighted imaging, and molecular imaging of vascular cell adhesion molecule-1 after ICH. Last, we performed neurological testing, including neuroscore, actimetry, and gait analysis (Catwalk), to study the influence of NBO on neurological outcome of mice presenting ICH. RESULTS:Our results demonstrated that NBO, even during a short period of time, dramatically reduces the sensitivity of T2*-weighted imaging to detect ICH. Moreover, we provide evidence that the disappearance of ICH on T2*-weighted imaging could be used to improve accuracy of perfusion-weighted imaging and to allow molecular imaging after ICH. Importantly, a 30-minute NBO preparation 24 hours after ICH onset does not influence neurological outcome. CONCLUSIONS:We provide an experimental demonstration that NBO significantly affects T2*-weighted imaging in ICH. Although this phenomenon could lead to inaccurate assessment of ICH volume, it could also be safely used to allow perfusion-weighted imaging and molecular imaging.

journal_name

Stroke

journal_title

Stroke

authors

Gaberel T,Gakuba C,Hebert M,Montagne A,Agin V,Rubio M,Emery E,Vivien D,Gauberti M

doi

10.1161/STROKEAHA.113.002045

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

3482-9

issue

12

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.113.002045

journal_volume

44

pub_type

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