Abstract:
BACKGROUND AND PURPOSE:The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs). METHODS:Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or NBO. The effects of NBO were also investigated on perfusion-weighted imaging, susceptibility-weighted imaging, and molecular imaging of vascular cell adhesion molecule-1 after ICH. Last, we performed neurological testing, including neuroscore, actimetry, and gait analysis (Catwalk), to study the influence of NBO on neurological outcome of mice presenting ICH. RESULTS:Our results demonstrated that NBO, even during a short period of time, dramatically reduces the sensitivity of T2*-weighted imaging to detect ICH. Moreover, we provide evidence that the disappearance of ICH on T2*-weighted imaging could be used to improve accuracy of perfusion-weighted imaging and to allow molecular imaging after ICH. Importantly, a 30-minute NBO preparation 24 hours after ICH onset does not influence neurological outcome. CONCLUSIONS:We provide an experimental demonstration that NBO significantly affects T2*-weighted imaging in ICH. Although this phenomenon could lead to inaccurate assessment of ICH volume, it could also be safely used to allow perfusion-weighted imaging and molecular imaging.
journal_name
Strokejournal_title
Strokeauthors
Gaberel T,Gakuba C,Hebert M,Montagne A,Agin V,Rubio M,Emery E,Vivien D,Gauberti Mdoi
10.1161/STROKEAHA.113.002045subject
Has Abstractpub_date
2013-12-01 00:00:00pages
3482-9issue
12eissn
0039-2499issn
1524-4628pii
STROKEAHA.113.002045journal_volume
44pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:We sought to establish the pattern of blood pressure (BP) change after hospitalization for acute hemispheric stroke. METHODS:In 292 patients from the Leicester teaching hospitals with acute hemispheric stroke within the previous 24 hours (139 men; median age, 75 years [range, 42 to 98 years]), w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.9.1726
更新日期:1994-09-01 00:00:00
abstract::We assessed the potential of 2-MHz pulsed-wave transorbital Doppler ultrasonography to delineate the role of the ophthalmic artery as a source of collateral cerebral blood supply by comparing oculopneumoplethysmography, transorbital Doppler ultrasonography, periorbital continuous-wave Doppler ultrasonography, and tran...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.1.31
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process. We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid pla...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.114.004775
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. METHODS:In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007584
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In major cerebral arterial steno-occlusive diseases, there can be remarkably decreased hemodynamic reserve without marked neurological impairments. In such settings, it is not known whether the neural activity is well maintained or disturbed according to the severity of cerebral ischemia. The pre...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0102.101816
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The risk of stroke and death in patients with atrial fibrillation is strongly associated with age and concomitant comorbidities. The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation. METHODS:This study is a po...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.004903
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective is to compare the effects of high-intensity interval training (HIIT) with long versus short intervals on endurance and motor performance. Their influence on neuroplasticity markers is assessed in the ipsilesional and contralesional cortex and hippocampus since their remodeling could...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031873
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The collagen alpha2(I) gene (COL1A2) on chromosome 7q22.1, a positional and functional candidate for intracranial aneurysm (IA), was extensively screened for susceptibility in Japanese IA patients. METHODS:Twenty-one single nucleotide polymorphisms (SNPs) of COL1A2 were genotyped in genomic DNA ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000110788.45858.DC
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improved methods of identifying patients at high risk of thromboembolism would allow improved targeting of therapy. One such situation is carotid artery stenosis. This is associated with an increased risk of stroke, which can be reduced by carotid endarterectomy. However, the risk-benefit ratio i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.7.1440
更新日期:1999-07-01 00:00:00
abstract::Background and Purpose- Cerebral small vessel disease (cSVD) is the major vascular cause of cognitive decline and dementia. The pathogenesis of cSVD remains largely unknown, although several studies suggest a role for systemic inflammation. In certain pathophysiological situations, monocytes can reprogram toward a lon...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.023192
更新日期:2018-12-01 00:00:00
abstract::Experimental subarachnoid hemorrhage was induced in 52 adult male Wistar rats by microsurgical transclival basilar artery puncture. Telencephalic blood flow measured in 24 rats with subarachnoid hemorrhage was compared with that in 23 sham-operated rats and 10 unoperated control rats using the [14C]butanol indicator f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.4.577
更新日期:1990-04-01 00:00:00
abstract::Background and Purpose- Delirium is a common and serious complication of acute illness. We describe delirium occurrence in an unselected, acute stroke population. Methods- We collected data from consecutive stroke admissions. We performed comprehensive cognitive assessment within the first week including Diagnostic St...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.119.025993
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sulcal effacement with preserved underlying gray-white matter junction (isolated sulcal effacement [ISE]) in acute ischemic stroke may not represent irreversible parenchymal injury. We aimed to evaluate the frequency and significance of ISE in patients with large vessel occlusion acute ischemic s...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.115.009304
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset. METHODS:Ischemic lesion volumes were measured for intrarater reliability using diffusion-weighted (DWI), mean transit time (MTT) perfusio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000249416.77132.1a
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We assessed whether the load of cerebral small vessel disease (cSVD) and its individual markers, including lacunes, white matter hyperintensities, microbleeds, and enlarged perivascular spaces (EPVS), are associated with arterial stiffness. METHODS:We evaluated cSVD markers in a cohort of 782 hy...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020163
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) after stroke increases risk of hemorrhagic transformation, particularly in areas with blood-brain barrier leakage. Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000023534.37670.f7
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thrombin, heme oxygenase, complement, microglia activation, and leukocyte infiltration are all actively upregulated in intracerebral hemorrhage (ICH). Experimental evidence suggests that all these factors are involved in ICH-induced brain injury. This suggests a scenario whereby ICH actively (thr...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000170701.41507.e1
更新日期:2005-07-01 00:00:00
abstract::Background and Purpose- Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, in at least one third of ischemic strokes, existing investigative protocols fail to determine the underlying cause. Establishing etiology is complicated by variation in clinical practice,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027123
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated. METHODS:We examined gender differences in the prevalence of prese...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.543371
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multiple studies have shown that negative computed tomographic angiograms (CTAs) are reliable in excluding aneurysms in patients with isolated perimesencephalic subarachnoid hemorrhage (pSAH). We evaluate the use of digital subtraction angiography versus CTA for initial diagnosis and of angiograp...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.114.007370
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The natural history of stroke is still incompletely understood. The aim of this study was to present detailed data on survival, recurrence, and all types of healthcare utilization before and after a stroke event in patients with stroke. METHODS:Three hundred ninety stroke survivors constituted t...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.556720
更新日期:2009-11-01 00:00:00
abstract::As part of a prospective study of the neurologic and neuropsychological complications of coronary artery bypass graft surgery, 312 patients were compared with a control group of 50 patients undergoing major surgery for peripheral vascular disease. The purpose of comparing the 2 groups was to determine to what extent n...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.4.700
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.015957
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated low density lipoprotein and reduced high density lipoprotein cholesterol may increase the risk of atherothrombotic brain infarction, but the metabolic mechanisms accounting for this relation are poorly understood. METHODS:The kinetic parameters of low density and high density lipoprotei...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1265
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is a valid, reproducible scale that measures neurological deficit. Of 42 possible points, 7 points are directly related to measurement of language compared with only 2 points related to neglect. METHODS:We examined the placebo arm of the NIN...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.11.2355
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Changes in stroke incidence are likely to occur as a consequence of aging of the population, but evidence for this hypothesis is lacking. METHODS:A prospective community-based registry of first-ever strokes (1994 to 1998) classified according to the International Classification of Diseases, 9th ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.12.2500
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Quantitative data on sensory impairment in stroke patients are limited. We measured the perception thresholds for temperature and thermal pain in patients with different lacunar syndromes, correlated the results with clinical and magnetic resonance imaging (MRI) findings, and studied the long-ter...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.11.2165
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia. METHODS:With the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postis...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.6.1107
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Determination of vasomotor reserve (VMR) with the transcranial Doppler-CO(2) (TCD-CO(2)) test is used to assess the risk of impending cerebral ischemia in patients with high-grade stenosis or occlusion of the internal carotid artery. In patients with a poor temporal window, however, this examinat...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.6.1298
更新日期:2001-06-01 00:00:00
abstract::Background and Purpose- The optimal antithrombotic strategy to balance thromboembolic and bleeding events, especially acute stroke, for patients with atrial fibrillation following coronary stenting remains a matter of debate. We conducted a network meta-analysis to identify the antithrombotic regimen associated with t...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.119.026078
更新日期:2019-08-01 00:00:00