Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice.

abstract：BACKGROUND AND PURPOSE:Genetic factors involved in the pathogenesis of primary intracerebral hemorrhage (PICH) remain unknown. One of the candidate genes is SERPINA3. Results of a Spanish study suggested that TT genotype of the A/T SERPINA3 polymorphism in the signal peptide sequence was a risk factor for PICH in normo...

journal_title：Stroke

authors： Pera J,Slowik A,Dziedzic T,Szczudlik A

更新日期：2006-03-01 00:00:00

abstract：:Background and Purpose- Ischemic stroke is one of the leading causes of morbidity and mortality worldwide and a major cause of long-term disability. Recently, long noncoding RNAs have been revealed, which are tightly associated with several human diseases. However, the functions of long noncoding RNAs in ischemic stro...

journal_title：Stroke

authors： Deng Y,Chen D,Wang L,Gao F,Jin B,Lv H,Zhang G,Sun X,Liu L,Mo D,Ma N,Song L,Huo X,Yan T,Miao Z

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia. METHODS:Adult male wild-type or PAR-1 knock...

journal_title：Stroke

authors： Wang J,Jin H,Hua Y,Keep RF,Xi G

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sulcal effacement with preserved underlying gray-white matter junction (isolated sulcal effacement [ISE]) in acute ischemic stroke may not represent irreversible parenchymal injury. We aimed to evaluate the frequency and significance of ISE in patients with large vessel occlusion acute ischemic s...

journal_title：Stroke

authors： Haussen DC,Lima A,Frankel M,Anderson A,Belagaje S,Nahab F,Rangaraju S,Nogueira RG

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The neck clipping of cerebral aneurysms is a well-established treatment for subarachnoid hemorrhage (SAH) caused by aneurysmal rupture. However, it is still unclear how great a risk of recurrence patients with a successfully treated aneurysm carry over a long-term period. METHODS:Of 425 patients...

journal_title：Stroke

authors： Tsutsumi K,Ueki K,Usui M,Kwak S,Kirino T

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of...

journal_title：Stroke

authors： Vila N,Castillo J,Dávalos A,Esteve A,Planas AM,Chamorro A

更新日期：2003-03-01 00:00:00

abstract：:Before surgery, we evaluated major intracranial collateral pathways using transcranial Doppler ultrasonography (TCD) in 50 patients who then underwent carotid endarterectomy with concurrent multimodality cerebral monitoring. Patients were grouped with respect to collateral pathways demonstrated preoperatively by TCD: ...

journal_title：Stroke

authors： Schneider PA,Ringelstein EB,Rossman ME,Dilley RB,Sobel DF,Otis SM,Bernstein EF

更新日期：1988-11-01 00:00:00

abstract：:In an attempt to elucidate the mechanism by which hypertension acts as a risk factor for major non-haemorrhagic stroke, its effect on the prevalence of carotid atheroma has been studied angiographically. The carotid angiograms of 269 patients with cerebral tumours have been reviewed for evidence of coincidental athero...

journal_title：Stroke

authors： Harrison MJ,Wilson LA

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early CT signs of cerebral ischemia are subtle. Little is known of which factors influence the detection of infarct signs. We compared neuroradiologists' scan readings with those of other specialists involved in the care of stroke patients. METHODS:We used the Internet to show 63 CT scans, all a...

journal_title：Stroke

authors： Wardlaw JM,Farrall AJ,Perry D,von Kummer R,Mielke O,Moulin T,Ciccone A,Hill M,Acute Cerebral CT Evaluation of Stroke Study (ACCESS) Study Group.

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Follow-up imaging is often performed in intracranial aneurysms that are not treated. We performed a systematic review and meta-analysis on patient- and aneurysm-specific risk factors for aneurysm growth. METHODS:We searched EMBASE and MEDLINE for cohort studies describing risk factors for aneury...

journal_title：Stroke

authors： Backes D,Rinkel GJ,Laban KG,Algra A,Vergouwen MD

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats,...

journal_title：Stroke

authors： Moriwaki T,Takagi Y,Sadamasa N,Aoki T,Nozaki K,Hashimoto N

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fish consumption has been postulated to reduce the risk of stroke. We conducted a dose-response meta-analysis to summarize the evidence from prospective studies regarding the association between fish consumption and stroke risk. METHODS:Pertinent studies were identified by searching Embase and P...

journal_title：Stroke

authors： Larsson SC,Orsini N

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke-related physical disability can diminish quality of daily living, place care burden on families, and increase need for long-term institutionalization. We developed a prognostic index for use in research and with potential for adaptation to clinical practice that establishes the likelihood ...

journal_title：Stroke

authors： Stineman MG,Maislin G,Fiedler RC,Granger CV

更新日期：1997-03-01 00:00:00

abstract：:Functional assessment of animals following experimental cerebral ischemia is often difficult due to the passive nature of many neurologic exams. We attempted to increase the objectivity of motor function evaluation by adapting quantifiable behavioral tests and actively testing rats' motor capability following a cerebr...

journal_title：Stroke

authors： Combs DJ,D'Alecy LG

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:CT remains the most commonly used imaging technique in acute stroke but is often delayed after minor stroke. Interobserver reliability in distinguishing hemorrhagic transformation of infarction from intracerebral hemorrhage may depend on delays to CT but has not been reported previously despite t...

journal_title：Stroke

authors： Lovelock CE,Anslow P,Molyneux AJ,Byrne JV,Kuker W,Pretorius PM,Coull A,Rothwell PM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In acute ischemic stroke, the hypoperfused but viable tissue is the main therapeutic target. In clinical routine, time-to-peak (TTP) maps are frequently used to estimate the hemodynamic compromise and to calculate the mismatch volume. We evaluated the accuracy of TTP maps to identify penumbral fl...

journal_title：Stroke

authors： Sobesky J,Zaro Weber O,Lehnhardt FG,Hesselmann V,Thiel A,Dohmen C,Jacobs A,Neveling M,Heiss WD

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An increase in intima-media thickness (IMT) in the common carotid artery (CCA) is commonly used as a marker of atherosclerosis. The purpose of this study was to investigate the relationship between IMT in the CCA and atherosclerosis in the carotid bifurcation. METHODS:182 consecutive patients (m...

journal_title：Stroke

authors： Rosfors S,Hallerstam S,Jensen-Urstad K,Zetterling M,Carlström C

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke guidelines recommend time-limited trials of nasogastric feeding prior to percutaneous endoscopic gastrostomy (PEG) tube placement. We sought to describe timing of PEG placement and identify factors associated with early PEG for acute ischemic stroke. METHODS:We designed a retrospective ob...

journal_title：Stroke

authors： George BP,Kelly AG,Albert GP,Hwang DY,Holloway RG

更新日期：2017-02-01 00:00:00

abstract：:Cardiac arrhythmias were more frequent (p less than 0.001) in 312 stroke patients admitted to an intensive care stroke unit, than in 92 patients admitted to the unit and subsequently found not to have strokes. This significant difference remained when a stroke subgroup and the non-stroke group were matched for age, se...

journal_title：Stroke

authors： Norris JW,Froggatt GM,Hachinski VC

更新日期：1978-07-01 00:00:00

abstract：:Background and Purpose- High-resolution vessel wall magnetic resonance imaging is a promising technique for assessing wall structures of unruptured intracranial aneurysms (UIAs). However, the relationship between aneurysmal high-resolution vessel wall magnetic resonance imaging features and their histopathologic mecha...

journal_title：Stroke

authors： Quan K,Song J,Yang Z,Wang D,An Q,Huang L,Liu P,Li P,Tian Y,Zhou L,Zhu W

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent studies have shown that the cerebral arteriolar dilation from hypercapnic acidosis is blocked by agents which inhibit KATP channels. These findings suggested that this response is due to opening of KATP channels. Because the repose to CO2 is a continuum, with hypercapnic acidosis causing v...

journal_title：Stroke

authors： Wei EP,Kontos HA

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is unclear which harmonic imaging mode (power Doppler or gray-scale imaging) is superior and which measuring method is the most robust for the description of brain perfusion. METHODS:We performed an animal study on 6 beagles through the intact skull using a SONOS 5500 device and Optison injec...

journal_title：Stroke

authors： Seidel G,Algermissen C,Christoph A,Katzer T,Kaps M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Efforts to increase the availability and shorten the time delivery of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for tissue plasminogen activator administration in patients with diseases other than stroke, that is, stroke mimics (SMs). We aimed to determin...

journal_title：Stroke

authors： Tsivgoulis G,Alexandrov AV,Chang J,Sharma VK,Hoover SL,Lao AY,Liu W,Stamboulis E,Alexandrov AW,Malkoff MD,Frey JL

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracranial internal carotid artery calcification is associated with cerebrovascular risk factors and stroke, but few quantification methods are available. We tested the reliability of visual scoring, semiautomated Agatston score, and calcium volume measurement in patients with recent stroke. M...

journal_title：Stroke

authors： Subedi D,Zishan US,Chappell F,Gregoriades ML,Sudlow C,Sellar R,Wardlaw J

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving clinical skills may accelerate patient progress through the emergency department. We aimed to determine the frequency and nature of stroke mimics and to identify the key clinical features tha...

journal_title：Stroke

authors： Hand PJ,Kwan J,Lindley RI,Dennis MS,Wardlaw JM

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Preceding infection as an important risk factor for ischemic stroke has been reported but neglected for hemorrhagic stroke, especially in young and middle-aged patients. This study investigates whether newly diagnosed leptospirosis is associated with an increased risk of stroke. METHODS:We ident...

journal_title：Stroke

authors： Li KY,Chou MC,Wei JC,Lin MC,Hung YM,Chang R

更新日期：2021-01-26 00:00:00

abstract：BACKGROUND AND PURPOSE:Animal studies of cerebral arteries 2 to 3 days after experimental subarachnoid hemorrhage (SAH) provide evidence of arterial change such as hyperresponsiveness to contractile agonists. There is evidence that small arteries, as well as those large enough to be seen on angiography, may be involved...

journal_title：Stroke

authors： Bevan JA,Bevan RD,Walters CL,Wellman T

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ. This study tested the hypothesis that the level of circulating EPCs is substantially increased and p...

journal_title：Stroke

authors： Yip HK,Chang LT,Chang WN,Lu CH,Liou CW,Lan MY,Liu JS,Youssef AA,Chang HW

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke symptoms can be very stressful for family caregivers, but most knowledge about the prevalence and stressfulness of stroke-related patient problems is derived from convenience samples. In addition, little is known about perceived benefits of the stroke caregiving experience. The purpose of ...

journal_title：Stroke

authors： Haley WE,Allen JY,Grant JS,Clay OJ,Perkins M,Roth DL

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence now exists for a pathogenic role for neutrophils in acute cerebral ischemia. We have studied the patterns and temporal profile of cerebral neutrophil recruitment to areas of acute ischemic stroke (IS) and have attempted to correlate this with neurological status and outcome. METHODS:Pat...

journal_title：Stroke

authors： Price CJ,Menon DK,Peters AM,Ballinger JR,Barber RW,Balan KK,Lynch A,Xuereb JH,Fryer T,Guadagno JV,Warburton EA

更新日期：2004-07-01 00:00:00