Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke.

Abstract:

BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of interleukin (IL)-10 and IL-4 in deteriorating ischemic stroke. METHODS:Two hundred thirty-one patients with ischemic stroke within the first 24 hours from onset were included. Neurological worsening was defined when the Canadian Stroke Scale score fell at least 1 point during the first 48 hours after admission. Anti-inflammatory cytokines were determined in plasma obtained on admission. RESULTS:Eighty-three patients (35.9%) worsened within the first 48 hours after stroke onset. Significantly lower concentrations of IL-10 were found in patients with neurological worsening (P<0.05), but IL-4 levels were similar in patients with or without deterioration. Lower plasma concentrations of IL-10 (<6 pg/mL) were associated with clinical worsening on multivariate analysis (odds ratio=3.1, 95% CI=1.1 to 8.9) independently of hyperthermia, hyperglycemia, or neurological condition on admission. Further analysis disclosed that early worsening was independently associated with lower IL-10 plasma levels in patients with subcortical infarcts or lacunar stroke but not in patients with cortical lesions. CONCLUSIONS:Anti-inflammatory cytokine IL-10 is associated with the early clinical course of patients with acute ischemic stroke, especially in patients with small vessel disease or subcortical infarctions.

journal_name

Stroke

journal_title

Stroke

authors

Vila N,Castillo J,Dávalos A,Esteve A,Planas AM,Chamorro A

doi

10.1161/01.STR.0000057976.53301.69

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

671-5

issue

3

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000057976.53301.69

journal_volume

34

pub_type

临床试验,杂志文章

相关文献

STROKE文献大全
  • Prevalence and time course of microembolic signals in patients with acute stroke. A prospective study.

    abstract:BACKGROUND AND PURPOSE:Cerebral emboli can be identified by the presence of typical microembolic signals (MES) in transcranial Doppler (TCD) spectral curves. The usefulness of this technique was studied by evaluating the prevalence and time course of MES in patients with acute stroke. In addition, we examined the influ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.2.358

    authors: Sliwka U,Lingnau A,Stohlmann WD,Schmidt P,Mull M,Diehl RR,Noth J

    更新日期:1997-02-01 00:00:00

  • Effects of a community-based intensive motor training program combined with early supported discharge after treatment in a comprehensive stroke unit: a randomized, controlled trial.

    abstract:BACKGROUND AND PURPOSE:Increased amount of therapy seems to be beneficial for motor recovery after stroke. The primary aim of the present study was to evaluate the effect of a 4-week community-based intensive motor training program combined with early supported discharge after initial treatment in a comprehensive strok...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.110.584284

    authors: Askim T,Mørkved S,Engen A,Roos K,Aas T,Indredavik B

    更新日期:2010-08-01 00:00:00

  • Differences between ischemic stroke subtypes in vascular outcomes support a distinct lacunar ischemic stroke arteriopathy: a prospective, hospital-based study.

    abstract:BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.558221

    authors: Jackson CA,Hutchison A,Dennis MS,Wardlaw JM,Lewis SC,Sudlow CL

    更新日期:2009-12-01 00:00:00

  • Dabigatran or Aspirin After Embolic Stroke of Undetermined Source in Patients With Patent Foramen Ovale: Results From RE-SPECT ESUS.

    abstract:BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) may increase the risk of embolic stroke of undetermined source (ESUS). Guidelines suggest anticoagulation may be more effective than antiplatelets in preventing stroke in patients with ESUS and PFO when interventional closure is not performed. METHODS:Patients with ESU...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.031237

    authors: Diener HC,Chutinet A,Easton JD,Granger CB,Kleine E,Marquardt L,Meyerhoff J,Zini A,Sacco RL

    更新日期:2021-01-28 00:00:00

  • Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis.

    abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is a relatively rare cause of stroke with a high rate of morbidity and mortality, primarily due to the occurrence of delayed vasospasm. To date, many therapies have been proposed to help prevent vasospasm, but very few have been proven effective. The initiation of st...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.107.508341

    authors: Sillberg VA,Wells GA,Perry JJ

    更新日期:2008-09-01 00:00:00

  • The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g) : results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators.

    abstract:BACKGROUND AND PURPOSE:The Thrombolytic Therapy in Acute Ischemic Stroke Study, which started in August of 1991, was designed to assess the efficacy and safety of intravenous rtPA (alteplase) in patients with acute (0 to 6 hours) ischemic stroke. In October 1993 enrollment was halted because of Safety Committee (DMSB) ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.str.31.4.811

    authors: Clark WM,Albers GW,Madden KP,Hamilton S

    更新日期:2000-04-01 00:00:00

  • Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats.

    abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.618496

    authors: Chiba T,Itoh T,Tabuchi M,Ooshima K,Satou T,Ezaki O

    更新日期:2012-02-01 00:00:00

  • Sensory symptoms and signs and results of quantitative sensory thermal testing in patients with lacunar infarct syndromes.

    abstract:BACKGROUND AND PURPOSE:Quantitative data on sensory impairment in stroke patients are limited. We measured the perception thresholds for temperature and thermal pain in patients with different lacunar syndromes, correlated the results with clinical and magnetic resonance imaging (MRI) findings, and studied the long-ter...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.11.2165

    authors: Samuelsson M,Samuelsson L,Lindell D

    更新日期:1994-11-01 00:00:00

  • Prognosis for survival after an initial stroke.

    abstract:BACKGROUND AND PURPOSE:We studied prognosis for survival after an initial stroke in 662 patients who survived at least 30 days after onset while taking into account age, sex, the number of neurological deficits from the initial stroke, stroke type, and five selected medical conditions: hypertension, myocardial infarcti...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.11.2011

    authors: Lai SM,Alter M,Friday G,Sobel E

    更新日期:1995-11-01 00:00:00

  • Distribution of the blood flow supplied by the vertebral artery in humans as assessed by emission CT.

    abstract::Though unilateral blood distribution of the vertebral artery has not been studied in humans, it is significant when considering the ischemic events especially embolic occlusion in vertebrobasilar system. To clarify the blood distribution, Krypton-81m was continuously infused into the vertebral arteries of 10 patients....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.3.469

    authors: Taki W,Handa H,Higa T,Tanada S,Fukuyama H,Fujita T,Yonekawa Y,Kameyama M,Torizuka K

    更新日期:1984-05-01 00:00:00

  • New insights into brain damage in stroke-prone rats: a nuclear magnetic imaging study.

    abstract:BACKGROUND AND PURPOSE:The spontaneously hypertensive stroke-prone rat (SHRSP) is an animal model for a complex form of cerebrovascular pathology. MRI provides an efficient and noninvasive tool for studying the time course of brain damage. The aim of this study was to gain new insights into the pathological phenomena r...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0302.104111

    authors: Guerrini U,Sironi L,Tremoli E,Cimino M,Pollo B,Calvio AM,Paoletti R,Asdente M

    更新日期:2002-03-01 00:00:00

  • Sex differences in US mortality rates for stroke and stroke subtypes by race/ethnicity and age, 1995-1998.

    abstract:BACKGROUND AND PURPOSE:Ischemic stroke accounts for 70% to 80% of all strokes, but intracerebral and subarachnoid hemorrhagic strokes have greater fatality. Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/eth...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000015028.52771.d1

    authors: Ayala C,Croft JB,Greenlund KJ,Keenan NL,Donehoo RS,Malarcher AM,Mensah GA

    更新日期:2002-05-01 00:00:00

  • An uncommon cause of recurrent strokes: Tropheryma whippelii endocarditis.

    abstract:BACKGROUND:Cardiac involvement in Whipple's disease is not an uncommon phenomenon in autopsies, but its clinical occurrence is often overshadowed by gastrointestinal symptoms. We report a very atypical manifestation of this disorder. SUMMARY OF REPORT:An extraordinary presentation of an extremely long-lasting, culture...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.8.2002

    authors: Naegeli B,Bannwart F,Bertel O

    更新日期:2000-08-01 00:00:00

  • Intra-arterial thrombolytic therapy for acute basilar occlusion: pro.

    abstract::Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.STR.0000247897.33267.42

    authors: Smith WS

    更新日期:2007-02-01 00:00:00

  • Insulin Resistance Is a Risk Factor for Silent Lacunar Infarction.

    abstract:BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.014097

    authors: Lee JE,Shin DW,Yun JM,Kim SH,Nam YS,Cho B,Lim JS,Jeong HY,Kwon HM,Park JH

    更新日期:2016-12-01 00:00:00

  • Effect of PCO2 changes induced by head-upright tilt on transcranial Doppler recordings.

    abstract:BACKGROUND AND PURPOSE:Transcranial Doppler (TCD) monitoring of mean blood flow velocity (mV) during head-upright tilt can allow testing of cerebral autoregulation. Nonetheless, head-upright tilt can induce changes in the ventilation-perfusion relationship and/or respiratory activity that might influence TCD data. MET...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.6.1195

    authors: Cencetti S,Bandinelli G,Lagi A

    更新日期:1997-06-01 00:00:00

  • Eliciting information on differential sensation of heat in those with and without poststroke aphasia using a visual analogue scale.

    abstract:BACKGROUND AND PURPOSE:Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia c...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000198872.75377.34

    authors: Korner-Bitensky N,Kehayia E,Tremblay N,Mazer B,Singer F,Tarasuk J

    更新日期:2006-02-01 00:00:00

  • Minimally invasive surgery for spontaneous supratentorial intracerebral hemorrhage: a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.112.667535

    authors: Zhou X,Chen J,Li Q,Ren G,Yao G,Liu M,Dong Q,Guo J,Li L,Guo J,Xie P

    更新日期:2012-11-01 00:00:00

  • Carotid artery thrombus associated with severe iron-deficiency anemia and thrombocytosis.

    abstract:BACKGROUND:Thrombus within the carotid artery usually occurs in vessels with severe atherosclerotic disease and may embolize to cause transient ischemic attacks and cerebral infarctions. The risk factors for carotid artery thrombus formation in the absence of atherosclerosis are not well characterized. A case series is...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.5.1002

    authors: Akins PT,Glenn S,Nemeth PM,Derdeyn CP

    更新日期:1996-05-01 00:00:00

  • Mild hypothermia after intravenous thrombolysis in patients with acute stroke: a randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. METHODS:Patients were randomized 1:1 to mild hypothermia (35°C) or to standard str...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.113.003180

    authors: Piironen K,Tiainen M,Mustanoja S,Kaukonen KM,Meretoja A,Tatlisumak T,Kaste M

    更新日期:2014-02-01 00:00:00

  • Age dependence of risk factors for stroke and death in young patients with atrial fibrillation: a nationwide study.

    abstract:BACKGROUND AND PURPOSE:The risk of stroke and death in patients with atrial fibrillation is strongly associated with age and concomitant comorbidities. The aim of this study was to examine the age dependence of risk factors for stroke and mortality in young patients with atrial fibrillation. METHODS:This study is a po...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.004903

    authors: Melgaard L,Rasmussen LH,Skjøth F,Lip GY,Larsen TB

    更新日期:2014-05-01 00:00:00

  • Classification of walking handicap in the stroke population.

    abstract:BACKGROUND AND PURPOSE:The limited walking ability that follows a stroke restricts the patient's independent mobility about the home and community, a significant social handicap. To improve the in-hospital prediction of functional outcome, the relationships between impairment, disability, and handicap were assessed wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.6.982

    authors: Perry J,Garrett M,Gronley JK,Mulroy SJ

    更新日期:1995-06-01 00:00:00

  • Intraventricular thrombolysis in intracerebral hemorrhage requiring ventriculostomy: a decade-long real-world experience.

    abstract:BACKGROUND AND PURPOSE:Intraventricular thrombolysis (IVT) is a promising treatment in facilitating intraventricular clot resolution after intraventricular hemorrhage. We examined in-hospital outcomes and resource utilization after thrombolysis in patients with intraventricular hemorrhage requiring ventriculostomy in a...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.006067

    authors: Moradiya Y,Murthy SB,Newman-Toker DE,Hanley DF,Ziai WC

    更新日期:2014-09-01 00:00:00

  • Cerebrovascular reserve in patients with carotid occlusive disease assessed by stable xenon-enhanced ct cerebral blood flow and transcranial Doppler.

    abstract:BACKGROUND AND PURPOSE:Cerebrovascular reserve (CVR) by both transcranial Doppler ultrasonography (TCD) and quantitative cerebral blood flow (CBF) can identify subgroups of patients at increased risk for stroke. A direct comparison of CVR measurements obtained with both technologies in patients with cerebrovascular occ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.8.1811

    authors: Pindzola RR,Balzer JR,Nemoto EM,Goldstein S,Yonas H

    更新日期:2001-08-01 00:00:00

  • Transesophageal two-dimensional echocardiography in young patients with cerebral ischemic events.

    abstract::Using transesophageal echocardiography, cardiac structures can be imaged with high resolution. The aim of our study was to evaluate whether transesophageal echocardiography is superior in detecting mitral valve prolapse and other cardiac abnormalities compared with transthoracic echocardiography in an age-matched cont...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.3.345

    authors: Zenker G,Erbel R,Krämer G,Mohr-Kahaly S,Drexler M,Harnoncourt K,Meyer J

    更新日期:1988-03-01 00:00:00

  • Effects of global cerebral ischemia in the pregnant rat.

    abstract:BACKGROUND AND PURPOSE:Stroke during pregnancy is an emerging concern. Although females undergo many physiological, endocrine, and neurological alterations during pregnancy, the consequences of such changes on outcome after stroke are unclear. It is predicted that increases in steroid hormones observed during pregnancy...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.497016

    authors: Spencer SJ,Galic MA,Tsutsui M,Pittman QJ,Mouihate A

    更新日期:2008-03-01 00:00:00

  • Baseline Quality of Life and Risk of Stroke in the ALLHAT Study (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).

    abstract:BACKGROUND AND PURPOSE:The visual analogue scale is a self-reported, validated tool to measure quality of life (QoL). Our purpose was to determine whether baseline QoL predicted strokes in the ALLHAT study (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) and evaluate determinants of poststr...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.117.016062

    authors: Shams T,Auchus AP,Oparil S,Wright CB,Wright J,Furlan AJ,Sila CA,Davis BR,Pressel S,Yamal JM,Einhorn PT,Lerner AJ,ALLHAT Collaborative Research Group.

    更新日期:2017-11-01 00:00:00

  • Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury.

    abstract::Nontraumatic intracerebral hemorrhage (ICH) remains a devastating condition with 30-day mortality rates of 35% to 52%. Until the pathophysiology of this condition is better understood, it will not be possible to develop effective therapies. Studies of cerebral blood flow and metabolism in patients with acute ICH show ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.595058

    authors: Powers WJ

    更新日期:2010-10-01 00:00:00

  • Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited.

    abstract:BACKGROUND AND PURPOSE:Thick cisternal clot on CT is a well-recognized risk factor for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). Whether intraventricular hemorrhage (IVH) or intracerebral hemorrhage (ICH) predisposes to DCI is unclear. The Fisher CT grading scale identifies thick SAH but does...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/hs0901.095677

    authors: Claassen J,Bernardini GL,Kreiter K,Bates J,Du YE,Copeland D,Connolly ES,Mayer SA

    更新日期:2001-09-01 00:00:00

  • Blend Sign on Computed Tomography: Novel and Reliable Predictor for Early Hematoma Growth in Patients With Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Early hematoma growth is not uncommon in patients with intracerebral hemorrhage and is an independent predictor of poor functional outcome. The purpose of our study was to report and validate the use of our newly identified computed tomographic (CT) blend sign in predicting early hematoma growth....

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009185

    authors: Li Q,Zhang G,Huang YJ,Dong MX,Lv FJ,Wei X,Chen JJ,Zhang LJ,Qin XY,Xie P

    更新日期:2015-08-01 00:00:00