Insulin Resistance Is a Risk Factor for Silent Lacunar Infarction.

abstract：BACKGROUND AND PURPOSE:The aim of this study was to identify quantitative trait loci (QTL) for carotid intima-media thickness (CIMT) a risk factor for stroke and cardiovascular disease. METHODS:Probands were selected from Caribbean Hispanic subjects of the population-based Northern Manhattan Study. CIMT was measured b...

journal_title：Stroke

authors： Sacco RL,Blanton SH,Slifer S,Beecham A,Glover K,Gardener H,Wang L,Sabala E,Juo SH,Rundek T

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The CHA2DS2-VASc stroke score (congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65-74, female) is used in most guidelines for risk stratification in atrial fibrillation (AF), but most data for ...

journal_title：Stroke

authors： Kim TH,Yang PS,Uhm JS,Kim JY,Pak HN,Lee MH,Joung B,Lip GYH

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is little reported of the safety and efficacy of high-dose intravenous recombinant tissue plasminogen activator (alteplase) in combination with heparin anticoagulation in patients presenting with acute ischemic stroke. METHODS:Thirty-two patients with severe hemispheric stroke syndrome cau...

journal_title：Stroke

authors： von Kummer R,Hacke W

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Limited data exist on the performance of the revised Framingham Stroke Risk Score (R-FSRS) and the R-FSRS in conjunction with nontraditional risk markers. We compared the R-FSRS, original FSRS, and the Pooled Cohort Equation for stroke prediction and assessed the improvement in discrimination by ...

journal_title：Stroke

authors： Flueckiger P,Longstreth W,Herrington D,Yeboah J

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The vitamin K-dependent protein Z (PZ) has been shown to possess anticoagulant as well as procoagulant properties. Plasma levels of PZ show a broad interindividual variation, but it is unknown to which extent this variation is under genetic control. Recent clinical studies revealed contradictory ...

journal_title：Stroke

authors： Lichy C,Kropp S,Dong-Si T,Genius J,Dolan T,Hampe T,Stoll F,Reuner K,Grond-Ginsbach C,Grau A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevated plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease. Variation in the levels of this amino acid has been shown to be due to nutritional status and methylenetetrahydrofolate reductase (MTHFR) genotype. METHODS:Under a case-cont...

journal_title：Stroke

authors： McIlroy SP,Dynan KB,Lawson JT,Patterson CC,Passmore AP

更新日期：2002-10-01 00:00:00

abstract：:The protective properties of PY 108-068 against ischemic disturbances in the brain were investigated in vitro and in vivo. The calcium antagonistic effects were demonstrated on isolated, calcium-loaded arterial rings of feline cerebral arteries. Determination of brain tissue oxygenation with pO2 microelectrodes showed...

journal_title：Stroke

authors： Wiernsperger N,Gygax P,Hofmann A

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Matrix metalloproteinases (MMPs) and cysteine proteases (calpain and cathepsin B) play an important role in cell death and are upregulated after focal cerebral ischemia. Because there is a significant interaction between MMP-9 with calpain and cathepsin B, we investigated the role of E64d (a calp...

journal_title：Stroke

authors： Tsubokawa T,Solaroglu I,Yatsushige H,Cahill J,Yata K,Zhang JH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracranial cerebral atherosclerosis causes ischemic stroke in a significant number of patients. Technological advances over the past 10 years have enabled endovascular treatment of intracranial atherosclerotic stenosis. The number of patients treated with angioplasty or stent-assisted angioplas...

journal_title：Stroke

authors： Schumacher HC,Meyers PM,Higashida RT,Derdeyn CP,Lavine SD,Nesbit GM,Sacks D,Rasmussen P,Wechsler LR

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Determination of vasomotor reserve (VMR) with the transcranial Doppler-CO(2) (TCD-CO(2)) test is used to assess the risk of impending cerebral ischemia in patients with high-grade stenosis or occlusion of the internal carotid artery. In patients with a poor temporal window, however, this examinat...

journal_title：Stroke

authors： Rohrberg M,Brodhun R

更新日期：2001-06-01 00:00:00

abstract：:Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...

journal_title：Stroke

authors： Puy L,Barbay M,Roussel M,Canaple S,Lamy C,Arnoux A,Leclercq C,Mas JL,Tasseel-Ponche S,Constans JM,Godefroy O,GRECogVASC Study Group.

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The goal of this study was to characterize cortical reorganization after stroke and its relation with the site of the stroke-induced lesion and degree of motor recovery using functional MRI (fMRI). METHODS:Fourteen stroke patients with an affected upper limb were studied longitudinally. Three fM...

journal_title：Stroke

authors： Feydy A,Carlier R,Roby-Brami A,Bussel B,Cazalis F,Pierot L,Burnod Y,Maier MA

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Analysis of quality of care for in-hospital stroke has not been previously performed at the national level. This study compares patient characteristics, process measures of quality, and outcomes for in-hospital strokes with those for community-onset strokes in a national cohort. METHODS:We perfo...

journal_title：Stroke

authors： Cumbler E,Wald H,Bhatt DL,Cox M,Xian Y,Reeves M,Smith EE,Schwamm L,Fonarow GC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to validate the diagnosis of self-reported stroke. METHODS:During 1994-1995, 27 159 people attended a population health survey in the community of Tromso, Norway, a response rate of 77%. A total of 418 attenders reported a history of stroke. In 1997, all individuals wit...

journal_title：Stroke

authors： Engstad T,Bonaa KH,Viitanen M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis of intracranial atherosclerosis requires availability of appropriate imaging techniques. The objective was to evaluate the proportion of European hospitals where imaging techniques necessary to detect intracranial atherosclerosis are available. Method- We randomly selected 886 hospi...

journal_title：Stroke

authors： Balucani C,Leys D,Ringelstein EB,Kaste M,Hacke W,Executive Committee of the European Stroke Initiative.

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The premotor cortex (PMC) (Brodmann 6) contributes uniquely to proximal upper and lower limb power and plays a role in the organization of motor behaviors. We assessed the degree to which PMC damage affected functional outcome. METHODS:We prospectively compared the functional outcome of patients...

journal_title：Stroke

authors： Miyai I,Suzuki T,Kang J,Kubota K,Volpe BT

更新日期：1999-07-01 00:00:00

abstract：:Acute thromboembolic occlusion of the basilar artery accounts for 6% to 10% of large-vessel stroke in humans. Because of the brain region supplied by this artery, the case fatality rate is the highest for all ischemic stroke subtypes, ranging from 40% to 86%. Patients who undergo successful recanalization of the basil...

journal_title：Stroke

authors： Smith WS

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tacrolimus, an immunosuppressant agent, has been shown to reduce tissue injury and leukocyte accumulation after transient ischemia. This study was designed to evaluate quantitatively the inhibitory effects of tacrolimus on leukocyte rolling and on subsequent leukocyte accumulation in vivo after t...

journal_title：Stroke

authors： Tsujikawa A,Ogura Y,Hiroshiba N,Miyamoto K,Kiryu J,Honda Y

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:The method described provides a rational means for determining whether to institute chronic anticoagulation to prevent stroke in patients with chronic atrial fibrillation under a variety of clinical circumstances. SUMMARY OF COMMENT:The concept of expected value is used in conjunction with data from clinica...

journal_title：Stroke

authors： Nadeau SE

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral white matter changes (WMC) and lacunar infarct are both believed to be consequence of small vessel disease. Whether the extent of WMC affect the type and degree of cognitive impairment in patients with lacunar infarct is not clear. The study was undertaken to determine if WMC influences ...

journal_title：Stroke

authors： Wen HM,Mok VC,Fan YH,Lam WW,Tang WK,Wong A,Huang RX,Wong KS

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. METHODS:Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonat...

journal_title：Stroke

authors： Eggers J,König IR,Koch B,Händler G,Seidel G

更新日期：2008-05-01 00:00:00

abstract：UNLABELLED:Background and Purpose-Hemiplegic shoulder pain is not uncommon after stroke. Its origin is still unknown, and although many different methods of treatment are applied, none have yet been proved to be effective. We sought to study the efficacy of 3 injections of intra-articular triamcinolone acetonide on pai...

journal_title：Stroke

authors： Snels IA,Beckerman H,Twisk JW,Dekker JH,Peter De Koning,Koppe PA,Lankhorst GJ,Bouter LM

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multipotent mesenchymal stromal cell (MSC) harvested exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17-92 cluster promotes oligodendrogenesis, neurogenesis, and axonal outgrowth. We, therefore, investigated whether the miR-17-92 cluster-enriched exosomes har...

journal_title：Stroke

authors： Xin H,Katakowski M,Wang F,Qian JY,Liu XS,Ali MM,Buller B,Zhang ZG,Chopp M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The treatment of large brain arteriovenous malformations (BAVMs) is challenging, and embolization alone is seldom curative. The study goal is to enhance the efficacy of arteriovenous malformation embolization by adding a beta-emitting isotope to the embolic agent. METHODS:The pig rete mirabile w...

journal_title：Stroke

authors： Roy D,Soucy JP,Hartman NG,Janicki C,Weill A,Guilbert F,Papineau K,Raymond J

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is evidence of unequal access to health care interventions even where universal health systems operate. We investigated associations between patients' sociodemographic characteristics and the provision of acute and longer-term stroke care in a multiethnic urban population. METHODS:We used ...

journal_title：Stroke

authors： McKevitt C,Coshall C,Tilling K,Wolfe C

更新日期：2005-02-01 00:00:00

abstract：:The presence of hyperglycemia prior to stroke or cardiac arrest can increase neuronal damage caused by brain ischemia. Acute hyperglycemia shows this effect in animal models of stroke. However, chronic hyperglycemia and chronic hyperglycemia with additional acute elevation of blood glucose are more common premorbid st...

journal_title：Stroke

authors： Duckrow RB,Beard DC,Brennan RW

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patent foramen ovale (PFO) may increase the risk of embolic stroke of undetermined source (ESUS). Guidelines suggest anticoagulation may be more effective than antiplatelets in preventing stroke in patients with ESUS and PFO when interventional closure is not performed. METHODS:Patients with ESU...

journal_title：Stroke

authors： Diener HC,Chutinet A,Easton JD,Granger CB,Kleine E,Marquardt L,Meyerhoff J,Zini A,Sacco RL

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiology of stroke in the young is different from that in older patients and remains unknown in almost one third of the cases. To gain further insight into both pathogenic and etiologic determinants, we prospectively studied a large number of consecutive young adults with focal cerebral ische...

journal_title：Stroke

authors： Carolei A,Marini C,Ferranti E,Frontoni M,Prencipe M,Fieschi C

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early hematoma growth is not uncommon in patients with intracerebral hemorrhage and is an independent predictor of poor functional outcome. The purpose of our study was to report and validate the use of our newly identified computed tomographic (CT) blend sign in predicting early hematoma growth....

journal_title：Stroke

authors： Li Q,Zhang G,Huang YJ,Dong MX,Lv FJ,Wei X,Chen JJ,Zhang LJ,Qin XY,Xie P

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of lithium as a neuroprotective agent has been demonstrated using various models in which improvements in infarct size, DNA damage, and neurological function were reported. We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic e...

journal_title：Stroke

authors： Kim YR,van Meer MP,Tejima E,Murata Y,Mandeville JB,Dai G,Chuang DM,Rosen BR,Lo EH

更新日期：2008-02-01 00:00:00