Abstract:
:Nontraumatic intracerebral hemorrhage (ICH) remains a devastating condition with 30-day mortality rates of 35% to 52%. Until the pathophysiology of this condition is better understood, it will not be possible to develop effective therapies. Studies of cerebral blood flow and metabolism in patients with acute ICH show similar abnormalities to those that occur in patients with traumatic brain injury, thus raising the question of whether there are common mechanisms of injury shared by the 2 conditions. In both ICH and traumatic brain injury, there is an early reduction in the cerebral metabolic rate of oxygen without ischemia, mitochondrial dysfunction, and transient focal increases in regional glucose metabolism that occur after a few days. ICH and traumatic brain injury share barotrauma from pressure waves that propagate through the intracranial contents as a common mechanism of brain injury. Recent data demonstrating contralateral hemispheric damage in patients with acute ICH provide further support for this theory of common injury mechanisms.
journal_name
Strokejournal_title
Strokeauthors
Powers WJdoi
10.1161/STROKEAHA.110.595058subject
Has Abstractpub_date
2010-10-01 00:00:00pages
S107-10issue
10 Suppleissn
0039-2499issn
1524-4628pii
41/10_suppl_1/S107journal_volume
41pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Type 2 diabetes is associated with a high cardiovascular morbidity and mortality. Recent advances of intervention studies in type 2 diabetes with use of carotid intima-media thickness (CIMT) measurement as a surrogate end point may allow for better understanding of the undetermined process of ath...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000236632.58323.cd
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because stroke management is aimed at facilitating community reintegration, it would be logical that the sooner the patient can be discharged home, the sooner reintegration can commence. The purpose of this study was to determine the effectiveness of prompt discharge combined with home rehabilita...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.31.5.1016
更新日期:2000-05-01 00:00:00
abstract::Neurogenically caused cardiac arrhythmias and their correlation to lesions within the central nervous system were examined prospectively in 54 patients with spontaneous intracerebral hemorrhage. All patients were examined neurologically daily for 3 weeks, with special attention given to signs of brainstem compression ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.6.688
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Some studies have suggested a link between impaired cerebral hemodynamics and stroke in patients with carotid stenosis. The aim of this study was to assess the effects of severe carotid stenosis on cerebrovascular reactivity and the possible changes after endarterectomy. METHODS:Using bilateral ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.11.1970
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Shoulder pain is a common complication after stroke that can impede participation in rehabilitation and has been associated with poorer outcomes. Evidence-based treatments for hemiplegic shoulder pain are limited. Suprascapular nerve block (SSNB) is a safe and effective treatment of shoulder pain...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.113.002471
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials evaluated the safety and efficacy of thrombectomy in the treatment of intracranial arterial occlusions within 8 hours of symptom onset. We sought to determine the predictors of clinical and angiographic outcomes in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.561431
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of our study was to characterize the patient profile and prognostic value associated with high positive IgG (>100 GPL) anticardiolipin antibodies (aCL). METHODS:We studied the clinical, laboratory, radiological, and prospective historical features of ischemic cerebrovascular disease in p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.11.2245
更新日期:1998-11-01 00:00:00
abstract:UNLABELLED:Background and Purpose-Hemiplegic shoulder pain is not uncommon after stroke. Its origin is still unknown, and although many different methods of treatment are applied, none have yet been proved to be effective. We sought to study the efficacy of 3 injections of intra-articular triamcinolone acetonide on pai...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.31.10.2396
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The effect of statins on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT in Japanese patients with noncardioembolic ischemic stroke. METHODS:This ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.117.018387
更新日期:2018-01-01 00:00:00
abstract::We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/alpha-chloralose (alpha-chloralose), and ketamine/halothane/N2O (halothane). S...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.5.795
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series. METHODS:By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy und...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.12.2448
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:While brain tissue lactate increases during cerebral ischemia and is known to be important in the pathogenesis of ischemic brain injury, patterns of extracellular lactate accumulation have been less well characterized, and the influence of brain temperature has not been previously investigated. M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.9.1634
更新日期:1995-09-01 00:00:00
abstract::Before surgery, we evaluated major intracranial collateral pathways using transcranial Doppler ultrasonography (TCD) in 50 patients who then underwent carotid endarterectomy with concurrent multimodality cerebral monitoring. Patients were grouped with respect to collateral pathways demonstrated preoperatively by TCD: ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.11.1328
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) growth predicts mortality and functional outcome. We hypothesized that irregular hematoma shape and density heterogeneity, reflecting active, multifocal bleeding or a variable bleeding time course, would predict ICH growth. METHODS:Three raters examined baseline su...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.108.536888
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dipyridamole increases the concentration of circulating adenosine, which is a potent vasodilator, by inhibition of uptake of adenosine into the erythrocytes, and hence produces coronary vasodilation. However, the effects of dipyridamole on cerebral circulation is not pronounced. This study invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.8.1616
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is a valid, reproducible scale that measures neurological deficit. Of 42 possible points, 7 points are directly related to measurement of language compared with only 2 points related to neglect. METHODS:We examined the placebo arm of the NIN...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.11.2355
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:We report the clinical and neuroimaging findings of a patient who sustained multiple cerebral infarcts after the ingestion of concentrated hydrogen peroxide solution sold as a "health food" product. CASE DESCRIPTION:An 84-year-old man sustained focal neurological deficits immediately after ingesting 30 mL o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.5.1065
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke-related physical disability can diminish quality of daily living, place care burden on families, and increase need for long-term institutionalization. We developed a prognostic index for use in research and with potential for adaptation to clinical practice that establishes the likelihood ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.3.550
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aim to evaluate if good collateral flow (CF) modifies endovascular therapy (EVT) efficacy on large-vessel stroke. To do that, we used final degree of reperfusion and number of device-passes performed, factors previously associated with better functional outcome, as main outcome measures. METH...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031338
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In 6% to 9% of patients with subarachnoid hemorrhage (SAH), familial aggregation occurs; truly familial cases carry a worse prognosis than sporadic cases and raise the question of screening. If relatives have died from SAH, the family history is often the only available clue to the diagnosis, but...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.4.630
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endovascular treatment can improve the outcome of patients treated for ruptured intracranial aneurysms as compared with surgical clipping, but angiographic recurrences are frequent. Endothelial denudation before coil embolization may prevent recanalization and improve results of endovascular trea...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000126042.76153.f7
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Gene transfer to peripheral arteries has been accomplished with catheter-based approaches. Recently, gene transfer to the carotid artery and intracranial vessels has been achieved both in vitro and in vivo. Although gene therapy for cerebral vascular disease may not be accomplished for years, currently avail...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.27.9.1688
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I). We tested the hypothesis that topical pretreatment with the selective potassium channel agonists NS1619 and aprikalim preserves the vasc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.4.837
更新日期:1998-04-01 00:00:00
abstract::The gerbil model was used to assess the therapeutic effects of the calcium antagonist nimodipine on cerebral ischemia. Transient cerebral ischemia was produced in each gerbil by bilateral common carotid occlusion of 10-, 15- or 20-min duration. Nimodipine (0.01 or 0.1 mg/kg) was administered intraperitoneally just bef...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.748
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.527713
更新日期:2009-03-01 00:00:00
abstract::Background and Purpose- Case reports suggest that unruptured intracranial aneurysms may serve as a nidus for thrombus formation and downstream embolic stroke. However, few data exist to support an association between unruptured aneurysms and ischemic stroke. Methods- We conducted a within-subjects case-control study o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021985
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The onset of spontaneous intracerebral hemorrhage (ICH) is often accompanied by transient blood pressure (BP) elevation. The prognostic value and the determinants of this BP reaction have not entirely been solved, and the present study was focused on these questions. METHODS:From 1985 to 1991 in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.7.1396
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endovascular treatment of carotid stenosis may be an alternative to surgical endarterectomy. We conducted a systematic review of the randomized evidence to assess the benefits and risks of endovascular treatment compared to surgery. METHODS:Cochrane registers and online databases were searched a...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.108.531228
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486217
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Vasogenic brain edema is a frequent complication of ischemic stroke. The mechanism of the blood-brain barrier opening that underlies the edema formation is poorly understood. In the present study we examined the response of endothelial cells cultured from adult human brain to thrombogenic and fib...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.2.265
更新日期:1995-02-01 00:00:00