Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury.

Abstract:

:Nontraumatic intracerebral hemorrhage (ICH) remains a devastating condition with 30-day mortality rates of 35% to 52%. Until the pathophysiology of this condition is better understood, it will not be possible to develop effective therapies. Studies of cerebral blood flow and metabolism in patients with acute ICH show similar abnormalities to those that occur in patients with traumatic brain injury, thus raising the question of whether there are common mechanisms of injury shared by the 2 conditions. In both ICH and traumatic brain injury, there is an early reduction in the cerebral metabolic rate of oxygen without ischemia, mitochondrial dysfunction, and transient focal increases in regional glucose metabolism that occur after a few days. ICH and traumatic brain injury share barotrauma from pressure waves that propagate through the intracranial contents as a common mechanism of brain injury. Recent data demonstrating contralateral hemispheric damage in patients with acute ICH provide further support for this theory of common injury mechanisms.

journal_name

Stroke

journal_title

Stroke

authors

Powers WJ

doi

10.1161/STROKEAHA.110.595058

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

S107-10

issue

10 Suppl

eissn

0039-2499

issn

1524-4628

pii

41/10_suppl_1/S107

journal_volume

41

pub_type

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