Abstract:
BACKGROUND AND PURPOSE:Genetic factors involved in the pathogenesis of primary intracerebral hemorrhage (PICH) remain unknown. One of the candidate genes is SERPINA3. Results of a Spanish study suggested that TT genotype of the A/T SERPINA3 polymorphism in the signal peptide sequence was a risk factor for PICH in normotensive subjects. The aim of the present study was to investigate whether SERPINA3 A/T polymorphism is associated with PICH in a Polish population. METHODS:We analyzed 95 PICH patients and 190 unrelated healthy controls matched for age and sex. A/T polymorphism of the SERPINA3 gene was investigated using polymerase chain reaction restriction fragment length polymorphism method. RESULTS:The distribution of SERPINA3 genotypes was similar among PICH patients (AA 27.4%; AT 46.3%; TT 26.3%) and controls (AA 23.7%; AT 50.5%; TT 25.8%; P=NS). There were also no significant differences in genotype distribution when analyzing separately hypertensive and normotensive PICH patients as well as patients with lobar and deeply located hemorrhage. CONCLUSIONS:We failed to find an association between SERPINA3 A/T polymorphism and PICH in a Polish population.
journal_name
Strokejournal_title
Strokeauthors
Pera J,Slowik A,Dziedzic T,Szczudlik Adoi
10.1161/01.STR.0000202655.64413.0csubject
Has Abstractpub_date
2006-03-01 00:00:00pages
906-7issue
3eissn
0039-2499issn
1524-4628pii
01.STR.0000202655.64413.0cjournal_volume
37pub_type
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