Abstract:
BACKGROUND AND PURPOSE:Elevated urinary albumin excretion (UAE) is associated with an increased carotid intima-media thickness (IMT). Because angiotensin-converting enzyme inhibitors as well as statins have been shown to lower UAE and the progression of IMT, we assessed the effects of fosinopril and pravastatin on carotid IMT in subjects with an increased UAE (15 to 300 mg/24 h). METHODS:IMT was measured at the posterior wall of the left common carotid artery using radio-frequency signal analysis obtained by M-mode ultrasonography. 642 subjects were double-blind randomized to fosinopril 20 mg or matching placebo and to pravastatin 40 mg or matching placebo and were available for intention-to-treat analysis. RESULTS:Mean age was 51+/-11 years, 65% were male, the median UAE was 22.5 (15.5 to 40.8) mg/24 h, and the mean IMT at baseline was 0.77+/-0.18 mm. The overall progression rate of IMT in 4 years was 0.037+/-0.006 mm. No significant difference in IMT progression was found between fosinopril, pravastatin, or matching placebo. IMT after 4 years was predicted by IMT at baseline, age, gender, pulse pressure, and low-density lipoprotein cholesterol levels. Furthermore, a higher incidence of clinical events was observed in subjects with an IMT >1 mm after a mean follow-up of 46+/-7 months (hazard ratio, 3.13; 95% confidence interval, 1.59 to 6.16; P=0.001). CONCLUSIONS:In subjects with an increased UAE, treatment with fosinopril and pravastatin showed no significant effect on carotid IMT. Furthermore, an IMT <1 mm at baseline is an important indicator for event-free survival.
journal_name
Strokejournal_title
Strokeauthors
Asselbergs FW,van Roon AM,Hillege HL,de Jong PE,Gans RO,Smit AJ,van Gilst WH,PREVEND IT Investigators.doi
10.1161/01.STR.0000155731.92786.e9subject
Has Abstractpub_date
2005-03-01 00:00:00pages
649-53issue
3eissn
0039-2499issn
1524-4628pii
01.STR.0000155731.92786.e9journal_volume
36pub_type
临床试验,杂志文章,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Lower concentrations of albumin have been positively related to coronary disease. The aim of this project was to assess the association between serum albumin and carotid atherosclerosis. METHODS:B-mode ultrasound was used to assess carotid plaques and intima-media thickness (IMT) among white sub...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.0000048675.97975.84
更新日期:2003-01-01 00:00:00
abstract::Coarctation of the aorta is an uncommon cause of cerebral hemorrhage in the full- or near-term infant. The clinical, radiologic, and neurologic findings of four infants with aortic coarctation and cerebral hemorrhage are presented. In all four infants, cerebral hemorrhage was associated with only moderate elevation of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.4.491
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in di...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0901.095601
更新日期:2001-09-01 00:00:00
abstract::We studied 1,273 patients with ischemic cerebral infarction who were entered into the Stroke Data Bank, a prospective, observational study involving four university hospitals and the Biometry and Field Studies Branch of the National Institute of Neurological Disorders and Stroke. Forty patients had noniatrogenic recur...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.983
更新日期:1989-08-01 00:00:00
abstract::Recent success with thrombolytic therapy for acute myocardial infarction has stimulated interest in its use for stroke. To determine the hemorrhagic potential of thrombolytic therapy in experimental cerebral infarction, we compared a group of tissue plasminogen activator-treated rabbits (n = 4) with 2 groups of strept...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.6.1148
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS:We tested the hy...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.013837
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Determination of vasomotor reserve (VMR) with the transcranial Doppler-CO(2) (TCD-CO(2)) test is used to assess the risk of impending cerebral ischemia in patients with high-grade stenosis or occlusion of the internal carotid artery. In patients with a poor temporal window, however, this examinat...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.6.1298
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy seri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.010797
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The CHADS(2) score is used for risk stratification of ischemic stroke in patients with nonvalvular atrial fibrillation and high CHADS(2) scores are associated with increased risk of stroke. Most components of the CHADS(2) score are also risk factors for atherosclerosis. Therefore, high CHADS(2) s...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.602987
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We evaluated the impact of lifestyle factors on the risk of ischemic stroke. METHODS:We used a nested case-control design. The cases comprised 163 persons (median age 69 years) admitted to a stroke unit and diagnosed with acute cerebral infarction. All cases had earlier participated in the North...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.6.829
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke, but the underlying mechanisms remain unclear. In this study, we aimed to validate the use of PTEN regulation of gamma-amino...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.579011
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is scant information available on the incidence of transient ischemic attack (TIA) in a defined population. This study defines incidence rates of first TIA and subtypes of TIA during 1985-1989 and compares the incidence to that obtained from a 1960-1972 cohort study. METHODS:Medical record...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.10.2109
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke on board aircraft has been reported in retrospective case series, mainly focusing on economy class stroke syndrome. Data on the actual incidence, pathogenesis, and prognosis of stroke in commercial flights are lacking. METHODS:A prospective registry was designed to include all consecutive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.012637
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In 6% to 9% of patients with subarachnoid hemorrhage (SAH), familial aggregation occurs; truly familial cases carry a worse prognosis than sporadic cases and raise the question of screening. If relatives have died from SAH, the family history is often the only available clue to the diagnosis, but...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.4.630
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.618496
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.558221
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prompt recognition of stroke symptoms is critical to timely treatment and women have increased delay to treatment. Women may be more likely to present with atypical symptoms, but this hypothesis has not been extensively evaluated. METHODS:We examined gender differences in the prevalence of prese...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.543371
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Watershed ischemia is a significant cause of stroke in severe carotid disease, but its pathophysiology is unsettled. Although hemodynamic compromise has long been regarded as the main mechanism-particularly with deep watershed infarction-there is some contradictory evidence from clinical and path...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.580415
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that circulating microRNAs (miRNAs) present in plasma might display a specific signature in patients with intracerebral hemorrhage. METHODS:Global miRNA profiles were determined with the Agilent Human miRNA Microarray platform, and validated by quantitative polymerase ch...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000835
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Antiplatelet therapy is currently one of the methods for preventing transient ischemic attacks and cerebral thrombosis. Because antiplatelet agents are generally administered on a long-term basis, patient compliance is an important factor. The purpose of this study was to determine the compliance...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.25.12.2337
更新日期:1994-12-01 00:00:00
abstract::To study the effects of antithrombotic therapy in experimental stroke, we have characterized a baboon model of acute cerebrovascular thrombosis. In this model an inflatable silastic balloon cuff has been implanted by transorbital approach around the right middle cerebral artery (MCA), proximal to the take-off of the l...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1254
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients with angiographically documented proximal middle cerebral artery ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.29.1.4
更新日期:1998-01-01 00:00:00
abstract::In a postasphyxia neonatal lamb model, the responses of the cerebral circulation to hypoxic hypoxia and changes in systemic arterial blood pressure were examined. Ventilated newborn lambs (n = 14) were subjected to a gradual asphyxial insult, resuscitated, and returned to control ventilator settings. During the time 2...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.2.239
更新日期:1988-02-01 00:00:00
abstract::Internal carotid blood flow, taken as an index of cerebral blood flow (CBF); arterial pressure; and respiratory O2 and CO2 concentrations, were measured in halothane (1%)-anesthetized, paralyzed and mechanically ventilated rabbits. CBF was determined at end-tidal CO2 of 4% (normocapnia) and 8%, as inspired O2 [O2]I) w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.3.286
更新日期:1980-05-01 00:00:00
abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.2.322
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs). METHODS:We enrolled 124 patients with acute stroke who were treated at our unive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000063373.70993.CD
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Unaccustomed strenuous physical exertion can trigger myocardial infarction, but little is known about the mechanisms precipitating subarachnoid hemorrhage (SAH). METHODS:We identified all cases of first-ever SAH among the combined populations (2.8 million) of 4 urban centers in Australia and New...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000077015.90334.A7
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with cerebral amyloid angiopathy (CAA) are at high risk for intracerebral hemorrhage (ICH), but no effective prevention strategies have been established. The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group. METHODS:T...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.109.563932
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia is a common stroke symptom and leads to serious complications such as aspiration and pneumonia. Early dysphagia screening can reduce these complications. In many hospitals, dysphagia screening is performed by speech-language therapists who are often not available on weekends/holidays, w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.018157
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous work has shown that cerebral microembolism detected with transcranial Doppler sonography distal to internal carotid artery stenosis occurs more frequently in recently symptomatic compared with asymptomatic patients. It has remained unclear whether cerebral microembolism also indicates a ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.11.2184
更新日期:1995-11-01 00:00:00