Intracerebral hemorrhage in the very old: future demographic trends of an aging population.

Abstract:

BACKGROUND AND PURPOSE:In most European societies and in the United States, the percentage of patients ≥80 years has been rising over the past century. The present study was conducted to observe this demographic change and its impact on patients with intracerebral hemorrhage (ICH). METHODS:We reviewed patients' data with the diagnosis of ICH from January 2007 to December 2009. All data were collected out of a prospective stroke registry covering the entire state of Hesse, Germany. Incidence rates and absolute numbers of patients with ICH for 2009 to 2050 were calculated. RESULTS:Of 3448 patients, 34% had an age ≥80 years. Hospital mortality was 35.9% for patients ≥80 years and 20.0% for patients <80 years. Unfavorable outcome (modified Rankin Scale score >2) was more often found in patients ≥80 years compared with patients <80 years (84.9% versus 74.8%). By the year 2050, the proportion of all patients with ICH ≥80 years will be 2.5-fold higher than in 2009. The total number of ICH cases will increase approximately 35.2% assuming that ICH probability stays the same. The number of patients who die in the hospital will increase approximately 60.2%. The total number of patients with severe disability due to ICH will increase approximately 36.8%. CONCLUSIONS:If current treatment strategies according to age remain unchanged, an increase of in-hospital mortality and a higher proportion of patients who need lifelong care after ICH can be expected in the coming decades.

journal_name

Stroke

journal_title

Stroke

authors

Stein M,Misselwitz B,Hamann GF,Scharbrodt W,Schummer DI,Oertel MF

doi

10.1161/STROKEAHA.111.644716

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

1126-8

issue

4

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.111.644716

journal_volume

43

pub_type

杂志文章

相关文献

STROKE文献大全
  • Cerebroprotective effect of lamotrigine after focal ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:Glutamate receptor antagonists are protective in animal models of focal cerebral ischemia. Lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) is an anticonvulsant drug that blocks voltage-gated sodium channels and inhibits the ischemia-induced release of glutamate. We describe the ce...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.1.117

    authors: Smith SE,Meldrum BS

    更新日期:1995-01-01 00:00:00

  • Multiple Soluble Components of the Glycocalyx Are Increased in Patient Plasma After Ischemic Stroke.

    abstract::Background and Purpose- The GLX (glycocalyx) is a protein/polysaccharide meshwork at the cellular surface. Consisting largely of glycosaminoglycans and proteoglycans, the GLX can shed in response to stress. In this study, we assay 11 components of the GLX in plasma from patients with ischemic stroke from a longitudina...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.025953

    authors: DellaValle B,Hasseldam H,Johansen FF,Iversen HK,Rungby J,Hempel C

    更新日期:2019-10-01 00:00:00

  • Predicting long-term independency in activities of daily living after middle cerebral artery stroke: does information from MRI have added predictive value compared with clinical information?

    abstract:BACKGROUND AND PURPOSE:To investigate whether neuroimaging information has added predictive value compared with clinical information for independency in activities of daily living (ADL) 1 year after stroke. METHODS:Seventy-five first-ever middle cerebral artery stroke survivors were evaluated in logistic regression an...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000206462.09410.6f

    authors: Schiemanck SK,Kwakkel G,Post MW,Kappelle LJ,Prevo AJ

    更新日期:2006-04-01 00:00:00

  • Hemodynamic changes by flow diverters in rabbit aneurysm models: a computational fluid dynamic study based on micro-computed tomography reconstruction.

    abstract:BACKGROUND AND PURPOSE:The effect of flow diverter (FD) on hemodynamic changes observed in aneurysms is inevitably affected by the actual structural configuration of deployed FD. We studied the resultant hemodynamic changes after implantation of FDs using computational fluid dynamic simulations based on micro-computed ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.001202

    authors: Huang Q,Xu J,Cheng J,Wang S,Wang K,Liu JM

    更新日期:2013-07-01 00:00:00

  • Parity and risk of subarachnoid hemorrhage in women: a nested case-control study based on national Swedish registries.

    abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is the only type of stroke with female predominance, suggesting that reproductive factors may play a role in the etiology. We conducted a population-based study to examine the influence of parity on the risk of SAH in women. METHODS:We linked data from 3 national Sw...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000105933.16654.B4

    authors: Gaist D,Pedersen L,Cnattingius S,Sørensen HT

    更新日期:2004-01-01 00:00:00

  • Should decompressive surgery be performed in malignant cerebral venous thrombosis?: a series of 12 patients.

    abstract:BACKGROUND AND PURPOSE:In malignant cerebral venous thrombosis (CVT) patients, emergency decompressive surgery has been suggested as a life-saving procedure. We report 12 patients with malignant CVT, among whom 8 underwent operation. METHODS:Retrospective study of 12 patients from 3 stroke units who had a malignant CV...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.572909

    authors: Théaudin M,Crassard I,Bresson D,Saliou G,Favrole P,Vahedi K,Denier C,Bousser MG

    更新日期:2010-04-01 00:00:00

  • Risk of thromboembolic events in atrial fibrillation with chronic kidney disease.

    abstract:BACKGROUND AND PURPOSE:Chronic kidney disease may increase the risk for ischemic stroke or systemic embolism in patients with nonvalular atrial fibrillation (AF). We conducted a meta-analysis to summarize all published studies to investigate the link between chronic kidney disease and risk of thromboembolic events in A...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.114.006881

    authors: Zeng WT,Sun XT,Tang K,Mei WY,Liu LJ,Xu Q,Cheng YJ

    更新日期:2015-01-01 00:00:00

  • Childhood Stature and Growth in Relation to First Ischemic Stroke or Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). MET...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019880

    authors: Gjærde LK,Truelsen TC,Baker JL

    更新日期:2018-03-01 00:00:00

  • Perimesencephalic subarachnoid hemorrhage. Additional perspectives from four cases.

    abstract:BACKGROUND:Nonaneurysmal perimesencephalic hemorrhage, a distinct form of subarachnoid hemorrhage, is a recently described variant of intracranial hemorrhage. We describe two patients who presented with unusual features of this type of subarachnoid hemorrhage and also two patients who had a perimesencephalic pattern of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.7.1507

    authors: Schievink WI,Wijdicks EF,Piepgras DG,Nichols DA,Ebersold MJ

    更新日期:1994-07-01 00:00:00

  • Methionine sulfoximine reduces cortical infarct size in rats after middle cerebral artery occlusion.

    abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.2.322

    authors: Swanson RA,Shiraishi K,Morton MT,Sharp FR

    更新日期:1990-02-01 00:00:00

  • Transient Ischemic Attack Results in Delayed Brain Atrophy and Cognitive Decline.

    abstract:BACKGROUND AND PURPOSE:Transient ischemic attack (TIA) initiates an ischemic cascade without resulting in frank infarction and, as such, represents a novel model to study the effects of this ischemic cascade and secondary neurodegeneration in humans. METHODS:Patients with suspected TIA underwent acute brain perfusion ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019276

    authors: Bivard A,Lillicrap T,Maréchal B,Garcia-Esperon C,Holliday E,Krishnamurthy V,Levi CR,Parsons M

    更新日期:2018-02-01 00:00:00

  • Monocyte Count and 30-Day Case Fatality in Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Monocytes may contribute to secondary injury after intracerebral hemorrhage (ICH). We tested the association of absolute monocyte count with 30-day ICH case fatality in a multiethnic cohort. METHODS:Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a prospective, multicenter,...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.115.009880

    authors: Walsh KB,Sekar P,Langefeld CD,Moomaw CJ,Elkind MS,Boehme AK,James ML,Osborne J,Sheth KN,Woo D,Adeoye O

    更新日期:2015-08-01 00:00:00

  • Recovery of upper limb function after cerebellar stroke: lesion symptom mapping and arm kinematics.

    abstract:BACKGROUND AND PURPOSE:Loss of movement coordination is the main postacute symptom after cerebellar infarction. Although the course of motor recovery has been described previously, detailed kinematic descriptions of acute stage ataxia are rare and no attempt has been made to link improvements in motor function to measu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.583641

    authors: Konczak J,Pierscianek D,Hirsiger S,Bultmann U,Schoch B,Gizewski ER,Timmann D,Maschke M,Frings M

    更新日期:2010-10-01 00:00:00

  • Patterns of alcohol intake and risk of stroke in middle-aged British men.

    abstract:BACKGROUND AND PURPOSE:The relationship between the pattern of alcohol intake and the risk of stroke is unclear, in particular the increased risk observed in abstainers and the possible protective effect of light to moderate drinking. For that reason, we examined in a large prospective study the role of alcohol consump...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.6.1033

    authors: Wannamethee SG,Shaper AG

    更新日期:1996-06-01 00:00:00

  • Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity.

    abstract:BACKGROUND AND PURPOSE:We sought to measure the overall rate of usage of tissue-type plasminogen activator (tPA) for ischemic stroke at academic medical centers, and to determine whether ethnicity was associated with usage. METHODS:Between June and December 1999, 42 academic medical centers in the United States each i...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.str.32.5.1061

    authors: Johnston SC,Fung LH,Gillum LA,Smith WS,Brass LM,Lichtman JH,Brown AN

    更新日期:2001-05-01 00:00:00

  • Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Microvascular basal lamina damage occurs after cerebral ischemia and is important for the development of hemorrhage. The aim of this study was to determine whether hypothermia could maintain microvascular integrity in ischemic stroke. METHODS:Using the suture model, we subjected 12 rats to 3 hou...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000116866.60794.21

    authors: Hamann GF,Burggraf D,Martens HK,Liebetrau M,Jäger G,Wunderlich N,DeGeorgia M,Krieger DW

    更新日期:2004-03-01 00:00:00

  • Translesional Pressure Gradient Alters Relationship Between Blood Pressure and Recurrent Stroke in Intracranial Stenosis.

    abstract::Background and Purpose- There is debate over an optimal systolic blood pressure (SBP) in secondary stroke prevention of patients with symptomatic intracranial atherosclerotic stenosis (sICAS). We investigated whether translesional pressure gradient across sICAS would alter the relationship between SBP and risk of recu...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.119.028616

    authors: Feng X,Chan KL,Lan L,Abrigo J,Ip VHL,Soo YOY,Leung TW,Leng X

    更新日期:2020-06-01 00:00:00

  • Barthel index for stroke trials: development, properties, and application.

    abstract:BACKGROUND AND PURPOSE:Robust measures of functional outcome are required to determine treatment effects in stroke trials. Of the various measures available, the Barthel index (BI) is one of the more prevalent. We aimed to describe validity, reliability, and responsiveness (clinimetric properties) of the BI in stroke t...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.110.598540

    authors: Quinn TJ,Langhorne P,Stott DJ

    更新日期:2011-04-01 00:00:00

  • Coffee and tea consumption and risk of stroke subtypes in male smokers.

    abstract:BACKGROUND AND PURPOSE:Coffee and tea consumption could potentially reduce the risk of stroke because these beverages have antioxidant properties, and coffee may improve insulin sensitivity. We examined the associations of coffee and tea consumption with risk of stroke subtypes. METHODS:We used prospective data from t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.504183

    authors: Larsson SC,Männistö S,Virtanen MJ,Kontto J,Albanes D,Virtamo J

    更新日期:2008-06-01 00:00:00

  • Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

    abstract:BACKGROUND AND PURPOSE:Apolipoprotein E polymorphism may influence the early development of coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. METHODS:The apolipoprotein E phenotypes of 69 patients (mean +/- SD age, 72 +/- 11 years) who had suffered comple...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.5.661

    authors: Couderc R,Mahieux F,Bailleul S,Fenelon G,Mary R,Fermanian J

    更新日期:1993-05-01 00:00:00

  • Is the acetazolamide test valid for quantitative assessment of maximal cerebral autoregulatory vasodilation? An experimental study.

    abstract:BACKGROUND AND PURPOSE:The cerebral vasodilating effect of acetazolamide (ACZ) injection has been used as an index of the autoregulatory vasodilation (or cerebral perfusion reserve). The question of whether the ACZ test assesses the maximal autoregulatory vasodilating capacity is not definitely resolved. The effects of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.2.508

    authors: Démolis P,Florence G,Thomas L,Tran Dinh YR,Giudicelli JF,Seylaz J,Alkayed NJ

    更新日期:2000-02-01 00:00:00

  • Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction.

    abstract:BACKGROUND AND PURPOSE:Inflammation is thought to be a major contributor to carotid artery disease. Lipopolysaccharide (LPS) activates inflammatory mechanisms thought to contribute to endothelial dysfunction by mechanisms that are not well defined. The goal of this study was to determine whether overexpression of CuZn-...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000132764.06878.c5

    authors: Didion SP,Kinzenbaw DA,Fegan PE,Didion LA,Faraci FM

    更新日期:2004-08-01 00:00:00

  • Time course and predictors of neurological deterioration after intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Neurological deterioration (ND) is a devastating complication after intracerebral hemorrhage but little is known about time course and predictors. METHODS:We performed a retrospective cohort study of placebo patients in intracerebral hemorrhage trials. We performed computed tomographic scans wit...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.007704

    authors: Lord AS,Gilmore E,Choi HA,Mayer SA,VISTA-ICH Collaboration.

    更新日期:2015-03-01 00:00:00

  • Vegetable and fruit intake and stroke mortality in the Hiroshima/Nagasaki Life Span Study.

    abstract:BACKGROUND AND PURPOSE:Fruits and vegetables are known for their beneficial effects on chronic diseases. The purpose of the present study was to investigate the protective effect of a diet rich in fruits and vegetables on total stroke mortality and its 2 main subtypes in men and women separately. METHODS:A prospective...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000089293.29739.97

    authors: Sauvaget C,Nagano J,Allen N,Kodama K

    更新日期:2003-10-01 00:00:00

  • Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum versus brain stem.

    abstract:BACKGROUND AND PURPOSE:Potassium channels are important regulators of resting tone in large cerebral arteries, but their activity and distribution may vary according to vessel location and species studied. In the cerebral microcirculation in vivo, however, these channels appear to be silent at rest. Our goal was to det...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.1.218

    authors: Horiuchi T,Dietrich HH,Tsugane S,Dacey RG Jr

    更新日期:2001-01-01 00:00:00

  • Mobile aortic plaques are a cause of multiple brain infarcts seen on diffusion-weighted imaging.

    abstract:BACKGROUND AND PURPOSE:Multiple brain infarcts are often seen on diffusion-weighted images in cardioembolic stroke patients. Recently, mobile aortic plaques (MAPs) have been proposed as embolic sources. However, the clinical characteristics of patients with MAPs are unclear. METHODS:We prospectively studied patients w...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.482497

    authors: Ueno Y,Kimura K,Iguchi Y,Shibazaki K,Inoue T,Hattori N,Urabe T

    更新日期:2007-09-01 00:00:00

  • Perfusion CT in patients with spontaneous lobar intracerebral hemorrhage: effect of surgery on perihemorrhagic perfusion.

    abstract:BACKGROUND AND PURPOSE:The aim of the present study was to investigate cerebral hemodynamics in patients requiring surgical treatment for lobar intracerebral hemorrhage. METHODS:Twenty patients who underwent surgery to remove a lobar spontaneous intracerebral hemorrhage were scanned before and after surgery using perf...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.616730

    authors: Etminan N,Beseoglu K,Turowski B,Steiger HJ,Hänggi D

    更新日期:2012-03-01 00:00:00

  • Age-matched normal values and topographic maps for regional cerebral blood flow measurements by Xe-133 inhalation.

    abstract::The relationship between normal aging and regional cerebral blood flow (rCBF) computed as initial slope index (ISI) by Fourier method was investigated in 105 right-handed healthy volunteers (132 measurements) by Xe-133 inhalation method, and age-matched normal values were calculated. Mean brain ISI values showed signi...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.2.336

    authors: Matsuda H,Maeda T,Yamada M,Gui LX,Tonami N,Hisada K

    更新日期:1984-03-01 00:00:00

  • Prospective quality initiative to maximize dysphagia screening reduces hospital-acquired pneumonia prevalence in patients with stroke.

    abstract:BACKGROUND AND PURPOSE:Dysphagia can lead to pneumonia and subsequent death after acute stroke. However, no prospective study has demonstrated reduced pneumonia prevalence after implementation of a dysphagia screen. METHODS:We performed a single-center prospective interrupted time series trial of a quality initiative ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.111.000204

    authors: Titsworth WL,Abram J,Fullerton A,Hester J,Guin P,Waters MF,Mocco J

    更新日期:2013-11-01 00:00:00

  • Sympathetic control of the cerebral vasculature in humans.

    abstract:BACKGROUND AND PURPOSE:The role of the sympathetic nervous system in cerebral autoregulation remains poorly characterized. We examined cerebral blood flow responses to augmented arterial pressure oscillations with and without sympathetic blockade and compared them with responses in the forearm circulation. METHODS:An ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.557132

    authors: Hamner JW,Tan CO,Lee K,Cohen MA,Taylor JA

    更新日期:2010-01-01 00:00:00