Abstract:
BACKGROUND AND PURPOSE:Parental stroke has been related to an increased risk of stroke in the offspring. This study examines whether parental stroke is also associated with increased vascular brain injury and poorer cognitive performance among offspring free of clinical stroke. METHODS:Multivariable regression analyses were used to relate parental stroke to cross-sectional and change in brain magnetic resonance imaging measures and cognitive function among the offspring, with and without adjustment for vascular risk factors. RESULTS:Stroke- and dementia-free Framingham Offspring (n=1297, age, 61±9 years, 54% women) were studied. Parental stroke by age 65 years was associated with a higher baseline white matter hyperintensity volume (β=0.17±0.08; P=0.027) and with lower visual memory performance (β= -0.80±0.34; P=0.017). During a 6-year follow-up, parental stroke was also associated with increase in white matter hyperintensity volume (odds ratio [OR], 1.87; 95% confidence interval [CI], 1.03-3.38) and decline in executive function (Trails B-A; OR, 1.81; 95% CI, 1.06-3.09). The associations with white matter hyperintensity volume and visual memory attenuated after additional adjustment for concomitant vascular risk factors. CONCLUSIONS:Parental stroke by age 65 years is associated with increased vascular brain injury and lower memory in offspring equivalent to 3 and 7 years of brain aging, respectively. This may be partly attributed to inheritance of vascular risk factors.
journal_name
Strokejournal_title
Strokeauthors
Weinstein G,Beiser AS,Au R,Decarli C,Wolf PA,Seshadri Sdoi
10.1161/STROKEAHA.112.680520subject
Has Abstractpub_date
2013-03-01 00:00:00pages
812-5issue
3eissn
0039-2499issn
1524-4628pii
STROKEAHA.112.680520journal_volume
44pub_type
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