Abstract:
BACKGROUND AND PURPOSE:Acute ischemic stroke in humans is associated with profound alterations in the immune system. Hallmarks of this stroke-induced immunodepression syndrome are: lymphocytopenia, impairment of T helper cell and monocyte function. We studied which stroke-specific factors predict these immunologic alterations and subsequent infections. METHODS:Leukocyte/lymphocyte subsets were assessed serially by white blood cell count and fluorescence-activated cell sorter analysis in ischemic stroke patients (n=50) at baseline, day 1, and day 4 after stroke onset and compared to an age-matched control group (n=40). Concomitantly, monocytic human leukocyte antigen-DR expression and the in vitro function of blood monocytes measured by the production of tumor necrosis factor-alpha upon stimulation with lipopolysaccharide were assessed. Associations of these immunologic parameters with stroke specific factors (National Institutes of Health Stroke Scale, infarct size) were explored. Multivariable logistic regression analysis was applied to identify early predictors for poststroke respiratory and urinary tract infections. RESULTS:Infarct volume was the main factor associated with lymphocytopenia on day 1 and day 4 poststroke. Particularly, blood natural killer cell counts were reduced after stroke. Monocyte counts increased after ischemia paralleled by a profound deactivation predominantly after extensive infarcts. Reduced T helper cell counts, monocytic human leukocyte antigen-DR expression, and monocytic in vitro production of tumor necrosis factor-alpha were associated with infections in univariate analyses. However, only stroke volume prevailed as independent early predictor for respiratory infections (OR 1.03; CI 1.01 to 1.04). CONCLUSIONS:Infarct volume determines the extent of lymphocytopenia, monocyte dysfunction, and is a main predictor for subsequent infections.
journal_name
Strokejournal_title
Strokeauthors
Hug A,Dalpke A,Wieczorek N,Giese T,Lorenz A,Auffarth G,Liesz A,Veltkamp Rdoi
10.1161/STROKEAHA.109.557967subject
Has Abstractpub_date
2009-10-01 00:00:00pages
3226-32issue
10eissn
0039-2499issn
1524-4628pii
STROKEAHA.109.557967journal_volume
40pub_type
杂志文章相关文献
STROKE文献大全abstract::An overview of the possible factors that might contribute to the development of cerebral vasospasm is presented, with particular emphasis on the possibility that spasm arises from a malfunction of the regulatory or contractile processes in smooth muscle cells. This possibility is emphasized because the evidence for ce...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.16.4.573
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It has been proposed that spin trap agents such as N:-t-butyl-phenylnitrone (PBN) may be useful as neuroprotective agents in the treatment of ischemia and stroke. However, to date, there is little information concerning the effectiveness of spin trap agents when administered in combination with t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.1.147
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Policy makers require evidence on the costs and outcomes of different ways of organizing stroke care. This study compared the costs and survival of different ways of providing stroke care. METHODS:Hospitalized stroke patients from 13 European centers were included, with demographic, case-mix, an...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.32.7.1684
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recovery from hemiparesis due to corticospinal tract infarction is well documented, but the mechanism of recovery is unknown. Functional MRI (fMRI) provides a means of identifying focal brain activity related to movement of a paretic hand. Although prior studies have suggested that supplementary ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.3.656
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. METHODS:The ongoing Nort...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000185926.05011.72
更新日期:2005-11-01 00:00:00
abstract::A patient with diffuse and focal cerebral dysfunction was found to have absent peripheral pulses. Cerbral angiography revealed evidence of an arteritis with bilateral high grade carotid stenosis. When there was no laboratory confirmation of the arteritis, an iatrogenic etiology (ergotism) was suspected. This was later...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.1.88
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1829
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm grow...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.008198
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebrovascular disease can complicate head and neck radiotherapy and result in transient ischemic attack and ischemic stroke. Although the incidence of radiation vasculopathy is predicted to rise with improvements in median cancer survival, the pathogenesis, natural history, and management of th...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.111.615203
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The clinical syndrome of transient ischemic attacks is accompanied in a significant percentage of patients by brain lesions or neuroimaging abnormalities whose structural counterparts have not been defined. The objective of this study was to analyze, in an experimental model of short-term (< 25 m...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.11.2303
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.112.667535
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is controversy about the optimal patient position for the detection of right-to-left shunt (RLS). The study was performed to investigate which patient position best detects RLS during contrast-enhanced transcranial Doppler. METHODS:We prospectively evaluated consecutive patients with ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609875
更新日期:2011-08-01 00:00:00
abstract::The media cross-sectional area, the media thickness, the internal radius and the ratio between media thickness and internal radius were determined in consecutive sections of extraparenchymal cerebral arteries of 7- and 12-month-old normotensive and spontaneously hypertensive rats. The study included intracranial pial ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.2.313
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent evidence suggests a possible role for leukocytes in ischemic brain injury. This study examined the effect of activation of endogenous circulating leukocytes on cerebral blood flow in normal and neutrophil-depleted rats. METHODS:Leukocytes were activated by rapid injection of either 50 mic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.1977
更新日期:1993-12-01 00:00:00
abstract::We produced unilateral photochemical infarcts in the hindlimb sensorimotor neocortex of 186 rats by intravenous injection of the fluorescein derivative rose bengal and focal illumination of the intact skull surface. Infarcted rats showed specific, long-lasting deficits in tactile and proprioceptive placing reactions o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.10.1383
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The integrin-linked kinase (ILK) signaling pathway contributes to regulation of cellular adhesion, migration, and differentiation, and to apoptotic cell death after a variety of cell death stimuli. We have reported that overexpression of copper/zinc superoxide dismutase (SOD1) reduces apoptotic c...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000144653.32853.ed
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pathophysiology of borderzone infarcts is not well understood. We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts. METHODS:Seventeen patients with borderzone i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.5.1090
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arteriopathy is common in childhood arterial ischemic stroke (AIS) and predicts stroke recurrence. Currently available vascular imaging techniques mainly image the arterial lumen rather than the vessel wall and have a limited ability to differentiate among common arteriopathies. We aimed to inves...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019827
更新日期:2018-04-01 00:00:00
abstract::Functional assessment of animals following experimental cerebral ischemia is often difficult due to the passive nature of many neurologic exams. We attempted to increase the objectivity of motor function evaluation by adapting quantifiable behavioral tests and actively testing rats' motor capability following a cerebr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.503
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.658427
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Cincinnati Prehospital Stroke Scale (CPSS) is recommended for emergency medical services use in identifying patients with stroke. Data evaluating its performance in the field are limited. We assessed the impact of training and use of the CPSS on the accuracy of paramedics' stroke patient iden...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.531285
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The natural product baicalein is a specific inhibitor of 12/15-lipoxygenase, but it also has antioxidant properties. The current study was designed to test if the neuroprotective properties of baicalein are related to its lipoxygenase inhibition. METHODS:The presence of 12/15-lipoxygenase in the...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000249004.25444.a5
更新日期:2006-12-01 00:00:00
abstract::We report the case of a young man with recurrent posterior circulation strokes over the course of 6 years. Standard stroke evaluation was unremarkable until careful review of catheter angiogram and CT angiogram images revealed a bony protuberance from the occiput impinging on the left vertebral artery. Local vessel in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.612176
更新日期:2011-05-01 00:00:00
abstract::Leukoaraiosis quantified by computerized densitometric measurements of reduced Hounsfield numbers was correlated with local cerebral blood flow on the same computed tomographic images of 35 patients with multi-infarct dementia and 16 age-matched elderly normal volunteers. The ratio for area of frontal leukoaraiosis to...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.5.609
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Determinants of long-term outcome are not well defined in minor stroke patients. This study aims to evaluate which factors are independent long-term predictors of death and major stroke recurrence in a cohort of minor ischemic strokes. METHODS:A cohort of 322 patients with first-ever minor ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.1.126
更新日期:1998-01-01 00:00:00
abstract::We examined cerebral lipid peroxidation, estimated by a thiobarbituric acid test, in rat brain regions after 30 minutes of severe forebrain ischemia and at recirculation periods of up to 72 hours. The lipid peroxide levels remained unaltered in all brain regions during ischemia and during the first hour of recirculati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.7.918
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several hundred studies have been published over the last few years on imaging and measurement of carotid stenosis. Despite all this research, there is still no consensus about how best to image and measure stenosis. One possible explanation for this is that many of the studies have not been larg...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.31.6.1444
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is not known what fraction of patients with symptomatic cerebral aneurysms are misdiagnosed at initial medical presentation. It is also not clear whether misdiagnosed patients more frequently deteriorate before definitive aneurysm diagnosis and therapy or achieve a poorer outcome than correctl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.9.1558
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocytes contribute to cerebral ischemia-reperfusion injury. However, few experimental models examine both in vivo behavior of leukocytes and microvascular rheology after stroke. The purpose of the present study was to characterize patterns of leukocyte accumulation in the cerebral microcircula...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.5.1153
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study was performed to determine the relation between distribution of atherosclerosis and risk factors in Japanese patients with atherothrombotic occlusion. METHODS:We studied 154 patients with atherothrombotic occlusion of the extracranial internal carotid artery (n = 75, ICA group)...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.2.206
更新日期:1993-02-01 00:00:00