Leukoaraiosis correlates with cerebral hypoperfusion in vascular dementia.

Abstract:

:Leukoaraiosis quantified by computerized densitometric measurements of reduced Hounsfield numbers was correlated with local cerebral blood flow on the same computed tomographic images of 35 patients with multi-infarct dementia and 16 age-matched elderly normal volunteers. The ratio for area of frontal leukoaraiosis to total area of parenchyma among the patients was significantly greater than that among the normal volunteers (5.8 +/- 2.3% compared with 3.1 +/- 1.3%, p less than 0.001). Severity of leukoaraiosis around the frontal horns of the lateral ventricles correlated significantly with severity of leukoaraiosis of the centrum semiovale adjacent to the bodies of the lateral ventricles. Cerebral blood flow values for all representative cerebral regions except the parietal white matter were reduced among the patients compared with the normal volunteers. Multivariate regression analysis revealed that reduced cerebral perfusion in the putamen and thalamus correlated significantly with the severity of leukoaraiosis. Cerebral hypoperfusion in territories supplied by deep penetrating arteries may contribute to the pathogenesis of leukoaraiosis.

journal_name

Stroke

journal_title

Stroke

authors

Kawamura J,Meyer JS,Terayama Y,Weathers S

doi

10.1161/01.str.22.5.609

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

609-14

issue

5

eissn

0039-2499

issn

1524-4628

journal_volume

22

pub_type

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