Abstract:
BACKGROUND AND PURPOSE:Enhanced thromboxane (TX) biosynthesis has previously been reported in the acute phase after ischemic stroke. We investigated whether enhanced urinary excretion of 11-dehydro-TXB2, a noninvasive index of platelet activation, was present in the chronic phase after a transient ischemic attack (TIA) or stroke, including intracerebral hemorrhage. METHODS:We obtained a single urinary sample from 92 patients between 3 and 9 months after onset of stroke or TIA. The urinary excretion of the major enzymatic metabolite of TXA2, 11-dehydro-TXB2, was measured by a previously validated radioimmunoassay. The excretion rates were compared with those of 20 control patients with nonvascular neurological diseases. RESULTS:Urinary 11-dehydro-TXB2 averaged 294+/-139, 413+/-419, and 557+/-432 pmol/mmol creatinine for patients with TIA, ischemic stroke, and intracerebral hemorrhage, respectively; the values were higher in all subgroups (P<0.01) than that in control patients (119+/-66 pmol/mmol). Increased 11-dehydro-TXB2 excretion was present in 59% of all patients, in 60% (P<0.001) of patients with TIA, in 56% (P<0.001) of patients with ischemic stroke, and in 73% (P<0.001) of patients with intracerebral hemorrhage. Atrial fibrillation, no aspirin use, and severity of symptoms at follow-up contributed independently to the level of 11-dehydro-TXB2 excretion in a multiple linear regression analysis. CONCLUSIONS:Platelet activation is often present in patients in the chronic phase after stroke, including those with intracerebral hemorrhage. Persistent platelet activation, which is associated with atrial fibrillation and poor stroke outcome, can be substantially suppressed by aspirin treatment.
journal_name
Strokejournal_title
Strokeauthors
van Kooten F,Ciabattoni G,Koudstaal PJ,Dippel DW,Patrono Cdoi
10.1161/01.str.30.3.546subject
Has Abstractpub_date
1999-03-01 00:00:00pages
546-9issue
3eissn
0039-2499issn
1524-4628journal_volume
30pub_type
杂志文章相关文献
STROKE文献大全abstract::The relationship between central conduction time (CCT) and levels of regional blood flow were studied in 9 primates. Flows were recorded in both hemispheres using the method of hydrogen (2 min) clearance. The somatosensory evoked potentials were recorded over the contralateral cortex and the dorsal columns, following ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.6.637
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analy...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.115.011328
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of the cerebral microcirculation in delayed ischemia after subarachnoid hemorrhage remains obscure. To test the hypothesis that cerebral arterioles have a reduced capacity to dilate after subarachnoid hemorrhage, we studied the microvascular responses to papaverine (PPV) in patients unde...
journal_title:Stroke
pub_type: 信件
doi:10.1161/STROKEAHA.108.522375
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.618496
更新日期:2012-02-01 00:00:00
abstract::Visually apparent EEG changes associated with clamping the internal carotid artery appeared in 55 of 176 consecutive patients (31%) undergoing carotid endarterectomy without shunt. Attenuation of higher frequency activity was the most common change. Changes were moderate in 33 patients (19%) and major in 22 (12.5%). M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.5.891
更新日期:1986-09-01 00:00:00
abstract::Functional assessment of animals following experimental cerebral ischemia is often difficult due to the passive nature of many neurologic exams. We attempted to increase the objectivity of motor function evaluation by adapting quantifiable behavioral tests and actively testing rats' motor capability following a cerebr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.503
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Global cerebral blood flow (CBF) is an important yet largely unknown quantity in the treatment of neurological intensive care patients. Color duplex sonography of the extracranial cerebral arteries can be used to measure global CBF volume directly at the bedside. To establish reference data on gl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.1.147
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series. METHODS:By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy und...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.12.2448
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that intravenous administration of basic fibroblast growth factor (bFGF) during 4 hours of permanent focal ischemia would affect acute brain injury. METHODS:Halothane-anesthetized cats underwent left middle cerebral artery (MCA) occlusion for 4 hours. Control cats receiv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.3.609
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ventricular assist devices (VADs) have advanced the management of end-stage heart failure. However, these devices are associated with hemorrhagic and thrombotic complications, including stroke. We assessed the incidence, risk factors, and outcomes of ischemic and hemorrhagic stroke after VAD plac...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014049
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke Health and Risk Education Project was a cluster-randomized, faith-based, culturally sensitive, theory-based multicomponent behavioral intervention trial to reduce key stroke risk factor behaviors in Hispanics/Latinos and European Americans. METHODS:Ten Catholic churches were randomize...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.115.010678
更新日期:2015-10-01 00:00:00
abstract::In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.1.86
更新日期:1986-01-01 00:00:00
abstract::We produced cerebral vasospasm in 29 dogs by the "two-hemorrhage" method of intracisternal injections, 2 days apart, of autogenous arterial blood. Leukotriene (LT) C4, LTD4, and LTE4 were purified from incubated basilar artery, medulla oblongata, hypothalamus, median eminence, and blood clot from around the basilar ar...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.4.527
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke MRI protocols provide useful information about underlying vessel pathologies in the anterior circulation by means of intracranial time-of-flight angiography. However, these protocols mostly fail in the posterior circulation to differentiate between congenital variants and secondary thrombo...
journal_title:Stroke
pub_type: 信件
doi:10.1161/STROKEAHA.107.512772
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid artery intima-media thickness (IMT) is a marker of cardiovascular disease associated with incident stroke. We studied whether IMT rate of change is associated with stroke. METHODS:We studied 5028 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) comprising white, Chinese, ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.625186
更新日期:2011-11-01 00:00:00
abstract::We looked at FiO2, choice of anesthetic, nutritional status, and body temperature in a gerbil model of forebrain ischemia to determine their effect on data interpretation, ischemic outcome, and extent of pharmacologic protection. We subjected 484 gerbils to 5 minutes of forebrain ischemia under different experimental ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.11.1545
更新日期:1989-11-01 00:00:00
abstract::Background and Purpose- Carotid web (CW) is a rare form of focal fibromuscular dysplasia defined as an abnormal shelf-like projection of intimal fibrous tissue into the carotid bulb. It is theorized that CW leads to ischemic stroke secondary to blood flow stasis and subsequent embolization. The natural history and opt...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021907
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.107.493601
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Abnormalities of dermal connective tissue have been detected in patients with spontaneous cervical artery dissections (sCAD), suggesting an underlying structural defect of the arterial wall. Alpha1-antitrypsin (A1-AT) is a circulating serine proteinase inhibitor of proteolytic enzymes that helps ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000085085.20390.A3
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke produces diaschisis in adjacent and connected regions. The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined. METHODS:Small cortical strokes were produced...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000117235.11156.55
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors at different ages in a sample of the general population. METHODS:B-mode ultrasonography was used to investigate the carotid district in 457 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.6.1133
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neurological deterioration (ND) is a devastating complication after intracerebral hemorrhage but little is known about time course and predictors. METHODS:We performed a retrospective cohort study of placebo patients in intracerebral hemorrhage trials. We performed computed tomographic scans wit...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007704
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although insulin resistance and hyperinsulinemia play a crucial role in the pathogenesis of atherosclerosis, little is known about their roles in ischemic stroke. The purpose of this study was to clarify whether insulin resistance and hyperinsulinemia are causative factors in the pathogenesis of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.1.37
更新日期:1996-01-01 00:00:00
abstract::Spontaneously hypertensive rats (SHR) have been shown to have an increased capacity for superior cervical sympathetic nerve activity which may protect against stroke (Mueller et al: Stroke 13: 115, 1982). Sympathetic nerve activity has never been examined in the stroke-prone substrain of SHR (SP). In this study we mea...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.1.73
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebrovascular reserve (CVR) by both transcranial Doppler ultrasonography (TCD) and quantitative cerebral blood flow (CBF) can identify subgroups of patients at increased risk for stroke. A direct comparison of CVR measurements obtained with both technologies in patients with cerebrovascular occ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.8.1811
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:A number of clinical syndromes describing the presentation of deep brain infarcts are called lacunar syndromes resulting from small vessel occlusion (SVO). To verify the reliability of the clinical diagnosis "lacunar syndrome," the value was investigated with diffusion-weighted MRI (DWI). METHODS AND RESULT...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000158908.48022.d7
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Symptomatic intracranial hemorrhage (SICH) is the most feared complication after tissue plasminogen activator (tPA) stroke treatment. Endogenous fibrinolysis inhibitors play an essential role in the coagulation/fibrinolysis balance and may be involved in the bleeding process. We aim to determine ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000137608.73660.4c
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reliable data on the risk of carotid endarterectomy (CEA) in relation to clinical indication and timing of surgery are necessary to target CEA more effectively, to inform patients, to adjust risks for case mix, and to understand the mechanisms of operative stroke. METHODS:We performed a systemat...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/01.STR.0000087785.01407.CC
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The effect of smoking reduction on cardiovascular disease outcomes has not been studied in Asian populations. METHODS:A total of 475 734 Korean men aged 30 to 58 years, stratified into 9 groups based on smoking status at 2 different time points (1990 and 1992), were followed from 1992 to 2001 fo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.512632
更新日期:2008-09-01 00:00:00
abstract::A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described. Complete resolution of symptoms and return of upper limb and carotid artery pulses to normal occurred within four days of cessation of the ergot...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.5.811
更新日期:1983-09-01 00:00:00