Abstract:
:An overview of the possible factors that might contribute to the development of cerebral vasospasm is presented, with particular emphasis on the possibility that spasm arises from a malfunction of the regulatory or contractile processes in smooth muscle cells. This possibility is emphasized because the evidence for cellular damage and the delayed occurrence of vasospasm are suggestive of pathological alteration. Data regarding the development of spasm in vivo has been reviewed and, to the extent possible, correlated with in vitro studies of cerebrovascular smooth muscle contractility. Short-term in vitro studies of normal cerebral arteries may be of little relevance to the prolonged and severe cerebral vasoconstriction that occurs only after a delay of several days from the initial insult.
journal_name
Strokejournal_title
Strokeauthors
Wellum GR,Peterson JW,Zervas NTdoi
10.1161/01.str.16.4.573subject
Has Abstractpub_date
1985-07-01 00:00:00pages
573-81issue
4eissn
0039-2499issn
1524-4628journal_volume
16pub_type
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