Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage.

abstract：BACKGROUND AND PURPOSE:A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. METHODS:A total of 1198 patients with major ischemic stroke a...

journal_title：Stroke

authors： Lyden P,Shuaib A,Ng K,Levin K,Atkinson RP,Rajput A,Wechsler L,Ashwood T,Claesson L,Odergren T,Salazar-Grueso E,CLASS-I\/H\/T Investigators.

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke. METHODS:The relations between blood calcium level obtained early (<4.5 hours), and del...

journal_title：Stroke

authors： Ovbiagele B,Starkman S,Teal P,Lyden P,Kaste M,Davis SM,Hacke W,Fierus M,Saver JL,VISTA Investigators.

更新日期：2008-08-01 00:00:00

abstract：UNLABELLED:The pathophysiology of postischemic encephalopathy is complex, and includes tissue acidosis, edema, hypoperfusion, membrane dysfunction, impaired energy production, and possibly hypermetabolism. We tested the hypothesis that this multifactorial clinical problem must be approached with multifaceted therapy, w...

journal_title：Stroke

authors： Gisvold SE,Safar P,Rao G,Moossy J,Kelsey S,Alexander H

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lacunes are thought to occur in patients with hypertension or diabetes mellitus as a result of small-vessel disease. This study evaluated the importance of other stroke mechanisms in a population of patients with lacunar infarction. METHODS:We evaluated 108 consecutive patients with a lacune in ...

journal_title：Stroke

authors： Horowitz DR,Tuhrim S,Weinberger JM,Rudolph SH

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...

journal_title：Stroke

authors： Söderholm M,Zia E,Hedblad B,Engström G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...

journal_title：Stroke

authors： Klijn CJ,Kappelle LJ,van Schooneveld MJ,Hoppenreijs VP,Algra A,Tulleken CA,van Gijn J

更新日期：2002-03-01 00:00:00

abstract：:Brain injury, including ischemia, changes normal astrocytes into reactive species that hypertrophy and begin to proliferate. Understanding the mechanisms that underlie these changes could lead to new abilities to promote regeneration and retard neural degeneration after ischemia. Because ionic changes occur after nonn...

journal_title：Stroke

authors： Kraig RP,Jaeger CB

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Admission infarct core lesion size is an important determinant of management and outcome in acute (<9 hours) stroke. Our purposes were to: (1) determine the optimal CT perfusion parameter to define infarct core using various postprocessing platforms; and (2) establish the degree of variability in...

journal_title：Stroke

authors： Kamalian S,Kamalian S,Maas MB,Goldmacher GV,Payabvash S,Akbar A,Schaefer PW,Furie KL,Gonzalez RG,Lev MH

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke. METHODS:A total of 317 consecutive patients treated with thrombolys...

journal_title：Stroke

authors： Amaro S,Urra X,Gómez-Choco M,Obach V,Cervera A,Vargas M,Torres F,Rios J,Planas AM,Chamorro A

更新日期：2011-01-01 00:00:00

abstract：:Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...

journal_title：Stroke

authors： Culebras A,Otero C,Toledo JR,Rubin BS

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...

journal_title：Stroke

authors： Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although family studies have suggested a genetic influence on hemorrhagic stroke, the underlying genetic risk factors remain poorly defined. Coagulation factor XIII, which is involved in hemostasis, fibrinolysis, vascular remodeling, and tissue repair, represents a candidate gene for hemorrhagic ...

journal_title：Stroke

authors： Reiner AP,Schwartz SM,Frank MB,Longstreth WT Jr,Hindorff LA,Teramura G,Rosendaal FR,Gaur LK,Psaty BM,Siscovick DS

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The greater mortality and residual physical impairments among black stroke patients may be attributable to differential utilization of rehabilitation services. This report examines, within an equal-access healthcare system, racial differences in time to initiation of stroke rehabilitation service...

journal_title：Stroke

authors： Horner RD,Swanson JW,Bosworth HB,Matchar DB,VA Acute Stroke (VAST) Study Team.

更新日期：2003-04-01 00:00:00

abstract：:Many patients suffer a stroke early after a transient ischemic attack, but the reason why is often unclear. We studied 12 patients with less than 75% stenosis of the internal carotid artery and a single hemispheric transient ischemic attack lasting less than 1 hour who had a normal neurologic examination 3-13 hours la...

journal_title：Stroke

authors： Bogousslavsky J,Delaloye-Bischof A,Regli F,Delaloye B

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stent placement has been applied in small case series as a rescue therapy in combination with different thrombolytic agents, percutaneous balloon angioplasty (PTA), and mechanical thromboembolectomy (MT) in acute stroke treatment. These studies report a considerable mortality and a high rate of i...

journal_title：Stroke

authors： Brekenfeld C,Schroth G,Mattle HP,Do DD,Remonda L,Mordasini P,Arnold M,Nedeltchev K,Meier N,Gralla J

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke symptoms can be very stressful for family caregivers, but most knowledge about the prevalence and stressfulness of stroke-related patient problems is derived from convenience samples. In addition, little is known about perceived benefits of the stroke caregiving experience. The purpose of ...

journal_title：Stroke

authors： Haley WE,Allen JY,Grant JS,Clay OJ,Perkins M,Roth DL

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program systematically implements, at the time of acute transient ischemic attack (TIA) or ischemic stroke admission, 8 medication/behavioral secondary prevention measures known to improve outcome in...

journal_title：Stroke

authors： Ovbiagele B,Saver JL,Fredieu A,Suzuki S,Selco S,Rajajee V,McNair N,Razinia T,Kidwell CS

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We tested the hypothesis that circulating microRNAs (miRNAs) present in plasma might display a specific signature in patients with intracerebral hemorrhage. METHODS:Global miRNA profiles were determined with the Agilent Human miRNA Microarray platform, and validated by quantitative polymerase ch...

journal_title：Stroke

authors： Guo D,Liu J,Wang W,Hao F,Sun X,Wu X,Bu P,Zhang Y,Liu Y,Liu F,Zhang Q,Jiang F

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To investigate the incidence of retrograde flow from complex plaques (> or =4-mm-thick, ulcerated, or superimposed thrombi) of the descending aorta (DAo) and its potential role in embolic stroke. METHODS:Ninety-four consecutive acute stroke patients with aortic plaques > or =3-mm-thick in transe...

journal_title：Stroke

authors： Harloff A,Simon J,Brendecke S,Assefa D,Helbing T,Frydrychowicz A,Weber J,Olschewski M,Strecker C,Hennig J,Weiller C,Markl M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Apolipoprotein E (ApoE) genotypes have been associated with lobar intracerebral hemorrhage (ICH). Although statins have been associated with an increased risk of ICH, meta-analyses have not consistently shown a statin-induced risk of ICH. Here, we test whether hypercholesterolemia (HC) and ApoE p...

journal_title：Stroke

authors： Woo D,Deka R,Falcone GJ,Flaherty ML,Haverbusch M,Martini SR,Greenberg SM,Ayres AM,Sauerbeck L,Kissela BM,Kleindorfer DO,Moomaw CJ,Anderson CD,Broderick JP,Rosand J,Langefeld CD,Woo JG

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present investigation aimed to quantify functional activity in rat brains after long-term recovery from transient forebrain ischemia. METHODS:With the use of the [14C]2-deoxyglucose method, local cerebral glucose utilization was measured in 62 cortical and subcortical brain regions in postis...

journal_title：Stroke

authors： Beck T,Goller HJ,Wree A

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:High-dose human albumin (ALB) is robustly neuroprotective in rodent stroke models. A phase I dose-escalation study was conducted to assess the safety of ALB therapy in ischemic stroke. We analyzed the data for preliminary evidence of treatment efficacy. METHODS:Eighty-two subjects with acute isc...

journal_title：Stroke

authors： Palesch YY,Hill MD,Ryckborst KJ,Tamariz D,Ginsberg MD

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population. METHODS:We studied 3466 Japanese individuals (35-93 years old) in the Suita Stu...

journal_title：Stroke

authors： Ohara T,Kokubo Y,Toyoda K,Watanabe M,Koga M,Nakamura S,Nagatsuka K,Minematsu K,Nakagawa M,Miyamoto Y

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Exposure to vascular risk factors has a gradual deleterious effect on brain MRI and cognitive measures. We explored whether a pattern of these measures exists that predicts stroke and Alzheimer disease (AD) risk. METHODS:A cognitive battery was administered to 1679 dementia and stroke-free Frami...

journal_title：Stroke

authors： Weinstein G,Beiser AS,Decarli C,Au R,Wolf PA,Seshadri S

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Physical and psychological characteristics in adolescence are associated with subsequent stroke risk. Our aim is to investigate their relevance to length of hospital stay and risk of second stroke. METHODS:Swedish men born between 1952 and 1956 (n=237 879) were followed from 1987 to 2010 using i...

journal_title：Stroke

authors： Bergh C,Udumyan R,Appelros P,Fall K,Montgomery S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multiple acute ischemic lesions on diffusion-weighted magnetic resonance imaging (DWI-MRI) are thought to be of embolic origin. However, in several patients with multiple ischemic lesions on DWI-MRI, no embolic source was detected, despite a thorough clinical work-up. Stroke etiology in such case...

journal_title：Stroke

authors： Jauss M,Wessels T,Trittmacher S,Allendörfer J,Kaps M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite its high prevalence in stroke survivors, there is little clinical research on bowel dysfunction in this population. This is the first randomized controlled trial to evaluate treatment of constipation and fecal incontinence in stroke survivors. METHODS:Stroke patients with constipation or...

journal_title：Stroke

authors： Harari D,Norton C,Lockwood L,Swift C

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Therapeutic temperature modulation is widely used in neurocritical care but commonly causes shivering, which can hamper the cooling process and result in increases in systemic metabolism. We sought to validate a grading scale to assist in the monitoring and control of shivering. METHODS:A simple...

journal_title：Stroke

authors： Badjatia N,Strongilis E,Gordon E,Prescutti M,Fernandez L,Fernandez A,Buitrago M,Schmidt JM,Ostapkovich ND,Mayer SA

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Motor dysfunction after unilateral deafferentation in primates can be overcome by restraining the unaffected limb. We asked whether a constraint-induced movement (CIM) program could be implemented within 2 weeks after stroke and whether CIM is more effective than traditional upper-extremity (UE) ...

journal_title：Stroke

authors： Dromerick AW,Edwards DF,Hahn M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Randomized clinical trials testing aspirin in relatively low-risk, middle-aged people have consistently shown small increases in stroke associated with aspirin use. We analyzed the relationship between the regular use of aspirin and incident ischemic and hemorrhagic stroke among people aged 65 ye...

journal_title：Stroke

authors： Kronmal RA,Hart RG,Manolio TA,Talbert RL,Beauchamp NJ,Newman A

更新日期：1998-05-01 00:00:00