Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia.

abstract：:Brief episodes of ischemia can protect against subsequent damaging ischemic events; however, the molecular mechanisms responsible for protection are poorly understood. Identifying genes involved in this process could provide insight into cell survival and treatment of stroke. We developed a murine model of ischemic pr...

journal_title：Stroke

authors： Stenzel-Poore MP,Stevens SL,Simon RP

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The introduction of cereal grain folic acid fortification in 1998 has reduced homocyst(e)ine (tHcy) concentrations in the US population. We performed a case-control study to determine the risk of stroke and transient ischemic attack (TIA) associated with tHcy and low vitamin status in a postforti...

journal_title：Stroke

authors： Kelly PJ,Shih VE,Kistler JP,Barron M,Lee H,Mandell R,Furie KL

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with stroke and patients with transient ischemic attack (TIA) are at high risk for vascular events and may not exhibit the signs and symptoms of peripheral arterial disease (PAD). We investigated if asymptomatic PAD detected by ankle brachial index <0.9 is independently associated with r...

journal_title：Stroke

authors： Sen S,Lynch DR Jr,Kaltsas E,Simmons J,Tan WA,Kim J,Beck J,Rosamond W

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Visit-to-visit and day-to-day variability in systolic blood pressure (SBP) are associated with an increased risk of stroke, more strongly than variability on 24-hour ambulatory BP monitoring, but underlying physiological mechanisms are unclear. We related potentially relevant physiological charac...

journal_title：Stroke

authors： Webb AJ,Rothwell PM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:White matter hyperintensities (WMH) are frequently seen on neuroimaging of elderly and are associated with cognitive decline and the development of dementia. Yet, the temporal dynamics of conversion of normal-appearing white matter (NAWM) into WMH remains unknown. We examined whether and when pro...

journal_title：Stroke

authors： van Leijsen EMC,Bergkamp MI,van Uden IWM,Ghafoorian M,van der Holst HM,Norris DG,Platel B,Tuladhar AM,de Leeuw FE

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Endovascular treatment of intracranial aneurysms is safe and effective but too often is followed by recurrences. Gene therapy may improve healing after embolization, and endovascular approaches may offer future in situ delivery systems designed to prevent aneurysm rupture. SUMMARY OF REVIEW:Advances in coil...

journal_title：Stroke

authors： Ribourtout E,Raymond J

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In the early stage of stroke, the occurrence of neurologic and medical complications is associated with clinical deterioration. Previous studies were focused on the first week after stroke onset. The aim of this study was to evaluate the impact of complications on clinical outcome in patients wit...

journal_title：Stroke

authors： Rocco A,Pasquini M,Cecconi E,Sirimarco G,Ricciardi MC,Vicenzini E,Altieri M,Di Piero V,Lenzi GL

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness. METHODS:Consecutive subjects participating in a prospective cohort study of aging and mild cognitive impair...

journal_title：Stroke

authors： Cardenas VA,Reed B,Chao LL,Chui H,Sanossian N,DeCarli CC,Mack W,Kramer J,Hodis HN,Yan M,Buonocore MH,Carmichael O,Jagust WJ,Weiner MW

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral blood flow is coupled to brain metabolism by means of active modulation of cerebrovascular resistance. This homeostatic vasogenic activity is reflected in slow waves of cerebral blood flow velocities (FV) which can also be detected in intracranial pressure (ICP). However, effects of incr...

journal_title：Stroke

authors： Haubrich C,Czosnyka Z,Lavinio A,Smielewski P,Diehl RR,Pickard JD,Czosnyka M

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The objective of this study was to determine the prevalence of intracranial plaques and stenoses and their causal role in patients with fatal stroke. Intracranial atherosclerosis is considered to be a rare condition with a severe prognosis. However, disease prevalence may be underestimated due to...

journal_title：Stroke

authors： Mazighi M,Labreuche J,Gongora-Rivera F,Duyckaerts C,Hauw JJ,Amarenco P

更新日期：2008-04-01 00:00:00

abstract：:We reviewed demographic data on patients having 2,256 carotid endarterectomies in eight large hospitals in North Carolina to determine the frequency of blacks among these patients. Blacks comprised only 4.6% of the patients having carotid endarterectomy even though they comprised 26% of all patients discharged and 22%...

journal_title：Stroke

authors： Maxwell JG,Rutherford EJ,Covington D,Clancy TV,Tackett AD,Robinson N,Johnson G Jr

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP me...

journal_title：Stroke

authors： Lin L,Bivard A,Levi CR,Parsons MW

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several hundred small RNAs called microRNAs (miRNAs) have been identified and characterized from various organisms, including humans. In humans, some of these miRNAs have been found to regulate (patho)physiologic conditions such as tumor progression/regression, cholesterol and glucose homeostasis...

journal_title：Stroke

authors： Jeyaseelan K,Lim KY,Armugam A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The method described provides a rational means for determining whether to institute chronic anticoagulation to prevent stroke in patients with chronic atrial fibrillation under a variety of clinical circumstances. SUMMARY OF COMMENT:The concept of expected value is used in conjunction with data from clinica...

journal_title：Stroke

authors： Nadeau SE

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To increase the reliability of 99mTc-hexamethyl propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) study in the evaluation of hemodynamic change with balloon test occlusion (BTO) of the internal carotid artery, we attempted to clarify the usefulness of additional moni...

journal_title：Stroke

authors： Kaminogo M,Ochi M,Onizuka M,Takahata H,Shibata S

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. METHODS:we genotyped single nucleotide polymorphisms (...

journal_title：Stroke

authors： Ronald J,Rajagopalan R,Cerrato F,Nord AS,Hatsukami T,Kohler T,Marcovina S,Heagerty P,Jarvik GP

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pneumonia has been estimated to occur in about one third of patients after acute stroke. Only limited data are available on stroke-associated pneumonia (SAP) in specialized neurological intensive care units (NICUs). METHODS:We enrolled 124 patients with acute stroke who were treated at our unive...

journal_title：Stroke

authors： Hilker R,Poetter C,Findeisen N,Sobesky J,Jacobs A,Neveling M,Heiss WD

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...

journal_title：Stroke

authors： Finlayson O,John V,Yeung R,Dowlatshahi D,Howard P,Zhang L,Swartz R,Aviv RI

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In prehension tasks with objects placed within arm's reach, patients with hemiparesis caused by stroke use excessive trunk movement to compensate for arm motor impairments. Compensatory trunk movements may improve motor function in the short term but may limit arm recovery in the long term. Previ...

journal_title：Stroke

authors： Michaelsen SM,Levin MF

更新日期：2004-08-01 00:00:00

abstract：:Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. ...

journal_title：Stroke

authors： Jiang Y,Liu N,Wang Q,Yu Z,Lin L,Yuan J,Guo S,Ahn BJ,Wang XJ,Li X,Lo EH,Sun X,Wang X

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is known that atherosclerosis does not involve both carotid arteries to the same extent. Pathological investigations have demonstrated that lesions develop in regions of low wall shear stress. The aims of the present study were to verify the degree of carotid atherosclerosis asymmetry in a pop...

journal_title：Stroke

authors： Gnasso A,Irace C,Carallo C,De Franceschi MS,Motti C,Mattioli PL,Pujia A

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic stroke patients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS:This was a retrospective cohort study analyzing data from a p...

journal_title：Stroke

authors： Kim BS,Chung PW,Park KY,Won HH,Bang OY,Chung CS,Lee KH,Kim GM

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mild hypothermia has been shown to ameliorate neuronal damage due to cerebral ischemia. In our study, the influence of mild-to-moderate hypothermia was examined in a rabbit model of focal cerebral ischemia. METHODS:After 4 hours of permanent ischemia induced by occlusion of the anterior and midd...

journal_title：Stroke

authors： Lo EH,Steinberg GK

更新日期：1992-06-01 00:00:00

abstract：:Correlations between changes in regional, cortical, cerebral blood flow (rCBF) and histological changes in the corresponding brain regions were examined following middle cerebral arterial occlusion in 24 cats. In all animals, the duration of arterial occlusion was 2 hours followed by 2 hours of recirculation. The anim...

journal_title：Stroke

authors： Tamura A,Asano T,Sano K

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. METHODS:The ongoing Nort...

journal_title：Stroke

authors： Juo SH,Rundek T,Lin HF,Cheng R,Lan MY,Huang JS,Boden-Albala B,Sacco RL

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The majority of patients with spontaneous cerebral artery dissection show ultrastructural alterations in dermal collagen and elastic fibers. METHODS:We studied the gene encoding tropoelastin (ELN) by reverse transcription-polymerase chain reaction and subsequent sequence analysis in 10 patients ...

journal_title：Stroke

authors： Grond-Ginsbach C,Thomas-Feles C,Werner I,Weber R,Wigger F,Hausser I,Brandt T

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:5' adenosine monophosphate-dependent protein kinase (AMPK) acts as a metabolic sensor. AMPK is elevated under ischemic conditions, but the role of AMPK in ischemic brain remains controversial. In this study, we examined the effects of AMPK inhibition using both pharmacological and genetic approac...

journal_title：Stroke

authors： Li J,Zeng Z,Viollet B,Ronnett GV,McCullough LD

更新日期：2007-11-01 00:00:00

abstract：:Background and Purpose- Multifaceted quality improvement interventions of stroke care have been shown to improve hospital personnel adherence to evidence-based performance measures and subsequent stroke outcomes. This study aimed to evaluate the cost-effectiveness of a multifaceted quality improvement intervention for...

journal_title：Stroke

authors： Pan Y,Zhang L,Li Z,Meng X,Wang Y,Li H,Liu L,Wang Y

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Mechanisms involved in stroke progression are incompletely understood. Ischemic brain injury is characterized by acute local inflammatory response mediated by cytokines. Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of...

journal_title：Stroke

authors： Vila N,Castillo J,Dávalos A,Esteve A,Planas AM,Chamorro A

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several prognostic scores have been developed to predict the risk of symptomatic intracranial hemorrhage (sICH) after ischemic stroke thrombolysis. We compared the performance of these scores in a multicenter cohort. METHODS:We merged prospectively collected data of patients with consecutive isc...

journal_title：Stroke

authors： Strbian D,Michel P,Seiffge DJ,Saver JL,Numminen H,Meretoja A,Murao K,Weder B,Forss N,Parkkila AK,Eskandari A,Cordonnier C,Davis SM,Engelter ST,Tatlisumak T

更新日期：2014-03-01 00:00:00