Gene therapy and endovascular treatment of intracranial aneurysms.

abstract：BACKGROUND AND PURPOSE:To investigate the efficacy of bone marrow mononuclear cell (BMMNC) treatment against ischemic white matter (WM) damage in a hypoperfused brain. METHODS:Mice were administered intravenous treatment of vehicle, spleen-derived marrow mononuclear cells (MNCs), or BMMNCs (5 × 10⁶ cells) obtained fro...

journal_title：Stroke

authors： Fujita Y,Ihara M,Ushiki T,Hirai H,Kizaka-Kondoh S,Hiraoka M,Ito H,Takahashi R

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Victims of air embolism often recover rapidly on hyperbaric treatment then deteriorate again, even if hyperbaric treatment is continued. In previous animal experiments, lidocaine has been shown to improve recovery of somatosensory evoked response amplitude after air embolism. However, animals in ...

journal_title：Stroke

authors： Dutka AJ,Mink R,McDermott J,Clark JB,Hallenbeck JM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence now exists for a pathogenic role for neutrophils in acute cerebral ischemia. We have studied the patterns and temporal profile of cerebral neutrophil recruitment to areas of acute ischemic stroke (IS) and have attempted to correlate this with neurological status and outcome. METHODS:Pat...

journal_title：Stroke

authors： Price CJ,Menon DK,Peters AM,Ballinger JR,Barber RW,Balan KK,Lynch A,Xuereb JH,Fryer T,Guadagno JV,Warburton EA

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiology of subarachnoid hemorrhage (SAH) is poorly understood. Reduced lung function, expressed as low forced expiratory volume in 1 second (FEV(1)) and low forced vital capacity (FVC), is a predictor of cardiovascular disease, but whether reduced lung function is a risk factor for SAH is no...

journal_title：Stroke

authors： Söderholm M,Zia E,Hedblad B,Engström G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Treatment of intracerebral hematoma (ICH) is controversial. An advantage of neurosurgical intervention over conservative treatment of ICH has not been established. Recent reports suggest a favorable effect of stereotactic blood clot removal after liquefaction by means of a plasminogen activator. ...

journal_title：Stroke

authors： Teernstra OP,Evers SM,Lodder J,Leffers P,Franke CL,Blaauw G,Multicenter randomized controlled trial (SICHPA).

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to evaluate the efficacy of remote ischemic conditioning (RIC) in patients with cerebral small-vessel disease. METHODS:Thirty patients with cerebral small-vessel disease-related mild cognitive impairment were enrolled in this prospective, randomized controlled study for 1 year. Besides ...

journal_title：Stroke

authors： Wang Y,Meng R,Song H,Liu G,Hua Y,Cui D,Zheng L,Feng W,Liebeskind DS,Fisher M,Ji X

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on ...

journal_title：Stroke

authors： Czosnyka M,Smielewski P,Kirkpatrick P,Menon DK,Pickard JD

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is unclear whether anxiety is a risk factor for stroke. We assessed the association between anxiety and the risk of incident stroke. METHODS:This population-based cohort study was based on 2 rounds of the Rotterdam Study. Each round was taken separately as baseline. In 1993 to 1995, anxiety s...

journal_title：Stroke

authors： Portegies ML,Bos MJ,Koudstaal PJ,Hofman A,Tiemeier HW,Ikram MA

更新日期：2016-04-01 00:00:00

abstract：:Many patients suffer a stroke early after a transient ischemic attack, but the reason why is often unclear. We studied 12 patients with less than 75% stenosis of the internal carotid artery and a single hemispheric transient ischemic attack lasting less than 1 hour who had a normal neurologic examination 3-13 hours la...

journal_title：Stroke

authors： Bogousslavsky J,Delaloye-Bischof A,Regli F,Delaloye B

更新日期：1990-01-01 00:00:00

abstract：:The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...

journal_title：Stroke

authors： Roth EJ,Mueller K,Green D

更新日期：1988-01-01 00:00:00

abstract：:The effects of hypoxic hypoxia on cerebral hemodynamics and somatosensory evoked potential (SEP) were studied in 10 pentobarbital anestheteized dogs. Cerebral blood flow (CBF) was measured using the venous outflow technique and cerebral oxygen consumption (CMRO2) was calculated from the arterio-cerebro-venous oxygen d...

journal_title：Stroke

authors： McPherson RW,Zeger S,Traystman RJ

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Delayed cerebral infarction (DCI) is an important cause of poor outcome after subarachnoid hemorrhage. Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the development of...

journal_title：Stroke

authors： Bakker AM,Dorhout Mees SM,Algra A,Rinkel GJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...

journal_title：Stroke

authors： Robinson TG,Potter JF

更新日期：1995-10-01 00:00:00

abstract：:Background and Purpose- Information on what effect disability before stroke can have on stroke outcome is lacking. We assessed prestroke disability in relation to poststroke hospital outcome. Methods- Analysis of prospectively collected data from the Sentinel Stroke National Audit Programme. A total of 1656 men (mean ...

journal_title：Stroke

authors： Han TS,Fry CH,Gulli G,Affley B,Robin J,Irvin-Sellers M,Fluck D,Kakar P,Sharma S,Sharma P

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Comparative effectiveness and safety of oral anticoagulants in patients with atrial fibrillation and high polypharmacy are unknown. METHODS:We used Medicare administrative data to evaluate patients with new atrial fibrillation diagnosis from 2015 to 2017, who initiated an oral anticoagulant with...

journal_title：Stroke

authors： Mentias A,Heller E,Vaughan Sarrazin M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The rarity of intracranial vascular malformations (IVMs) and the infrequency of their outcomes make large, prolonged cohort studies the best means to evaluate their frequency and prognosis. METHODS:The Scottish Intracranial Vascular Malformation Study (SIVMS) is a prototype prospective, populati...

journal_title：Stroke

authors： Al-Shahi R,Bhattacharya JJ,Currie DG,Papanastassiou V,Ritchie V,Roberts RC,Sellar RJ,Warlow CP,Scottish Intracranial Vascular Malformation Study Collaborators.

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...

journal_title：Stroke

authors： Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Arteriopathy is common in childhood arterial ischemic stroke (AIS) and predicts stroke recurrence. Currently available vascular imaging techniques mainly image the arterial lumen rather than the vessel wall and have a limited ability to differentiate among common arteriopathies. We aimed to inves...

journal_title：Stroke

authors： Dlamini N,Yau I,Muthusami P,Mikulis DJ,Elbers J,Slim M,Askalan R,MacGregor D,deVeber G,Shroff M,Moharir M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Physical and psychological characteristics in adolescence are associated with subsequent stroke risk. Our aim is to investigate their relevance to length of hospital stay and risk of second stroke. METHODS:Swedish men born between 1952 and 1956 (n=237 879) were followed from 1987 to 2010 using i...

journal_title：Stroke

authors： Bergh C,Udumyan R,Appelros P,Fall K,Montgomery S

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence is accumulating regarding the prognostic influence of hyperglycemia in patients with acute ischemic stroke. However, the level associated with poor outcome is unknown. Our objectives were to establish the capillary glucose threshold with the highest predictive accuracy of poor outcome an...

journal_title：Stroke

authors： Fuentes B,Castillo J,San José B,Leira R,Serena J,Vivancos J,Dávalos A,Nuñez AG,Egido J,Díez-Tejedor E,Stroke Project of the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Single and multiple lacunar infarctions may have some difference in underlying diseases and cerebral blood flows. To determine the difference, we investigated underlying diseases and cerebral blood flows in single and multiple lacunar infarctions. METHODS:Fifteen cases of lacunar infarction, 10 ...

journal_title：Stroke

authors： Mochizuki Y,Oishi M,Takasu T

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to measure the overall rate of usage of tissue-type plasminogen activator (tPA) for ischemic stroke at academic medical centers, and to determine whether ethnicity was associated with usage. METHODS:Between June and December 1999, 42 academic medical centers in the United States each i...

journal_title：Stroke

authors： Johnston SC,Fung LH,Gillum LA,Smith WS,Brass LM,Lichtman JH,Brown AN

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...

journal_title：Stroke

authors： Weise J,Sandau R,Schwarting S,Crome O,Wrede A,Schulz-Schaeffer W,Zerr I,Bähr M

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Embolism is believed to be the major cause of stroke in patients with nonvalvular atrial fibrillation (NVAF). The detection of asymptomatic embolic signals (ES) in individuals with NVAF might allow identification of patients at high risk of stroke and monitoring of therapy in individual subjects....

journal_title：Stroke

authors： Cullinane M,Wainwright R,Brown A,Monaghan M,Markus HS

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:One of the reasons for the failure of trials of neuroprotection in stroke may be the lack of white matter (WM) protection. However, whether patients entered into typical neuroprotection trials have WM involved in the ischemic process is unknown. We studied patients who were enrolled in neuroprote...

journal_title：Stroke

authors： Ho PW,Reutens DC,Phan TG,Wright PM,Markus R,Indra I,Young D,Donnan GA

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. METHODS:We recruited 2326 healthy Korean adults who took health checkups, including a brain magnetic resonance imaging. SLI was defined as an infarction measuring...

journal_title：Stroke

authors： Lee JE,Shin DW,Yun JM,Kim SH,Nam YS,Cho B,Lim JS,Jeong HY,Kwon HM,Park JH

更新日期：2016-12-01 00:00:00

abstract：:We studied ultrastructurally cerebral perforating arteries in 60 stroke-prone spontaneously hypertensive rats (SHRSP), which were sequentially killed at 4-52 weeks of age before showing symptoms of stroke. Another 24 SHRSP were killed soon after they showed symptoms of cerebral infarction. The initial vascular lesions...

journal_title：Stroke

authors： Tagami M,Nara Y,Kubota A,Sunaga T,Maezawa H,Fujino H,Yamori Y

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have...

journal_title：Stroke

authors： Zhao LR,Berra HH,Duan WM,Singhal S,Mehta J,Apkarian AV,Kessler JA

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In ischemic stroke, diffusion-weighted (DW) and perfusion-weighted (PW) magnet resonance imaging (MRI) is used to define the mismatch as the therapeutic target. With positron emission tomography (PET), we characterized the metabolic patterns of tissue compartments identified by MRI and compared t...

journal_title：Stroke

authors： Sobesky J,Zaro Weber O,Lehnhardt FG,Hesselmann V,Neveling M,Jacobs A,Heiss WD

更新日期：2005-05-01 00:00:00

abstract：:In 20 patients with acute major cerebral arterial occlusion, follow-up angiograms were obtained to inspect the occluded artery. These angiograms were compared with brain scans in the fourth week after the stroke. The angiograms revealed that frequent recanalization of the occluded arteries occurred within a week after...

journal_title：Stroke

authors： Irino T,Taneda M,Minami T

更新日期：1975-03-01 00:00:00