Abstract:
BACKGROUND AND PURPOSE:The majority of patients with spontaneous cerebral artery dissection show ultrastructural alterations in dermal collagen and elastic fibers. METHODS:We studied the gene encoding tropoelastin (ELN) by reverse transcription-polymerase chain reaction and subsequent sequence analysis in 10 patients with abnormalities in their elastic fibers. RESULTS:No mutations were found in the whole coding region of the ELN gene. The simultaneous visualization and quantification of ELN splice variants by gene scanning enabled the analysis of the regulation of alternative splicing of ELN mRNA. No differences could be detected between fibroblast cultures of the patients and a control subject. CONCLUSIONS:Neither mutations in the ELN gene nor dysregulation of its activity appears to be the cause of the connective tissue disorder that is found in most patients with spontaneous dissections.
journal_name
Strokejournal_title
Strokeauthors
Grond-Ginsbach C,Thomas-Feles C,Werner I,Weber R,Wigger F,Hausser I,Brandt Tdoi
10.1161/01.str.31.8.1935subject
Has Abstractpub_date
2000-08-01 00:00:00pages
1935-8issue
8eissn
0039-2499issn
1524-4628journal_volume
31pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:There is inconclusive evidence of the effectiveness of psychological interventions for depression after stroke. We report the results from a randomized controlled trial of cognitive behavioral therapy (CBT). METHODS:Stroke patients admitted to hospital were invited to complete mood questionnaire...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.0000044167.44670.55
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We systematically compared and appraised contemporary guidelines on management of asymptomatic and symptomatic carotid artery stenosis. METHODS:We systematically searched for guideline recommendations on carotid endarterectomy (CEA) or carotid angioplasty/stenting (CAS) published in any language...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.115.003390
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Outcome measurement fidelity within and between sites of multi-site, randomized, clinical trials is an essential element to meaningful trial outcomes. As important are the methods developed for randomized, clinical trials that can have practical utility for clinical practice. A standardized measu...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.110.592766
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective is to compare the effects of high-intensity interval training (HIIT) with long versus short intervals on endurance and motor performance. Their influence on neuroplasticity markers is assessed in the ipsilesional and contralesional cortex and hippocampus since their remodeling could...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.031873
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Indications for carotid endarterectomy have engendered considerable debate among experts and have resulted in publication of retrospective reviews, natural history studies, audits of community practice, position papers, expert opinion statements, and finally prospective randomized trials. The Ame...
journal_title:Stroke
pub_type: 共识发展会议,指南,杂志文章,实务指引,评审
doi:10.1161/01.str.26.1.188
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Motor dysfunction after unilateral deafferentation in primates can be overcome by restraining the unaffected limb. We asked whether a constraint-induced movement (CIM) program could be implemented within 2 weeks after stroke and whether CIM is more effective than traditional upper-extremity (UE) ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.31.12.2984
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hypothermia to core temperatures ranging from 16 degrees C to 24 degrees C has become an established procedure to extend the "safe" interval of cardiac arrest during open heart surgery in human infants. The present experiment was designed to ascertain whether differences in core (rectal) temperat...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.7.1433
更新日期:1994-07-01 00:00:00
abstract::Longitudinal stretch of the rabbit basilar artery produces local injury followed by prolonged circular constriction. After stretching and rapid release in vitro localized constrictions promptly occurred. This could be prevented by prior treatment with cyanide or calcium-free solution. Once produced, constrictions pers...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.7.2.174
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic su...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.635979
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The vitamin K-dependent protein Z (PZ) has been shown to possess anticoagulant as well as procoagulant properties. Plasma levels of PZ show a broad interindividual variation, but it is unknown to which extent this variation is under genetic control. Recent clinical studies revealed contradictory ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000106909.75418.E4
更新日期:2004-01-01 00:00:00
abstract::Endothelium dysfunction may result from increased production of reactive oxygen species and decreased availability of nitric oxide. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, statins) exert cholesterol-independent vasoprotective effects that are mediated, in part, through the inhibiti...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000143319.73503.38
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of acute and restorative stroke therapies. Summary of Review- At the STAIR VII recommendations for strategies to maximize the use of intravenous thrombolytics through targeting public educ...
journal_title:Stroke
pub_type: 杂志文章,实务指引
doi:10.1161/STROKEAHA.111.618850
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Flow Diverters (FD) are a new emerging therapy for intracranial aneurysms. Initial reports focused on the treatment of proximally located aneurysms. We report our experience with FDs in the treatment of aneurysms at and beyond the circle of Willis. METHODS:We treated 30 aneurysms at and beyond t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.636019
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also been reported in patients with late-onset familial and sporadic Alzheimer's disease (AD). The aim of this study was to investigate the deg...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.5.743
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:On the assumption that the majority of lacunes are caused by small-vessel diseases and that pial artery infarcts arise from cardio-embolic or large-vessel diseases, 194 patients from the Berlin Cerebral Ischemia Data Bank with either lacunar or pial artery infarcts were analyzed for the frequency...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.4.776
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The PIWI-interacting RNA (piRNA) is the most predominant RNA species in eukaryotes. The piRNA are a class of noncoding RNAs that bind and degrade the RNA formed by the transposons to control the transposon-induced gene mutations. The role of piRNA after focal ischemia is not yet evaluated. METHO...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.598391
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials evaluated the safety and efficacy of thrombectomy in the treatment of intracranial arterial occlusions within 8 hours of symptom onset. We sought to determine the predictors of clinical and angiographic outcomes in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.561431
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We examined patient demographic and hospital characteristics and clinical predictors of delay time from hospital arrival until CT among 20 374 patients enrolled in the North Carolina Collaborative Stroke Registry (January 2005 to April 2008). METHODS:Delay time was log-transformed in linear regr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.524686
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of our study was to compare lesion location between moyamoya disease-related intracerebral hemorrhage (MMD-ICH) and primary intracerebral hemorrhage (P-ICH). METHODS:Ninety-three patients each with MMD-ICH and P-ICH were compared. In patients with MMD-ICH, angiographic findings were ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.654004
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To estimate the effect of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors ("statins") on stroke ris, we combined the data of the randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors published so far. METHODS:The studies were identified using ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/01.str.28.5.946
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Questionnaire for Verifying Stroke-Free Status (QVSFS), a method for verifying stroke-free status in participants of clinical, epidemiological, and genetic studies, has not been validated in low-income settings where populations have limited knowledge of stroke symptoms. We aimed to validate ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.115.010374
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.482786
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The physiological function of cellular prion protein (PrPc) is not yet understood. Recent findings suggest that PrPc may have neuroprotective properties, and its absence increases susceptibility to neuronal injury. The purpose of this study was to elucidate the role of PrPc in ischemic brain inju...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000217262.03192.d4
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Coffee and tea consumption could potentially reduce the risk of stroke because these beverages have antioxidant properties, and coffee may improve insulin sensitivity. We examined the associations of coffee and tea consumption with risk of stroke subtypes. METHODS:We used prospective data from t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.504183
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lower concentrations of albumin have been positively related to coronary disease. The aim of this project was to assess the association between serum albumin and carotid atherosclerosis. METHODS:B-mode ultrasound was used to assess carotid plaques and intima-media thickness (IMT) among white sub...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.0000048675.97975.84
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite a high incidence of poststroke dementia, there is no specific treatment for this condition. Because the evaluation of poststroke cognitive deficits in animal models of stroke is exceedingly challenging, the preclinical evaluation of candidate drugs is limited. We aimed to explore the impa...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001907
更新日期:2014-02-01 00:00:00
abstract::Background and Purpose- Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic hydrocephalus and poor neurological outcomes. Iron has been implicated in ventriculomegaly, hippocampal injury, and poor outcomes following IVH. We hypothesized that levels of cerebrospinal fluid blood break...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.119.028744
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Animal studies of cerebral arteries 2 to 3 days after experimental subarachnoid hemorrhage (SAH) provide evidence of arterial change such as hyperresponsiveness to contractile agonists. There is evidence that small arteries, as well as those large enough to be seen on angiography, may be involved...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2575
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Disabling anxiety affects a quarter of stroke survivors but access to treatment is poor. We developed a telemedicine model for delivering guided self-help cognitive behavioral therapy (CBT) for anxiety after stroke (TASK-CBT). We aimed to evaluate the feasibility of TASK-CBT in a randomized contr...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.120.029042
更新日期:2020-08-01 00:00:00
abstract::Cerebral blood flow (CBF) was determined in the rat under 70% nitrous oxide anesthesia and pentobarbital anesthesia. The application of the Fick principle technique of Kety et al. was modified utilizing 133Xe infused intravenously steadily for 30 seconds, at which time the animal was decapitated and the head frozen in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.6.630
更新日期:1975-11-01 00:00:00