Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis.

abstract：BACKGROUND AND PURPOSE:This study aimed to independently derive an intracerebral hemorrhage grading scale (ICH-GS) for prediction of 3 outcome measures. METHODS:We evaluated 378 patients with primary ICH at hospital arrival and during the next 30 days. Independent predictors were identified by multivariate models of i...

journal_title：Stroke

authors： Ruiz-Sandoval JL,Chiquete E,Romero-Vargas S,Padilla-Martínez JJ,González-Cornejo S

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A previous systematic review of randomized trials suggested a positive effect of antiplatelet therapy in patients with aneurysmal subarachnoid hemorrhage (SAH). We performed a randomized controlled trial to assess whether acetylsalicylic acid (ASA) reduces the risk of delayed ischemic neurologica...

journal_title：Stroke

authors： van den Bergh WM,MASH Study Group.,Algra A,Dorhout Mees SM,van Kooten F,Dirven CM,van Gijn J,Vermeulen M,Rinkel GJ

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). MET...

journal_title：Stroke

authors： Gjærde LK,Truelsen TC,Baker JL

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is usually based on clinical assessment, blood test results, and CT findings. Intravenous thrombolysis of stroke mimics may occur but has not been studied in detail. METHODS:We determined frequency, clinical characteristics, and outcome of mimic...

journal_title：Stroke

authors： Winkler DT,Fluri F,Fuhr P,Wetzel SG,Lyrer PA,Ruegg S,Engelter ST

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The neck clipping of cerebral aneurysms is a well-established treatment for subarachnoid hemorrhage (SAH) caused by aneurysmal rupture. However, it is still unclear how great a risk of recurrence patients with a successfully treated aneurysm carry over a long-term period. METHODS:Of 425 patients...

journal_title：Stroke

authors： Tsutsumi K,Ueki K,Usui M,Kwak S,Kirino T

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lamotrigine (LTG) is an anticonvulsant drug whose mechanism of action may involve the inhibition of glutamate release by blocking voltage-dependent sodium channels. Glutamate neurotoxicity may contribute to cerebral ischemic damage after recovery from cardiac arrest. Thus, LTG may prevent the bra...

journal_title：Stroke

authors： Crumrine RC,Bergstrand K,Cooper AT,Faison WL,Cooper BR

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Historically, the use of tissue plasminogen activator (tPA) thrombolysis in pregnancy has been regarded as relatively contraindicated. Underlying this stance has been the concern over the risk of bleeding complications in both mother and child. SUMMARY OF CASE:We report the successful use of int...

journal_title：Stroke

authors： Wiese KM,Talkad A,Mathews M,Wang D

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inflammatory cytokines are involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). This study was conducted to examine the role of p38 mitogen-activated protein kinase (MAPK) in the development of vasospasm and cytokine production. METHODS:We measured the expressi...

journal_title：Stroke

authors： Sasaki T,Kasuya H,Onda H,Sasahara A,Goto S,Hori T,Inoue I

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Although a host of genetic, biochemical, physiological, anatomic, and histological factors have been implicated, to varying degrees, in the pathogenesis of stroke, biophysical factors are believed t...

journal_title：Stroke

authors： Hademenos GJ,Massoud TF

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the stroke rate associated with atrial fibrillation has declined over the last 10 years, the emerging atrial fibrillation epidemic threatens to increase the incidence of cardioembolic stroke. Summary of Review-Oral anticoagulants are superior antithrombotic agents but are underused due t...

journal_title：Stroke

authors： Medi C,Hankey GJ,Freedman SB

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chlamydia pneumoniae infection has recently become noteworthy in relation to atherosclerosis. We investigated by immunohistochemistry the distribution of C pneumoniae infection in the atherosclerotic carotid artery. METHODS:Twenty carotid atherosclerotic lesions that were resected during carotid...

journal_title：Stroke

authors： Yamashita K,Ouchi K,Shirai M,Gondo T,Nakazawa T,Ito H

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The composition of carotid atherosclerosis was visualized by using 3D MRI at high resolution with 200-micrometer (3) voxels. Magnetic resonance signal characteristics were correlated with plaque components, including collagenous cap, necrotic core, and calcification, to define resolution and othe...

journal_title：Stroke

authors： Coombs BD,Rapp JH,Ursell PC,Reilly LM,Saloner D

更新日期：2001-11-01 00:00:00

abstract：:Background and Purpose- Intracranial thrombi can be characterized according to their permeability as measured by contrast agent penetration. Thrombus composition and its associated pathogenesis are important factors affecting treatment and secondary prevention. We aimed to explore the histopathologic factors explainin...

journal_title：Stroke

authors： Berndt M,Friedrich B,Maegerlein C,Moench S,Hedderich D,Lehm M,Zimmer C,Straeter A,Poppert H,Wunderlich S,Schirmer L,Oberdieck P,Kaesmacher J,Boeckh-Behrens T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multiple brain infarcts are often seen on diffusion-weighted images in cardioembolic stroke patients. Recently, mobile aortic plaques (MAPs) have been proposed as embolic sources. However, the clinical characteristics of patients with MAPs are unclear. METHODS:We prospectively studied patients w...

journal_title：Stroke

authors： Ueno Y,Kimura K,Iguchi Y,Shibazaki K,Inoue T,Hattori N,Urabe T

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hemodynamic properties of brain arteriovenous malformations (AVMs) with risk factors for a future hemorrhage are essentially unknown. We hypothesized that AVMs with anatomic properties, which are associated with an increased rupture risk, exhibit different hemodynamic characteristics than those w...

journal_title：Stroke

authors： Illies T,Forkert ND,Saering D,Wenzel K,Ries T,Regelsberger J,Wegscheider K,Fiehler J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to investigate the mechanisms for oxidative injury caused by subarachnoid hemolysate, a pro-oxidant. METHODS:Injection of 50 microL of subarachnoid hemolysate or saline was performed in CD1 mice (n=75), mutant mice deficient in Mn-superoxide dismutase (Sod2+/-; n=23), and their wild-ty...

journal_title：Stroke

authors： Matz PG,Fujimura M,Lewen A,Morita-Fujimura Y,Chan PH

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Unstable atherosclerotic plaques are characterized by increased macrophages and reduced smooth muscle cells (SMCs) and collagen content. Endoglin, an accessory transforming growth factor-beta (TGFbeta) receptor, is a modulator of TGFbeta signaling recently found to be expressed on SMCs in atheros...

journal_title：Stroke

authors： Bot PT,Hoefer IE,Sluijter JP,van Vliet P,Smits AM,Lebrin F,Moll F,de Vries JP,Doevendans P,Piek JJ,Pasterkamp G,Goumans MJ

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) after stroke increases risk of hemorrhagic transformation, particularly in areas with blood-brain barrier leakage. Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers....

journal_title：Stroke

authors： Dijkhuizen RM,Asahi M,Wu O,Rosen BR,Lo EH

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid endarterectomy (CE) has been shown to be beneficial in patients with symptomatic high-grade (70% to 99%) internal carotid artery stenosis. To achieve this benefit, complications must be kept to a minimum. Complications not associated with the procedure itself, but related to medical condi...

journal_title：Stroke

authors： Paciaroni M,Eliasziw M,Kappelle LJ,Finan JW,Ferguson GG,Barnett HJ

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to define the influence of feeding mean arterial pressure (FMAP) in conjunction with other morphological or clinical risk factors in determining the probability of hemorrhagic presentation in patients with cerebral arteriovenous malformations (AVMs). METHODS:Clinical and angiograp...

journal_title：Stroke

authors： Duong DH,Young WL,Vang MC,Sciacca RR,Mast H,Koennecke HC,Hartmann A,Joshi S,Mohr JP,Pile-Spellman J

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Warfarin reduces stroke risk by approximately 60% in patients with atrial fibrillation (AF). Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatm...

journal_title：Stroke

authors： Meschia JF,Merrill P,Soliman EZ,Howard VJ,Barrett KM,Zakai NA,Kleindorfer D,Safford M,Howard G

更新日期：2010-04-01 00:00:00

abstract：:Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 ...

journal_title：Stroke

authors： Bradley RH,Kent TA,Eisenberg HM,Quast MJ,Ward GA,Campbell GA,Hillman G

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute Ischemic Stroke [DEDAS]). The DIAS-2 phase III trial did not replicate the positive pha...

journal_title：Stroke

authors： Fiebach JB,Al-Rawi Y,Wintermark M,Furlan AJ,Rowley HA,Lindstén A,Smyej J,Eng P,Warach S,Pedraza S

更新日期：2012-06-01 00:00:00

abstract：:Visually apparent EEG changes associated with clamping the internal carotid artery appeared in 55 of 176 consecutive patients (31%) undergoing carotid endarterectomy without shunt. Attenuation of higher frequency activity was the most common change. Changes were moderate in 33 patients (19%) and major in 22 (12.5%). M...

journal_title：Stroke

authors： Blume WT,Ferguson GG,McNeill DK

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The neuroprotective role of mild therapeutic hypothermia was established in animal models of cerebral ischemia. Still, several issues, including optimal target temperature, remain unclear. The optimal depth of hypothermia in a rat model of focal cerebral ischemia was investigated. METHODS:Eighty...

journal_title：Stroke

authors： Kollmar R,Blank T,Han JL,Georgiadis D,Schwab S

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of our study was to characterize the patient profile and prognostic value associated with high positive IgG (>100 GPL) anticardiolipin antibodies (aCL). METHODS:We studied the clinical, laboratory, radiological, and prospective historical features of ischemic cerebrovascular disease in p...

journal_title：Stroke

authors： Verro P,Levine SR,Tietjen GE

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transcranial direct current stimulation is emerging as a promising tool for the treatment of several neurological conditions, including cerebral ischemia. The therapeutic role of this noninvasive treatment is, however, limited to chronic phases of stroke. We thus ought to investigate whether diff...

journal_title：Stroke

authors： Peruzzotti-Jametti L,Cambiaghi M,Bacigaluppi M,Gallizioli M,Gaude E,Mari S,Sandrone S,Cursi M,Teneud L,Comi G,Musco G,Martino G,Leocani L

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leukocytes have been implicated in the development of ischemic atherosclerotic vascular diseases. In a prospective study we investigated whether the plasma concentrations of inflammatory mediators, ie, proteases and cytokines, as markers for systemic leukocyte activation, are increased in patient...

journal_title：Stroke

authors： Elneihoum AM,Falke P,Axelsson L,Lundberg E,Lindgärde F,Ohlsson K

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Follow-up imaging is often performed in intracranial aneurysms that are not treated. We performed a systematic review and meta-analysis on patient- and aneurysm-specific risk factors for aneurysm growth. METHODS:We searched EMBASE and MEDLINE for cohort studies describing risk factors for aneury...

journal_title：Stroke

authors： Backes D,Rinkel GJ,Laban KG,Algra A,Vergouwen MD

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Most patients have elevated blood pressure (BP) in the early phase after an acute ischemic stroke. Mechanism and effects of this BP elevation are not well understood. The benefits of intervention by lowering the initial BP or waiting for spontaneous return to normal values remain debated. We stud...

journal_title：Stroke

authors： Yong M,Diener HC,Kaste M,Mau J

更新日期：2005-12-01 00:00:00