Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model.

abstract：BACKGROUND AND PURPOSE:Emergency medical services routing of patients with acute stroke to designated centers may increase the proportion of patients receiving care at facilities meeting national standards and augment recruitment for prehospital stroke research. METHODS:We analyzed consecutive patients enrolled within...

journal_title：Stroke

authors： Sanossian N,Liebeskind DS,Eckstein M,Starkman S,Stratton S,Pratt FD,Koenig W,Hamilton S,Kim-Tenser M,Conwit R,Saver JL,FAST-MAG Investigators and Coordinators.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The role of genetics in cerebrovascular disease remains controversial. The purpose of this study was to assess the influence of family history on atherothrombotic infarction or transient ischemic attack. METHODS:Ninety patients with stroke or transient ischemic attack and 90 age- and sex-matched...

journal_title：Stroke

authors： Graffagnino C,Gasecki AP,Doig GS,Hachinski VC

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries. SUMMARY OF REVIEW:We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality a...

journal_title：Stroke

authors： Bereczki D,Liu M,Prado GF,Fekete I

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The collagen alpha2(I) gene (COL1A2) on chromosome 7q22.1, a positional and functional candidate for intracranial aneurysm (IA), was extensively screened for susceptibility in Japanese IA patients. METHODS:Twenty-one single nucleotide polymorphisms (SNPs) of COL1A2 were genotyped in genomic DNA ...

journal_title：Stroke

authors： Yoneyama T,Kasuya H,Onda H,Akagawa H,Hashiguchi K,Nakajima T,Hori T,Inoue I

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Numerous studies indicate that mild hypothermia provides substantial neuroprotection. However, current systems transfer insufficient heat to rapidly vary core temperature. We thus evaluated the safety and efficacy of endovascular cooling and rewarming for the induction and reversal of hypothermia...

journal_title：Stroke

authors： Dae MW,Gao DW,Ursell PC,Stillson CA,Sessler DI

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994. METHODS:The Carotid Revascularization Endarterectomy ...

journal_title：Stroke

authors： Mantese VA,Timaran CH,Chiu D,Begg RJ,Brott TG,CREST Investigators.

更新日期：2010-10-01 00:00:00

abstract：:Background and Purpose- Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response. The unfolded protein response consists of 3 branches controlled by ER stress sensor proteins, which include PERK (protein kinase RNA-like ER kinase). Activated PERK phosph...

journal_title：Stroke

authors： Wang YC,Li X,Shen Y,Lyu J,Sheng H,Paschen W,Yang W

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The composition of carotid atherosclerosis was visualized by using 3D MRI at high resolution with 200-micrometer (3) voxels. Magnetic resonance signal characteristics were correlated with plaque components, including collagenous cap, necrotic core, and calcification, to define resolution and othe...

journal_title：Stroke

authors： Coombs BD,Rapp JH,Ursell PC,Reilly LM,Saloner D

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Cerebrovascular mortality has declined in the general population of Sweden. The objective of the present study was to investigate causes of death among stroke patients in a long-term perspective. RESEARCH DESIGN AND METHODS:A population-based study was conducted of first-ever strokes in the municipality of ...

journal_title：Stroke

authors： Terént A

更新日期：2004-07-01 00:00:00

abstract：:Background and Purpose- Aneurysmal subarachnoid hemorrhage (aSAH) has a high healthcare cost burden. Methods- We performed a cross-sectional analysis of the costs of clipping and coiling of aSAH using the National Inpatient Sample and Vizient databases. We conducted multiple regression analyses to estimate national co...

journal_title：Stroke

authors： Yoon S,Yoon JC,Winkler E,Liu C,Lawton MT

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND AND PURPOSE:Intake of fruits and vegetables has been related to lower risk of ischemic stroke, but nutrients responsible for this apparent benefit remain ill-defined. Tocopherols (vitamin E) have also been proposed to be protective. METHODS:We conducted a prospective, nested case-control analysis among male...

journal_title：Stroke

authors： Hak AE,Ma J,Powell CB,Campos H,Gaziano JM,Willett WC,Stampfer MJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The impact of asymptomatic coronary artery disease on the risk of major vascular events in patients with cerebral infarction is unknown. METHODS:Four hundred five patients with acute cerebral infarction underwent carotid, femoral artery, thoracic, and abdominal aorta ultrasound examination. Of 3...

journal_title：Stroke

authors： Amarenco P,Lavallée PC,Labreuche J,Ducrocq G,Juliard JM,Feldman L,Cabrejo L,Meseguer E,Guidoux C,Adraï V,Ratani S,Kusmierek J,Lapergue B,Klein IF,Gongora-Rivera F,Jaramillo A,Abboud H,Olivot JM,Mazighi M,Touboul PJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Systemic administration of Toll-like receptor (TLR) 4 and TLR9 agonists before cerebral ischemia have been shown to reduce ischemic injury by reprogramming the response of the brain to stroke. Our goal was to explore the mechanism of TLR-induced neuroprotection by determining whether a TLR7 agoni...

journal_title：Stroke

authors： Leung PY,Stevens SL,Packard AE,Lessov NS,Yang T,Conrad VK,van den Dungen NN,Simon RP,Stenzel-Poore MP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Data on long-term outcome after intravenous tissue-type plasminogen activator (tPA) in ischemic stroke are limited. We examined the risk of long-term mortality, recurrent ischemic stroke, and major bleeding, including intracranial and gastrointestinal bleeding, in intravenous tPA-treated patients...

journal_title：Stroke

authors： Schmitz ML,Simonsen CZ,Hundborg H,Christensen H,Ellemann K,Geisler K,Iversen H,Madsen C,Rasmussen MJ,Vestergaard K,Andersen G,Johnsen SP

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease that clinically involves only the brain. Particularly early in the disease, patients can show substantial or complete recovery after individual strokes. Cortic...

journal_title：Stroke

authors： Reddy H,De Stefano N,Mortilla M,Federico A,Matthews PM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We sought to investigate whether the combination of blood flow measurements in the major cerebral arteries and measurements of cerebral metabolism can provide new insight into the hemodynamic effect of carotid lesions in patients with severe stenosis (> 70% reduction in diameter) of the internal ...

journal_title：Stroke

authors： van der Grond J,Eikelboom BC,Mali WP

更新日期：1996-11-01 00:00:00

abstract：:Cardiac arrhythmias were more frequent (p less than 0.001) in 312 stroke patients admitted to an intensive care stroke unit, than in 92 patients admitted to the unit and subsequently found not to have strokes. This significant difference remained when a stroke subgroup and the non-stroke group were matched for age, se...

journal_title：Stroke

authors： Norris JW,Froggatt GM,Hachinski VC

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:European directives and legislation in some countries forbid inclusion of subjects incapable of consent in research if recruitment of patients capable of consent will yield similar results. We compared brain lesion volumes in stroke patients deemed to have capacity to consent with those defined a...

journal_title：Stroke

authors： Dani KA,McCormick MT,Muir KW

更新日期：2008-08-01 00:00:00

abstract：:Unilateral stimulation of the cervical sympathetic in dogs had no effect on cerebral blood flow (CBF) measured by the venous outflow technique. Since this technique measured CBF from both cerebral hemispheres, small changes induced by unilateral stimulation could have been masked by a large constant CBF measured from ...

journal_title：Stroke

authors： Barber BJ,Martin JS,Rapela CE

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We evaluated the neuroprotective effect of UK-279,276 (also referred to as recombinant neutrophil inhibitory factor), a selective CD11b/CD18 antagonist, in combination with thrombolytic therapy on focal cerebral ischemia. METHODS:Male Wistar rats (n=88) were subjected to embolic middle cerebral ...

journal_title：Stroke

authors： Zhang L,Zhang ZG,Zhang RL,Lu M,Krams M,Chopp M

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Controlled multicenter studies have demonstrated the efficacy of systemic recombinant tissue-type plasminogen activator (rtPA) treatment in selected cases of acute ischemic stroke. The feasibility of this therapeutic option in clinical practice was assessed in a community-based approach. METHODS...

journal_title：Stroke

authors： Grond M,Stenzel C,Schmülling S,Rudolf J,Neveling M,Lechleuthner A,Schneweis S,Heiss WD

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Occluding a large intracranial artery in rats produces a brain lesion that grows in terms of an increase in both surface area and number of necrotic neurons. The present study investigated whether reperfusing the ischemic territory 30 to 60 minutes after the arterial occlusion would have a benefi...

journal_title：Stroke

authors： Garcia JH,Wagner S,Liu KF,Hu XJ

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The benefits of chronic disease self-management programs for stroke survivors are uncertain because individuals with severe impairments have been excluded from previous research. We undertook a phase II randomized controlled trial to determine whether a self-management program designed for surviv...

journal_title：Stroke

authors： Cadilhac DA,Hoffmann S,Kilkenny M,Lindley R,Lalor E,Osborne RH,Batterbsy M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The management of carotid atherosclerosis is well-established for symptomatic stenosis above 69%, but the optimal approach for managing lower degrees of narrowing remains uncertain. Because the risk of stroke increases with higher grades of stenosis, we are inclined to consider low-grade disease ...

journal_title：Stroke

authors： Wasserman BA,Wityk RJ,Trout HH 3rd,Virmani R

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Combined Lysis of Thrombus in Brain Ischemia With Transcranial Ultrasound and Systemic T-PA-Hands-Free (CLOTBUST-HF) study is a first-in-human, National Institutes of Health-sponsored, multicenter, open-label, pilot safety trial of tissue-type plasminogen activator (tPA) plus a novel operator...

journal_title：Stroke

authors： Barreto AD,Alexandrov AV,Shen L,Sisson A,Bursaw AW,Sahota P,Peng H,Ardjomand-Hessabi M,Pandurengan R,Rahbar MH,Barlinn K,Indupuru H,Gonzales NR,Savitz SI,Grotta JC

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A high incidence of arteriovenous malformations (AVMs) is associated with hereditary hemorrhagic telangiectasia type 1. Endoglin, the gene mutated in this disorder, is expressed at reduced levels on blood vessels of these patients. Since endoglin is a component of the transforming growth factor-b...

journal_title：Stroke

authors： Matsubara S,Bourdeau A,terBrugge KG,Wallace C,Letarte M

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...

journal_title：Stroke

authors： Itabashi R,Nishio Y,Kataoka Y,Yazawa Y,Furui E,Matsuda M,Mori E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral microbleeds are frequently seen in the general elderly population, but it is unknown at what rate they occur with aging and whether once present can disappear over time. METHODS:As part of the Rotterdam Scan Study, 831 persons (mean age, 68.5 years) underwent repeated brain MRI with a m...

journal_title：Stroke

authors： Poels MM,Ikram MA,van der Lugt A,Hofman A,Krestin GP,Breteler MM,Vernooij MW

更新日期：2011-03-01 00:00:00

abstract：:Various concentrations of acetylcholine (ACh) produced dose dependent relaxations of isolated, helical preparations of human cerebral arteries and these responses were blocked by atropine. The median effective concentration (EC50) of ACh was 6.1 +/- 0.2 X 10(-6)M. ACh produced dual responses in isolated dog cerebral a...

journal_title：Stroke

authors： Tsukahara T,Usui H,Taniguchi T,Shimohama S,Fujiwara M,Handa H

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The modified Rankin Scale (mRS) is the recommended functional outcome assessment in stroke trials. Utility of mRS may be limited by interobserver variability. prestroke function, described using mRS, is often used as trial entry criterion. We assessed the reliability and validity of prestroke mRS...

journal_title：Stroke

authors： Fearon P,McArthur KS,Garrity K,Graham LJ,McGroarty G,Vincent S,Quinn TJ

更新日期：2012-12-01 00:00:00