Abstract:
BACKGROUND AND PURPOSE:Data on long-term outcome after intravenous tissue-type plasminogen activator (tPA) in ischemic stroke are limited. We examined the risk of long-term mortality, recurrent ischemic stroke, and major bleeding, including intracranial and gastrointestinal bleeding, in intravenous tPA-treated patients when compared with intravenous tPA eligible but nontreated patients with ischemic stroke. METHODS:We conducted a register-based nationwide propensity score-matched follow-up study among patients with ischemic stroke in Denmark (2004-2011). Cox regression analysis was used to compute adjusted hazard ratios for all outcomes. RESULTS:Among 4292 ischemic strokes (2146 intravenous tPA-treated and 2146 propensity score-matched nonintravenous tPA-treated patients), with a follow-up for a median of 1.4 years, treatment with intravenous tPA was associated with a lower risk of long-term mortality (adjusted hazard ratio, 0.66; 95% confidence interval, 0.49-0.88). The long-term risk of recurrent ischemic stroke (adjusted hazard ratio, 1.05; 95% confidence interval, 0.68-1.64) and major bleeding (adjusted hazard ratio, 0.59; 95% confidence interval, 0.24-1.47) did not differ significantly between the intravenous tPA-treated and nontreated patients. CONCLUSIONS:Treatment with intravenous tPA in patients with ischemic stroke was associated with improved long-term survival.
journal_name
Strokejournal_title
Strokeauthors
Schmitz ML,Simonsen CZ,Hundborg H,Christensen H,Ellemann K,Geisler K,Iversen H,Madsen C,Rasmussen MJ,Vestergaard K,Andersen G,Johnsen SPdoi
10.1161/STROKEAHA.114.006570subject
Has Abstractpub_date
2014-10-01 00:00:00pages
3070-2issue
10eissn
0039-2499issn
1524-4628pii
STROKEAHA.114.006570journal_volume
45pub_type
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