Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man.

Abstract:

:The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere in one patient. The prostaglandin was dissolved from the crystalline state without the aid of alcohol. It was given intracarotidly as a constant infusion at a rate of 5 ng per kilogram per minute for five minutes before the measurement and continued during the measurement. In every patient a mild increase in blood flow during the prostaglandin infusion was seen. The flow increase took place in all parts of the hemisphere. It averaged 11.2% (p less than 0.01). During the infusion, the skin supplied by the internal carotid artery and the conjunctiva on the infused side became red and sometimes swollen. A slight pressure was noted by most patients, but none had pain. No side effects of the infusion were noted.

journal_name

Stroke

journal_title

Stroke

authors

Olesen J

doi

10.1161/01.str.7.6.566

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

566-9

issue

6

eissn

0039-2499

issn

1524-4628

journal_volume

7

pub_type

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