Abstract:
BACKGROUND AND PURPOSE:Inflammatory and immune mechanisms can precipitate cerebrovascular thrombosis and hemorrhage. Immunologic tolerance can be induced to a specific antigen by intranasal instillation of that antigen. Lymphocytes tolerized in this way provide local immunosuppression on restimulation with the same antigen. This study tests whether tolerization of lymphocytes to E-selectin can suppress local vessel activation and prevent stroke. METHODS:Spontaneously hypertensive genetically stroke-prone rats (n=113) were distributed among the following studies: comparison of ischemic infarcts/intraparenchymal hemorrhages after single or repetitive tolerization schedules with ovalbumin, E-selectin, or PBS; comparison of E-selectin tolerization- and PBS tolerization-induced suppression of delayed-type hypersensitivity in animals subsequently sensitized to E-selectin; and comparison of PBS-, ovalbumin-, and E-selectin-tolerized groups (after intravenous lipopolysaccharide to activate vessels) regarding transforming growth factor-beta1-positive splenocyte counts, plasma interferon-gamma levels, anti-human E-selectin antibodies, endothelial intercellular adhesion molecule-1, and anti-endothelial cell antibodies. RESULTS:Nasal instillation of E-selectin, which is specifically expressed on activated endothelium, potently inhibited the development of ischemic and hemorrhagic strokes in spontaneously hypertensive stroke-prone rats with untreated hypertension. Repeated schedules of tolerization were required to maintain the resistance to stroke. Suppression of delayed-type hypersensitivity to E-selectin and increased numbers of transforming growth factor-beta1-positive splenocytes showed that intranasal exposure to E-selectin induced immunologic tolerance. E-selectin tolerization also reduced endothelial activation and immune responses after intravenous lipopolysaccharide, as shown by marked suppression of intercellular adhesion molecule-1 expression, anti-endothelial cell antibodies on luminal endothelium, and plasma interferon-gamma levels compared with the control condition. CONCLUSIONS:The novel findings in this study support further investigation of immunologic tolerance as applied to the prevention of stroke.
journal_name
Strokejournal_title
Strokeauthors
Takeda H,Spatz M,Ruetzler C,McCarron R,Becker K,Hallenbeck Jdoi
10.1161/01.str.0000029821.82531.8bsubject
Has Abstractpub_date
2002-09-01 00:00:00pages
2156-63issue
9eissn
0039-2499issn
1524-4628journal_volume
33pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:We sought to identify variables associated with intracerebral hemorrhage in patients with acute ischemic stroke who receive tissue plasminogen activator (t-PA). METHODS:We performed subgroup analyses of data from a randomized, double-blind, placebo-controlled trial of intravenous t-PA administer...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.28.11.2109
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.116.015957
更新日期:2017-04-01 00:00:00
abstract::A patient developed a cerebellar infarction five weeks after a car accident. The pathophysiology and the medico-legal implications are discussed. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.4.617
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial Doppler (TCD) monitoring of mean blood flow velocity (mV) during head-upright tilt can allow testing of cerebral autoregulation. Nonetheless, head-upright tilt can induce changes in the ventilation-perfusion relationship and/or respiratory activity that might influence TCD data. MET...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.6.1195
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previously, we have shown that hyperthermia significantly increased neuronal damage after ischemic injury in a focal embolic model of stroke in rats. In the present study, we examined the effects of hyperthermia on the efficacy of thrombolytic therapy in this stroke model. METHODS:In part A, eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000155684.20864.58
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Visit-to-visit variability in systolic blood pressure (SBP) is associated with an increased risk of stroke and was reduced in randomized trials by calcium channel blockers and diuretics but not by renin-angiotensin system inhibitors. However, time of day effects could not be determined. Day-to-da...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005982
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of genetics in cerebrovascular disease remains controversial. The purpose of this study was to assess the influence of family history on atherothrombotic infarction or transient ischemic attack. METHODS:Ninety patients with stroke or transient ischemic attack and 90 age- and sex-matched...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.8.1599
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:MRI characterization of carotid plaque has been studied recently as a potential tool to predict stroke caused by carotid atherosclerosis. We performed a systematic review and meta-analysis to summarize the association of MRI-determined intraplaque hemorrhage, lipid-rich necrotic core, and thinnin...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.113.002551
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is controversy about the optimal patient position for the detection of right-to-left shunt (RLS). The study was performed to investigate which patient position best detects RLS during contrast-enhanced transcranial Doppler. METHODS:We prospectively evaluated consecutive patients with ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609875
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia is common after stroke and is a marker of poor prognosis. Early identification is important. This article reviews the merits and limitations of various assessment methods available to clinicians. METHODS:An electronic database search was performed of MEDLINE, EMBASE, and the Cochrane d...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.STR.0000066309.06490.B8
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite its low efficacy, aspirin is the most widely used drug for secondary stroke prevention. The reasons why stroke recurs while patients are on aspirin are unknown. We have analyzed a series of patients who had recurrent strokes while on aspirin. METHODS:Out of 2231 consecutive patients who ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.25.2.275
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multiple acute ischemic lesions on diffusion-weighted magnetic resonance imaging (DWI-MRI) are thought to be of embolic origin. However, in several patients with multiple ischemic lesions on DWI-MRI, no embolic source was detected, despite a thorough clinical work-up. Stroke etiology in such case...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000231645.22128.ab
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Identification of single-nucleotide polymorphisms (SNPs) associated with increased risk of new intracranial hemorrhage (ICH) after brain arteriovenous malformation (BAVM) diagnosis would facilitate risk stratification and identify potential targets for therapeutic intervention. METHODS:Patients ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000195133.98378.4b
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hyperglycemia may worsen brain injury during acute cerebral infarction. We tested the feasibility and tolerability of aggressive hyperglycemia correction with intravenous insulin compared with usual care during acute cerebral infarction. METHODS:We conducted a randomized, multicenter, blinded pi...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.107.493544
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Pending the results of randomized controlled trials, the benefit and safety of bridging therapy (combined intravenous and intra-arterial thrombolysis) remain to be determined. The aim of this analysis was to give reliable estimates of efficacy and safety outcomes of bridging therapy. METHODS:We ...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.111.635029
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.558221
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine the alterations in contractile and dilatory responses and ultrastructure of the feline middle cerebral artery after hemorrhagic hypotension. METHODS:In the sodium pentobarbital anesthetized cats, a steady 50 mm Hg level of hypotension was reached by bleedi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.12.1541
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Delayed cerebral infarction (DCI) is an important cause of poor outcome after subarachnoid hemorrhage. Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the development of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.484220
更新日期:2007-09-01 00:00:00
abstract::To clarify the nature of ischemic striatal dopamine release during the earliest periods of neuronal injury, we used chronoamperometry to measure dopamine levels every 60 seconds during various durations of ischemia in 32 gerbils. Catecholamine-selective electrodes were implanted into the brains of anesthetized gerbils...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.5.674
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Acute cerebral ischemia is frequently associated with headache. It is unknown whether concomitant headache reflects a partly different pathogenesis, and thus, may influence long-term prognosis after stroke. Here, we compared the long-term risk of recurrent vascular events in patients in whom a tr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002217
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported on the correlation of ultrasonic carotid plaque morphology, cerebrovascular symptoms, and intraplaque hemorrhage. This study correlates ultrasonic carotid plaque morphology with the degree of carotid stenosis. METHODS:Carotid arteries (n=2460) were examined by using...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000019127.11189.b5
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. METHODS:We propose to use tests to assess treatment differences addressing the metric, "if a patient is chosen at random from each treatment ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.632935
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several hundred studies have been published over the last few years on imaging and measurement of carotid stenosis. Despite all this research, there is still no consensus about how best to image and measure stenosis. One possible explanation for this is that many of the studies have not been larg...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.31.6.1444
更新日期:2000-06-01 00:00:00
abstract::Neurologic deficits that occur simultaneously with or subsequent to internal carotid artery occlusion may be influenced by the adequacy of the intracerebral collateral circulation. Transcranial Doppler ultrasonography was used to evaluate mean middle cerebral artery blood velocity and blood flow in major collateral ar...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.5.589
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Hypertension occurs frequently after carotid endarterectomy and may lead to cerebral vascular complications and myocardial infarction. Its pathophysiology has recently been related to surgically induced damage of carotid baroreceptors. CASE DESCRIPTION:A 45-year-old normotensive man with no history of epile...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.3.488
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Autonomic dysfunction is frequently present in patients with cerebrovascular accidents (CVA). However, the pathophysiological mechanisms of these disorders are not clear. The purpose of the study was to assess the effects of CVA on the autonomic nervous system. METHODS:In eight male patients wit...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.3.607
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arterial stiffness is associated with an increased risk of myocardial infarction and stroke, independent of classical vascular risk factors. Vascular factors and stroke are associated with cognitive function and dementia. We examined whether arterial stiffness was independently associated with co...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000257998.33768.87
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Conventional diets may cause hyperglycemia in patients with neurological injuries. The purpose of this study was to examine the effect on the severity of cerebral infarction of replacing carbohydrates as the primary dietary source of nonprotein calories. METHODS:Sixty-nine Long-Evans rats were e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.4.564
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this study is to investigate whether apocynin, an NADPH oxidase inhibitor, attenuates vasospasm after experimental subarachnoid hemorrhage (SAH) in rats. METHODS:Rats were subjected to endovascular perforation of the right anterior cerebral artery or sham surgery. Beginning 2 hour...
journal_title:Stroke
pub_type: 杂志文章,收录出版
doi:10.1161/01.STR.0000163102.49888.b7
更新日期:2005-05-01 00:00:00
abstract::Naloxone has been reported to have potential benefit in the treatment of stroke. We evaluated the effect of naloxone in a double-blind trial conducted with 15 stroke patients whose deficits ranged from 8 to 60 hours in duration. All but one patient sustained a cerebral infarction. Neurologic function was assessed befo...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.15.4.627
更新日期:1984-07-01 00:00:00