Abstract:
BACKGROUND AND PURPOSE:Electrocardiographic abnormalities are common after subarachnoid hemorrhage, but their significance remains uncertain. The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes.
METHODS:This was a substudy of the Intraoperative Hypothermia Aneurysm Surgery Trial, which was designed to determine whether intraoperative hypothermia would improve neurological outcome in patients with subarachnoid hemorrhage undergoing aneurysm surgery. The outcome was the 3-month Glasgow Outcome Score treated as both a categorical measure (Glasgow Outcome Score 1 [good outcome] to 5 [death]) and dichotomously (mortality/Glasgow Outcome Score 5 versus Glasgow Outcome Score 1 to 4). The predictor variables were preoperative electrocardiographic characteristics, including heart rate, corrected QT interval, and ST- and T-wave abnormalities. Univariate logistic regression was performed to screen for significant electrocardiographic variables, which were then tested for associations with the outcome by multivariate logistic regression adjusting for clinical covariates.
RESULTS:The study included 588 patients, of whom 31 (5%) died. There was a significant, nonlinear association between heart rate and mortality such that lowest quartile (
journal_name
Strokejournal_title
Strokeauthors
Coghlan LA,Hindman BJ,Bayman EO,Banki NM,Gelb AW,Todd MM,Zaroff JG,IHAST Investigators.doi
10.1161/STROKEAHA.108.528778subject
Has Abstractpub_date
2009-02-01 00:00:00pages
412-8issue
2eissn
0039-2499issn
1524-4628pii
STROKEAHA.108.528778journal_volume
40pub_type
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