Analysis of the effect of bilateral sympathetic stimulation of cerebral and cephalic blood flow in the dog.

Abstract:

:Unilateral stimulation of the cervical sympathetic in dogs had no effect on cerebral blood flow (CBF) measured by the venous outflow technique. Since this technique measured CBF from both cerebral hemispheres, small changes induced by unilateral stimulation could have been masked by a large constant CBF measured from the contralteral hemisphere. To test this possibility the effect of simultaneous bilateral sympathetic stimulation was studied when the dog was breathing either normal air or a gas mixture of 10%CO2. During normocapnia, no changes in CBF occurred; during hypercapnia CBF increased 19% following passively the increase in blood pressure. These data indicate that bilateral stimulation of extracranial sympathetic nerves does not exert a significant effect on CBF. We show mathematically and experimentally that unoccluded anastomses will cause CBF to appear to decrease in response to sympathetic stimulation. This may explain why others have observed changes in CBF during sympathetic stimulation.

journal_name

Stroke

journal_title

Stroke

authors

Barber BJ,Martin JS,Rapela CE

doi

10.1161/01.str.9.1.29

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

29-34

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

9

pub_type

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