Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study.

abstract：BACKGROUND AND PURPOSE:Striatal GABAergic neuron is known as a key regulator in adult neurogenesis. However, the specific role of striatal GABAergic neuronal activity in the promotion of neurological recovery after ischemic stroke remains unknown. Here, we used optogenetic approach to investigate these effects and mech...

journal_title：Stroke

authors： Jiang L,Li W,Mamtilahun M,Song Y,Ma Y,Qu M,Lu Y,He X,Zheng J,Fu Z,Zhang Z,Yang GY,Wang Y

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effect of tissue-type plasminogen activator on functional outcome decreases progressively over time. However, given the differential pattern of arterial occlusion, stroke severity, and speed of ischemic lesion growth among candidates for reperfusion, the time window should be adjusted accordi...

journal_title：Stroke

authors： Muchada M,Rubiera M,Rodriguez-Luna D,Pagola J,Flores A,Kallas J,Sanjuan E,Meler P,Alvarez-Sabin J,Ribo M,Molina CA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Data from epidemiological and case-control studies suggest that increased total homocysteine (tHcy) levels are associated with increased risk for thromboembolic disease. The mechanisms by which hyperhomocysteinemia contributes to thrombogenesis are incompletely understood. The main objectives of ...

journal_title：Stroke

authors： Kristensen B,Malm J,Nilsson TK,Hultdin J,Carlberg B,Dahlén G,Olsson T

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of our study was to clarify the pathophysiology of perioperative cerebral complications during carotid endarterectomy in our series. METHODS:By means of transcranial Doppler ultrasonography and stump pressure measurement, we monitored 112 patients who underwent carotid endarterectomy und...

journal_title：Stroke

authors： Finocchi C,Gandolfo C,Carissimi T,Del Sette M,Bertoglio C

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized ...

journal_title：Stroke

authors： Labeyrie PE,Goulay R,Martinez de Lizarrondo S,Hébert M,Gauberti M,Maubert E,Delaunay B,Gory B,Signorelli F,Turjman F,Touzé E,Courthéoux P,Vivien D,Orset C

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Delayed cerebral infarction (DCI) is an important cause of poor outcome after subarachnoid hemorrhage. Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the development of...

journal_title：Stroke

authors： Bakker AM,Dorhout Mees SM,Algra A,Rinkel GJ

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...

journal_title：Stroke

authors： Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is still unclear that impaired cerebrovascular reactivity (CVR) to acetazolamide is comparable to elevated oxygen extraction fraction (OEF) on positron emission tomography (PET) in patients with occlusive carotid diseases. Therefore, in this study, the authors aimed to clarify whether OEF is e...

journal_title：Stroke

authors： Kuroda S,Shiga T,Houkin K,Ishikawa T,Katoh C,Tamaki N,Iwasaki Y

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevated urinary albumin excretion (UAE) is associated with an increased carotid intima-media thickness (IMT). Because angiotensin-converting enzyme inhibitors as well as statins have been shown to lower UAE and the progression of IMT, we assessed the effects of fosinopril and pravastatin on caro...

journal_title：Stroke

authors： Asselbergs FW,van Roon AM,Hillege HL,de Jong PE,Gans RO,Smit AJ,van Gilst WH,PREVEND IT Investigators.

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to describe the frequency and characteristics of acute ischemic stroke and transient ischemic attacks presenting predominantly with amnesia (ischemic amnesia) and to identify clinical clues for differentiating them from transient global amnesia (TGA). METHODS:We retrospectively analyzed...

journal_title：Stroke

authors： Michel P,Beaud V,Eskandari A,Maeder P,Demonet JF,Eskioglou E

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Perfusion-weighted magnetic resonance imaging (PWI) is a reliable and semiquantitative method for estimating cerebral hemodynamics. We sought to evaluate the potential of PWI for assessing cerebral blood flow (CBF) and metabolism compared with positron emission tomography (PET) in patients with c...

journal_title：Stroke

authors： Kajimoto K,Moriwaki H,Yamada N,Hayashida K,Kobayashi J,Miyashita K,Naritomi H

更新日期：2003-07-01 00:00:00

abstract：:Background and Purpose- Case reports suggest that unruptured intracranial aneurysms may serve as a nidus for thrombus formation and downstream embolic stroke. However, few data exist to support an association between unruptured aneurysms and ischemic stroke. Methods- We conducted a within-subjects case-control study o...

journal_title：Stroke

authors： Chen ML,Gupta A,Chatterjee A,Khazanova D,Dou E,Patel H,Gialdini G,Merkler AE,Navi BB,Kamel H

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Platelet-rich thrombi are resistant to thrombolytics. Matrix metalloproteinases (MMPs) may be involved in platelet aggregation and contribute to thrombolysis failure in stroke patients. METHODS:Plasma samples from 23 stroke patients who had received thrombolytics and from 47 healthy volunteers w...

journal_title：Stroke

authors： Heo JH,Kim SH,Lee KY,Kim EH,Chu CK,Nam JM

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prophylactic administration of simvastatin has been shown to protect against brain damage and its long-lasting behavioral consequences in neonatal rats. To establish the drug treatment window, we evaluated the effectiveness of simvastatin administered at different intervals before and after strok...

journal_title：Stroke

authors： Balduini W,Mazzoni E,Carloni S,De Simoni MG,Perego C,Sironi L,Cimino M

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebral ischemia and stroke are leading causes of morbidity and mortality. An approach to protecting the brain during ischemia is to try to increase the delivery of oxygen via the residual blood flow through and around ischemic tissue. To test this hypothesis, we used a novel oxygen delivery age...

journal_title：Stroke

authors： Watson JC,Doppenberg EM,Bullock MR,Zauner A,Rice MR,Abraham D,Young HF

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Patients with cerebral amyloid angiopathy (CAA) are at high risk for intracerebral hemorrhage (ICH), but no effective prevention strategies have been established. The objective is to determine whether lowering of blood pressure (BP) provides protection for this high-risk patient group. METHODS:T...

journal_title：Stroke

authors： Arima H,Tzourio C,Anderson C,Woodward M,Bousser MG,MacMahon S,Neal B,Chalmers J,PROGRESS Collaborative Group.

更新日期：2010-02-01 00:00:00

abstract：:Eighteen patients with recent ischemic stroke were compared with an equal number of matched controls. Standardized suspensions of red cells as well as of red and white cells were filtered in a new filtration apparatus capable of discriminating between cell deformability and filter occlusion. Results show that red cell...

journal_title：Stroke

authors： Ernst E,Matrai A,Paulsen F

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Arachidonic acid that is released following cerebral ischemia can be metabolized to 20-hydroxyeicosatetraenoic acid (20-HETE). 20-HETE is a potent vasoconstrictor that may contribute to ischemic injury. This study examined the effects of blockading the synthesis of 20-HETE with TS-011 on infarct ...

journal_title：Stroke

authors： Omura T,Tanaka Y,Miyata N,Koizumi C,Sakurai T,Fukasawa M,Hachiuma K,Minagawa T,Susumu T,Yoshida S,Nakaike S,Okuyama S,Harder DR,Roman RJ

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multimodal CT imaging consisting of nonenhanced CT, CT angiography (CTA), and whole-brain volume perfusion CT is increasingly used for acute stroke imaging. In these patients, presence of vessel occlusion is an important factor governing treatment decisions and possible endovascular therapy. The ...

journal_title：Stroke

authors： Frölich AM,Psychogios MN,Klotz E,Schramm R,Knauth M,Schramm P

更新日期：2012-01-01 00:00:00

abstract：:In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...

journal_title：Stroke

authors： Svendgaard NA,Brismar J,Delgado TJ,Rosengren E,Stenevi U

更新日期：1986-01-01 00:00:00

abstract：:We examined the 21-aminosteroid U74006F, a potent inhibitor of lipid peroxidation, for potential neuroprotective effects in a canine model of complete cerebral ischemia. Two 1.5-mg/kg boluses were administered to six dogs, the first bolus 15 minutes prior to a 12-minute episode of complete cerebral ischemia and the se...

journal_title：Stroke

authors： Perkins WJ,Milde LN,Milde JH,Michenfelder JD

更新日期：1991-07-01 00:00:00

abstract：:The purpose of this work was to study the contractile activity of intracerebral microarterioles and their sensitivity to the calcium antagonist nimodipine. Potassium depolarization evoked contraction and rhythmic activity that was blocked by nimodipine (IC50 0.08 nM). High concentrations of noradrenaline and prostagla...

journal_title：Stroke

authors： Godfraind T,Morel N,Dessy C

更新日期：1990-12-01 00:00:00

abstract：:Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...

journal_title：Stroke

authors： Chang CF,Massey J,Osherov A,Angenendt da Costa LH,Sansing LH

更新日期：2020-02-01 00:00:00

abstract：:Experimental subarachnoid hemorrhage (SAH) was induced in baboons by repeated injections of autologous blood into cisterna chiasmatis and cisterna magna, a total of 14-33 ml being injected over 3-4 days. Cerebral blood flow (CBF; 133xenon clearance) and cerebral metabolic rate of oxygen (CMRO2) were measured before, a...

journal_title：Stroke

authors： Sahlin C,Delgado T,Owman C,Svendgaard NA

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent Icelandic studies have demonstrated linkage for common forms of stroke to chromosome 5q12 and association between phosphodiesterase4D (PDE4D) and ischemic stroke. Using a candidate region approach, we wanted to test the validity of these findings in a different population from northern Swe...

journal_title：Stroke

authors： Nilsson-Ardnor S,Wiklund PG,Lindgren P,Nilsson AK,Janunger T,Escher SA,Hallbeck B,Stegmayr B,Asplund K,Holmberg D

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Electrocardiographic abnormalities are common after subarachnoid hemorrhage, but their significance remains uncertain. The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes. METHODS:This was ...

journal_title：Stroke

authors： Coghlan LA,Hindman BJ,Bayman EO,Banki NM,Gelb AW,Todd MM,Zaroff JG,IHAST Investigators.

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebrovascular reserve (CVR) by both transcranial Doppler ultrasonography (TCD) and quantitative cerebral blood flow (CBF) can identify subgroups of patients at increased risk for stroke. A direct comparison of CVR measurements obtained with both technologies in patients with cerebrovascular occ...

journal_title：Stroke

authors： Pindzola RR,Balzer JR,Nemoto EM,Goldstein S,Yonas H

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of the study is to compare the reliability of the Barthel activities of daily living score, which assesses disability, with the Rankin scale, which assesses handicap, and to determine their mutual agreement. METHODS:Fifty patients with stroke of varying severity were identified by a ...

journal_title：Stroke

authors： Wolfe CD,Taub NA,Woodrow EJ,Burney PG

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis and quantification of microangiopathy in dementia is difficult. The assessment of small-vessel disease requires expensive and sophisticated nuclear medicine techniques. This study was performed to identify microangiopathy related to the integrity of cerebral microcirculation by sono...

journal_title：Stroke

authors： Puls I,Hauck K,Demuth K,Horowski A,Schliesser M,Dörfler P,Scheel P,Toyka KV,Reiners K,Schöning M,Becker G

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS:Patients with proximal middle cerebral artery occlusions included i...

journal_title：Stroke

authors： Leker RR,Eichel R,Gomori JM,Ramirez de Noriega F,Ben-Hur T,Cohen JE

更新日期：2012-12-01 00:00:00