Abstract:
BACKGROUND AND PURPOSE:We describe the clinical, diagnostic, and outcome features of a cohort of white patients with idiopathic moyamoya disease treated in a German institution. METHODS:Our cohort included 21 white patients with moyamoya disease. Clinical and diagnostic features were obtained by retrospective chart review; follow-up information and outcome were obtained prospectively. We used the Kaplan-Meier methods to estimate stroke risk by treatment status. RESULTS:The mean age at onset of symptoms was 31 years. The female predominance was 4.25:1. In our cohort, the initial symptom was a cerebral ischemic event in all patients. There was no patient with a hemorrhage at onset; only one patient experienced subarachnoidal hemorrhage in the further course of disease. The Kaplan-Meier risk for recurrent stroke was very high after the first ischemic event and smaller after angiographic diagnosis. The 5-year-Kaplan-Meier risk of recurrent stroke was 80.95% after the first ischemic event for all patients. Most subsequent ischemic events appeared in the first 2 years after symptom onset. Eleven patients (52.3%) underwent neurosurgical revascularizing procedures. After surgery, the Kaplan-Meier risk of perioperative or subsequent stroke was 27.27% within the first month and was stable thereafter. CONCLUSIONS:Clinical features and course of moyamoya disease of whites analyzed in this German study are comparable to American results. Moyamoya disease in whites differs clearly from Asian moyamoya disease in timing of onset of vasculopathy and lower rate of hemorrhages.
journal_name
Strokejournal_title
Strokeauthors
Kraemer M,Heienbrok W,Berlit Pdoi
10.1161/STROKEAHA.107.513408subject
Has Abstractpub_date
2008-12-01 00:00:00pages
3193-200issue
12eissn
0039-2499issn
1524-4628pii
STROKEAHA.107.513408journal_volume
39pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.112.667535
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objective of this study was to determine the clinical features, angiographic findings, and response to treatment with thrombolytic therapy in patients with ischemic stroke caused by acute occlusion of the distal internal carotid artery. METHODS:This is a retrospective case series from a pros...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000020363.23725.67
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Treatment of stroke patients in specialized stroke units has become more frequent, yet the effect of this treatment has not been determined. METHODS:In a community-based, prospective, and consecutive study of 1241 unselected acute stroke patients, we compared outcome of stroke treatment between ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.7.1178
更新日期:1995-07-01 00:00:00
abstract::We examined the 21-aminosteroid U74006F, a potent inhibitor of lipid peroxidation, for potential neuroprotective effects in a canine model of complete cerebral ischemia. Two 1.5-mg/kg boluses were administered to six dogs, the first bolus 15 minutes prior to a 12-minute episode of complete cerebral ischemia and the se...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.7.902
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A significant number of patients with aneurysmal subarachnoid hemorrhage are active smokers and at risk for acute nicotine withdrawal. There is conflicting literature regarding the vascular effects of nicotine and theoretical concern that it may worsen vasospasm. The literature on the safety of n...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.620955
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA? METHODS:We performed a sequential year-to-year cumulative meta-analysis of ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/01.STR.0000072513.72262.7E
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous studies have evaluated the association of body mass index (BMI) with the risk of all-cause and cardiovascular disease mortality among diabetic patients, and results were controversial. No studies have focused on the association between BMI and stroke risk among diabetic patients. We aime...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006718
更新日期:2015-01-01 00:00:00
abstract::Cerebral blood flow and clinical parameters were studied in 30 stroke patients at 15th, 30th, 60th, 90th days after the cerebral insult (Xenon 133 inhalation method). The clinical improvement was not accompanied by a progressive normalization of the CBF at rest. No relationship was found between the clinical data and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.1.77
更新日期:1983-01-01 00:00:00
abstract::Background and Purpose- Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalatine ganglion (SPG) stimulation to enhance collateral flow and stabilize...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.024582
更新日期:2019-05-23 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.113.001318
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data on safety of intravenous thrombolysis with recombinant tissue-type plasminogen activator for acute ischemic stroke in patients with coexisting cerebral cavernous malformations (CCMs) are scarce. We assessed the risk of thrombolysis-associated hemorrhage in these patients. METHODS:We searche...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.113.004559
更新日期:2014-06-01 00:00:00
abstract::Experimental subarachnoid hemorrhage (SAH) was induced in baboons by repeated injections of autologous blood into cisterna chiasmatis and cisterna magna, a total of 14-33 ml being injected over 3-4 days. Cerebral blood flow (CBF; 133xenon clearance) and cerebral metabolic rate of oxygen (CMRO2) were measured before, a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.2.220
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. We investigated the validity, reliability, and feasibility of the Montr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007253
更新日期:2015-04-01 00:00:00
abstract::Regional cerebral ischemia was produced by common carotid artery occlusion in gerbils and by middle cerebral artery occlusion in dogs, cats, and squirrel monkeys. Anesthesia was induced with either pentobarbital or halothane and maintained for two to three hours after vessel occlusion. In acute studies, the effect of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.4.405
更新日期:1975-07-01 00:00:00
abstract::Clinicopathologic correlations were reviewed in 100 cases of recent cerebral infarctions in the internal carotid artery distribution. The most frequent cause of death was transtentorial herniation, followed in frequency by pneumonia, cardiac causes, and pulmonary embolism. Thirty-six percent of all patients and 47% of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.4.474
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke, the hypoperfused but viable tissue is the main therapeutic target. In clinical routine, time-to-peak (TTP) maps are frequently used to estimate the hemodynamic compromise and to calculate the mismatch volume. We evaluated the accuracy of TTP maps to identify penumbral fl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000147043.29399.f6
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although a lower serum homocysteine concentration is associated with a reduced risk of stroke in epidemiologic studies, randomized, controlled trials have yielded mixed findings regarding the effect of therapeutic homocysteine lowering on stroke prevention. We performed a meta-analysis of randomi...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.109.573410
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. METHODS:Using the Nationwide In...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002567
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent evidence suggests that physiological changes in the concentration of endogenous estrogens may influence stroke outcome. The purpose of this study was to determine a menstrual cycle-related profile of blood flow through the carotid arteries and its correlation with estrogen concentration. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.32.1.30
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It has been suggested that the interleukin-1A (IL-1A) allele 2 is a risk factor for Alzheimer's disease (AD). Because cerebral amyloid angiopathy-related hemorrhage (CAAH) often coexists with AD, we examined the IL-1A polymorphism in CAAH. METHODS:In a case-control study, patients with pathologi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000089294.85447.1E
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:High-sensitivity C-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are hypothesized to be biomarkers of systemic inflammation and risk of myocardial infarction (MI) and stroke. Little is known, however, about the stability of these markers over time, and in particul...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.552802
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment of patients with an alternate diagnosis (stroke...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.000126
更新日期:2013-04-01 00:00:00
abstract::Correlations between changes in regional, cortical, cerebral blood flow (rCBF) and histological changes in the corresponding brain regions were examined following middle cerebral arterial occlusion in 24 cats. In all animals, the duration of arterial occlusion was 2 hours followed by 2 hours of recirculation. The anim...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.5.487
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994. METHODS:The Carotid Revascularization Endarterectomy ...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.110.595330
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.534396
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Accumulating evidence indicates that inflammatory responses cause secondary injury after intracerebral hemorrhage (ICH). We recently demonstrated the involvement of toll-like receptor 4 (TLR4) signaling in these processes. The purpose of the current study was to investigate the protective effect ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001038
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke unit care is one of the most powerful interventions available to help stroke patients. There are limited data available to assess the impact of stroke units in routine clinical practice outside randomized clinical trials. This article uses data from the 2001 to 2002 National Stroke Audit t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000149618.14922.8a
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Develop achievable benchmarks for 9 stroke performance measures (PM) and to identify organizational factors associated with adherence. METHODS:Adherence rates and achievable benchmarks were determined for 9 PM within a study of patients (n=2294) admitted with acute ischemic stroke at 17 hospital...
journal_title:Stroke
pub_type: 信件,多中心研究
doi:10.1161/STROKEAHA.107.496570
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that intravenous administration of basic fibroblast growth factor (bFGF) during 4 hours of permanent focal ischemia would affect acute brain injury. METHODS:Halothane-anesthetized cats underwent left middle cerebral artery (MCA) occlusion for 4 hours. Control cats receiv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.3.609
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We hypothesize that in acute middle cerebral artery stroke, thrombus lengths measured in thin-slice nonenhanced CT images define a limit beyond which systemic thrombolysis will fail to recanalize occluded arteries. METHODS:In 138 patients who presented with acute middle cerebral artery stroke an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609693
更新日期:2011-06-01 00:00:00