Hyperglycemia, recognized and unrecognized, as a risk factor for stroke and transient ischemic attacks.

Abstract:

:Glycosylated hemoglobin concentration (GHb), which is considered an indication of glycemia over the preceding several months, was examined in 50 patients hospitalized for recent stroke or transient ischemic attacks (TIA), and compared to that in several reference populations. Patients with stroke or TIA had GHb (mean %A1 +/- SD, 10.2 +/- 2.3) higher than in hospital controls without cerebrovascular disease (8.3 +/- 0.9, p less than 0.005), and equivalent to values for ambulatory diabetic patients treated with diet or diet plus oral agents (9.5 +/- 2.4) or with insulin (10.7 +/- 2.9). Twenty percent (10/50) of the stroke/TIA group were previously known to have abnormal glucose tolerance or diabetes; when this subgroup was excluded, there remained 42% of the original group (21/50) with abnormal GHb (greater than 10% A1) not previously known to have hyperglycemia, and the difference between GHb values for the stroke/TIA patients not known to have glycemic abnormality and for the hospital control group remained significant (p less than 0.005). Sixty-two percent of stroke/TIA patients (31/50) were under treatment for glycemic abnormality, or had high GHb, or both. The high prevalence of elevated GHb in this population could not be attributed to a relationship to age, sex, smoking history, hypercholesterolemia, or hypertension. We conclude that hyperglycemia commonly precedes stroke and TIA, is usually unrecognized, and has been under-appreciated as a risk factor for cerebrovascular disease.

journal_name

Stroke

journal_title

Stroke

authors

Riddle MC,Hart J

doi

10.1161/01.str.13.3.356

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

356-9

issue

3

eissn

0039-2499

issn

1524-4628

journal_volume

13

pub_type

杂志文章

相关文献

STROKE文献大全
  • Characteristics of Intracranial Aneurysms According to Levels of Coronary Artery Calcium.

    abstract::Background and Purpose- Several vascular risk factors are known to be associated with the occurrence of intracranial aneurysms (IAs). Coronary artery calcium (CAC), which reflects the atherosclerotic burden of the coronary arteries, is a known predictor of cardiovascular events and stroke. We investigated the relation...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.024726

    authors: Cho BH,Kim JH,Suh SH,Baik SJ,Lee HS,Kim J,Lee KY

    更新日期:2019-06-01 00:00:00

  • Declining Admission and Mortality Rates for Subarachnoid Hemorrhage in Canada Between 2004 and 2015.

    abstract::Background and Purpose- The purpose of this study was to assess recent trends in the admission and mortality rates for subarachnoid hemorrhage in Canada. Methods- This retrospective cross-sectional study was based on data retrieved from the Canadian Institute for Health Information for all patients diagnosed with suba...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.022332

    authors: Chan V,Lindsay P,McQuiggan J,Zagorski B,Hill MD,O'Kelly C

    更新日期:2018-11-21 00:00:00

  • Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils.

    abstract:BACKGROUND AND PURPOSE:Our aim in this study was to assess the incidence and determining factors of angiographic recurrences after endovascular treatment of aneurysms. METHODS:A retrospective analysis of all patients with selective endosaccular coil occlusion of intracranial aneurysms prospectively collected from 1992...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000073841.88563.E9

    authors: Raymond J,Guilbert F,Weill A,Georganos SA,Juravsky L,Lambert A,Lamoureux J,Chagnon M,Roy D

    更新日期:2003-06-01 00:00:00

  • Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and Wistar rats.

    abstract:BACKGROUND AND PURPOSE:We have developed a minimally invasive model of photothrombotic occlusion of the distal middle cerebral artery in rats and have evaluated the patterns and features of the resulting histopathologic injury in two normotensive strains. METHODS:Food-deprived male Sprague-Dawley (n = 14) and Wistar (...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.2.286

    authors: Markgraf CG,Kraydieh S,Prado R,Watson BD,Dietrich WD,Ginsberg MD

    更新日期:1993-02-01 00:00:00

  • PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.

    abstract::Background and Purpose- Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response. The unfolded protein response consists of 3 branches controlled by ER stress sensor proteins, which include PERK (protein kinase RNA-like ER kinase). Activated PERK phosph...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.029071

    authors: Wang YC,Li X,Shen Y,Lyu J,Sheng H,Paschen W,Yang W

    更新日期:2020-05-01 00:00:00

  • PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism.

    abstract:BACKGROUND AND PURPOSE:To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a randomized trial of recombinant pro-urokinase (rpro-UK) versus placebo was undertaken in patients with angiographically documented proximal middle cerebral artery ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.str.29.1.4

    authors: del Zoppo GJ,Higashida RT,Furlan AJ,Pessin MS,Rowley HA,Gent M

    更新日期:1998-01-01 00:00:00

  • Late stroke: comparison of percutaneous coronary intervention versus coronary artery bypass grafting in patients with multivessel disease and unprotected left main disease: a meta-analysis and review of literature.

    abstract:BACKGROUND AND PURPOSE:Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析,评审

    doi:10.1161/STROKEAHA.113.003323

    authors: Athappan G,Chacko P,Patvardhan E,Gajulapalli RD,Tuzcu EM,Kapadia SR

    更新日期:2014-01-01 00:00:00

  • Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.107.493601

    authors: Diringer MN,Skolnick BE,Mayer SA,Steiner T,Davis SM,Brun NC,Broderick JP

    更新日期:2008-03-01 00:00:00

  • Racial/Ethnic differences in ischemic stroke rates and the efficacy of warfarin among patients with atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:Warfarin reduces stroke risk in studies of predominantly white patients with atrial fibrillation (AF). Whether nonwhites also have lower rates of stroke while treated with warfarin is unclear. METHODS:A multiethnic stroke-free cohort hospitalized with nonrheumatic AF was identified in a large he...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.508580

    authors: Shen AY,Yao JF,Brar SS,Jorgensen MB,Wang X,Chen W

    更新日期:2008-10-01 00:00:00

  • What makes family caregivers happy during the first 2 years post stroke?

    abstract:BACKGROUND AND PURPOSE:This study aimed to identify aspects of the caregiving situation contributing to family caregivers' psychological well-being. METHODS:Longitudinal cohort study with structured quantitative interviews 1, 3, 6, and 12 months post stroke. A subset of participants also completed surveys 18 and 24 mo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.004309

    authors: Cameron JI,Stewart DE,Streiner DL,Coyte PC,Cheung AM

    更新日期:2014-04-01 00:00:00

  • Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W).

    abstract:BACKGROUND AND PURPOSE:In ACTIVE-W, oral anticoagulation (OAC) was more efficacious than combined clopidogrel plus aspirin (C+A) in preventing vascular events in patients with atrial fibrillation. However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify pa...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.107.500199

    authors: Healey JS,Hart RG,Pogue J,Pfeffer MA,Hohnloser SH,De Caterina R,Flaker G,Yusuf S,Connolly SJ

    更新日期:2008-05-01 00:00:00

  • The angiopathy of subarachnoid hemorrhage: angiographic and morphologic correlates.

    abstract::In patients with subarachnoid hemorrhage, particularly hemorrhage due to aneurysmal rupture, there was a positive significant relation between angiographic vessel constriction and vessel pathology (angiopathy). Furthermore, there was a positive relationship between post-hemorrhage survival time and the severity of ang...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.2.240

    authors: Smith RR,Clower BR,Peeler DF Jr,Yoshioka J

    更新日期:1983-03-01 00:00:00

  • Cancer in young adults with ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Cancer is a risk factor for ischemic stroke. Little is known about cancer among young adults with ischemic stroke. We studied the frequency of cancer and its association with long-term risk of death among young patients with first-ever ischemic stroke. METHODS:1002 patients aged 15 to 49 years, ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.008694

    authors: Aarnio K,Joensuu H,Haapaniemi E,Melkas S,Kaste M,Tatlisumak T,Putaala J

    更新日期:2015-06-01 00:00:00

  • Internal carotid artery redundancy is significantly associated with dissection.

    abstract:BACKGROUND AND PURPOSE:Redundant internal carotid arteries have been considered a risk factor in tonsillectomy, adenoidectomy, and surgical treatment of peritonsillar abscess and also a potentially treatable cause of stroke. However, an association between internal carotid artery redundancy and spontaneous dissection h...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.6.1201

    authors: Barbour PJ,Castaldo JE,Rae-Grant AD,Gee W,Reed JF 3rd,Jenny D,Longennecker J

    更新日期:1994-06-01 00:00:00

  • Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Thromboxane prostaglandin receptors have been implicated to be involved in the atherosclerotic process. We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid pla...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.114.004775

    authors: Bots ML,Ford I,Lloyd SM,Laurent S,Touboul PJ,Hennerici MG,Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin With Terutroban in Patients With a History of Ischemic Stroke or Transient Ischemic Attack Vascular Ultrasou

    更新日期:2014-08-01 00:00:00

  • Etiologic Workup in Cases of Cryptogenic Stroke: A Systematic Review of International Clinical Practice Guidelines.

    abstract::Background and Purpose- Identifying the etiology of acute ischemic stroke is essential for effective secondary prevention. However, in at least one third of ischemic strokes, existing investigative protocols fail to determine the underlying cause. Establishing etiology is complicated by variation in clinical practice,...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.027123

    authors: McMahon NE,Bangee M,Benedetto V,Bray EP,Georgiou RF,Gibson JME,Lane DA,Al-Khalidi AH,Chatterjee K,Chauhan U,Clegg AJ,Lightbody CE,Lip GYH,Sekhar A,Watkins CL

    更新日期:2020-05-01 00:00:00

  • Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunction.

    abstract:BACKGROUND AND PURPOSE:Inflammation is thought to be a major contributor to carotid artery disease. Lipopolysaccharide (LPS) activates inflammatory mechanisms thought to contribute to endothelial dysfunction by mechanisms that are not well defined. The goal of this study was to determine whether overexpression of CuZn-...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000132764.06878.c5

    authors: Didion SP,Kinzenbaw DA,Fegan PE,Didion LA,Faraci FM

    更新日期:2004-08-01 00:00:00

  • Daily functioning and quality of life in a randomized controlled trial of therapeutic exercise for subacute stroke survivors.

    abstract:BACKGROUND AND PURPOSE:The ability of therapeutic exercise after stroke to improve daily functioning and quality of life (QOL) remains controversial. We examined treatment effects on these outcomes in a randomized controlled trial (RCT) of exercise in subacute stroke survivors. METHODS:This is a secondary analysis of ...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000174192.87887.70

    authors: Studenski S,Duncan PW,Perera S,Reker D,Lai SM,Richards L

    更新日期:2005-08-01 00:00:00

  • White Matter Hyperintensities Are Under Strong Genetic Influence.

    abstract:BACKGROUND AND PURPOSE:The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritability of WMH in both sexes and in different brain regions, and the influence of age. METHODS:Participants from the Older Australian Twins Study were recruited (n=320; 92 monozygotic and 68 d...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.012532

    authors: Sachdev PS,Thalamuthu A,Mather KA,Ames D,Wright MJ,Wen W,OATS Collaborative Research Team.

    更新日期:2016-06-01 00:00:00

  • The influence of depression, social activity, and family stress on functional outcome after stroke.

    abstract:BACKGROUND AND PURPOSE:This study was designed to assess the quality of life after an active poststroke period of rehabilitation and to investigate the possibility of a return to a working environment for those still of working age. METHODS:The study was conducted on 180 consecutive patients affected by stroke who wer...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.10.1478

    authors: Angeleri F,Angeleri VA,Foschi N,Giaquinto S,Nolfe G

    更新日期:1993-10-01 00:00:00

  • Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis.

    abstract:BACKGROUND AND PURPOSE:Recanalization status after intravenous thrombolysis (IVT) in patients with ischemic stroke is a reference point to proceed with a rescue reperfusion intervention, although early neurological improvement (NI) may preclude endovascular procedures. We aimed to evaluate the importance of restoration...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.000048

    authors: Kharitonova TV,Melo TP,Andersen G,Egido JA,Castillo J,Wahlgren N,SITS investigators.

    更新日期:2013-09-01 00:00:00

  • Distinguishing between stroke and mimic at the bedside: the brain attack study.

    abstract:BACKGROUND AND PURPOSE:The bedside clinical assessment of the patient with suspected stroke has not been well studied. Improving clinical skills may accelerate patient progress through the emergency department. We aimed to determine the frequency and nature of stroke mimics and to identify the key clinical features tha...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000204041.13466.4c

    authors: Hand PJ,Kwan J,Lindley RI,Dennis MS,Wardlaw JM

    更新日期:2006-03-01 00:00:00

  • Sex differences in the management of patients hospitalized with ischemic cerebrovascular disease.

    abstract:BACKGROUND AND PURPOSE:Previous studies suggest that the management of coronary artery disease differs for women compared with men. We examined this issue for ischemic cerebrovascular disease. METHODS:We reviewed the use of angiography and carotid endarterectomy among patients discharged from Connecticut hospitals dur...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.4.577

    authors: Patrick SJ,Concato J,Viscoli C,Chyatte D,Brass LM

    更新日期:1995-04-01 00:00:00

  • Characterization of the cardiac effects of acute subarachnoid hemorrhage in dogs.

    abstract:BACKGROUND AND PURPOSE:We know that significant cardiac involvement can occur in patients with acute intracranial hemorrhage, particularly in those with subarachnoid hemorrhage. These patients may present with electrocardiographic abnormalities that were previously thought to be benign. However, many die of cardiovascu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.4.737

    authors: Elrifai AM,Bailes JE,Shih SR,Dianzumba S,Brillman J

    更新日期:1996-04-01 00:00:00

  • Poor long-term functional outcome after stroke among adults aged 18 to 50 years: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation (FUTURE) study.

    abstract:BACKGROUND AND PURPOSE:Stroke in young adults has a dramatic effect on life; therefore, we investigated the long-term functional outcome after transient ischemic attack, ischemic stroke, or intracerebral hemorrhage in adults aged 18 to 50 years. METHODS:We studied 722 young patients with first-ever stroke admitted bet...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.113.004411

    authors: Synhaeve NE,Arntz RM,Maaijwee NA,Rutten-Jacobs LC,Schoonderwaldt HC,Dorresteijn LD,de Kort PL,van Dijk EJ,de Leeuw FE

    更新日期:2014-04-01 00:00:00

  • Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population.

    abstract:BACKGROUND AND PURPOSE:Disruption of the endothelial layer is the first step in the atherogenic process. Experimental studies have shown that endothelial progenitor cells (EPCs) are involved in endothelial homeostasis and repair. Conversely, EPC depletion has been demonstrated in the setting of established atherosclero...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000236064.19293.79

    authors: Fadini GP,Coracina A,Baesso I,Agostini C,Tiengo A,Avogaro A,de Kreutzenberg SV

    更新日期:2006-09-01 00:00:00

  • Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs.

    abstract:BACKGROUND AND PURPOSE:The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS:In 44 0- to 3-day-old piglets, hypoxic-ische...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.7.1055

    authors: LeBlanc MH,Huang M,Vig V,Patel D,Smith EE

    更新日期:1993-07-01 00:00:00

  • The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study.

    abstract:BACKGROUND AND PURPOSE:Evidence is accumulating regarding the prognostic influence of hyperglycemia in patients with acute ischemic stroke. However, the level associated with poor outcome is unknown. Our objectives were to establish the capillary glucose threshold with the highest predictive accuracy of poor outcome an...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.108.519926

    authors: Fuentes B,Castillo J,San José B,Leira R,Serena J,Vivancos J,Dávalos A,Nuñez AG,Egido J,Díez-Tejedor E,Stroke Project of the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.

    更新日期:2009-02-01 00:00:00

  • An epidemiological survey of stroke in Lhasa, Tibet, China.

    abstract:BACKGROUND AND PURPOSE:There have not been any new epidemiological studies related to stroke in Tibet for 20 years. This study aimed to collect stroke data from The City Staff Medical Insurance Registry in Lhasa, Tibet, to describe the incidence, clinical subtypes, and associated risk factors of stroke. METHODS:We use...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.586669

    authors: Zhao Y,Yao Z,D'Souza W,Zhu C,Chun H,Zhuoga C,Zhang Q,Hu X,Zhou D

    更新日期:2010-12-01 00:00:00

  • Transfer function analysis of cerebral autoregulation dynamics in autonomic failure patients.

    abstract:BACKGROUND AND PURPOSE:Autonomic nervous system diseases affect systemic blood pressure regulation. Patients with autonomic nervous system diseases have consistently larger drops in blood pressure associated with standing than the normal population. Autonomic dysfunction and/or these changes in blood pressure may affec...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.9.1686

    authors: Blaber AP,Bondar RL,Stein F,Dunphy PT,Moradshahi P,Kassam MS,Freeman R

    更新日期:1997-09-01 00:00:00