Abstract:
BACKGROUND AND PURPOSE:The ability of therapeutic exercise after stroke to improve daily functioning and quality of life (QOL) remains controversial. We examined treatment effects on these outcomes in a randomized controlled trial (RCT) of exercise in subacute stroke survivors. METHODS:This is a secondary analysis of a single-blind RCT of a 12-week program versus usual care. Baseline, post-treatment and 6-month post-treatment daily functioning and QOL were assessed by Barthel index, Functional Independence Measure, instrumental activities of daily living, Medical Outcomes Study short-form 36-item questionnaire (SF-36), and Stroke Impact Scale (SIS). RESULTS:Of 100 randomized subjects, 93 completed the postintervention assessment, (mean age 70; 54% male; 81% white; mean Orpington Prognostic Score 3.4), and 80 had 6-month post-treatment assessment. Immediately after intervention, the intervention group improved more than usual care in SF-36 social function (14.0 points; P=0.0051) and in SIS (strength [9.2 points; P=0.0003], emotion [5.6 points; P=0.0240], social participation [6.6 points; P=0.0488], and physical function [5.0 points; P=0.0145]). Treatment was marginally more effective on Barthel score (3.3 points; P=0.0510), SF-36 (physical function [6.8 points; P=0.0586], physical role function [14.4 points; P=0.0708]), and SIS upper extremity function (7.2 points; P=0.0790). Effects were diluted 6 months after treatment ended. CONCLUSIONS:This rehabilitation exercise program led to more rapid improvement in aspects of physical, social, and role function than usual care in persons with subacute stroke. Adherence interventions to promote continued exercise after treatment might be needed to continue benefit.
journal_name
Strokejournal_title
Strokeauthors
Studenski S,Duncan PW,Perera S,Reker D,Lai SM,Richards Ldoi
10.1161/01.STR.0000174192.87887.70subject
Has Abstractpub_date
2005-08-01 00:00:00pages
1764-70issue
8eissn
0039-2499issn
1524-4628pii
01.STR.0000174192.87887.70journal_volume
36pub_type
杂志文章,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Accumulating evidence indicates that a variety of infections contribute to the pathogenesis of atherosclerosis, but there is controversy concerning the impact of Helicobacter pylori infections in atherosclerosis. METHODS:We evaluated seropositivity to H pylori and to its cytotoxin-associated gen...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000058481.82639.EF
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-tr...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs1201.99512
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Microvascular basal lamina damage occurs after cerebral ischemia and is important for the development of hemorrhage. The aim of this study was to determine whether hypothermia could maintain microvascular integrity in ischemic stroke. METHODS:Using the suture model, we subjected 12 rats to 3 hou...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000116866.60794.21
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although a lower serum homocysteine concentration is associated with a reduced risk of stroke in epidemiologic studies, randomized, controlled trials have yielded mixed findings regarding the effect of therapeutic homocysteine lowering on stroke prevention. We performed a meta-analysis of randomi...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.109.573410
更新日期:2010-06-01 00:00:00
abstract::A 26-year-old woman had a peripartum venous thrombotic stroke involving the right parietal lobe. The initial thrombus was present only in the right channel of a congenitally bifurcated superior sagittal sinus. This diagnosis and subsequent thrombus extension were readily shown by magnetic resonance imaging in contrast...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.3.396
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000027638.19392.7e
更新日期:2002-09-01 00:00:00
abstract::Three leukotrienes (LTB4, C4, D4) were locally applied to cerebral arterioles in doses varying from 3 X 10(-8) to 4 X 10(-7) M and each produced a dose related constriction. LTC was tested in the presence and absence of FPL-55712, a relatively specific inhibitor of leukotriene receptors. A low dose (10(-8) M) of FPL-5...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.2.262
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prediction of stroke in healthy individuals is challenging and there is a diurnal variation of stroke onset. We hypothesized that heart rate variability with a focus on nighttime heart rate variability will predict the risk of stroke in apparently healthy middle-age and elderly subjects. METHODS...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.607697
更新日期:2011-11-01 00:00:00
abstract::In a case-control study of 73 cases of cerebral hematoma diagnosed by CT scan, significant risk factors were history of hypertension, chronic alcoholism, evidence of hepatic disease, EKG abnormalities and high hematocrit values. Initial blood pressure was significantly higher in cases, but blood pressure on the third ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1126
更新日期:1986-11-01 00:00:00
abstract::Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,评审
doi:10.1161/01.str.19.8.1043
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0302.104619
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A locus containing the elastin gene has been linked to familial intracranial aneurysms in 2 distinct populations. We investigated the association of single-nucleotide polymorphisms (SNPs) and haplotypes of SNPs in the elastin gene with the occurrence of subarachnoid hemorrhage (SAH) from sporadic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000139380.50649.5c
更新日期:2004-09-01 00:00:00
abstract::Background and Purpose- The importance of weight change for the risk of stroke is not well known. We examined the associations between early- and mid-life weight change and risks of stroke and death during long-term follow-up of healthy men. Methods- We recruited healthy men aged between 40 and 59 years and performed ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027233
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prophylactic administration of simvastatin has been shown to protect against brain damage and its long-lasting behavioral consequences in neonatal rats. To establish the drug treatment window, we evaluated the effectiveness of simvastatin administered at different intervals before and after strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000080677.24419.88
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone or to carotid endarterectomy and appropriate medication. Successful carotid endarterectomy significantly reduced 10-year stroke risk in yo...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.111.000348
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2074
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It remains uncertain whether lower dose intravenous tissue-type plasminogen activator (tPA) for stroke is as effective and safe as the standard dose. METHODS:We analyzed data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Patients who were treate...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.114.005989
更新日期:2014-08-01 00:00:00
abstract::Results from 1,039 combined cervical and transcranial Doppler examinations are reported. Satisfactory transcranial signals were not found in 2.7% of the cases. Compared with angiography, the accuracy of transcranial criteria in assessing collateral flow over the circle of Willis was 94 and 88% for anterior and posteri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.6.1018
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The *2 allele of the aldehyde dehydrogenase 2 gene (ALDH2) is the most common variant in Asian populations. The variant resulting in enzyme dysfunction was highly related to coronary artery disease. Recently, genome-wide association studies also discovered that the 12q24 locus near ALDH2 gene was...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013204
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to describe the clinical and imaging features of patients with tumor-like presentation of primary angiitis of the central nervous system. METHODS:We retrospectively analyzed 10 patients enrolled in the French primary angiitis of the central nervous system cohort, who initially presented...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013917
更新日期:2016-09-01 00:00:00
abstract::Changes of regional cerebral blood flow from rest to mental activation by a visually presented spatial reasoning test were measured during normo- and hypercapnia in 10 healthy subjects. Hypercapnia, elicited by inhalation of 6% CO2, resulted in similar flow increases in all 32 cortical regions measured. Increases of f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.11.4.342
更新日期:1980-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated. METHODS:This incident ...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.30.10.2013
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endovascular treatment can improve the outcome of patients treated for ruptured intracranial aneurysms as compared with surgical clipping, but angiographic recurrences are frequent. Endothelial denudation before coil embolization may prevent recanalization and improve results of endovascular trea...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000126042.76153.f7
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Early carotid surgery or stenting after thrombolytic treatment for stroke has become more common during recent years. It is unclear whether this carries an increased risk of postoperative complications and death. The aim of this nationwide population-based study was, therefore, to investigate the...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.003763
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with unilateral significant carotid artery stenosis present with a variable intracranial hemodynamic status. In the majority of patients, hemodynamics are normal because of sufficient collateral flow. One subgroup shows poor ipsilateral hemodynamics because of a severely reduced blood su...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.10.1952
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Policy makers require evidence on the costs and outcomes of different ways of organizing stroke care. This study compared the costs and survival of different ways of providing stroke care. METHODS:Hospitalized stroke patients from 13 European centers were included, with demographic, case-mix, an...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.str.32.7.1684
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population. METHODS:We studied 3466 Japanese individuals (35-93 years old) in the Suita Stu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002957
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A number of studies have shown that reduced intrauterine growth and low birth weight are associated with raised rates of fatal and nonfatal stroke in adult life. Whether this increased risk of stroke is modified by growth in childhood or by socioeconomic status in adult life is not known. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.4.869
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. METHODS:A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001187
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Embolization with coils is increasingly used for the treatment of intracranial aneurysms. To assess the percentage of complications, the percentage of aneurysm occlusion, and the short-term outcome, we performed a systematic review of studies on embolization with controlled detachable or pushable coils. SUM...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.30.2.470
更新日期:1999-02-01 00:00:00