Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study.

Abstract:

BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was developed. We investigated the effects of the Lokomat when used with hemiparetic patients. METHODS:The authors conducted a randomized, controlled pilot study of 30 acute stroke survivors. The treatment group received 30 minutes of robotic training daily and the control group 30 minutes of conventional physiotherapy daily in addition to 30 minutes of conventional physiotherapy for each group. Outcome measures were independence of gait, gait speed, gait parameters, and body tissue composition. RESULTS:After 4 weeks of therapy, the walking ability of the Lokomat group and the control group expressed as the functional ambulation classification was significantly improved. The functional ambulation category (median+/- interquartile range) was at baseline 0+/-0 in control and 0+/-1 in the therapy group and increased after therapy to 1+/-3 in both groups significantly (P=0.01). There was no significant difference in gain of these parameters between the groups. The Lokomat group had a significantly longer single stance phase (sec; mean+/-SEM) on the paretic leg when walking on the floor. At baseline, it was 0.19+/-0.17 and after therapy 0.49+/-0.07 (P=0.014). The control group had increased their body weight approximately 1.33+/-1.40 kg (mean+/-SEM; P=0.046), mostly as fat mass, whereas the Lokomat group had lost fat mass approximately -2.9+/-1.0 kg (mean+/-SEM; P=0.016) and increased their muscle mass approximately 3.36+/-1.4 kg (mean+/- SEM; P=0.031). CONCLUSIONS:This pilot study indicates that Lokomat therapy is a promising intervention for gait rehabilitation. Although there was no difference between groups in gain of functional scores, the Lokomat group showed an advantage of robotic training over conventional physiotherapy in improvement of gait abnormality and body tissue composition.

journal_name

Stroke

journal_title

Stroke

authors

Husemann B,Müller F,Krewer C,Heller S,Koenig E

doi

10.1161/01.STR.0000254607.48765.cb

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

349-54

issue

2

eissn

0039-2499

issn

1524-4628

pii

01.STR.0000254607.48765.cb

journal_volume

38

pub_type

杂志文章,随机对照试验

相关文献

STROKE文献大全
  • Impaired dynamic cerebral autoregulation in carotid artery stenosis.

    abstract:BACKGROUND AND PURPOSE:If it could be determined whether cerebral blood flow can be maintained (autoregulated) during transient falls in arterial blood pressure, we might be able to identify patients with carotid stenosis who are at risk of stroke. However, conventional methods of determining autoregulation in such pat...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.7.1340

    authors: White RP,Markus HS

    更新日期:1997-07-01 00:00:00

  • Dietary nonprotein calories and cerebral infarction size in rats.

    abstract:BACKGROUND AND PURPOSE:Conventional diets may cause hyperglycemia in patients with neurological injuries. The purpose of this study was to examine the effect on the severity of cerebral infarction of replacing carbohydrates as the primary dietary source of nonprotein calories. METHODS:Sixty-nine Long-Evans rats were e...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.4.564

    authors: Robertson C,Goodman JC,Grossman RG,Claypool M,White A

    更新日期:1992-04-01 00:00:00

  • Acoustic shadowing on B-mode ultrasound of the carotid artery predicts ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:BACKGROUND AND PURPOSE:We examined the relationship of carotid artery lesions (CALs), with and without acoustic shadowing (AS), to incident ischemic stroke events in the Atherosclerosis Risk in Communities study cohort. METHODS:The study population consisted of 13 123 men and women aged 45 to 64 years, and free of str...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.5.1120

    authors: Hunt KJ,Evans GW,Folsom AR,Sharrett AR,Chambless LE,Tegeler CH,Heiss G

    更新日期:2001-05-01 00:00:00

  • Embolic stroke by compression maneuver during transcranial Doppler sonography.

    abstract:BACKGROUND AND PURPOSE:Embolic complications during ultrasound examinations are a rare cause of neurological deficits. The present case documents the occurrence of embolism by a nonobstructive compression maneuver during transcranial Doppler examination, resulting in a minor stroke. CASE DESCRIPTION:A 63-year-old man ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.5.1056

    authors: Khaffaf N,Karnik R,Winkler WB,Valentin A,Slany J

    更新日期:1994-05-01 00:00:00

  • Does the application of constraint-induced movement therapy during acute rehabilitation reduce arm impairment after ischemic stroke?

    abstract:BACKGROUND AND PURPOSE:Motor dysfunction after unilateral deafferentation in primates can be overcome by restraining the unaffected limb. We asked whether a constraint-induced movement (CIM) program could be implemented within 2 weeks after stroke and whether CIM is more effective than traditional upper-extremity (UE) ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.31.12.2984

    authors: Dromerick AW,Edwards DF,Hahn M

    更新日期:2000-12-01 00:00:00

  • Characteristics in Non-Vitamin K Antagonist Oral Anticoagulant-Related Intracerebral Hemorrhage.

    abstract::Background and Purpose- Given inconclusive studies, it is debated whether clinical and imaging characteristics, as well as functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus non-vitamin K antagonist (NOAC)-related ICH. Notably, clinical character...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.118.023492

    authors: Gerner ST,Kuramatsu JB,Sembill JA,Sprügel MI,Hagen M,Knappe RU,Endres M,Haeusler KG,Sobesky J,Schurig J,Zweynert S,Bauer M,Vajkoczy P,Ringleb PA,Purrucker JC,Rizos T,Volkmann J,Müllges W,Kraft P,Schubert AL,Erbgut

    更新日期:2019-06-01 00:00:00

  • Perforating branches of the middle cerebral artery. Microanatomy and clinical significance of their intracerebral segments.

    abstract::Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.6.1022

    authors: Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

    更新日期:1985-11-01 00:00:00

  • Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis.

    abstract:BACKGROUND AND PURPOSE:Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA? METHODS:We performed a sequential year-to-year cumulative meta-analysis of ...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/01.STR.0000072513.72262.7E

    authors: Wardlaw JM,Sandercock PA,Berge E

    更新日期:2003-06-01 00:00:00

  • Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats.

    abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.618496

    authors: Chiba T,Itoh T,Tabuchi M,Ooshima K,Satou T,Ezaki O

    更新日期:2012-02-01 00:00:00

  • Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:The neuroprotective efficacy of an intravenous formulation of the antioxidant ebselen has been comprehensively assessed with specific regard to conventional quantitative histopathology, subcortical axonal damage, neurological deficit, and principal mechanism of action. METHODS:Transient focal is...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0901.095725

    authors: Imai H,Masayasu H,Dewar D,Graham DI,Macrae IM

    更新日期:2001-09-01 00:00:00

  • Epidemiology and costs of acute hospital care for cerebrovascular disease in diabetic and nondiabetic populations.

    abstract:BACKGROUND AND PURPOSE:Little is known about the pattern of cerebrovascular disease (CVD) for diabetic and nondiabetic patients or about the cost of treatment for CVD in the United Kingdom. The purpose of this study was to extend previous work to describe the epidemiology and cost of acute care of CVD as a frequent com...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.6.1142

    authors: Currie CJ,Morgan CL,Gill L,Stott NC,Peters JR

    更新日期:1997-06-01 00:00:00

  • Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:Zinc protoporphyrin (ZnPP) has multiple actions. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. Interleukin-1 is produced in ischemic brain and probably contributes to ischemic injury, although the role of heme oxygenase during ischemia is unknown. Whether ZnPP treatment ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.6.1035

    authors: Kadoya C,Domino EF,Yang GY,Stern JD,Betz AL

    更新日期:1995-06-01 00:00:00

  • Gene therapy and endovascular treatment of intracranial aneurysms.

    abstract:BACKGROUND:Endovascular treatment of intracranial aneurysms is safe and effective but too often is followed by recurrences. Gene therapy may improve healing after embolization, and endovascular approaches may offer future in situ delivery systems designed to prevent aneurysm rupture. SUMMARY OF REVIEW:Advances in coil...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.STR.0000117577.94345.CC

    authors: Ribourtout E,Raymond J

    更新日期:2004-03-01 00:00:00

  • Pressure-flow relations in canine collateral-dependent cerebrum.

    abstract:BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.7.988

    authors: Muhonen MG,Sawin PD,Loftus CM,Heistad DD

    更新日期:1992-07-01 00:00:00

  • Insulin resistance as a risk factor for carotid atherosclerosis: a comparison of the Homeostasis Model Assessment and the short insulin tolerance test.

    abstract:BACKGROUND AND PURPOSE:The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. METHODS:A t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.502799

    authors: Sourij H,Schmoelzer I,Dittrich P,Paulweber B,Iglseder B,Wascher TC

    更新日期:2008-04-01 00:00:00

  • Pulse pressure in youth and carotid intima-media thickness in adulthood: the cardiovascular risk in young Finns study.

    abstract:BACKGROUND AND PURPOSE:Large pulse pressure associates with atherosclerosis, but it is unclear if it contributes to the development of atherosclerosis or if atherosclerosis leads to pulse pressure widening. We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.525253

    authors: Raitakari OT,Juonala M,Taittonen L,Jula A,Laitinen T,Kähönen M,Viikari JS

    更新日期:2009-04-01 00:00:00

  • Anticoagulant therapy in cerebrovascular disease: review and meta-analysis.

    abstract::Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,评审

    doi:10.1161/01.str.19.8.1043

    authors: Jonas S

    更新日期:1988-08-01 00:00:00

  • Health-related quality of life among long-term survivors of stroke : results from the Auckland Stroke Study, 1991-1992.

    abstract:BACKGROUND AND PURPOSE:The consequences of stroke are a major health concern. This study was conducted to compare the health-related quality of life among long-term survivors of stroke with that of the general population. METHODS:Our data are taken from a population-based case-control study of all 6-year survivors of ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.2.440

    authors: Hackett ML,Duncan JR,Anderson CS,Broad JB,Bonita R

    更新日期:2000-02-01 00:00:00

  • Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: an interhospital comparison.

    abstract:BACKGROUND AND PURPOSE:We sought to evaluate the efficacy of testing the laryngeal cough reflex in identifying pneumonia risk in acute stroke patients. METHODS:We performed a prospective study of 400 consecutive acute stroke patients examined using the reflex cough test (RCT) compared with 204 consecutive acute stroke...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.6.1203

    authors: Addington WR,Stephens RE,Gilliland KA

    更新日期:1999-06-01 00:00:00

  • High Serum Level of Matrix Metalloproteinase-7 Is Associated With Increased Risk of Spontaneous Subarachnoid Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Increased degradation of the extracellular matrix in the arterial wall by matrix metalloproteinases (MMPs) may be an important mechanism in the pathogenesis of intracranial aneurysms and subarachnoid hemorrhage (SAH). MMP-2 and MMP-9 have been suggested to be involved in matrix degradation preced...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.020660

    authors: Söderholm M,Nordin Fredrikson G,Nilsson J,Engström G

    更新日期:2018-07-01 00:00:00

  • Transesophageal echocardiography in the detection of potential cardiac source of embolism in stroke patients.

    abstract::To compare the diagnostic yields of transesophageal and transthoracic echocardiography in the detection of potential cardiac sources of embolism, 63 patients (mean +/- SD age 63 +/- 15 [range 18-87] years) with transient ischemic attacks or stroke underwent both procedures. Transthoracic echocardiography revealed a po...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.22.6.727

    authors: Cujec B,Polasek P,Voll C,Shuaib A

    更新日期:1991-06-01 00:00:00

  • Prospective study of major dietary patterns and stroke risk in women.

    abstract:BACKGROUND AND PURPOSE:Many foods have been suggested to influence the risk of stroke. However, no previous studies have examined the relationship between overall dietary patterns and risk of stroke. METHODS:Using dietary information collected in 1984 from 71,768 women aged 38 to 63 years without a history of cardiova...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000135762.89154.92

    authors: Fung TT,Stampfer MJ,Manson JE,Rexrode KM,Willett WC,Hu FB

    更新日期:2004-09-01 00:00:00

  • Childhood Stature and Growth in Relation to First Ischemic Stroke or Intracerebral Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). MET...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.019880

    authors: Gjærde LK,Truelsen TC,Baker JL

    更新日期:2018-03-01 00:00:00

  • Standard-dose intravenous tissue-type plasminogen activator for stroke is better than low doses.

    abstract:BACKGROUND AND PURPOSE:It remains uncertain whether lower dose intravenous tissue-type plasminogen activator (tPA) for stroke is as effective and safe as the standard dose. METHODS:We analyzed data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Patients who were treate...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.114.005989

    authors: Liao X,Wang Y,Pan Y,Wang C,Zhao X,Wang DZ,Wang C,Liu L,Wang Y,Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China Investigators.

    更新日期:2014-08-01 00:00:00

  • Striatal dopamine in acute cerebral ischemia of stroke-resistant rats.

    abstract::We devised the present experiments to assess the effects of ischemia on the production of dopamine in the caudate nucleus of spontaneously hypertensive stroke-resistant rats. Ringer's solution was continuously perfused at a rate of 10 microliters/min through 0.2-mm-diameter dialysis tubing implanted in the rat's cauda...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.12.1540

    authors: Kawano T,Tsutsumi K,Miyake H,Mori K

    更新日期:1988-12-01 00:00:00

  • Evaluation of genetic risk factors for silent brain infarction.

    abstract:BACKGROUND AND PURPOSE:Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.9.1881

    authors: Notsu Y,Nabika T,Park HY,Masuda J,Kobayashi S

    更新日期:1999-09-01 00:00:00

  • The pilot Stroke Data Bank: definition, design, and data.

    abstract::Four university centers collaborated to contribute 1158 patients with acute episodes of cerebrovascular disease to the pilot Stroke Data Bank, initiated by NINCDS in 1978. During the pilot project a standard set of data collection forms were developed and used at each of the collaborating centers. Data on clinical cou...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.4.740

    authors: Kunitz SC,Gross CR,Heyman A,Kase CS,Mohr JP,Price TR,Wolf PA

    更新日期:1984-07-01 00:00:00

  • Strictly Lobar Microbleeds Reflect Amyloid Angiopathy Regardless of Cerebral and Cerebellar Compartments.

    abstract:BACKGROUND AND PURPOSE:We aimed to determine whether lobar cerebellar microbleeds or concomitant lobar cerebellar and deep microbleeds, in the presence of lobar cerebral microbleeds, attribute to underlying advanced cerebral amyloid angiopathy pathology or hypertensive arteriopathy. METHODS:We categorized 71 patients ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.028487

    authors: Jung YH,Jang H,Park SB,Choe YS,Park Y,Kang SH,Lee JM,Kim JS,Kim J,Kim JP,Kim HJ,Na DL,Seo SW

    更新日期:2020-12-01 00:00:00

  • Tuberculosis and the risk of ischemic stroke: a 3-year follow-up study.

    abstract:BACKGROUND AND PURPOSE:The aim of this study is to estimate the risk of ischemic stroke during a 3-year follow-up period after a tuberculosis diagnosis using a nationwide, population-based study and a retrospective cohort design. METHOD:The study cohort comprised 2283 patients who had received treatment for tuberculos...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.567735

    authors: Sheu JJ,Chiou HY,Kang JH,Chen YH,Lin HC

    更新日期:2010-02-01 00:00:00

  • Interobserver agreement of ASPECT score distribution for noncontrast CT, CT angiography, and CT perfusion in acute stroke.

    abstract:BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.665208

    authors: Finlayson O,John V,Yeung R,Dowlatshahi D,Howard P,Zhang L,Swartz R,Aviv RI

    更新日期:2013-01-01 00:00:00