Abstract:
BACKGROUND AND PURPOSE:Previously published meta-analyses exploring the effect of statins on stroke incidence included 20,000 patients and found a 2% to 30% risk reduction. It is not clear whether this is attributable to low-density lipoprotein-cholesterol (LDL-C) reduction. Statin trials have now included >90,000 patients. We have determined the effect of statins and LDL-C reduction on stroke prevention. SUMMARY OF REVIEW:We performed a systematic review and meta-analysis of all randomized trials testing statin drugs published before August 2003. The trials were identified using a computerized PubMed search. We analyzed separately statin effect on incident strokes and on carotid intima-media thickness (IMT) according to LDL-C reduction. The relative risk reduction for stroke was 21% (odds ratio [OR], 0.79 [0.73 to 0.85]), with no heterogeneity between trials. Fatal strokes were reduced but not significantly: by 9% (OR, 0.91 [0.76 to 1.10]). There was no increase in hemorrhagic strokes (OR, 0.90 [0.65 to 1.22]). Statin size effect was closely associated with LDL-C reduction. Each 10% reduction in LDL-C was estimated to reduce the risk of all strokes by 15.6% (95% CI, 6.7 to 23.6) and carotid IMT by 0.73% per year (95% CI, 0.27 to 1.19). CONCLUSIONS:Statins may reduce the incidence of all strokes without any increase in hemorrhagic strokes, and this effect is mainly driven by the extent of between-group LDL-C reduction. Carotid IMT progression also strongly correlated with LDL-C reduction.
journal_name
Strokejournal_title
Strokeauthors
Amarenco P,Labreuche J,Lavallée P,Touboul PJdoi
10.1161/01.STR.0000147965.52712.fasubject
Has Abstractpub_date
2004-12-01 00:00:00pages
2902-9issue
12eissn
0039-2499issn
1524-4628pii
01.STR.0000147965.52712.fajournal_volume
35pub_type
杂志文章,meta分析,评审相关文献
STROKE文献大全abstract::Background and Purpose- We aimed to compare outcomes of ischemic stroke patients with nonvalvular atrial fibrillation between earlier and later initiation of direct oral anticoagulants (DOACs) after stroke onset. Methods- From data for 1192 nonvalvular atrial fibrillation patients with acute ischemic stroke or transie...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.119.028118
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral sinovenous thrombosis is a rare disease with severe neurological sequelae. The aim of this retrospective multicenter study was to investigate the clinical course, possible risk factors, and outcome of a cohort of neonatal patients with sinovenous thrombosis and, second, to estimate the i...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.110.583542
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pathophysiology of borderzone infarcts is not well understood. We investigated whether combined diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) could identify pathophysiologically meaningful categories of borderzone infarcts. METHODS:Seventeen patients with borderzone i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.5.1090
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ultrasonographic plaque echolucency has been studied as a stroke risk marker in carotid atherosclerotic disease. We performed a systematic review and meta-analysis to summarize the association between ultrasound-determined carotid plaque echolucency and future ipsilateral stroke risk. METHODS:We...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.114.006091
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lower birth weight is associated with increased risk of stroke, but little is known about the mechanism for this association or influence in addition to vascular risk factors. We investigated whether there was an association between birth parameters and imaging markers of white matter integrity i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.527259
更新日期:2009-04-01 00:00:00
abstract::The trends in age adjusted and age and sex specific mortality rates for the period 1968-1980 are compared for ischaemic heart disease and cerebrovascular disease. For both sexes and at all ages over 45 the mortality rates for cerebrovascular disease have fallen significantly. However, the mortality rates for ischaemic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.5.582
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid angioplasty and stenting (CAS) is associated with higher risk of periprocedural stroke and death when compared with carotid endarterectomy (CEA). By contrast, the risk of myocardial infarction (MI) was higher after CEA than after CAS in randomized trials. However, numbers were small, and ...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.115.010052
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patient selection is crucial in the endovascular treatment of acute ischemic stroke patients. Baseline computed tomographic (CT) images, evaluated with the Alberta Stroke Program Early CT Scale (ASPECTS), are considered significant predictors of outcome. In this study, we evaluated CT images and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001068
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The watershed cortical areas are the first to be deprived of sufficient blood flow in the event of cerebral hypoperfusion and will be the sites of watershed microinfarcts. Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed corti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.0000024523.82311.77
更新日期:2002-08-01 00:00:00
abstract::Background and Purpose- To identify the specific post-endovascular stroke therapy (EVT) peak systolic blood pressure (SBP) threshold that best discriminates good from bad functional outcomes (a priori hypothesized to be 160 mm Hg), we conducted a prospective, multicenter, cohort study with a prespecified analysis plan...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.119.026889
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Questionnaire for Verifying Stroke-Free Status (QVSFS), a method for verifying stroke-free status in participants of clinical, epidemiological, and genetic studies, has not been validated in low-income settings where populations have limited knowledge of stroke symptoms. We aimed to validate ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.115.010374
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program systematically implements, at the time of acute transient ischemic attack (TIA) or ischemic stroke admission, 8 medication/behavioral secondary prevention measures known to improve outcome in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000147967.49567.d6
更新日期:2004-12-01 00:00:00
abstract::Background and Purpose- Besides the established spot sign (SS) in computed tomography angiography (CTA), there is growing evidence that different imaging markers in noncontrast CT offer great value for outcome prediction in patients with intracerebral hemorrhage (ICH). However, it is unclear how the concurrent presenc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021625
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. METHODS:We examined primary outcomes by National Institutes of Heal...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001126
更新日期:2013-11-01 00:00:00
abstract::Background and Purpose- Diffusion-weighted imaging (DWI) hyperintensities in intracerebral hemorrhage (ICH) are associated with increased risk of recurrent ICH, cognitive impairment, and death, but whether these lesions are specific to a subtype of ICH remains uncertain. We investigated the association between DWI les...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021407
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid angioplasty may offer an effective treatment for carotid stenosis, but there has been concern about the incidence and clinical consequences of distal embolization. Transcranial Doppler monitoring in carotid endarterectomy has demonstrated embolic signals during this procedure. We used thi...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.25.12.2403
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to evaluate the efficacy of testing the laryngeal cough reflex in identifying pneumonia risk in acute stroke patients. METHODS:We performed a prospective study of 400 consecutive acute stroke patients examined using the reflex cough test (RCT) compared with 204 consecutive acute stroke...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.6.1203
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Estrogen receptor alpha (ESR1) gene variation is associated with a range of important estrogen-dependent characteristics, including responses of lipid profile and atherosclerotic severity to hormone replacement therapy, coronary heart disease risk, and migraine. The roles that reproductive steroi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000181088.76518.ec
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Coronary artery bypass grafting (CABG) is a frequently performed surgical procedure that can be associated with neurological complications. Some studies have demonstrated that new focal brain lesions, detected by MRI, can develop after CABG. Furthermore, it has been suggested that the presence of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000040408.75704.15
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We studied whether the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine reduces focal cerebral ischemic damage in a relatively noninvasive stroke model in which the rat middle cerebral artery (MCA) is occluded using an intravascular filament. METHODS:In rats anesthetized with halo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.2.317
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. METHODS:Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonat...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.107.503870
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke. METHODS:The relations between blood calcium level obtained early (<4.5 hours), and del...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.513499
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transorbital sonography may help establish diagnosis of central retinal artery occlusion (CRAO). Next to Doppler sonographic proof of CRAO, an intra-arterial spot sign can be detected in some cases. We hypothesized that it reflects calcified components. It may be associated with embolization from...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.009839
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ischemic brain injury secondary to an arterial occlusion is characterized by acute local inflammation. Blood polymorphonuclear leukocytes (PMNL), primarily neutrophils, adhere to endothelial cells and rapidly invade the injured brain after the arterial occlusion. This neutrophilic invasion might ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.2.462
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Eligibility criteria determine the external validity (generalizability) of the results of randomized controlled trials. To increase the number of outcome events, and hence statistical power, some recent stroke prevention trials have required additional vascular risk factors for eligibility. METH...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/01.STR.0000195125.59349.23
更新日期:2006-01-01 00:00:00
abstract::The reactivity of cerebral blood vessels to changes in PaCO2 in areas of the cerebral cortex with or without diaschisis was investigated in 13 patients in a subacute or chronic stage after a small capsular infarct. A focal area of hypoperfusion (area of diaschisis) was detected in the ipsilateral sensorimotor cortex i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.840
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid angioplasty and stenting (CAS) has a higher incidence of periprocedural stroke compared with endarterectomy. Identifying CAS steps with the highest likelihood of embolization may have important implications. We evaluated CAS safety by correlating the findings of procedural transcranial Do...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000659
更新日期:2013-05-01 00:00:00
abstract::Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in v...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.1085
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Some strokes of unknown etiology may be the result of a paradoxical embolism traversing through a nonfused foramen ovale (patent foramen ovale [PFO]). The utility of percutaneously placed devices for treatment of patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO is unkno...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.110.593376
更新日期:2010-12-01 00:00:00
abstract::A retrospective analysis of 248 patients with stroke (average age 67, range 17-98) admitted to a stroke rehabilitation unit over a sixteen month period showed that 80% of these patients were able to return home after an average length of stay (LOS) of 43 days. At discharge 85% of the group were ambulatory and 56% requ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.6.651
更新日期:1977-11-01 00:00:00