Birth parameters are associated with late-life white matter integrity in community-dwelling older people.

Abstract:

BACKGROUND AND PURPOSE:Lower birth weight is associated with increased risk of stroke, but little is known about the mechanism for this association or influence in addition to vascular risk factors. We investigated whether there was an association between birth parameters and imaging markers of white matter integrity in community-dwelling older people. METHODS:One hundred seven volunteers, age 75 to 81 years, had birth parameters (weight, length, placental weight, gestational age) extracted from archives. Neuroimaging included assessment of white matter lesions and diffusion tensor-magnetic resonance imaging parameters in normal-appearing white matter. RESULTS:Lower placental weight was correlated with increased white matter lesion load (P<0.05) and diffusion tensor-magnetic resonance imaging parameters (P<0.05). Birth weight and frontal white matter fractional anisotropy were significantly correlated (P<0.05). These associations were only slightly attenuated when corrected for gestational age, sex, age at scan, and vascular risk factors. CONCLUSIONS:Lower placental and possibly lower birth weight were associated with sensitive neuroimaging measures of white matter lesions in this cohort, independent of vascular risk factors later in life. Further studies are required to confirm these findings to explore life-long risk factors for age-related white matter changes.

journal_name

Stroke

journal_title

Stroke

authors

Shenkin SD,Bastin ME,Macgillivray TJ,Deary IJ,Starr JM,Wardlaw JM

doi

10.1161/STROKEAHA.108.527259

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1225-8

issue

4

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.108.527259

journal_volume

40

pub_type

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